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Behavioral strategies to prevent and mitigate COVID-19 infection

Sports Medicine and Health Science 2020年第3期2卷 115-125页

作者： noah t.hutchinson Andrew Steelman Jeffrey A.Woods Division of Nutritional Sciences University of Illinois at Urbana-ChampaignChampaignILUSA Department of Animal Sciences University of Illinois at Urbana-ChampaignChampaignILUSA Neuroscience Program University of Illinois at Urbana-ChampaignChampaignILUSA Carle R.Woese Institute for Genomic Biology University of Illinois at Urbana-ChampaignChampaignILUSA Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignChampaignILUSA

the single stranded RNA virus SARS-CoV-2 has caused a massive addition to the already leading global cause of mortality,viral respiratory tract *** by and associated with early and deleteriously enhanced production of pro-inflammatory cytokines by respiratory epithelial cells,severe COVID-19 illness has the potential to inflict acute respiratory distress syndrome and even *** to the fast spreading nature of COVID-19 and the current lack of a vaccine or specific pharmaceutical treatments,understanding of viral pathogenesis,behavioral prophylaxis,and mitigation tactics are of great public health *** review article outlines the immune response to viral pathogens,and due to the novelty of COVID-19 and the large body of evidence suggesting the respiratory and immune benefits from regular moderate intensity exercise,provides observational and mechanistic evidence from research on other viral infections that suggests strategically planned exercise regimens may help reduce susceptibility to infection,while also mitigating severe immune responses to infection commonly associated with poor COVID-19 *** propose that regular moderate intensity exercise should be considered as part of a combinatorial approach including widespread hygiene initiatives,properly planned and well-executed social distancing policies,and use of efficacious facial coverings like N95 *** discerning COVID-19 pathogenesis mechanisms,transfer dynamics,and individual responses to pharmaceutical and adjunct treatments are needed to reduce viral transmission and bring an end to the COVID-19 pandemic.

关键词： Exercise COVID-19 Prophylaxis Pathogenesis Cytokine

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the COVID-19 pandemic and physical activity

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Sports Medicine and Health Science 2020年第2期2卷 55-64页

作者： Jeffrey A.Woods noah t.hutchinson Scott K.Powers William O.Roberts Mari Carmen Gomez-Cabrera Zsolt Radak Istvan Berkes Anita Boros Istvan Boldogh Christiaan Leeuwenburgh Helio Jose Coelho-Júnior Emanuele Marzetti Ying Cheng Jiankang Liu J.Larry Durstine Junzhi Sun Li Li Ji Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignUSA Division of Nutritional Sciences University of Illinois at Urbana-ChampaignUSA Department of Applied Physiology and Kinesiology University of FloridaGainesvilleUSA Department of Family Medicine and Community Health University of Minnesota Medical SchoolMinneapolisUSA Freshage Research Group Department of Physiology Faculty of MedicineUniversity of Valencia and CIBERFES.Fundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain Research Institute of Sport Science University of Physical EducationBudapestHungary National University of Public Service BudapestHungary Department of Microbiology and Immunology University of Texas Medical Branch at GalvestonUSA Institute on Aging College of MedicineUniversity of FloridaGainesvilleUSA Universita Cattolica Del Sacro Cuore RomeItaly Fondazione Policlinico Universitario“Agostino Gemelli”IRCCS Universita Cattolica Del Sacro CuoreRomeItaly Center for Mitochondrial Biology and Medicine The Key Laboratory of Biomedical Information Engineering of Ministry of EducationSchool of Life Science and TechnologyXi'an Jiaotong UniversityXi'anChina Department of Exercise Science Norman J.Arnold School of Public HealthUniversity of South CarolinaColumbiaUSA Institute of Sports Medicine and Health Chengdu Sport UniversityChengduChina the Laboratory of Physiological Hygiene and Exercise Science School of KinesiologyUniversity of Minnesota Twin CitiesMinneapolisUSA

the SARS-CoV-2-caused COVID-19 pandemic has resulted in a devastating threat to human society in terms of health,economy,and *** the virus usually first invades and infects the lung and respiratory track tissue,in extreme cases,almost all major organs in the body are now known to be negatively impacted often leading to severe systemic failure in some ***,there is currently no effective treatment for this ***-existing pathological conditions or comorbidities such as age are a major reason for premature death and increased morbidity and *** immobilization due to hospitalization and bed rest and the physical inactivity due to sustained quarantine and social distancing can downregulate the ability of organs systems to resist to viral infection and increase the risk of damage to the immune,respiratory,cardiovascular,musculoskeletal systems and the *** cellular mechanisms and danger of this“second wave”effect of COVID-19 to the human body,along with the effects of aging,proper nutrition,and regular physical activity,are reviewed in this article.

关键词： Aging Brain Cardiovascular COVID-19 Immune Muscle Nutrition Physical inactivity Respiratory

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Peptide-based targeting of immunosuppressive cells in cancer

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Bioactive Materials 2020年第1期5卷 92-101页

作者： noah t.trac Eun Ji Chung Department of Biomedical Engineering University of Southern CaliforniaLos AngelesCAUSA Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCAUSA Division of Nephrology and Hypertension Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Vascular Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research University of Southern CaliforniaLos AngelesCAUSA Norris Comprehensive Cancer Center Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Cancer progression is marked by the infiltration of immunosuppressive cells,such as tumor-associated macrophages(tAMs),regulatory t lymphocytes(tregs),and myeloid-derived suppressor cells(MDSCs).these cells play a key role in abrogating the cytotoxic t lymphocyte-mediated(CtL)immune response,allowing tumor growth to proceed ***,targeting these immunosuppressive cells through the use of peptides and peptide-based nanomedicine has shown promising *** we review the origins and functions of immunosuppressive cells in cancer progression,peptide-based systems used in their targeting,and explore future avenues of research regarding cancer *** success of these studies demonstrates the importance of the tumor immune microenvironment in the propagation of cancer and the potential of peptide-based nanomaterials as immunomodulatory agents.

关键词： Immunosuppression tumor microenvironment Peptide Nanoparticle

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Superconductivity in antiperovskites

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npj Computational Materials 2022年第1期8卷 1424-1433页

作者： noah Hoffmann tiago F.t.Cerqueira Jonathan Schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga3004-516CoimbraPortugal

We present a comprehensive theoretical study of conventional superconductivity in cubic antiperovskites materials with composition XYZ_(3) where X and Z are metals,and Y is H,B,C,N,O,and *** starting point are electron–phonon calculations for 397 materials performed with density-functional perturbation *** 43%of the materials are dynamically unstable,we discovered 16 compounds close to thermodynamic stability and with t_(c) higher than 5 *** these results to train interpretable machine-learning models,leads us to predict a further 57(thermodynamically unstable)materials with superconducting transition temperatures above 5 K,reaching a maximum of 17.8 K for ***,the models give us an understanding of the mechanism of superconductivity in *** combination of traditional approaches with interpretable machine learning turns out to be a very efficient methodology to study and systematize whole classes of materials and is easily extendable to other families of compounds or physical properties.

关键词： properties theory perovskite

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Searching for ductile superconducting Heusler X_(2)YZ compounds

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npj Computational Materials 2023年第1期9卷 919-927页

作者： noah Hoffmann tiago F.t.Cerqueira Pedro Borlido Antonio Sanna Jonathan Schmidt Miguel A.L.Marques Institut für Physik Martin-Luther-Universität Halle-WittenbergD-06099 HalleGermany CFisUC Department of PhysicsUniversity of CoimbraRua Larga 3004-516 CoimbraPortugal Max-Planck-Institut für Mikrostrukturphysik Weinberg 2D-06120 HalleGermany

Heusler compounds attract a great deal of attention from researchers thanks to a wealth of interesting properties,among which is *** we perform an extensive study of the superconducting and elastic properties of the cubic(full-)Heusler family using a mixture of ab initio methods,as well as interpretable and predictive machine-learning *** analyzing the statistical distributions of these properties and comparing them to anti-perovskites,we recognize universal behaviors that should be common to all conventional superconductors while others turn out to be specific to the material *** total,we discover a total of eight hypothetical materials with critical temperatures above 10 K to be compared with the current record of t_(c)=4.7 K in this ***,we expect most of these materials to be highly ductile,making them potential candidates for the manufacture of wires and tapes for superconducting magnets.

关键词： ductile compounds superconducting

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the formation of orthogonal joint systems and cuboidal blocks:New insights gained from flat-lying limestone beds in the region of Havre-Saint-Pierre(Quebec,Canada)

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第12期15卷 3079-3093页

作者： Shaocheng Ji Yvéric Rousseau Denis Marcotte noah John Phillips Département des Génies Civil Géologique et des MinesÉcole Polytechnique de MontréalMontréalQuébecH3C 3A7Canada Department of Geology Lakehead UniversityThunder BayOntarioP7B 5E1Canada

Vertical orthogonal joints are a common feature in shallow crustal *** are several competing theories for their formation despite the *** examined the exceptional exposures of orthogonal joints in flat-lying Ordovician limestone beds from the Havre-Saint-Pierre Region in Quebec,Canada(north shore of Saint-Lawrence River)to test conceptual models of joint formation in a natural *** the region,the spacing of cross-joints is consistently larger than the spacing of systematic joints by a factor of 1.5 *** joint-spacing-to-bed-thickness ratios(s/t)are much larger in these beds(s/t=4.3 for systematic joints,and 6.4 for cross-joints)than those in higher strained strata along the south shore of the Saint-Lawrence River(s/t=1),highlighting the effect of tectonic strain in decreasing fracture spacing and block *** high values of s/t indicate that cross-joint formation was unlikely caused by a switch from compression to tension once a critical s/t ratio for systematic joints was reached(as hypothesized in previous studies).We proposed a new model for the formation of orthogonal joint systems where the principal stress axes locally switch during the formation of systematic *** presence of ladder-shaped orthogonal joints suggests a state of effective stress withσ_(1)^(∗)≫0>σ_(2)^(∗)>σ_(3)^(∗)and whereσ_(2)^(∗)-σ_(3)^(∗)is within the range of fracture strength variability at the time of *** research provides a new mechanical model for the formation of orthogonal joint systems and cuboidal blocks.

关键词： Plato's cuboids Orthogonal joints Fracture spacing Limestone Layered rock mechanics Appalachian geology

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利用真实地震模拟技术解释曲流河点沙坝沉积

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国外油气勘探 1993年第2期 215-218页

作者： J.t.noah 张申

本文介绍了一个以拉勒米河的某一段作样板建立的三维地震模型。这个地震模型的主要目的是分析包裹在低速页岩之中的高速点沙坝砂岩的地震响应,以揭示二维资料的解释陷井以及显示三维资料和非零井源距VSP的优点;其次是要说明:在某些情况... 详细信息

本文介绍了一个以拉勒米河的某一段作样板建立的三维地震模型。这个地震模型的主要目的是分析包裹在低速页岩之中的高速点沙坝砂岩的地震响应,以揭示二维资料的解释陷井以及显示三维资料和非零井源距VSP的优点;其次是要说明:在某些情况下,点砂坝可利用各种地震方法加以检测和开发。模式分为三种类型:二维模型、三维模型和非零并源距VSP模型。建立这一模型的想法最初来自D.C斯旺森的著作《曲流河沉积》(CygnetGroup,1976)。他利用拉勒米河某段的航空照片来说明曲流河道的复杂性,并大致地勾画出了漫滩和一些点沙坝沉积。模拟的点沙坝的最大厚度为40ft,埋深8000ft。本文详细介绍了模

关键词：地震模拟三维解释垂直地震剖面法二维模型三维模型

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte thomas Gawne thomas Campbell Shenyuan Ren YuanFeng Shi trevor hutchinson Oliver Humphries thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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State of Knowledge on Starch as an Alternative Solution to Petrochemical Resources—A Review

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Journal of Minerals and Materials Characterization and Engineering 2023年第2期11卷 49-62页

作者： Jonas Peequeur Essome Mbang Pierre Marcel Anicet noah Laurent Libog téclaire Ngoup Michel Mbere taoga Fabien Betene Ebanda Laboratory of Mechanical ENSET University of Douala Douala Cameroon Department of Mechanical Engineering National Advanced School of Engineering University of Yaoundé I Yaoundé Cameroon Laboratory of Mechanics and Materials Adapted (LAMMA) ENSET University of Douala Douala Cameroon

the use of plastics from petrochemical resources poses environmental impacts, and one of the alternative solutions is the use of starch. the objective of this present work has been to present the literature on starch, and to highlight the debate in the development of composite films. the approach adopted was to present the state of the art on starch and thermoplastic starch matrix composites. the work shows that starch is available worldwide and can be used in the manufacture of biodegradable plastics;the debate remains on the reinforcement of thermoplastic starch to improve its physical and mechanical properties poor;then researchers must diversify the reinforcements to see the impact on the properties of thermoplastic starch.

关键词： Plastics Starch Composite Films thermoplastic Starch Biodegradable

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MicroRNA signature in patients with hepatocellular carcinoma associated with type 2 diabetes

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World Journal of Gastroenterology 2019年第42期25卷 6322-6341页

作者： Moustafa Nouh Elemeery Marwa Anwar Mohamed Marwa Ahmed Madkour Mohammed Mohammed Shamseya Noha Mahmoud Issa Ahmed noah Badr Doaa Ahmed Ghareeb Cheol-Ho Pan Département de Neurosciences CRCHUMUniversitéde MontréalMontréalQuebec H2X 3E4Canada Medical Biotechnology Laboratory Genetic Engineering and Biotechnology Research DivisionNational Research CentreCairo 12622Egypt Natural Product Informatics Research Center KIST Gangneung Institute of Natural ProductsGangneung 25451South Korea Division of Bio-Medical Science and technology KIST SchoolKorea University of Science and TechnologySeoul 02792South Korea Department of Chemical Pathology Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Experimental and Clinical Internal Medicine Department Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Human Genetics Department Medical Research InstituteAlexandria UniversityAlexandria 21511Egypt Food toxicology and Contaminates Department National Research CentreDokkiCairo 12622Egypt Bioscreening and preclinical trial lab Biochemistry DepartmentFaculty of ScienceAlexandria UniversityAlexandria 12522Egypt Pharmaceutical and fermentation industries development center the city of scientific research and technological applicationsAlexandria 26411Egypt

BACKGROUND Nonalcoholic steatohepatitis-related cirrhosis is one of the liver complications in type 2 diabetes mellitus(t2DM)and reported to be a risk factor for developing hepatocellular carcinoma(HCC).A reliable screening biomarker of liver cirrhosis(LC)and HCC among t2DM patients is important to reduce the morbidity and mortality of this ***(miRNA)is considered a key player in HCC and t2DM,and it might be a hidden culprit in diabetes-associated HCC,making it a promising reliable prognostic *** to investigate the signature of serum miRNAs as early biomarkers for the screening of HCC among diabetic *** Expression profiles of miRNAs in serum samples of diabetic LC and diabetic HCC patients were assessed using Illumina sequencing;then,Rt-qPCR was used to validate significantly altered miRNAs between the two *** miRNAs were tested in serum samples of 200 t2DM patients,270 LC patients,200 HCC patients,and 225 healthy control ***,receiver operating characteristic(ROC)analysis,with area under the curve(AUC),was performed to assess the diagnostic performance of the screened miRNAs for discriminating HCC from LC and nonmalignant patients(LC+t2DM).RESULtS Expression of the sequenced miRNAs in serum was different in HCC vs LCpositive t2DM *** miRNAs(miR-34a,miR-221)were significantly upregulated and five miRNAs(miR-16,miR-23-3p,miR-122-5p,miR-198,miR-199a-3p)were significantly down-regulated in HCC compared to LC *** of ROC curve demonstrated that the combination of these seven miRNAs can be used as a reliable biomarker for detection of HCC in diabetic patients,as it could identify HCC with high diagnostic accuracy in diabetic LC patients(AUC=0.993)and in diabetic nonmalignant patients(AUC=0.961).CONCLUSION this study validates a panel of serum miRNAs that can be used as a reliable noninvasive screening biomarker of HCC among t2DM cirrhotic and noncirrhotic *** study recommends furt

关键词： MicroRNA Hepatocellular carcinoma type 2 diabetes Nonalcoholic fatty liver disease

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