检索结果-南通市图书馆

青藏高原牦牛驯化的考古学与遗传学研究进展及展望

在线全文

学校读者我要写书评

暂无评论

科学通报 2024年第11期69卷 1417-1428页

作者：陈顺港高玉陈宁博邱强王昱程杨晓燕陈发虎中国科学院青藏高原研究所古生态与人类适应团队北京100101 中国科学院青藏高原研究所青藏高原地球系统与资源环境重点实验室北京100101 中国科学院大学北京100049 西北农林科技大学动物科技学院陕西省动物遗传育种与繁殖重点实验室杨凌712100 西北工业大学生态环境学院西安710072 Department of Zoology University of CambridgeCambridge CB23EJUK 兰州大学资源环境学院西部环境教育部重点实验室兰州730000 寒区旱区生物考古国家文物局重点科研基地兰州730000

家牦牛在史前人类定居青藏高原的过程中起到了巨大作用,但牦牛的驯化过程仍存在诸多未解决的科学问题.本文梳理了牦牛驯化的考古学和遗传学研究进展,展望了开展牦牛驯化与人类定居青藏高原过程研究的未来方向.家牦牛最早的考古学证据来... 详细信息

家牦牛在史前人类定居青藏高原的过程中起到了巨大作用,但牦牛的驯化过程仍存在诸多未解决的科学问题.本文梳理了牦牛驯化的考古学和遗传学研究进展,展望了开展牦牛驯化与人类定居青藏高原过程研究的未来方向.家牦牛最早的考古学证据来自距今3750年前的青藏高原南部拉萨河谷,但现代遗传学研究显示,牦牛的驯化可追溯至全新世中期,驯化地点最有可能位于西藏东南部的昌都地区,其种群数量增长与人类大规模长年定居青藏高原高海拔地区的历史高度相关,且黄牛的基因渗入对牦牛的驯化过程产生了深刻影响.基于现有研究进展,本文建议:(1)针对青藏高原考古遗址开展系统性的动物考古学研究;(2)应用ZooMS和古DNA技术筛选和鉴定牦牛骨骼遗存,结合古环境DNA进行遗传学研究,追溯牦牛驯化的时间和地点;(3)开展野牦牛与黄牛的杂交驯化模式研究,理解牦牛驯化及其扩散对史前人类在青藏高原生存和发展的促进作用.

关键词：牦牛动物驯化考古学遗传学古DNA

结直肠癌患者复发风险监测与预测的数字孪生模型:一项临床研究方案

在线全文

学校读者我要写书评

暂无评论

肿瘤代谢与营养电子杂志 2024年第2期11卷 264-269页

作者：谭馨罗斌陈宁波王奇江华成都中医药大学医学与生命科学学院四川成都611137 急诊医学与灾难医学研究所四川省急危重症临床医学研究中心电子科技大学附属医院·四川省人民医院四川成都610072 电子科技大学附属医院·四川省人民医院胃肠外科四川成都610072 电子科技大学附属医院·四川省人民医院急救中心四川成都610072 南卡罗来纳大学数学系美国哥伦比亚南卡罗来纳州29208

背景结直肠癌是全球最常见的三大肿瘤种类之一,到目前为止,对肿瘤复发早期预警是提高结直肠癌患者术后生存率的重要课题。当前,结直肠癌肿瘤患者的复发预测主要依靠临床医师根据患者的临床检查、血液检验及影像检查等临床资料进行经验... 详细信息

背景结直肠癌是全球最常见的三大肿瘤种类之一,到目前为止,对肿瘤复发早期预警是提高结直肠癌患者术后生存率的重要课题。当前,结直肠癌肿瘤患者的复发预测主要依靠临床医师根据患者的临床检查、血液检验及影像检查等临床资料进行经验性判断,缺乏全面、可靠的客观依据,可能使患者错过最佳干预时机。近几年出现的新型诊断方法费用相对昂贵而难以普及;同时也是一种“事后汇报”模式,即肿瘤已在体内发展到一定程度才能检出。方法本研究是一项基于回顾性队列数据的前瞻性研究项目,拟纳入来自电子科技大学附属医院·四川省人民医院胃肠外科及急诊中心2013年1月至2018年10月的所有结直肠癌术后患者。根据排除纳入标准筛选患者,拟收集纳入结肠癌患者术前与术后5年内的临床数据,将数据进行清洗、预处理后分类与增强,最终采用数据驱动与机理互动的方式进行动力学建模,构建能够早期预测结直肠癌患者5年内肿瘤复发的监测与预测数字孪生模型。结论目前研究表明,结直肠癌术后5年的复发率高达30%,目前临床急需对于结直肠癌术后复发早期预警的可靠工具,数字孪生技术能够实现多维度数据处理,建立多模块模型预测,并建立具有时间序列性的预测模型,适用于结直肠癌患者复发的预测研究。本研究拟基于数字孪生技术,建立结直肠癌患者术后5年内肿瘤复发的预测模型,以期实现对肿瘤复发的监测及早期预警,降低结直肠癌术后复发患者死亡率。

关键词：结直肠癌数字孪生肿瘤复发预测模型

Recovery of photoacoustic images based on accurate ultrasound positioning

在线全文

学校读者我要写书评

暂无评论

Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 63-69页

作者： Yinhao Pan ningbo chen Liangjian Liu chengbo Liu Zhiqiang Xu Jianhui Zhang College of Mechanical and Electrical Engineering Guangzhou UniversityGuangzhou 510006China Research Laboratory for Biomedical Optics and Molecular Imaging CAS Key Laboratory of Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Photoacoustic microscopy is an in vivo imaging technology based on the photoacoustic *** is widely used in various biomedical studies because it can provide high-resolution images while being label-free,safe,and harmless to biological ***-scanning is an effective scanning method in photoacoustic microscopy that can realize fast imaging of biological tissue with a large field of ***,in polygon-scanning,fluctuations of the rotating motor speed and the geometric error of the rotating mirror cause image distortions,which seriously affect the photoacoustic-microscopy imaging *** improve the image quality of photoacoustic microscopy using polygon-scanning,an image correction method is proposed based on accurate ultrasound *** this method,the photoacoustic and ultrasound imaging data of the sample are simultaneously obtained,and the angle information of each mirror used in the polygon-scanning is extracted from the ultrasonic data to correct the photoacoustic *** results show that the proposed method can significantly reduce image distortions in photoacoustic microscopy,with the image dislocation offset decreasing from 24.774 to 10.365μm.

关键词： Photoacoustic microscopy Polygon-scanning Image correction Ultrasound positioning

Genomic analyses reveal distinct genetic architectures and selective pressures in Chinese donkeys

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2021年第8期48卷 737-745页

作者： Jiafei Shen Jie Yu Xuelei Da Mei Li Gang Wang ningbo chen Hong chen Chuzhao Lei Ruihua Dang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangtingShaanxi 712100China

Donkey(Equus asinus)is an important livestock animal in China because of its draft and medicinal *** a long period of natural and artificial selection,the variety and phenotype of donkeys have become *** clarified the genetic and demographic characteristics of Chinese domestic donkeys and the selection pressures by analyzing 78 whole genomes from 12 *** to population structure,most Chinese domestic donkeys showed a dominant ancestral ***,the Chinese donkeys still represented a significant geographical distribution *** the selective sweep,gene annotation,functional enrichment,and differential expression analyses between large and small donkey groups,we identified selective signals,including NCAPG and LCORL,which are related to rapid growth and large body *** findings elucidate the evolutionary history and formation of different donkey breeds and provide theoretical insights into the genetic mechanism underlying breed characteristics and molecular breeding programs of donkey clades.

关键词： Donkey Whole-genome resequencing NCAPG LCORL

BGVD:An Integrated Database for Bovine Sequencing Variations and Selective Signatures

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2020年第2期18卷 186-193页

作者： ningbo chen Weiwei Fu Jianbang Zhao Jiafei Shen Qiuming chen Zhuqing Zheng Hong chen Tad S.Sonstegard Chuzhao Lei Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China College of Information Engineering Northwest A&F UniversityYangling 712100China Recombinetics St PaulMN55104USA

Next-generation sequencing has yielded a vast amount of cattle genomic data for global characterization of population genetic diversity and identification of genomic regions under natural and artificial ***,efficient storage,querying,and visualization of such large datasets remain ***,we developed a comprehensive database,the Bovine Genome Variation Database(BGVD).It provides six main functionalities:gene search,variation search,genomic signature search,Genome Browser,alignment search tools,and the genome coordinate conversion *** contains information on genomic variations comprising^60.44 M SNPs,~6.86 M indels,76,634 CNV regions,and signatures of selective sweeps in 432 samples from modern cattle *** can quickly retrieve distribution patterns of these variations for 54 cattle breeds through an interactive source of breed origin map,using a given gene symbol or genomic region for any of the three versions of the bovine reference genomes(ARS-UCD1.2,UMD3.1.1,and Btau5.0.1).Signals of selection sweep are displayed as Manhattan plots and Genome Browser *** further investigate and visualize the relationships between variants and signatures of selection,the Genome Browser integrates all variations,selection data,and resources,from NCBI,the UCSC Genome Browser,and Animal ***,all these features make the BGVD a useful archive for in-depth data mining and analyses of cattle biology and cattle breeding on a global *** is publicly available at http://***/BosVar.

关键词： Bovine Sequence variation Selective signatures QTL Database

Siliceous mesocellular foam supported Cu catalysts for promoting non-thermal plasma activated CO_(2) hydrogenation toward methanol synthesis

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2024年第7期18卷 55-65页

作者： Yi chen Shaowei chen Yan Shao Cui Quan ningbo Gao Xiaolei Fan Huanhao chen State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 211816China School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an 710049China Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUK Nottingham ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048China Institute of Wenzhou Zhejiang UniversityWenzhou 325006China

Electrified non-thermal plasma (NTP) catalytic hydrogenation is the promising alternative to the thermal counterparts, being able to be operated under mild conditions and compatible with green electricity/hydrogen. Rational design of the catalysts for such NTP-catalytic systems is one of the keys to improve the process efficiency. Here, we present the development of siliceous mesocellular foam (MCF) supported Cu catalysts for NTP-catalytic CO_(2) hydrogenation to methanol. The findings show that the pristine MCF support with high specific surface area and large mesopore of 784 m2·g−1 and ~8.5 nm could promote the plasma discharging and the diffusion of species through its framework, outperforming other control porous materials (viz., silicalite-1, SiO_(2), and SBA-15). Compared to the NTP system employing the bare MCF, the inclusion of Cu and Zn in MCF (i.e., Cu1Zn1/MCF) promoted the methanol formation of the NTP-catalytic system with a higher space-time yield of methanol at ~275 μmol·g_(cat)^(−1)·h^(−1) and a lower energy consumption of 26.4 kJ^(−1)·mmol_(CH_(3)OH)^(-1) (conversely, ~225 μmol·g_(cat)^(−1)·h^(−1) and ~71 kJ^(−1)·mmol_(CH_(3)OH)^(-1), respectively, for the bare MCF system at 10.1 kV). The findings suggest that inclusion of active metal sites (especially Zn species) could stabilize the CO_(2)/CO-related intermediates to facilitate the surface reaction toward methanol formation.

关键词： non-thermal plasma(NTP)catalysis Cu catalyst CO_(2)hydrogenation methanol siliceous mesocellular foam(MCF)

Residual levels and health risk assessment of trace metals in Chinese resident diet

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第2期136卷 451-459页

作者： Yubing Dai Shuai Sun Rong Cao Haijun Zhang Jiping chen ningbo Geng CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Shenyang Pharmaceutical University Shenyang 110016China University of Chinese Academy of Sciences Beijing 100049China

Large-scale metal contamination across the food web is an intractable problem due to increasing pollutant emissions,atmospheric transport,and dry and wet deposition of *** present study focus on several trace metals that are rarely studied but have special toxicity,including tin(Sn),antimony(Sb),gold(Au),hafnium(Hf),palladium(Pd),platinum(Pt),ruthenium(Ru),tellurium(Te)and iridium(Ir).We investigated trace metals residues and distribution characteristics,and further evaluated the potential health risks from major daily food intakes in 33 cities in ***,Sb,Ir,Hf,and Au were frequently detected in food samples with the concentrations ranged from ND(not detected)to 24.78μg/kg ww(wet weight).Eggs exhibited the highest residual level of all detected metals(13.70±14.70μg/kg ww in sum),while the lowest concentrations were observed in vegetables(0.53±0.17μg/kg ww in sum).Sn accounting for more than 50%of the total trace metals concentration in both terrestrial and aquatic animal origin *** terrestrial plant origin foods,Sn and Ir were the most abundant *** and Au were the most abundant elements in egg *** addition,Sb and Ir showed a clear trophic dilution effect in terrestrial environments,while in aquatic ecosystems,Sn,Hf,and Au exhibited obvious trophic amplification *** calculated average estimated daily intake(EDI)via food consumption in five regions of China was 0.09μg/(kg·day),implying the health risk of aforementioned elements was acceptable.

关键词： Trace metals Accumulation characteristics Dietary exposure Estimated daily intake(EDI)

Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2018年第3期10卷 115-126页

作者： chengbo Liu Jingqin chen Ying Zhu Xiaojing Gong Rongqin Zheng ningbo chen Dong chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song Research Laboratory for Biomedical Optics and Molecular Imaging Shenzhen Key Laboratory for Molecular ImagingInstitute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-Sen University Translational Medicine R&D Center Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health Engineering Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences

Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.

关键词： MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging

50GHz~110GHz宽带信号下变频技术

在线全文

学校读者我要写书评

暂无评论

空间电子技术 2024年第4期21卷 48-58页

作者：刘路杰张波陈宁波丰益年牛中乾电子科技大学电子科学与工程学院成都611731 电子科技大学深圳高等研究院深圳518000

矢量信号分析仪作为传统扫频式频谱仪与快速傅里叶变换技术的结合,能够对信号进行数字化处理,分析各种调制信号,同时获得测量信号的幅度和相位信息,对于现代通信意义重大。随着电磁波的应用频率扩展到毫米波乃至太赫兹波段,矢量信号分... 详细信息

矢量信号分析仪作为传统扫频式频谱仪与快速傅里叶变换技术的结合,能够对信号进行数字化处理,分析各种调制信号,同时获得测量信号的幅度和相位信息,对于现代通信意义重大。随着电磁波的应用频率扩展到毫米波乃至太赫兹波段,矢量信号分析仪的测量频率也急需拓展到更高频段,在系统前端搭载下变频器可实现这一目的。基于50GHz~110GHz宽带信号的下变频技术开展研究,研制了变频系统中多个关键器件,包括频分50GHz~110GHz信号的宽带开关、抑制镜频信号的宽阻带波导滤波器以及基于倍频放大模块的本振,同时搭建了50GHz~110GHz宽带信号下变频系统,将50GHz~110GHz宽带信号下变频到4.6GHz~39.6GHz。实验表明,下变频后的信号在任意2GHz内平坦度小于±3.5dB,对镜频信号的抑制大于60dBc,输出杂散抑制度大于40dBc,本振泄漏抑制大于70dBc,满足系统指标要求。

关键词：矢量信号分析仪扩频模块变频系统超宽带