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Contrast-enhanced ultrasound imaging for intestinal lymphoma

World Journal of Gastroenterology 2021年第32期27卷 5438-5447页

作者： ning-yi cui Xuan-Tong Gong Yan-Tao Tian Yong Wang Rui Zhang Meng-Jia Liu Jie Han Bo Wang Di Yang Department of Ultrasound National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Ultrasound Fatou Community Health Service Center Chaoyang District BeijingBeijing 100023China Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Intestinal lymphoma is a rare ***-enhanced ultrasound(CEUS)findings of intestinal lymphoma have not been reported previously,and the relationship between CEUS and clinicopathological features and prognostic factors is still *** To describe the B-mode US and CEUS features of intestinal lymphoma and investigate the correlation of CEUS and histopathological *** This was a single-center retrospective *** patients with histologically confirmed intestinal lymphoma underwent B-mode US and CEUS examinations between October 2016 and November *** summarized the features of Bmode US and CUES imaging of intestinal lymphoma and compared the frequency of tumor necrosis in intestinal lymphomas with reference to different pathological subtypes(aggressive or indolent)and clinical stage(early or advanced).The time–intensity curve parameters of CEUS were also compared between patients with normal and elevated serum lactate *** In B-mode imaging,four patterns were observed in intestinal lymphoma:Mass type(12/18,66.7%),infiltration type(1/18,5.6%),mesentery type(4/18,22.2%)and mixed type(1/18,5.6%).All cases were hypoechoic and no cystic areas were *** CEUS,most cases(17/18,94.4%)showed arterial hyperechoic *** cases showed arterial enhancement followed by venous wash out.A relatively high rate of tumor necrosis(11/18,61.1%)was observed in this *** necrosis on CEUS was more frequent in aggressive subtypes(10/13,76.9%)than in indolent subtypes(1/5,20.0%)(P=0.047).There were no correlations between tumor necrosis and lesion size and Ann Arbor *** was no significant difference in time–intensity curve parameters between normal and elevated lactate dehydrogenase *** B-mode US and CEUS findings of intestinal lymphoma are *** observed a high rate of tumor necrosis,which appeared more frequently in aggressive pathological subtypes of intestinal lymphoma.

关键词： Intestinal lymphoma Contrast enhanced ultrasound B-mode ultrasound Histopathological features Lactate dehydrogenase Quantitative diagnosis

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Effect of ATRA Combined with Interferon Alpha-2a on the Animal Model of Bladder tumor

Effect of ATRA Combined with Interferon Alpha-2a on the Anim...

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第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： ning Song-yi, cui Fei-lun Department of Urology, the First Peoples Hospital of Zhen Jiang, Zhen Jiang 212002

Purpose: To observe the effect of all trans retinoic acid (ATRA) combined with Interferon α-2a on the Wistar rats model of bladder tumor and explore the mechanism of the therapeusis. Methods: 50 female Wistar rats, 6... 详细信息

关键词： Wistar rat MNU bladder tumor ATRA IFN-α-2a apoptosis

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua Wang yi-Xin Liu Lu Xu Lin Fu ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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AlN precipitation during steel solidification using CA model

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Journal of Iron and Steel Research International 2022年第11期29卷 1789-1799页

作者： Lei cui yi-han Shi Xiang-ning Meng Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

Based on the principles of metal solidification and cellular automaton(CA),as well as AlN precipitation thermodynamics and kinetics,a CA model of interdendritic AlN precipitation was established by coupling a large-size mesh describing the dendrite growth of Fe-C-Al-N alloys and a small-size mesh representing AlN precipitation based on transient chemical *** results of single dendrite growth stimulated by this model were compared with the Lipton-Glicksman-Kurz solution to verify the correctness of the matrix dendrite growth *** AlN morphology and dimensions obtained from the CA model simulations are following the experimental *** presence of equiaxed dendrite in the computational domain results in a significant coarsening of the columnar dendrite and a uniform solute distribution around them,and the AlN solid phase fraction *** of AlN precipitation at different wetting angles were also performed,and it was found that the solid phase fraction of AlN decreased with the increase in wetting ***,it is confirmed that the established model is an effective method to simulate interdendritic AlN precipitation.

关键词： Metal solidification Cellular automaton Wetting angle AlN precipitation Dendrite growth

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Recrystallization Behavior of the New Ni-Co-Based Superalloy with Fusion Structure Produced by Electron Beam Smelting Layered Solidification Technology

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Acta Metallurgica Sinica(English Letters) 2023年第12期36卷 2013-2030页

作者： Hongyang cui yi Tan Rusheng Bai Lidan ning Chuanyong cui Xiaogang You Pengting Li School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China Key Laboratory for Energy Beam Metallurgy and Advanced Materials Preparation of Liaoning Province Dalian 116024.China Superalloys Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou 450001China

The new Ni-Co-based superalloy featuring a"fusion structure"was produced utilizing electron beam smelting layered solidification technology(EBSL).Experimental examination of hot compression deformation with varied settings for EBSL and conventional duplex process melting Ni-Co superalloys was *** per the study,EBSL-Ni-Co superalloys exhibited enhanced recrystallization susceptibility during hot ***,elevating deformation temperature,lowering strain rate,and augmenting strain collectively contribute to enlarging the volume fraction of dynamically recrystallized *** growth of grains occurred when the deformation temperature equaledγ′sub-solvus temperature and the strain rate was ***,exceeding theγ′solvus temperature during deformation significantly increases the particle size of dynamic recrystallization(DRX)***γ′phase can effectively modulate the DRX grain size through the pegging ***,it was revealed that the presence of the fusion structure aids in the generation of continuous dynamic recrystallization,discontinuous dynamic recrystallization,and twinning-induced dynamic recrystallization while the alloy undergoes hot *** mechanism promotes DRX granule formation and permits complete ***,the fusion structure was identified as playing a catalytic role in the dynamic recrystallization process of the new Ni-Co superalloy.

关键词： Dynamic recrystallization Hot deformation Electron beam smelting Ni-Co-based superalloy Fusion structure

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A CA-LBM model for simulating dendrite growth with forced convection

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Journal of Iron and Steel Research International 2021年第8期28卷 997-1008页

作者： Xiang-ning Meng Lei cui yi-han Shi Miao-yong Zhu Key Laboratory for Ecological Metallurgy of Multi-Metallic Ores Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

A two-dimensional coupled model of the cellular automaton(CA)and the lattice Boltzmann method(LBM)was developed to simulate the solute dendrite growth of Fe-C-Mn-S alloy in the presence of forced *** model describes the transport phenomenon by the evolution of moving pseudo-particles distribution functions and utilizes the LBM to solve fluid flow and solute transport under forced convection *** on the solute field calculated by the CA technique,the dynamics of dendrite growth were determined by the previously proposed local solute balance *** accuracy of the forced convection dendrite growth model was verified by comparing the CA-LBM model with Lipton-Glicksman-Kurz analytical *** is revealed that the dendrite symmetry structure is destroyed compared to free diffusion,and the upstream arm is more developed than the downstream arm of the *** enriched solute segregates more at the downstream side than at the upstream side of the *** length of the upstream dendrite arm increases firstly and then becomes stable with the increase in the flow velocity,the dendrite necking is restrained,and the vertical dendrite arm becomes longer.

关键词： Two-dimensional coupled model Cellular automaton Lattice Boltzmann method Dendrite growth Forced convection

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Microstructure control and hot cracking behavior of the new Ni-Co based superalloy prepared by electron beam smelting layered solidification technology

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Journal of Materials Science & Technology 2024年第8期175卷 55-71页

作者： Hongyang cui yi Tan Lidan ning Rusheng Bai Xiaogang You Chuanyong cui Pengting Li School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China Key Laboratory for Energy Beam Metallurgy and Advanced Materials Preparation of Liaoning Province Dalian 116024China Superalloys Division Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

The prevention of hot cracking formation is of utmost importance in the production of the new Ni-Co based superalloys through the utilization of the electron beam smelting layered solidification technique(EBSL),as it ensures exceptional homogeneity and dependable consistency of the *** contrast to previous studies that focused on minimizing the liquid film and solidification range,our methodology adopts a distinct *** this research,a novel methodology was employed to mitigate internal stresses through the implementation of equiaxed grain layers via an alternately reduced cooling *** ultimately resulted in the elimination of hot *** be more specific,the transition from a columnar to an equiaxed structure was observed during the layer-by-layer construction process in the fabrication of the new Ni-Co based superalloy in *** EBSL-Ni-Co superalloy,when subjected to the alternating reduction cooling method,exhibited an internal stress of 49 *** value represents a significant reduction of 83.8%compared to the internal stress observed when employing the linear reduction cooling ***,the solvus temperature of theγ-γ’eutectic phases in EBSL-Ni-Co superalloys produced by the alternating reduction cooling method is significantly ***,the Nth layer of the EBSL-Ni-Co based superalloys produced by EBSL simultaneously heats treated with the preceding *** the low melting point phase gradually dissolved back into the *** implementation of an alternating reduced cooling method successfully mitigated the formation of the liquid film in theγ-γ’eutectic phase and the buildup of internal stresses in the EBSL-Ni-Co superalloy during its manufacturing *** discoveries open up a novel preparation procedure pathway for the manufacture of crack-free superalloys with superior mechanical characteristics using EBSL.

关键词： Electron beam smelting layered solidification technology CET Thermal cycling Hot cracking

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抗血小板药物联合抗结核药治疗急性非ST段抬高型心肌梗死合并肺结核的药学监护

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中国临床药理学杂志 2018年第7期34卷 878-880页

作者：周靓昉向倩何云霞谢秋芬王梓凝崔一民北京大学第一医院药剂科北京100034 宁波市第六医院药剂科宁波315040 北京大学药学院药事管理与临床药学系北京100191

目的分析临床药师在急性非ST段抬高型心肌梗死合并肺结核患者的给药方案的制订与用药监护中的工作要点。方法临床药师参与1例急性非ST段抬高型心肌梗死合并肺结核患者的药物治疗过程,通过分析患者的治疗方案,评估抗血小板药物的疗效,讨... 详细信息

目的分析临床药师在急性非ST段抬高型心肌梗死合并肺结核患者的给药方案的制订与用药监护中的工作要点。方法临床药师参与1例急性非ST段抬高型心肌梗死合并肺结核患者的药物治疗过程,通过分析患者的治疗方案,评估抗血小板药物的疗效,讨论基因多态性以及抗结核药物与抗血小板药物之间的相互作用对疗效的影响。结果和结论分析每个药物的作用特点,恰当地管理药物相互作用,为患者提供个体化给药方案,是临床药师参与临床团队工作的切入点。

关键词：抗血小板药物抗结核药物氯吡格雷替格瑞洛药学监护

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Beyond Performance of Learning Control Subject to Uncertainties and Noise: A Frequency-Domain Approach Applied to Wafer Stages

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 198-214页

作者： Fazhi Song ning cui Shuaiqi Chen Kai Zhang Yang Liu Xinkai Chen Jiubin Tan IEEE the Center of Ultra-precision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of Ultra-Precision Intelligent Instrumentation Ministry of Industry and Information Technology the State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology the Center of Ultraprecision Optoelectronic Instrument Engineering Harbin Institute of Technology the Key Laboratory of UltraPrecision Intelligent Instrumentation Ministry of Industry and Information Technology the Department of Electronic and Information Systems Shibaura Institute of Technology

The increasingly stringent performance requirement in integrated circuit manufacturing, characterized by smaller feature sizes and higher productivity, necessitates the wafer stage executing a extreme motion with the accuracy in terms of nanometers. This demanding requirement witnesses a widespread application of iterative learning control(ILC), given the repetitive nature of wafer scanning. ILC enables substantial performance improvement by using past measurement data in combination with the system model knowledge. However, challenges arise in cases where the data is contaminated by the stochastic noise, or when the system model exhibits significant uncertainties, constraining the achievable performance. In response to this issue, an extended state observer(ESO) based adaptive ILC approach is proposed in the frequency *** being model-based, it utilizes only a rough system model and then compensates for the resulting model uncertainties using an ESO, thereby achieving high robustness against uncertainties with minimal modeling effort. Additionally, an adaptive learning law is developed to mitigate the limited performance in the presence of stochastic noise, yielding high convergence accuracy yet without compromising convergence speed. Simulation and experimental comparisons with existing model-based and data-driven inversion-based ILC validate the effectiveness as well as the superiority of the proposed method.

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北师大版初中数学新教材的特色及变化分析

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教学与管理 2025年第1期 44-48页

作者：常海斌宁依敏首都师范大学教育学院北京100048 华东师范大学数学科学学院上海200241

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着... 详细信息

深刻理解和准确解读教材是有效使用教材的前提。北师大版初中数学新教材遵循“教育本位”的教材编写理念,在章首语、栏目设置、问题解决、习题设计和素材选取上各具特色;教材整体采用跨领域混编、螺旋式上升和小结整合式的编写模式,着重凸显课程内容的结构化和认知过程的进阶性;四个学习领域以“研究对象”的形式进行内容整合,具有重视代数推理、重构统计量的组合形式以及对综合与实践领域进行主题迭代和核心创变等变化。

关键词：初中数学新教材教材编写特色北师大版教材新教材变化分析

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