检索结果-南通市图书馆

Blockade of the Dopamine D3 Receptor Attenuates Opioids-Induced Addictive Behaviours Associated with Inhibiting the Mesolimbic Dopamine System

引用

Neuroscience Bulletin 2023年第11期39卷 1655-1668页

作者： Rong-Rong Hu Meng-Die Yang Xiao-Yan Ding ning Wu Jin Li Rui song State Key Laboratory of Toxicology and Medical Countermeasures Beijing Key Laboratory of NeuropsychopharmacologyBeijing Institute of Pharmacology and ToxicologyBeijing100850China Department of Nuclear Medicine Hainan Hospital of Chinese PLA General HospitalSanya572013China

Opioid use disorder(OUD)has become a considerable global public health challenge;however,potential medications for the management of OUD that are effective,safe,and nonaddictive are not available.Accumulating preclinical evidence indicates that antagonists of the dopamine D3 receptor(D3R)have effects on addiction in different animal models.We have previously reported that YQA14,a D3R antagonist,exhibits very high affinity and selectivity for D3Rs over D2Rs,and is able to inhibit cocaine-or methamphetamine-induced reinforcement and reinstatement in self-administration tests.In the present study,our results illustrated that YQA14 dose-dependently reduced infusions under the fixed-ratio 2 procedure and lowered the breakpoint under the progressive-ratio procedure in heroin self-administered rats,also attenuated heroin-induced reinstatement of drug-seeking behavior.On the other hand,YQA14 not only reduced morphine-induced expression of conditioned place preference but also facilitated the extinguishing process in mice.Moreover,we elucidated that YQA14 attenuated opioid-induced reward or reinforcement mainly by inhibiting morphine-induced up-regulation of dopaminergic neuron activity in the ventral tegmental area and decreasing dopamine release in the nucleus accumbens with a fiber photometry recording system.These findings suggest that D3R might play a very important role in opioid addiction,and YQA14 may have pharmacotherapeutic potential in attenuating opioid-induced addictive behaviors dependent on the dopamine system.

关键词： Opioid use disorder D3 receptors Dopamine Self-administration Conditioned place preference

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compositional characteristics of sediment from Jiaozhou Bay in North China and the implication to the provenance

引用

Journal of Oceanology and Limnology 2023年第5期41卷 1729-1741页

作者： Ziwei SUN Jin LIU Yue ZHANG Jinming song Yuanyuan XIAO Huamao YUAN ning LI Xuegang LI College of Chemistry and Molecular Engineering College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Public Technology Service Center Institute of OceanologyChinese Academy of SciencesQingdao 266071China Key Laboratory of Marine Ecology&Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China Qingdao National Laboratory for Marine Science and Technology Qingdao 266061China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China

Rare earth elements(REEs)can be used to trace source materials and identify their provenances,because of significant conservation and immobility during chemical alteration processes after erosion of materials from the provenance.This study focused on the temporal variation of REEs for columnar sediments from the mouth of Jiaozhou Bay in North China to understand the potential controls for the geochemical variations of sediments.Through extraction experiments,we identified that the residual fraction is the main host for REEs compared with other fractions(i.e.,exchangeable and carbonate fraction,easily reducible oxides fraction,reducible oxides fraction,magnetite fraction).REE ratios(e.g.,La_(N)/Sm_(N)and La_(N)/Yb_(N);N:normalized by chondrite)lack correlations with grain size or the chemical index of alteration(CIA),which is correlated with major elements.All these indicate that these REE variations reflect the varying contribution of source materials from different provenances instead of grain size or chemical weathering effects.REE ratios(e.g.,La_(N)/Sm_(N)and La_(N)/Yb_(N))remain relatively constant until the depth of roughly 40 cm(equivalent to the year 1995),and show obvious changes beyond this depth.Compared REE characteristics of Jiaozhou Bay with those of neighboring rivers and bedrocks,the relative contributions of Dagu River-Jiaolai River,and Licun River may have been increased during the sedimentary processes,which could be caused by the construction of reservoir and related change of aquaculture(e.g.,rapid accumulation of organic materials).

关键词： Jiaozhou Bay sediments rare earth elements(REEs) sequential extraction provenance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

郭沫若历史剧《高渐离》的版本与修改

引用

现代中文学刊 2021年第6期 102-108页

作者：宋宁山东师范大学文学院

郭沫若历史剧《高渐离》的版本流变是"初刊本"→"初版本"→"群益修改本"→"文集本"。后两次的改版修改较多,剧作正文的文字改动分别达到554处和433处。这两次都"完全改换"了结尾,赋予不同的寓意;并不断修正秦始皇、赵高、高渐离等主要... 详细信息

郭沫若历史剧《高渐离》的版本流变是"初刊本"→"初版本"→"群益修改本"→"文集本"。后两次的改版修改较多,剧作正文的文字改动分别达到554处和433处。这两次都"完全改换"了结尾,赋予不同的寓意;并不断修正秦始皇、赵高、高渐离等主要角色的设置;在许多细微之处进行了合乎文化逻辑、生活逻辑或思维逻辑的修改;对于戏剧语言进行了规范化、流畅化的修改。《高渐离》的修改,既凸显郭沫若在不同时代背景下的文化政治实践,也体现其在戏剧艺术上的精益求精。

关键词：郭沫若《高渐离》版本修改

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

血液灌流器联合血液透析机治疗尿毒症的安全性与临床疗效

引用

中国医疗器械信息 2022年第15期28卷 138-140页

作者：宋宁宁天津北大医疗海洋石油医院天津300450

目的:分析血液灌流器联合血液透析机治疗尿毒症的安全性与临床疗效。方法:选取2018年3月~2020年3月本院收治的56例尿毒症患者为研究对象,应用随机数字表法将其分为两组。对照组患者采用血液透析机进行血液透析治疗,观察组患者采用血液... 详细信息

目的:分析血液灌流器联合血液透析机治疗尿毒症的安全性与临床疗效。方法:选取2018年3月~2020年3月本院收治的56例尿毒症患者为研究对象,应用随机数字表法将其分为两组。对照组患者采用血液透析机进行血液透析治疗,观察组患者采用血液灌流器联合血液透析机进行血液灌流联合血液透析治疗,观察两组患者治疗前后的甲状旁腺激素、血尿素氮、心功能以及不良反应发生率。结果:治疗前两组患者的甲状旁腺激素、血尿素氮以及各项心功能指标差异均无显著意义(P>0.05),治疗后观察组甲状旁腺激素和血尿素氮水平均显著优于对照组(P<0.05)。治疗后观察组的各项心功能指标均显著优于对照组(P<0.05)。观察组总不良反应发生率为25.00%(7/28),显著低于对照组的67.86%(19/28)(P<0.05)。结论:血液灌流器联合血液透析机治疗尿毒症效果显著。

关键词：血液灌流器血液透析机尿毒症临床疗效不良反应

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Identification and Pathogen Stimulation Patterns of Neuronal Nitric Oxide Synthase(nNOS)in Black Rockfish(Sebastes schlegelii)

引用

Journal of Ocean University of China 2023年第3期22卷 842-850页

作者： YAN Xu WANG ningning CAO Min LI Chao YANG ning XUE Ting FU Qiang song Lin College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266044China School of Marine Science and Engineering Qingdao Agricultural UniversityQingdao 266109China Shandong Provincial Key Laboratory of Biochemical Engineering College of Marine Science and Biological EngineeringQingdao University of Science and TechnologyQingdao 266042China Wuqiong Food Co. Ltd.Raoping 515726China

Neuronal nitric oxide synthase(nNOS)was the producer of nitric oxide(NO)which played important gas messenger molecules in biological process.It also can take effect as immune regulation molecule in organism.Black rockfish(Sebastes schlegelii)is an important economic fish which were widely farmed in East Asia countries.Meanwhile,the pathogenic bacteria such as the Edwardsiella tarda and Vibrio anguillarum in seawater always brought serious obstacles to their healthy growth.In order to explore the expression pattern of n NOS gene under the pathogen stimulation and predict its immune function,the n NOS gene in black rockfish named Ssn NOS was identified.It was 3780 bp in length,located on chromosome 6,and contained 27 coding domain sequence(CDs).According to the phylogenetic analysis,the Ssn NOS showed closest relative to the counterpart gene of swamp eel(Monopterus albus).Meanwhile,analysis of Ssn NOS expression in various healthy tissues showed that Ssn NOS expression level was highest in healthy brain tissues,followed by intestinal tissues.In addition,Ssn NOS showed significant expression changes in response to stimulation by two pathogens.Particular in gill,the expression of Ssn NOS after pathogenic stimulation increased significantly.The Elisa analysis showed the Ssn NOS content in gills was much higher than that in other tissues at all time points.Moreover,the expression patterns of Ssn NOS in brain,intestine and kidney after stimulation by pathogens showed a distinct expression pattern which first down-regulated and then up-regulated.Therefore,the Ssn NOS may be an important signaling molecule for fish to respond rapidly in immune stimulation.

关键词： neuronal nitric oxide synthase black rockfish immune function Edwardsiella tarda Vibrio anguillarum

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study

引用

World Journal of Clinical Cases 2024年第5期12卷 880-890页

作者： ning Wei Ming-Hui Liu Yu-Hu song Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Clinical studies have reported that patients with gastroesophageal reflux disease(GERD)have a higher prevalence of hypertension.AIM To performed a bidirectional Mendelian randomization(MR)analysis to investi-gate the causal link between GERD and essential hypertension.METHODS Eligible single nucleotide polymorphisms(SNPs)were selected,and weighted median,inverse variance weighted(IVW)as well as MR egger(MR-Egger)re-gression were used to examine the potential causal association between GERD and hypertension.The MR-Pleiotropy RESidual Sum and Outlier analysis was used to detect and attempt to reduce horizontal pleiotropy by removing outliers SNPs.The MR-Egger intercept test,Cochran’s Q test and“leave-one-out”sen-sitivity analysis were performed to evaluate the horizontal pleiotropy,heterogen-eities,and stability of single instrumental variable.RESULTS IVW analysis exhibited an increased risk of hypertension(OR=1.46,95%CI:1.33-1.59,P=2.14E-16)in GERD patients.And the same result was obtained in replication practice(OR=1.002,95%CI:1.0008-1.003,P=0.000498).Meanwhile,the IVW analysis showed an increased risk of systolic blood pressure(β=0.78,95%CI:0.11-1.44,P=0.021)and hypertensive heart disease(OR=1.68,95%CI:1.36-2.08,P=0.0000016)in GERD patients.Moreover,we found an decreased risk of Barrett's esophagus(OR=0.91,95%CI:0.83-0.99,P=0.043)in essential hypertension patients.CONCLUSION We found that GERD would increase the risk of essential hypertension,which provided a novel prevent and therapeutic perspectives of essential hypertension.

关键词： Gastroesophageal reflux disease Essential hypertension Hypertensive heart disease Mendelian randomization study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

论桐华小说《云中歌》的历史改编策略

引用

齐齐哈尔大学学报（哲学社会科学版） 2022年第3期 102-105,109页

作者：宋宁宁陕西师范大学文学院陕西西安710119

桐华擅长以传说或历史记载为依托,通过增删改编,演绎出既符合历史又不同于传统历史的古典爱情故事。其小说《云中歌》即是这方面的典型,我们通过分析《云中歌》,可以管窥桐华惯常使用的历史改编策略。我们发现,桐华在尊重历史大方向的... 详细信息

桐华擅长以传说或历史记载为依托,通过增删改编,演绎出既符合历史又不同于传统历史的古典爱情故事。其小说《云中歌》即是这方面的典型,我们通过分析《云中歌》,可以管窥桐华惯常使用的历史改编策略。我们发现,桐华在尊重历史大方向的前提下,主要通过合理想象填补历史细节、无中生有为小说情节服务、解构颠覆历史言说为小说主旨服务等策略对历史进行改编。分析其小说的历史改编策略,有助于更好地揭示其小说的叙事技巧、艺术成就乃至思想意义。

关键词：桐华《云中歌》历史改编

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vascular endothelial growth factor A promotes platelet adhesion to collagen Ⅳ and causes early brain injury after subarachnoid hemorrhage

引用

Neural Regeneration Research 2019年第10期14卷 1726-1733页

作者： Zun-Wei Liu Jun-Jie Zhao Hong-Gang Pang Jin-ning Song Department of Renal Transplantation Nephropathy Hospitalthe First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Institute of Organ Transplantation Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Neurosurgery the First Affiliated HospitalMedical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina The First Affiliated Hospital Medical College of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

The role of vascular endothelial growth factor A in platelet adhesion in cerebral microvessels in the early stage of subarachnoid hemorrhage remains unclear.In this study,the endovascular puncture method was used to produce a rat model of subarachnoid hemorrhage.Then,30 minutes later,vascular endothelial growth factor A antagonist anti-vascular endothelial growth factor receptor 2 antibody,10μg,was injected into the right ventricle.Immunohistochemistry and western blot assay were used to assess expression of vascular endothelial growth factor A,occludin and claudin-5.Immunohistochemical double labeling was conducted to examine co-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ collagen.TUNEL was used to detect apoptosis in the hippocampus.Neurological score was used to assess behavioral performance.After subarachnoid hemorrhage,the expression of vascular endothelial growth factor A increased in the hippocampus,while occludin and claudin-5 expression levels decreased.Co-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ collagen and the number of apoptotic cells increased,whereas behavioral performance was markedly impaired.After treatment with anti-vascular endothelial growth factor receptor 2 antibody,occludin and claudin-5 expression recovered,while co-expression of GP Ⅰa-Ⅱ integrin and type Ⅳ collagen and the number of apoptotic cells decreased.Furthermore,behavioral performance improved notably.Our findings suggest that increased vascular endothelial growth factor A levels promote platelet adhesion and contribute to early brain injury after subarachnoid hemorrhage.This study was approved by the Biomedical Ethics Committee,Medical College of Xi’an Jiaotong University,China in December 2015.

关键词： nerve regeneration vascular endothelial growth factor A vascular endothelial growth factor receptor 2 subarachnoid hemorrhage brain injuries platelet adhesion collagen blood-brain barrier neural regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research of a Near Room-temprature Organic-Inorganic Hybrid Perovskite:（S）-3-（Hydroxypyrrolidine）CdCl3

Research of a Near Room-temprature Organic-Inorganic Hybrid ...

引用

中国化学会2019年中西部地区无机化学化工学术研讨会

作者： ning Song Xingxian Dong Linsui Li YuHui Tan School of Metallurgy and Chemical Engineering Jiangxi University of Science and Technology

The（S）-3-Hydroxypyrrolidine hydrochloride was mixed with Cadmium Chloride at a molar ratio of 2:1 and then added into 15 mL methanol solution, which was heated and stirred for 1 h until the solution was clarify and then filtered. Thus we obtained a novel organic-inorganic hybrid perovskite（S）-3-（Hydroxypyrrolidine）CdCl3（1） with reversible phase transition under slowly evaporated at room temperature. The structure of 1 was determined by singlecrystal X-ray diffraction（SCXRD） and further characterized by elemental analysis（EA）, infrared spectra（IR） and powder X-ray diffraction（PXRD） measurements. SCXRD and structural analysis show that 1 crystallizes in a monoclinic space group P21 at 250 K. DSC and dielectric properties show that 1 undergoes a reversible structural phase transition with a Curie temperature of 290 K.

关键词： Organic-inorganic hybrid perovskite Reversible phase transition Dielectric property

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Basic Catalytic Performance of Amino and Acylamide Functionalized Metal-organic Framework in the Synthesis of Chloropropene Carbonate from CO2 Under Atmospheric Pressure

引用

Chemical Research in Chinese Universities 2016年第5期32卷 838-842页

作者： song Lili CHEN Chao CHEN Xiangbin ZHANG ning Institute of Applied Chemistry College of Chemistry Nanchang University Nanchang 330031 P. R. China

In this work, a metal-organic framework with free standing basic groups（e, g., amino and acylamide groups） decorated in the pore wall was utilized to catalyze the CO2 cycloaddition reaction and its basic properties were tested in Knoevenagel condensation reactions. The results reveal that the metal-organic frarnework（MOF） material has excellent catalytic activity and high repeatability for the synthesis of chloropropene carbonate from CO2 and epichlorohydrin with no co-catalyst under mild reaction conditions, suggesting that it is a promising heteroge- neous catalyst for CO2 cycloaddition reaction.

关键词： Metal-organic framework Heterogeneous catalysis C02 Chloropropene carbonate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：