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Plants Used as Antihypertensive

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Natural Products and Bioprospecting 2021年第2期11卷 155-184页

作者： Tarawanti Verma Manish Sinha nitin bansal Shyam Raj Yadav Kamal Shah Nagendra Singh Chauhan I.K.Gujral Punjab Technical University(IKGPTU) JalandharPunjabIndia Laureate Institute of Pharmacy KathogJwalamukhiKangraHimachal PradeshIndia Department of Pharmacology ASBASJSM College of PharmacyBELARoparPunjabIndia Department of Chemistry S.P.Jain College(Veer Kunwar Singh UniversityAra)SasaramBiharIndia Institute of Pharmaceutical Research GLA UniversityNH#2MathuraUttar Pradesh 281406India Drugs Testing Laboratory Avam Anusandhan Kendra 1st Floor Govt.Ayurvedic Hospital BuildingGovt.Ayurvedic College Campus G.E.RoadRaipurChhattisgarh 492010India

Hypertension is a critical health problem and worse other cardiovascular *** is mainly of two types:Primary or essential hypertension and Secondary *** is the primary possibility feature for coronary heart disease,stroke and renal vascular *** medicines have been used for millions of years for the management and treatment of hypertension with minimum side *** aim to write this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms,from the bottom of cell culture and ex-vivo tissue *** to WHO,natural herbs/shrubs are widely used in increasing order to treat almost all the ailments of the human *** are the regular industrial units for the invention of chemical constituents,they used as immunity booster to enhance the natural capacity of the body to fight against different health prob-lems as well as herbal medicines and food products *** percent population of the world(around 5.6 billion people)consume medicines from natural plants for major health *** review provides a bird’s eye analysis primarily on the traditional utilization,phytochemical constituents and pharmacological values of medicinal herbs used to normalize hypertension *** sabdariffa,Allium sativum,Andrographis paniculata,Apium graveolens,Bidenspilosa,Camel-lia sinensis,Coptis chinensis,Coriandrum sativum,Crataegus spp.,Crocus sativus,Cymbopogon citrates,Nigella sativa,Panax ginseng,Salviaemiltiorrhizae,Zingiber officinale,Tribulus terrestris,Rauwolfiaserpentina,Terminalia arjuna etc.

关键词： Hypertension Antihypertensive herbs Blood pressure Vasodilatation Herbal medicines Blood pressure regulation

Utility of starchy,lignocellulosics and cellulosics hydrolysates on cellulase production under liquid state fermentation

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Waste Disposal and Sustainable Energy 2019年第4期1卷 289-299页

作者： nitin Verma Vivek Kumar M.C.bansal Department of Paper Technology Indian Institute of TechnologyRoorkee Saharanpur CampusSaharanpurUttar Pradesh 247001India

Starch is one of the most abundant renewable carbohydrate reserves of higher *** can be used to produce many valuable food products in the food processing ***,starch is also used as an important feedstock in the fermentation industry to produce value-added *** materials such as agriculture and forestry wastes are considered as a renewable feedstock for bioenergy production through a biochemical conversion *** lignocellulosic biomass into fuels and chemicals entail a physicochemical pretreatment of the biomass,followed by enzymatic hydrolysis of the polysaccharide components such as cellulose and hemicellulose into monomeric *** sugars can then be further fermented into other desired compounds of *** the deconstruction processes,various inhibitory compounds are released due to the partial over-degradation of lignocellulose biomass,which inhibits the cell growth and metabolic capacity of fermenting *** materials such as waste paper in large quantities can also be used as potentially cheap feedstock for sustainable production of value-added *** present investigation is mainly focused on the utility of starchy hydrolysates(wheat,potato,and rice)and lignocellulosics hydrolysates(bagasse and wheat straw)in cellulase production under liquid state *** also depicts the potential of cellulosic hydrolysate(waste newspaper)in product formation.

关键词： Starch hydrolysate Bagasse hydrolysate Wheat straw hydrolysate Waste newspaper hydrolysate Cellulases

Coexistence of pneumothorax and chilaiditi sign:A case report

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Asian Pacific Journal of Tropical Biomedicine 2014年第1期4卷 75-77页

作者： Tangri nitin Singhal Sameer Sharma Priyanka Mehta Dinesh bansal Sachin Bhushan Neeraj Singla Sulbha Singh Puneet Department of Respiratory Medicine M.M Institute of Medical Sciences & Research Department of Biochemistry M.M Institute of Medical Sciences & Research

We present a case of 50 year old male patient with coexistence of Pneumothorax and Chilaiditi *** sign is an incidental radiographic finding of a usually asymptomatic condition in which a part of intestine is located between the liver and diaphragm;however,the term"Chilaiditi syndrome"is used for symptomatic hepatodiaphragmatic *** patient had no symptoms of abdominal pain,constipation,diarrhea,or ***,Chilaiditi sign was diagnosed on chest *** is defined as air in the pleural *** are classified as spontaneous or *** pneumothorax is labelled as primary when no underlying lung disease is present,or secondary,when it is associated with pre-existing lung *** case is the rare in the literature indicating the coexistence of Chilaiditi sign and pneumothorax.

关键词： Chilaiditi syndrome Chilaiditi’s sign Hepatodiaphragmatic interposition Pneumothorax Dyspnoea Chest pain

Immunophenotypic signature of primary glioblastoma multiforme: A case of extended progression free survival

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World Journal of Clinical Cases 2017年第6期5卷 247-253页

作者： Puneet Gandhi Richa Khare nitin Garg Sandeep Sorte Department of Research Bhopal Memorial Hospital and Research Centre Department of Neurosurgery Bhopal Memorial Hospital and Research Centre bansal Hospital

Glioblastoma-multiforme(GBM), the most aggressive glial tumor, has a worldwide age-adjusted incidence ranging from 0.59-3.69/100000 persons. Despite current multimodal-treatment approach, median-survival time and progression-free survival(PFS) remains short. Glioblastomas display a variety of molecular alterations, which necessitates determining which of these have a prognostic significance. This is a case of a 45-yearold patient who presented with progressive slurring of speech and features of raised intracranial pressure. Computed tomography(CT) scan revealed a large heterogeneously enhancing lesion in the left front-temporalperisylvian region with solid, cystic areas, suggestive of malignant glioma. Partial tumor-excision was followed by concurrent chemo-radiotherapy. Histopathologically, the tumor was astrocytoma grade-IV. Patient had an extended PFS of 12 mo, with an overall survival of 26 mo. Primary-GBM was confirmed using molecular markers and the immunophenotypic signature was defined by evaluating systemic expression of human telomerase reverse transcriptase, interleukin-6, neutrophil-lymphocyte ratio, tissue inhibitor of metalloproteinases-1, human chitinase-3-like-protein-1(YKL-40) and high mobility group-A1. Current findings suggest that this signature can identify worst outcomes, independent of clinical criteria.

关键词： Glioblastoma multiforme Immunophenotypic signature Progression free survival Molecular markers Human telomerase reverse transcriptase Interleukin-6 Tissue inhibitor of metalloproteinases-1 YKL-40 High mobility group-A1

Unique case of oligoastrocytoma with recurrence and grade progression:Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase

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World Journal of Clinical Cases 2016年第9期4卷 296-301页

作者： Puneet Gandhi Richa Khare Kavita Niraj nitin Garg Sandeep K Sorte Hanni Gulwani Department of Research Bhopal Memorial Hospital and Research Centre Department of Neurosurgery Bhopal Memorial Hospital and Research Centre and Bansal Hospital Department of Pathology Bhopal Memorial Hospital and Research Centre

Mixed gliomas, primarily oligoastrocytomas, account for about 5%-10% of all gliomas. Distinguishing oligoastrocytoma based on histological features alone has limitations in predicting the exact biological behavior, necessitating ancillary markers for greater specificity. In this case report, human telomerase reverse transcriptase(hT ERT) and high mobility group-A1(HMGA1); markers of proliferation and stemness, have been quantitatively analyzed in formalin-fixed paraffin-embedded tissue samples of a 34 years old patient with oligoastrocytoma. Customized florescence-based immunohistochemistry protocol with enhanced sensitivity and specificity is used in the study. The patient presented with a history of generalized seizures and his magnetic resonance imaging scans revealed infiltrative ill-defined mass lesion with calcified foci within the left frontal white matter, suggestive of glioma. He was surgically treated at our center for four consecutive clinical events. Histopathologically, the tumor was identified as oligoastrocytoma-grade Ⅱ followed by two recurrence events and final progression to grade Ⅲ. Overall survival of the patient without adjuvant therapy was more than 9 years. Glial fibrillary acidic protein, p53, Ki-67, nuclear atypia index, pre-operative neutrophillymphocyte ratio, are the other parameters assessed. Findings suggest that hT ERT and HMGA1 are linked to tumor recurrence and progression. Established markers can assist in defining precise histopathological grade in conjuction with conventional markers in clinical setup.

关键词： Human telomerase reverse transcriptase High mobility group-A1 Oligoastrocytoma Recurrence Tumor grade

Expert opinion on the preoperative medical optimization of adults with diabetes undergoing metabolic surgery

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World Journal of Diabetes 2021年第10期12卷 1587-1621页

作者： Saptarshi Bhattacharya Sanjay Kalra nitin Kapoor Rajiv Singla Deep Dutta Sameer Aggarwal Deepak Khandelwal Vineet Surana Atul Dhingra Viny Kantroo Sachin Chittawar Nilakshi Deka Vivek Bindal Puja Dutta Endocrinology Max Superspeciality HospitalNew Delhi 110092India Endocrinology Bharti HospitalKarnal 132001HaryanaIndia Endocrinology Christian Medical CollegeVellore 632004Tamil NaduIndia Endocrinology Kalpavriksh Super Speciality CenterNew Delhi 110075India Endocrinology CEDAR Superspecialty ClinicNew Delhi 110075India Endocrinology Apex Plus Superspeciality HospitalRohtak 124001HaryanaIndia Endocrinology Maharaja Agrasen HospitalNew Delhi 110026India Endocrinology Manipal HospitalsNew Delhi 110075India Endocrinology Gangaram Bansal Super Speciality HospitalSri Ganganagar 335001RajasthanIndia Respiratory Medicine&Critical Care Indraprastha Apollo HospitalsSarita ViharNew Delhi 110076India Endocrinology Gandhi Medical CollegeBhopal 462001Madhya PardeshIndia Endocrinology Apollo HospitalsGuwahati 781005AssamIndia Minimal Access Metabolic and Bariatric surgeryMax Superspeciality HospitalPatparganjNew Delhi 110092India Nutrition Max Superspeciality HospitalPatparganjNew Delhi 110092India

Diabetes mellitus(DM)and obesity are interrelated in a complex manner,and their coexistence predisposes patients to a plethora of medical *** surgery has evolved as a promising therapeutic option for both *** is recommended that patients,particularly those of Asian origin,maintain a lower body mass index threshold in the presence of uncontrolled ***,several comorbidities often accompany these chronic diseases and need to be addressed for successful surgical *** Roux-en-Y gastric bypass(RYGB)and laparoscopic sleeve gastrectomy(LSG)are the most commonly used bariatric procedures *** bariatric benefits of RYGB and LSG are similar,but emerging evidence indicates that RYGB is more effective than LSG in improving glycemic control and induces higher rates of long-term DM *** scoring systems have been formulated that are utilized to predict the chances of remission.A glycemic target of glycated hemoglobin<7%is a reasonable goal before ***,pulmonary,gastrointestinal,hepatic,renal,endocrine,nutritional,and psychological optimization of surgical candidates improves perioperative and long-term *** guidelines for preoperative care of individuals with obesity have been formulated,but very few specifically focus on the concerns arising from the presence of concomitant *** is hoped that this statement will lead to the standardization of presurgical management of individuals with DM undergoing metabolic surgery.

关键词： Diabetes Obesity Metabolic surgery Bariatric surgery Remission of diabetes