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Cancer Advances 2024年第10期7卷 1-8页

作者： ning-jia song Yuan Wang Ya-Ying Lin Department of Obstetrics and Gynecology Affiliated Hospital of Jiangnan UniversityWuxi 214000China Wuxi Medical School Jiangnan UniversityWuxi 214000China

Objective:This study used comprehensive bioinformatics analysis and network pharmacology analysis to investigate the potentially relevant mechanisms of Sophora flavescens against cervical squamous cell ***:Consistently altered genes involved in cervical squamous cell cancerization were analyzed in the GEO *** chemical ingredients and target genes of Sophora flavescens were explored using the TCMSP *** obtained the potential therapeutic targets of Sophora flavescens by intersecting the above genesets and validated them in the GEPIA *** interaction between Sophora flavescens and target genes was predicted by molecular ***-qPCR was used to verify the changes of target genes in HeLa cells treated with Sophora ***-gene GSEA functional analysis were performed to determine the molecular ***:Fifteen genes related to the transformation of cervical squamous cell carcinoma were identified,among which AR and ESR1 were confirmed as targets for kaempferol,wighteone,formononetin,and *** compounds are the active ingredients in Sophora *** expressions of AR and ESR1 correlate with a poor prognosis,while Sophora flavescens treatment increases the expression of AR and ESR1 in *** analysis showed that AR and ESR1 mainly participate in the epithelial-mesenchymal transition in cervical squamous cell ***:Sophora flavescens exert anti-tumor effects by targeting AR and ESR1,which may regulate cancer metastasis.

关键词： cervical squamous cell carcinoma biological analysis network pharmacology Sophora flavescens

Top-down Approach for Fabrication of Polymer Microspheres by Interfacial Engineering

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Chinese Journal of Polymer Science 2020年第12期38卷 1286-1293页

作者： Yue Fan De-Hui Wang Jin-Long Yang jia-ning song Xiao-Mei Li Cheng-Lin Zhang Dong-Sheng Wang Long-Quan Chen jia-Xi Cui Xu Deng Institute of Fundamental and Frontier Sciences Universityof Electronic Science and Technology of ChinaChengdu 610054China Deportment of Physics at Interfaces Max Planck Institute for Polymer ResearchAckermannweg 1055128MainzGermany School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinoChengdu 670054Chino School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

Polymer microspheres with uniform size,composition,and surface property have gained extensive researches in past *** bottom-up approaches are using monomers or oligomers to build up desired polymer ***,directly shaping high-molecular-weight polymers into well-ordered polymer microspheres remains a great ***,we reported a facile and efficient top-down approach tofabricate microspheres with high-molecular-weight polymer *** harnessing interfacial engineering-control during the polymer microspheres formation,uniformly sized microspheres could be produced with widely ranged diameters(from 10μm to the capillary length of each polymer melt).The size limitation of this approach could be further extended by a controllable Plateau-Rayleigh instability ***,the top-down approach allows fabrication of microspheres by various polymer melts with surface energy higher than 25 mN/*** work paves a way for green,cost-effective,and customizable production of a variety of functional polymer microspheres without any chemical reaction assistant.

关键词： Superamphiphobic surfaces Microfluidic spinning Microfibers Microspheres

Even-odd layer-dependent multiferroic in freestanding rare-earth orthorhombic perovskite

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 151-157页

作者： Shaowen Xu Fanhao jia ning Dai School of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Department of Physics College of ScienceHangzhou Dianzi UniversityHangzhou 310018China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China

Freestanding oxide perovskites possess strong interlayer coupling between adjacent atomic layers,thus exerting a determinative effect on the magnetism and ferroelectricity of these atomic-scale ***,we propose an effective strategy to manipulate magnetism and ferroelectricity in freestanding rare-earth orthorhombic perovskite via modulation of layer *** performing first-principles calculations,an even-odd oscillation is demonstrated in few-layer GdAlO_(3)perovskite(GAP).Specifically,odd-layer systems with charged atomic layers are ferromagnetic polar metals,while even-layer systems are antiferromagnetic ferroelectric *** thickness-dependent magnetic phase transition originates from carrier doping,as rationalized by the Stoner ***,we demonstrate the promotion of in-plane ferroelectricity via the concurrent application of two distinct antiferrodistortive displacements,each driven by formation and breaking of *** multiferroic phases may emerge in other transition metal oxide perovskites supporting multiple valence states,e.g.,few-layer Gd MO_(3)(M=V,Cr,Mn,and Ni).This work puts forward a strategy for layer thickness engineering of magnetism and ferroelectricity in 2D oxide perovskite multiferroic materials.

关键词： few-layer rare-earth perovskite multiferroicity size effect first principles calculations

Embracing connected intelligence with the YuanOS architecture:one OS kit for all

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Frontiers of Computer Science 2024年第1期18卷 1-3页

作者： Haibo CHEN ning jia Jie YIN Institute of Parallel and Distributed Systems School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China OS Kernel Lab Huawei Technologies Co.Ltd.Beijing 100085China

Operating system abstracts hardware and creates application execution environment,and thus is the key pillar for IT *** its first invention in 1956,operating system has been evolved over three main stages:Mainframe,PC&Internet,Mobile Internet[1].Now,the entire society is firmly stepping towards the connected intelligence era[2],how should operating system be evolved to embrace this new era?

关键词： hardware execution connected

Deployment analysis of composite thin-walled lenticular tubes with effect of storage time and temperature

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Chinese Journal of Aeronautics 2024年第1期37卷 162-172页

作者： Jinfeng DENG ning AN Qilong jia Xiaofei MA School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China State Key Laboratory for Strength and Vibration of Mechanical Structures School of AerospaceXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of TechnologyDalian 116024China Xi’an Institute of Space Radio Technology Xi’an 710100China

Composite Thin-walled Lenticular Tube(CTLT)is increasingly utilized in small satellites missions as a lightweight,foldable,and rollable structural material that facilitates the construction of large deployable *** CTLT is initially flattened and coiled around a central hub for storage before launch,during which elastic energy is stored as deformation energy,allowing it to be self-deployed on demand for use in *** work presents a comprehensive investigation into the coiling,storage and deployment behaviors of CTLT that wraps around a central hub.A nonlinear explicit dynamic finite element model was developed with both deformable CTLT and rigidbodies mechanisms including the central hub and guide rollers,as well as the complex interactions among *** coiling mechanics characteristics such as stored strain energy and rotational moment were presented and validated against experimental data in the ***,the dynamic deployment behaviors were analyzed in terms of two different deployment methods,namely,controlled deployment and free *** effect of material property change during storage was also discussed through numerical experiments.

关键词： Composite deployable structures Deployment dynamics Finite element method Stress relaxation Thin-walled booms

Rate Coecients and Kinetic Isotope E ects of Cl+XCl→XCl+Cl(X=H,D,Mu)Reactions from Ring Polymer Molecular Dynamics

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Chinese Journal of Chemical Physics 2021年第4期34卷 453-461,I0003页

作者： Jun-hua Fang Wen-bin Fan Hui Yang jia-ning song Yong-le Li Department of Chemistry Shanghai UniversityShanghai 200444China Department of Physics International Center for Quantum and Molecular Structuresand Shanghai Key Laboratory of High Temperature SuperconductorsShanghai UniversityShanghai 200444China

The ring-polymer molecular dynamics(RPMD)was used to calculate the thermal rate coefficients and kinetic isotope effects of the heavy-light-heavy abstract reaction Cl+XCl→XCl+Cl(X=H,D,Mu).For the Cl+HCl reaction,the excellent agreement between the RPMD and experimental values provides a strong proof for the accuracy of the RPMD *** the RPMD results are also consistent with results from other theoretical methods including improved-canonical-variational-theory and quantum *** most novel finding is that there is a double peak in Cl+MuCl reaction near the transition state,leaving a free energy *** comes from the mode softening of the reaction system at the peak of the potential energy *** an explicit free energy well suggests strongly there is an observable *** for the Cl+DCl reaction,the RPMD rate coefficient again gives very accurate results compared with experimental *** only exception is at the temperature of 312.5 K,results from RPMD and all other theoretical methods are close to each other but slightly lower than the experimental value,which indicates experimental or potential energy surface deficiency.

关键词： Ring-polymer molecular dynamics Quantum effects Recrossing effects Reaction rate coefficient Kinetic isotope effect

Dynamic analysis and bifurcation control of a delayed fractional-order eco-epidemiological migratory bird model with fear effect

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International Journal of Biomathematics 2024年第3期17卷 1-33页

作者： Caihong song ning Li College of Sciences Northeastern University 110819 ShenyangLiaoningP.R.China

In this paper,a new delayed fractional-order model including susceptible migratory birds,infected migratory birds and predators is proposed to discuss the spread of diseases among migratory *** of predators is considered in the model,as fear can reduce the reproduction rate and disease transmission rate among ***,some basic mathematical results of the proposed model are ***,time delay is regarded as a bifurcation parameter,and the delay-induced bifurcation conditions for such an uncontrolled system are established.A novel periodic pulse feedback controller is proposed to suppress the bifurcation *** is found that the control scheme can successfully suppress the bifurcation behavior of the system,and the pulse width can be arbitrarily selected on the premise of ensuring the control *** with the traditional time-delay feedback controller,the control scheme proposed in this paper has more advantages in practical application,which not only embodies the advantages of low control cost and easy operation but also caters to the periodic changes of the *** proposed control scheme,in particular,remains effective even after the system has been disrupted by a *** simulation verifies the correctness of the theoretical results.

关键词： Delayed fractional-order migratory birds fear Hopf bifurcation periodic pulse feedback

Design of acceleration control schedule for adaptive cycle engine based on direct simulation model

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Chinese Journal of Aeronautics 2024年第6期37卷 307-318页

作者： Keran song Linyuan jia Yuchun CHEN Tian TAN School of Power and Energy Northwestern Polytechnical UniversityXi’an 710072China

To design the optimum acceleration control schedule for the Adaptive Cycle Engine(ACE)in the full flight envelope,this paper establishes a direct simulation model of the ACE transient *** this model,geometric parameters are used to replace the component state *** corresponding relationship between geometric parameters and component state parameters is determined by sensitivity *** geometric variables are controlled when the geometric adjustment speed exceeds the limit,and at the same time the corresponding component state parameters are *** gradient optimization algorism is used to optimize the ground acceleration process of ACE,and the control schedule in terms of operating point of compression components and corrected acceleration rate is used as the full-envelope acceleration control schedule based on the similarity *** acceleration control schedules of the triple-bypass mode and the double-bypass mode are designed in this *** acceleration processes under various flight conditions are simulated using the acceleration control *** with the acceleration process with the linear geometric adjustment schedule,the acceleration performance of ACE is improved by the acceleration control schedule,with the impulse of the acceleration process of the triple-bypass mode being increased by 8.7%-12.3% and the impulse of the double-bypass mode acceleration process being increased by 11.8%-14.1%.

关键词： Adaptive Cycle Engine(ACE) Direct simulation method Acceleration Control schedule Full flight envelope

Gut microbiome and serum metabolome analyses identify Bacteroides fragilis as regulators of serotonin content and PRL secretion in broody geese

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Journal of Integrative Agriculture 2024年第6期23卷 2033-2051页

作者： Yu Zhang ning Zhou jia Wu Lina song Qiang Bao Kaiqi Weng Yang Zhang Wanwipa Vongsangnak Guohong Chen Qi Xu College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China Joint International Research Laboratory of Agriculture&Agri-Product Safety of Ministry of Education Yangzhou UniversityYangzhou 225009China Department of Zoology Faculty of ScienceKasetsart UniversityBangkok 10900Thailand

Broody behavior is regulated by hypothalamic prolactin secretion,which seriously affects egg production in poulty *** studies have provided evidence that animal behavior is governed by dynamic bidirectional communication between specific gut bacteria and their host via the brain-gut-microbiome ***,little research focused on how the gut microbiota influence broody behavior in *** this study,Zhedong white geese in laying and brooding phases were *** differentially abundant bacteria in cecum were detected between brooding and laying geese through metagenomic analyses and 16S rRNA sequencing(P<0.05),and Bacteroides fragilis was specifically identified as a key driver species in the brooding ***,the serum metabolites were quantified,and the 313 differentially abundant metabolites were found between the two groups of different physiological *** were primarily enriched in the tryptophan metabolism *** correlation analyses revealed there was a significant positive correlation between *** abundance and the context of 11 tryptophan metabolism-related metabolites(such as serotonin,etc.)in broody geese,which hinted that those tryptophan metabolites might be produced or driven by ***,the serum hormone levels were also *** found there was a positive correlation between *** abundance and content of ***,prolactin secreted by the pituitary gland was greater in brooding geese than that in laying geese,which was also highly correlated with *** *** result implied that *** could promote the secretion of prolactin by the pituitary ***,the current study findings provided the information on gut microbiota influencing broody behavior,*** produced or driven more serum serotonin,and stimulated the pituitary gland to secret more prolactin,which potentially offered a new enlightenment for the intervention of broody behavior in pou

关键词： geese broody behavior gut microbiota serotonin prolactin

Preparation and characterization of high-reactivity explosive-based nano-boron microspheres

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PARTICUOLOGY 2024年第10期93卷 125-136页

作者： Dong, Chen Wang, Yi jia, Kanghui song, Dan song, Xiaolan An, Chongwei North Univ China Sch Mat Sci & Engn Taiyuan 030051 Peoples R China Jinxi Grp Shanxi jiangyang Chem Co Ltd Taiyuan 030051 Peoples R China China Ordnance Inst Sci & Technol Beijing 100089 Peoples R China North Univ China Sch Environm & Safety Engn Taiyuan 030051 Peoples R China

Boron nanoparticles, with their remarkably high gravimetric and volumetric calorific values, emerge as the most promising fuel in energetic fields. However, challenges such as susceptibility to oxidation, high ignition temperature, and low combustion efficiency have constrained their further applications. In this study, we fabricated high explosives based nano-boron microspheres with uniform size using the electrostatic spray method, in which the boron nanoparticles and high explosives (CL-20 or PETN) are closely bonded together by fluorinated polymer (F-2602) and evenly distributed. The results indicated that the microspheres exhibited high sphericity and showed an enhanced antioxidant capability. The addition of high-energy explosives not only reduced the thermal oxidation temperature of nano-boron powder within the microspheres but also significantly enhanced the pressurization rate. Additionally, the microspheres with added high-energy explosives released more energy during the combustion process. Compared to physically mixed samples, electrostatically sprayed microspheres with a uniform microstructure still exhibited higher reactivity. Therefore, the design and synthesis of microspheres with controllable structures using the electrostatic spray method show promising application prospects. (c) 2024 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

关键词： Nano-boron CL-20 PETN Electrospraying Ignition and combustion NANOPARTICLES COMBUSTION