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Ohio solid organ transplantation consortium criteria for liver transplantation in patients with alcoholic liver disease

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World Journal of Hepatology 2016年第27期8卷 1149-1154页

作者： Kaveh Hajifathalian Annette Humberson Mohamad A Hanouneh David S Barnes Zubin Arora nizar n zein Bijan Eghtesad Dympna Kelly Ibrahim A Hanouneh Department of Internal Medicine Cleveland Clinic Foundation Department of Transplant Social Work Cleveland Clinic Foundation Department of Gastroenterology and Hepatology Cleveland Clinic Foundation Department of General Surgery Cleveland Clinic Foundation

AIM To evaluate risk of recidivism on a case-by-case *** From our center's liver transplant program,we selected patients with alcoholic liver disease who were listed for transplant based on Ohio Solid Organ Transplantation Consortium(OSOTC) exception *** were considered to have either a low or medium risk of recidivism,and had at least one or three or more months of abstinence,*** were matched based on gender,age,and Model for End-Stage Liver Disease(MELD) score to controls with alcohol-induced cirrhosis from Organ Procurement and Transplant network *** Thirty six patients with alcoholic liver disease were approved for listing based on OSOTC exception criteria and were matched to 72 *** patients(53%) with a median [Inter-quartile range(IQR)] MELD score of 24(13) received transplant and were followed for a median of 3.4 *** were matched to 38 controls with a median(IQR) MELD score of 25(9).At one and five years,cumulative survival rates(± standard error) were 90% ± 7% and 92% ± 5% and 73% ± 12% and 77% ± 8% in patients and controls,respectively(Log-rank test,P = 0.837).Four(21%) patients resumed drinking by last follow-up *** Compared to traditional criteria for assessment of risk of recidivism,a careful selection process with more flexibility to evaluate eligibility on a case-by-case basis can lead to similar survival rates after transplantation.

关键词： Alcohol-induced disorders Alcoholic liver cirrhosis Mortality Survival Liver transplantation

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Histological abnormalities of the small bowel mucosa in cirrhosis and portal hypertension

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World Journal of Gastroenterology 2008年第41期14卷 6370-6375页

作者： Jamilé Wakim-Fleming nizar n zein Ana Bennett Rocio Lopez Janice Santisi William D Carey Department of Gastroenterology and Hepatology Cleveland Clinic Foundation Cleveland Department of Pathology/Immunology Cleveland Clinic Foundation Cleveland Department of Quantitative Health Sciences Cleveland Clinic Foundation Cleveland

AIM: To study the small bowel (SB) mucosa on biopsy in cirrhotic patients with portal hypertension and in non-cirrhotic controls and grade fi ndings according to the Marsh criteria. METHODS: We prospectively enrolled 51 consecutive patients undergoing an upper endoscopy for their routine medical care. Twenty f ive patients with cirrhosis and portal hypertension were compared to 26 controls. We obtained coeliac serology and multiple upper small bowel biopsies on all 51 patients. A GI pathologist interpreted biopsies and graded fi ndings according to the Marsh criteria. We assessed equivalence in Marsh grade between cirrhotic and non-cirrhotic controls using the Mann-Whitney test for equivalence. RESULTS: Gender, ethnicity and age were similar between both groups. Marsh grades were equivalent between the groups. Grade of 0 was present in 96% and grade of 1 was present in 4% of both groups and there was no villus atrophy or decrease in villus/crypt ratio in patients with portal hypertension. COnCLUSIOn: This study provides evidence for the lack of villus atrophy in patients with cirrhosis and portal hypertension, and supports the continuous reliance on the Marsh criteria when the diagnosis of coeliac disease is to be made in the presence of cirrhosis.

关键词： Cirrhosis Portal hypertension Coeliac disease Marsh criteria Small bowel mucosa

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Metabolomics studies identify novel diagnostic and prognostic indicators in patients with alcoholic hepatitis

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World Journal of Hepatology 2016年第10期8卷 499-508页

作者： Mona Ascha Zeneng Wang Mustafa S Ascha Raed Dweik nizar n zein David Grove J Mark Brown Stephanie Marshall Rocio Lopez Ibrahim A Hanouneh Department of Gastroenterology and Hepatology Cleveland Clinic Department of Cellular and Molecular Medicine Cleveland Clinic Department of Pulmonary Allergy and Critical Care Medicine/Respiratory Institute Cleveland Clinic Department of Quantitative Health Science Cleveland Clinic Minnesota Gastroenterology Min- neapolis

AIM: To identify plasma analytes using metabolomics that correlate with the diagnosis and severity of liver disease in patients with alcoholic hepatitis(AH).METHODS: We prospectively recruited patients with cirrhosis from AH(n = 23) and those with cirrhosis with acute decompensation(AD) from etiologies other than alcohol(n = 25). We used mass spectrometry to identify 29 metabolic compounds in plasma samples from fasted subjects. A receiver operating characteristics analysis was performed to assess the utility of biomarkers in distinguishing acute AH from alcoholic cirrhosis. Logistic regression analysis was performed to build a predictive model for AH based on clinical characteristics. A survival analysis was used to construct Kaplan Meier curves evaluating transplant-free ***: A comparison of model for end-stage liver disease(MELD)-adjusted metabolomics levels between cirrhosis patients who had AD or AH showed that patients with AH had significantly higher levels of betaine, and lower creatinine, phenylalanine, homocitrulline, citrulline, tyrosine, octenoyl-carnitine, and symmetric dimethylarginine. When considering combined levels, betaine and citrulline were highly accurate predictors for differentiation between AH and AD(area under receiver operating characteristics curve = 0.84). The plasma levels of carnitine [0.54(0.18, 0.91); P = 0.005], homocitrulline [0.66(0.34, 0.99); P nd pentanoyl-carnitine [0.53(0.16, 0.90); P = 0.007] correlated with MELD scores in patients diagnosed with AH. Increased levels of many biomarkers(carnitine P = 0.005, butyrobetaine P = 0.32, homocitrulline P = 0.002, leucine P = 0.027, valine P = 0.024, phenylalanine P = 0.037, tyrosine P = 0.012, acetyl-carnitine P = 0.006, propionyl-carnitine P = 0.03, butyryl-carnitine P = 0.03, trimethyl-lisine P = 0.034, pentanoyl-carnitine P = 0.03, hexanoyl-carnitine P = 0.026) were associated with increased mortality in patients with AH. COnCLUSIOn: Metabolomics plasma anal

关键词： Metabolomics Biomarkers Liver disease Model for end-stage liver disease Cirrhosis Alcoholic hepatitis Liver biopsy

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Alpha-1 antitrypsin deficiency and the risk of hepatocellular carcinoma in end-stage liver disease

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World Journal of Hepatology 2015年第10期7卷 1427-1432页

作者： Clara Antoury Rocio Lopez nizar zein James K Stoller naim Alkhouri Department of Internal Medicine Cleveland Clinic Foundation Department of Quantitative Health Sciences Cleveland Clinic Foundation Department of Gastroenterology and Hepatology and Digestive Disease Institute Cleveland Clinic Foundation Departments of Pulmonary and Critical Care Respiratory Institute and Education InstituteCleveland Clinic Foundation

AIM:To evaluate the association between alpha-1 antitrypsin deficiency(A1ATD) and hepatocellular carcinoma(HCC) in patients with end-stage liver disease(ESLD).METHODS:Patients with cirrhosis and ESLD referred to the Cleveland Clinic Foundation for liver transplantation between 2003 and 2014 were included in the study(n = 675). ESLD was defined as having histological features of cirrhosis and/or radiological evidence of cirrhosis in the context of portal hypertension(ascites,variceal bleeding,thrombocytopenia,or hepatic encephalopathy). A1 ATD was diagnosed using phenotype characterization(MZ or ZZ),liver biopsy detection of PAS-positive diastaseresistant(PAS+) globules,or both. Patients with other causes of liver diseases such as hepatitis C virus(HCV),alcoholic liver disease and non-alcoholic steatohepatitis(nASH) or nASH were also included in the study. HCC was diagnosed by using imaging modalities,biopsy findings,or explanted liver inspection. Follow-up time was defined as the number of years from the diagnosis of cirrhosis to the diagnosis of hepatocellular carcinoma,or from the diagnosis of cirrhosis to the last follow up visit. The rate of HCC was assessed using time-tointerval analysis for interval censored ***:This study included 675 patients. 7% of subjects had A1ATD(n = 47). Out of all subjects who did not have A1 ATD,46% had HCV,17% had alcoholic liver disease,19% had nASH and 18% had another primary diagnosis. Of the 47 subjects with A1 ATD,15 had a primary diagnosis of A1ATD(PI*ZZ phenotype and PAS+ globules),8 had a PI*MZ phenotype alone,14 had PAS+ alone,and 10 had both the PI*MZ phenotype and PAS+. Median follow-up time was 3.4(25th,75 th percentiles:1,5.2) years. The overall rate of hepatocellular carcinoma in all subjects was 29%(n = 199). In the A1 ATD group,the incidence rate of HCC was 8.5% compared to 31% in the group of patients with other causes of cirrhosis(P = 0.001). Patients with ESLD due to A1 ATD had the lowest yearly cumulativ

关键词： Hepatocellular carcinoma Liver cirrhosis End-stage liver disease Hepatitis C virus Alpha-1antitrypsin deficiency

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肝硬化进展的特性：丙型肝炎感染人群老龄化的意义

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传染病网络动态 2007年第12期 37-39页

作者： nizar n. zein MD 杨露绮（编译）

在发现丙型肝炎病毒（HCV）后的早几年，HCV在输血后肝炎中的主要作用以及暴露后所引起持续感染的趋势已得到广泛证实。经过这些早期观察后，医学科学界就HCV是否可能导致威胁生命的并发症或增加被感染宿主死亡率的问题进行大量的讨论... 详细信息

在发现丙型肝炎病毒（HCV）后的早几年，HCV在输血后肝炎中的主要作用以及暴露后所引起持续感染的趋势已得到广泛证实。经过这些早期观察后，医学科学界就HCV是否可能导致威胁生命的并发症或增加被感染宿主死亡率的问题进行大量的讨论。然而，令人注目的证据证明，HCV感染与肝硬化密切相关，而且可引起肝衰竭、肝细胞肝癌（HCC）的相关性并发症。随后一系列精心设计的研究提示，HCV感染病人的肝相关性死亡率有所上升。目前，已确定地认为HCV感染与实际发病率和死亡率有关，且代表着全球性的公共卫生问题。

关键词：丙型肝炎病毒感染人群肝硬化老龄化 HCV感染相关性并发症公共卫生问题输血后肝炎

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Separation of Inorganic Anions Using Methacrylate-Based Monolithic Column Modified with Trimethylamine in Ion Chromatography Capillary System

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American Journal of Analytical Chemistry 2013年第9期4卷 451-456页

作者： Fitri Mairizki Athika Rahmah &nbsp Hilma Radhia Putri Rahmiana zein Lee Wah Lim Toyohide Takeuchi Edison Munaf Department of Chemistry Faculty of Engineering Gifu University Gifu Japan Department of Chemistry Faculty of Mathematics and Natural Sciences Andalas Universiy Padang Indonesia

Methacrylate-based monolithic column was prepared in fused-silica capillary (80 ′ 0.32 mm i.d.) by in situ polymerizetion reaction using glycidyl methacrylate as monomer;ethylene dimethacrylate as crosslinker;1-propanol, 1,4-butanediol, and water as porogenic solvents. The monolith matrix was modified with trimethylamine to create strong anion exchanger via ring opening reaction of epoxy groups. The morphology of the monolithic column was studied by using Scanning Electron Microscope (SEM). This column had good mechanical stability and permeability. The effects of various mobile phases for separation of inorganic anions were investigated. Iodate, bromate, nitrite, bromide, and nitrate were separated within 11 min using100 mMpotassium chloride as mobile phase and detected at 210 nm. This method showed good precision of retention time, acceptable linearity and good sensitivity. Under the optimum condition, the RSD of the retention time was in the range of 1.09%-1.75% (n = 6). The calibration curve showed linear relationships between the peak area and the concentration. The limits of detection (LOD) and the limits of quantitation (LOQ) were between 0.08-0.18 mM and 0.26-0.61 mM, respectively. This method was applied to the determination of inorganic anions in tap water and ground water samples.

关键词： Methacrylate-Based Monolithic Column Trimethylamine Ion Chromatography Capillary System Inorganic Anions Water Sample

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110kV及以下电压等级智能变电站过电压监测研究

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中国高新科技 2024年第14期 80-83页

作者：魏泽林珠海市恒源电力建设有限公司广东珠海519000

目前,传统电压监测已无法满足电力系统的质量需求,由于过电压故障而引起事故的概率越来越高,因此,提出110kV及以下电压等级智能变电站过电压监测研究。设置过电压在线监测装置,保证能够准确地收集测量数据。利用传感器采集过电压信号,... 详细信息

目前,传统电压监测已无法满足电力系统的质量需求,由于过电压故障而引起事故的概率越来越高,因此,提出110kV及以下电压等级智能变电站过电压监测研究。设置过电压在线监测装置,保证能够准确地收集测量数据。利用传感器采集过电压信号,对电压传感器的幅度线性度、响应频率和带宽等方面进行高要求。选取与分析过电压的特征数据,反映波形特性的特征参数。实验结果表明,直接监测方法相较于本研究方法的最大幅值误差为530kV,间接过电压监测方法相较于本研究方法的最大幅值误差为277kV。证明了110kV及以下电压等级智能变电站过电压监测方法能够有效地检测出过电压的幅值,有较高的准确性。

关键词：变电站电压监测智能 110kV

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基于字符级语言建模的汉蒙神经机器翻译方法研究

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昆明理工大学学报（自然科学版） 2023年第3期48卷 85-92页

作者：胡泽林高翊李淼曹宜超赣南师范大学物理与电子信息学院江西赣州341000 云南省少数民族语文指导工作委员会办公室云南昆明650499 中国科学院合肥智能机械研究所安徽合肥230031

随着机器学习技术的发展,文字翻译模型的翻译效率与准确率逐步提高,要达到理想的翻译效果离不开大量高质量的平行语料.疫情以来,我国坚持扩大内需、形成强大的国内市场,各民族间的联系比以往更为紧密,各种语言间的翻译尤为重要.蒙古语... 详细信息

随着机器学习技术的发展,文字翻译模型的翻译效率与准确率逐步提高,要达到理想的翻译效果离不开大量高质量的平行语料.疫情以来,我国坚持扩大内需、形成强大的国内市场,各民族间的联系比以往更为紧密,各种语言间的翻译尤为重要.蒙古语作为一类使用量较大的少数民族语言,不同词形涵义千差万别且缺少足够的平行语料支撑训练,导致现有的语言翻译模型效果不佳.本文针对以上问题,进行如下研究:(1)提出字符级语句分割,缓解平行语料不足带来的未登录词问题,降低了计算成本.(2)使用去噪自编码技术,迫使模型学习如何更加鲁棒地表达输入特征,增强模型的泛化能力.(3)使用无监督对偶式迭代翻译模型,将汉蒙翻译与蒙汉翻译以对偶方式同时进行无监督式迭代训练,实现语言建模与双向翻译,通过比较同数据集下该模型与传统Transformer模型训练的BLEU值得出,该模型具有更好的性能、更高的翻译准确率.

关键词：汉蒙神经机器翻译小语种语言翻译翻译模型去噪自编码字符级语言

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对未经治疗的慢性HCV感染患者用依那西普作为干扰素和利巴韦林的辅助用药:一项二期随机、双盲、安慰剂对照试验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 51-51页

作者： zein n.n. 王铮 Dept. of Gastroenterol. and Hepatol. Cleveland Clinic 9500 Euclid Avenue Cleveland OH 44195 United States

Background/Aims: Current therapies for patients with chronic hepatitis C viru s (HCV) do not achieve sustained viral clearance in most patients, and are assoc iated with severe toxic effects. Our aim was to investigate the efficacy and saf ety of etanercept as adjuvant to interferon and ribavirin in treatment- naive p atients with HCV. Methods: Double- blind, randomized, placebo controlled trial. Fifty patients with chronic HCV were randomly assigned to receive interferon al fa- 2b and ribavirin with either etanercept or placebo for 24 weeks. The main o utcome measure was the absence of HCV RnA at 24 weeks, the on treatment response at the end of the etanercept randomization period. Results: At 24 weeks, HCV Rn A was absent in 63% (12/19) etanercept patients compared to 32% (8/25) place bo patients (P=0.04). In addition, patients receiving etanercept had lower frequ ency of most adverse events categories compared to placebo. Conclusions: Etanerc ept given for 24 weeks as adjuvant therapy to interferon and ribavirin significa ntly improved virologic response at the end of the etanercept randomization peri od among patients with HCV, and was associated with decreased incidence of most adverse effects associated with interferon and ribavirin.

关键词：依那西普辅助用药安慰剂对照病毒学应答副作用发生率毒副作用 RnA

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DISSOCIATIOn OF THE ACUPUnCTURE EFFECT OF SOMATOSEnSORY nEEDLInG AnD nEEDLInG CREDIBILITY On LOW BACK PAIn PATIEnTS USInG fMRI

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Journal of Integrative Medicine 2014年第3期 221-221页

作者： Kyungmo Park Jeungchan Lee Seulgi Eun Abdalla zein E. Vitaly napadow Department of Biomedical Engineering Kyung Hee University Athinoula A.Martinos Center for Biomedical Imaging Department of RadiologyMassachusetts General Hospital

Background: Sham acupuncture as well as real acupuncture, a specific form of needling, is known to reduce low back pain(LBP), but the brain mechanism of placebo effect in sham acupuncture has not been clearly *** devised a novel form of sham acupuncture, so called phantom acupuncture which induces needling credibility without somatosensory *** we aimed to dissociate the brain correlates with somatosensory needling and needling credibility ***: Thirty LBP patients were randomized into the real(REAL, n=15) and phantom acupuncture(PHnT, n=15) *** threshold and LBP intensity(VAS) were measured before and after the fMRI *** the scanning, two steady state pain sessions were scanned before and after acupuncture stimulation(using low-back extension pain-model) and pain intensity(PAIn) induced by the pain model was *** acupuncture session, the REAL group got real acupuncture, while the PHnT group got only the visual stimulation(recorded needling manipulation video) to create needling *** response of heart rate(HR) and skin conductance(SC), and acupuncture sensation were ***: There was greater SC response, acupuncture sensation, signal increase in sensorimotor network(SMn), periaqueductal grey(PAG) and nucleus accumbense(nAC), and greater signal decrease in default mode network(DMn) in the REAL *** increase in vibration detection threshold and decrease in PAIn were *** HR decrease and signal increase in salience network(SLn), as well as the decrease in pressure pain threshold and unpleasantness of PAIn were observed both in the REAL and PHnT *** the PHnT group, decrease in VAS was *** correlation between the change in outcome measure and the change in resting state network connectivity was ***: Physical information processing and placebo/analgesic brain area were involved in somatosensory needling effect, while cognitive processing was rel

关键词： DISSOCIATIOn OF THE ACUPUnCTURE EFFECT OF SOMATOSEnSORY nEEDLInG AnD nEEDLInG CREDIBILITY On LOW BACK PAIn PATIEnTS USInG fMRI

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