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s.erm motility inhibitory effect of the benzene chromatographic fraction of the chloroform extract of the s.eds.of Carica papaya in langur monk.y, Pres.ytis.entellus.entellus

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As.an Journal of Andrology 2008年第2期10卷 298-306页

作者： nirmal k. lohiya boomi manivannan shipra goyal abdul s. ansari Centre for Advanced s.udies Department of Zoology University of Rajasthan Jaipur 302004 India

Aim： To as.es. the contraceptive efficacy of the benzene chromatographic fraction of the chloroform extract of the s.eds.of Carica papaya in langur monk.ys. Methods. The tes. s.bs.ance was.given p.o. to five monk.ys.at 50 mg/k. body weight/day for 360 days. Control animals.（n = 3） received olive oil as.vehicle. s.erm parameters.as.per World Health Organization s.andards. s.erm functional tes.s. morphology of tes.is.and epididymis. haematology, clinical biochemis.ry, s.rum tes.os.erone and libido were evaluated. Following completion of 360 days.treatment the animals.were withdrawn from the treatment and the recovery pattern was.as.es.ed by s.men analys.s.and s.erm functional tes.s. Res.lts. Total inhibition of s.erm motility was.obs.rved following 60 days.of treatment that continued until 360 days.s.udy period. s.erm count, percent viability and percent normal s.ermatozoa s.owed a dras.ic decline following 30 days.of treatment. s.erm morphology s.owed predominant mid piece abnormalities. s.erm functional tes.s.s.ored in s.erile range. His.ology and ultras.ructure of tes.is.revealed vacuolization in the s.rtoli cells.and germ cells. Los. of cytoplas.ic organelles.was.evident in s.ermatocytes.and round s.ermatids. His.ology and ultras.ructure of epididymis.of treated animals.were comparable to thos. of control animals. Hematological and s.rum clinical parameters.and tes.os.erone levels.fluctuated within the control range throughout the s.udy period. Recovery was.evident following 60--120 days.of treatment withdrawal. Conclus.on- The res.lts.s.gges. that the benzene chro- matographic fraction of the chloroform extract of the s.eds.of Carica papaya s.ows.contraceptive efficacy without advers. toxicity, mediated through inhibition of s.erm motility. （As.an JAndro12008 Mar; 10： 298-306）

关键词： male contraception Carica papaya s.eds s.erm motility inhibition tes.is epididymis langur monk.ys

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s.erm characteris.ics.and ultras.ructure of tes.es.of rats.after long-term treatment with the methanol s.bfraction of Carica papaya s.eds

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As.an Journal of Andrology 2009年第5期11卷 583-599,I0003页

作者： boomi manivannan[印度] Ruchi Mittal[印度] shipra goyal[印度] abdul s. ansari[印度] nirmal k. lohiya[印度] Department of Zoology Centre for Advanced Studies University of Rajasthan Jaipur 302004 India

The contraceptive efficacy of Carica papaya s.eds.after s.ort-term evaluation has.been well es.ablis.ed. We have examined the s.fety and mechanis. of contraception in rats.after long-term treatment with the methanol s.bfraction （Ms.） of C. papaya s.eds. The tes. s.bs.ance was.adminis.ered orally to the male albino rats.（n = 40） at 50 mg per k. body weight each day for 360 days. Control animals.（n = 40） received olive oil as.a vehicle. Recovery was.as.es.ed up to 120 days.after treatment withdrawal. s.erm parameters. s.rum tes.os.erone levels. fertility, his.ology and ultras.ructure of the tes.is. haematology and s.rum clinical chemis.ry were evaluated to es.ablis. the s.fety and efficacy of the tes. s.bs.ance. s.fety of long-term treatment was.evidenced by unaltered health s.atus. organ weight, haematology and clinical chemis.ry, and by an increas. in body weight. The mechanis. of contraception was.s.own by reduction in nuclear and cytoplas.ic volume, normal nuclear characteris.ics.and vacuolization in the cytoplas.ic organelles.of the s.rtoli cells. as.well as.nuclear degeneration in s.ermatocytes.and s.ermatids.indicating dis.urbed s.ermatogenes.s. Leydig cells.were normal. Initial effects.were obs.rved in s.rtoli cells.at 60 days.of treatment. s.ermatocytes.and s.ermatids.were affected after 120-240 days.of treatment. A s.gnificant decline in s.erm count and viability, total inhibition of s.erm motility, increas.d numbers.of s.erm abnormalities. normal s.rum tes.os.erone levels.and 100% s.erility were evident after 60 days.of treatment. All the altered parameters. including percent fertility, were res.ored to control level 120 days.after treatment withdrawal. It is.concluded that the Ms. is.s.fe for long-term treatment and the mechanis. of contraception is.s.own by its.effect on s.ermatid differentiation in the tes.is. pos.ibly mediated by the s.rtoli cell factors.

关键词： Carica papaya s.eds male contraception s.ermatozoa tes.is ultras.ructure

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