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Fabrication of Conductive Domain Walls in x-cut Congruent Thin-film Lithium Niobate Using an Electrical-field Poling Technique(Invited)

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激光与光电子学进展 2024年第11期61卷 50-56页

作者： Su Yawen Chen Haiwei Zhao Mengwei niu yunfei Li Chen Zhang Yong Yang Shaoguang Zhu Shining Hu Xiaopeng National Laboratory of Solid State Microstructures School of PhysicsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210008JiangsuChina Zhejiang Laboratory Hangzhou 311121ZhejiangChina

Conductive ferroelectric domain walls have attracted increasing research interest in the field of nanoelectronics,and the fabrication technique for such domain walls is *** this study,we investigated in detail the fabrication of conductive domain walls in x-cut congruent thin-film lithium niobate(TFLN)using an electrical-field poling *** ferroelectric domain structures can be controlled through the applied electrical field and applied pulse numbers,and the domain inversion process is related to the conduction characteristics of the domain *** domain structures in TFLN are revealed using confocal second-harmonic microscopy and piezoresponse force *** results provide further directions for the development and application of conductive domain walls in TFLN.

关键词： thin-film lithium niobate electric field poling head-to-head/tail-to-tail domain conduction characteristics of domain wall

被动源地震干涉成像技术在煤田采空区探测中的应用研究

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地质论评 2024年第5期70卷 1899-1905页

作者：张鑫孙文斌章强新韩建光牛云飞山东能源集团南美有限公司山东青岛266400 北京探创资源科技股份有限公司北京100067 上海勘察设计研究院(集团)股份有限公司上海200093 中国地质科学院北京100037

地震干涉方法能够从背景或环境噪声中提取有效信息并应用于地下地质构造成像。通过对煤田采空区产生的被动源地震信号进行干涉成像可以定位出采空区的范围。笔者等基于被动源干涉成像原理,采用被动源地震干涉方法进行震源定位研究。通... 详细信息

地震干涉方法能够从背景或环境噪声中提取有效信息并应用于地下地质构造成像。通过对煤田采空区产生的被动源地震信号进行干涉成像可以定位出采空区的范围。笔者等基于被动源干涉成像原理,采用被动源地震干涉方法进行震源定位研究。通过对不同界面数值模型进行被动源干涉成像测试,验证了方法的准确性,而且测试结果表明被动源干涉成像横向分辨率高于纵向分辨率,不同的偏移速度对纵向位置影响较大,但对横向位置定位几乎没有影响。最后将其应用于实际煤田的采空区定位,成像结果与实际情况相符,验证了笔者等提出的被动源地震干涉成像方法的有效性以及在实际煤田采空区探测应用中实用性。

关键词：被动源干涉成像采空区煤田

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透射槽波技术在煤田勘探中的应用研究

地质论评 2024年第4期70卷 1587-1594页

作者：张鑫韩建光牛云飞徐世业徐安全山东能源集团南美有限公司青岛266400 中国地质科学院北京100037 北京探创资源科技股份有限公司北京100067

槽波地震勘探技术可以有效探查煤层中小断层、陷落柱等地质异常体,在探测精度和距离上明显优于其他煤矿井下勘探方法。透射法作为基本的槽波地震探测方法,具有简单灵活、探测范围大、准确率高等优势。采用透射槽波方法对实际煤矿工作面... 详细信息

槽波地震勘探技术可以有效探查煤层中小断层、陷落柱等地质异常体,在探测精度和距离上明显优于其他煤矿井下勘探方法。透射法作为基本的槽波地震探测方法,具有简单灵活、探测范围大、准确率高等优势。采用透射槽波方法对实际煤矿工作面内断层构造进行探测研究,通过滤波、频散分析、波场及速度分析、能量分析以及透射CT成像等关键技术对实际透射槽波数据进行精细处理,获得准确的透射槽波成像剖面。根据槽波在煤层中受到断层阻断或遇到煤层破碎时其能量将急剧降低的特征,利用透射槽波能量CT剖面,并结合实际揭露情况,解释出12条可靠断层。通过实际煤层工作面透射槽波勘探方法测试,验证了透射槽波方法的有效性以及在煤田断层等构造探测中的实用价值。

关键词：透射槽波频散断层解释能量分析透射CT成像

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

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Science China(Life Sciences) 2018年第11期61卷 1320-1332页

作者： Dongdong Ti yunfei niu Zhiqiang Wu Xiaobing Fu Weidong Han Department of Immunology Institute of Basic Medicine Chinese PLA General Hospital Department of Orthopaedics Changhai Hospital Second Military Medical University

The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent *** date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed.

关键词： genetic engineering chimeric antigen receptors cancer immunotherapy

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韩明向辨治口干症经验撷英

中医药临床杂志 2024年第7期36卷 1285-1288页

作者：张艳丽张澳门牛云飞安徽中医药大学第一临床医学院安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

口干症是一种常见的临床症状,属于中医学“燥证”“燥痹”范畴,目前西医对该病的发病机制的认识仍有不足,治疗尚未有特效药。韩明向教授为国家级名老中医,安徽省中医内科重点学科带头人,临床经验颇丰,用药巧妙,对口干症的治疗有独到见... 详细信息

口干症是一种常见的临床症状,属于中医学“燥证”“燥痹”范畴,目前西医对该病的发病机制的认识仍有不足,治疗尚未有特效药。韩明向教授为国家级名老中医,安徽省中医内科重点学科带头人,临床经验颇丰,用药巧妙,对口干症的治疗有独到见解且疗效确切。韩教授提出口干症的病位在脾、胃、肺、肾。提出口干症的病机多为湿热中阻、肾阴不足等虚实两个方面。实证者多由津液不布所致,此类患者平素嗜食肥甘厚腻之品,损伤脾胃;虚证者多见于多种慢性疾病迁延日久,津液耗伤。其对口干症的临床诊治颇有心得,认为应分别从清热利湿、滋养肾阴两个方面进行辨治。每每诊治,屡获良效,现选取验案两则,为临证提供参考。

关键词：口干症湿热中阻肾阴不足名医经验

EARLY RECOGNITION OF INTERNET TRAFFIC BASED ON SIGNATURE INSPECTION

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Journal of Electronics(China) 2010年第2期27卷 230-236页

作者： niu Xiaona Guo yunfei Zhang Jin Wang Chao National Digital Switching System Engineering ＆ Technology Research Center （ NDSC） Zhengzhou 450002 China

The accurate and efficient classification of Internet traffic is the first and key step to ac-curate traffic management,network security and traffic analysis. The classic ways to identify flows is either inaccurate or inefficient,which are not suitable to be applied to real-time online classification. In this paper,we originally presented an early recognition method named Early Recognition Based on Deep Packet Inspection (ERBDPI) based on deep packet inspection,after analyzing the distribution of payload signature between packets of a flow in detail. The basic concept of ERBDPI is classifying flows based on the payload signature of their first some packets,so that we can identify traffic at the be-ginning of a flow connection. We compared the performance of ERBDPI with that of traditional sampling methods both synthetically and using real-world traffic traces. The result shows that ERBDPI can get a higher classification accuracy with a lower packet sampling rate,which makes it suitable to be applied to accurate real-time classification in high-speed links.

关键词： Traffic classification Packet sampling Payload signature inspection Early recognition

Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing

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Journal of Materials Science & Technology 2023年第2期133卷 195-208页

作者： Fan Wang Mengyao Wang Qingsong He Xuehong Wang Ping Sun Yinjun Ji yunfei niu Fengqian Li Jie Wei Shanghai Key Laboratory of Advanced Polymeric Materials School of Materials Science and EngineeringKey Laboratory for Ultrafine Materials of Ministry of EducationEast China University of Science and TechnologyShanghai 200237China Department of Orthopaedics Shanghai Eighth People’s HospitalShanghai 200235China Department of Orthopaedics Changhai HospitalSecond Military Medical UniversityShanghai 200433China

Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant *** this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial *** with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in *** with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in *** presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial *** summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone ***,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction.

关键词： Black tantalic oxide PEEK fibers Artificial ligament Photothermal antibacterial effects Ligament-bone healing

直接前方入路和后外侧入路半髋关节置换治疗老年痴呆股骨颈骨折的疗效比较

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中华老年骨科与康复电子杂志 2024年第5期10卷 287-293页

作者：茹江英廖启宇温国洪潘思华刘栋张皓琛牛云飞广州医科大学附属清远医院(清远市人民医院)关节外科清远511518 海军军医大学附属长海医院创伤骨科上海200433

目的比较直接前方入路(DAA)和后外侧入路(PLA)半髋关节置换治疗老年痴呆股骨颈骨折的疗效。方法回顾性分析2021年2月至2022年2月收治的57例老年痴呆股骨颈骨折患者的临床资料,骨折Garden分型为Ⅲ和Ⅳ型,年龄≥70岁,符合中国精神障碍分... 详细信息

目的比较直接前方入路(DAA)和后外侧入路(PLA)半髋关节置换治疗老年痴呆股骨颈骨折的疗效。方法回顾性分析2021年2月至2022年2月收治的57例老年痴呆股骨颈骨折患者的临床资料,骨折Garden分型为Ⅲ和Ⅳ型,年龄≥70岁,符合中国精神障碍分类与诊断标准第3版(CCMD-3)诊断标准;按手术入路分为两组,采用直接前方入路半髋关节置换术的病例为DAA组(n=27),采用后外侧入路半髋关节置换术的病例为PLA组(n=30)。比较两组患者的手术时间、术中出血量、下床时间、住院时间和并发症发生率;通过髋部骨折功能恢复量表(FRS)、欧洲五维度健康量表(EQ-5D)、简易智力状态检查量表(MMSE)和精神错乱评估方法(CAM),于术后1、3月评估患者的髋关节功能、生活质量和精神状态,并分别进行比较。采用t检验或校正t检验或卡方检验分析比较两组的数据。结果所有患者均获得随访,随访时间平均为(13.85±1.64)个月(8~20个月)。与PLA组相比,DAA组的手术时间显著延长[(78.32±10.63 min)vs(55.12±11.36 min),P0.05];术后1,3和6个月随访时,两组的MMSE评分和CAM评分差异均无统计学意义(P均>0.05);PLA组的总并发症的发生率(16.67%)显著高于DAA组(7.40%)(P<0.05)。结论采用DAA入路髋关节置换治疗老年痴呆股骨颈骨折患者,手术微创、术后康复快、利于早期下床活动、住院时间短、并发症少,且早期髋关节功能改善较好,与后外侧入路相比优势明显。

关键词：股骨颈骨折老年痴呆关节成形术

Efficient 671 nm red light generation in annealed proton-exchanged periodically poled LiNbO3 waveguides

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Chinese Optics Letters 2020年第11期18卷 68-71页

作者： yunfei niu Lei Yang Dongjie Guo Yan Chen Xiaoyang Li Gang Zhao Xiaopeng Hu National Laboratory of Solid State Microstructures College of Engineering and Applied Sciencesand School of PhysicsNanjing UniversityNanjing 210093China

We report efficient generation of 671 nm red light based on quasi-phase-matched second harmonic generation of 1342 nm in LiNbO3 waveguides. The design method and fabrication process of the high-quality annealed protonexchanged periodically poled channel waveguides were presented. A continuous-wave 1.71 mW red light was obtained with a single-pass conversion efficiency of 47%·W-1·cm-2, which is 88% that of the theoretical *** for 1 mW quasi-continuous-laser input, the corresponding peak power being 2 W, the conversion efficiency reached up to 60%. Our results indicate that the annealed proton-exchanged periodically poled LiNbO3 waveguide is promising for high-efficiency and low power consumption nonlinear generation of visible light.

关键词： lithium niobate second-harmonic generation optical waveguides proton exchange