检索结果-南通市图书馆

KI Catalyzed Nitrogenation of Aldehydes and Alcohols： Direct Synthesis of Carbamoyl Azides and Ureas

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2017年第6期35卷 845-848页

作者： song song Peng Feng Miancheng Zou ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University Beijing 100191 China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal University Shanghai 200062 China

An efficient KI catalyzed nitrogenation of aldehydes and alcohols for the direct synthesis of carbamoyl azides and ureas via a radical process has been developed. The simple operating procedures, the readily available starting materials including aldehydes, alcohols and amines, as well as the utility of the products all make this strategy very attractive.

关键词： nitrogenation aldehydes carbamoyl azides ureas KI TBHP

Aerial Silk Road Soars The“Silk Road in the Air”promoted by China Eastern Airlines will reach around the world to bring people in BRI partner countries even closer together

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Report ASEAN 2024年第1期9卷 42-44页

作者： Shui ning song Mengfei 不详

Two thousand years ago,the Silk Road connecting Xi’an to Rome was a long journey that took more than a year.Today,China Eastern Airlines makes the journey in just over 10 hours with the world’s most advanced wide-body airliner.The power of civil aviation has made the Silk Road more convenient than ever before.Over the last decade of the Belt and Road Initiative(BRI),the“Aerial Silk Road”has connected more and more destinations around the world.

关键词： Eastern Road closer

维普期刊数据库

Management of ductal spasm in a neonate with pulmonary atresia and an intact ventricular septum during cardiac catheterization:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第35期10卷 13015-13021页

作者： Xu Zhang ning Zhang Hai-Cheng song Yue-Yi Ren Department of Heart Center Qingdao Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina Department of Medical Technology Qingdao Women's and Children's Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina

BACKGROUND Ductal spasm is a rare but life-threatening complication of cardiac catheterization in neonates with pulmonary atresia and an intact ventricular septum.In patients with ductal-dependent pulmonary blood flow,ductal spasm may lead to refractory hypoxemia and severe hemodynamic instability,which need to be treated in perfect order.CASE SUMMARY We present a male infant with a gestational age of 39 wk,and his fetal echocardiography showed pulmonary atresia.At 28 d of age,transcatheter pulmonary valvuloplasty with balloon dilatation was performed.Two hours after the operation,the patient's pulse oxygen saturation continued to decrease.The patient was then transferred to receive cardiac catheterization.During catheterization,the invasive blood pressure and pulse oxygen saturation suddenly decreased,and repeated aortography revealed partial occlusion of the ductus arteriosus.It no longer changed when pulse oxygen saturation rose to 51%after approximately 20 min of maintenance therapy.Therefore,a ductal stent was used for implantation.Hemodynamics and hypoxemia were improved.CONCLUSION We should know that ductal spasm may occur during pulmonary atresia and intact ventricular septum cardiac catheterization.Understand the pathophysiology of ductal-dependent pulmonary blood flow and make comprehensive perioperative preparations essential to deal with hemodynamic disorders caused by ductal spasm.

关键词： Cardiac catheterization Ductus arteriosus Ductal stent Ductal spasm Intact ventricular septum Pulmonary atresia Case report

A new SINS/RCNS integrated navigation method based on star pixel coordinates

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2023年第9期66卷 295-296页

作者： Guangxin song Yuqing YANG Xiaolin ning Jiancheng FANG Weiren WU School of Instrumentation Science and Opto-electronics Engineering Beihang University School of Research Institute for Frontier Science Beihang University Lunar Exploration and Space Program Center China National Space Administration

The traditional strapdown inertial navigation system(SINS)/celestial navigation system(CNS) integrated navigation system using the starlight vector or posture difference calculated by SINS and CNS as a measurement can correct the posture error of SINS, but not the position error [1]. The refraction celestial navigation system(RCNS) can independently provide the position information.

关键词： SCHEME

Responses of nutrient biogeochemistry and nitrogen cycle to seasonal upwelling in coastal waters of the eastern Hainan Island

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2022年第6期41卷 99-113页

作者： Nan Zhou Sumei Liu Guodong song Yunyan Zhang Lingyan Wang Xiaoyan ning Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and Technology of Ministry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The coastal upwelling has profound influence on the surrounding ecosystem by supplying the nutrient-replete water to the euphotic zone.Nutrient biogeochemistry was investigated in coastal waters of the eastern Hainan Island in summer 2015 and autumn 2016.From perspectives of nutrient dynamics and physical transport,the nutrient fluxes entered the upper 50 m water depth(between the mixed layer and the euphotic zone)arisen from the upwelling were estimated to be 2.5-5.4 mmol/(m^(2)·d),0.15-0.28 mmol/(m^(2)·d),and 2.2-7.2 mmol/(m^(2)·d)for dissolved inorganic nitrogen(DIN),phosphate(DIP),and dissolved silicate(DSi),respectively,which were around 6-to 12-fold those in the background area.The upwelled nutrients supported an additional plankton growth of(14.70±8.95)mg/m^(2)for chlorophyll a(Chl a).The distributions of nitrateδ^(15)N andδ^(18)O above the 300 m water depth(top of the North Pacific Intermediate Water)were different among the upwelling area,background area in summer,and the stations in autumn,and the difference of environmental and biogeochemical conditions between seasons should be the reason.The higher DIN/DIP concentration ratio,nitrate concentration anomaly,and lower nitrate isotope anomaly(Δ(15,18))in the upper ocean in summer than in autumn indicated the stronger nitrogen fixation and atmospheric deposition,and the following fixed nitrogen regeneration in summer.The higher values of Chl a and nitrateδ^(15)N andδ^(18)O within the euphotic zone in autumn than the background area in summer suggested the stronger nitrate assimilation in autumn.The differences in relatively strength of the assimilation,nitrogen fixation and atmospheric deposition,and the following remineralization and nitrification between the two seasons made the higherδ^(18)O:δ^(15)N and larger difference of enzymatic isotope fractionation factors^(15)εand^(18)εfor nitrate assimilation in summer than in autumn above the North Pacific Tropical Water.

关键词： nutrients upwelling nitrateδ^(15)N andδ^(18)O nitrogen cycle South China Sea

维普期刊数据库

Engineering Saccharomyces cerevisiae for enhanced(–)-α-bisabolol production

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2023年第2期8卷 187-195页

作者： Yinkun Jiang Lu Xia song Gao ning Li Shiqin Yu Jingwen Zhou Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology Jiangnan University1800 Lihu RoadWuxiJiangsu214122China Science Center for Future Foods Jiangnan University1800 Lihu RoadWuxiJiangsu214122China Key Laboratory of Industrial Biotechnology Ministry of Education and School of BiotechnologyJiangnan University1800 Lihu RoadWuxiJiangsu214122China Jiangsu Province Engineering Research Center of Food Synthetic Biotechnology Jiangnan UniversityWuxi214122China

(–)-α-Bisabolol is naturally occurring in many plants and has great potential in health products and pharma-ceuticals.However,the current extraction method from natural plants is unsustainable and cannot fulfil the increasing requirement.This study aimed to develop a sustainable strategy to enhance the biosynthesis of(–)-α-bisabolol by metabolic engineering.By introducing the heterologous gene MrBBS and weakening the competitive pathway gene ERG9,a de novo(–)-α-bisabolol biosynthesis strain was constructed that could produce 221.96 mg/L(–)-α-bisabolol.Two key genes for(–)-α-bisabolol biosynthesis,ERG20 and MrBBS,were fused by a flexible linker(GGGS)3 under the GAL7 promoter control,and the titer was increased by 2.9-fold.Optimization of the mevalonic acid pathway and multi-copy integration further increased(–)-α-bisabolol production.To promote product efflux,overexpression of PDR15 led to an increase in extracellular production.Combined with the optimal strategy,(–)-α-bisabolol production in a 5 L bioreactor reached 7.02 g/L,which is the highest titer reported in yeast to date.This work provides a reference for the efficient production of(–)-α-bisabolol in yeast.

关键词： Metabolic engineering (–)-α-bisabolol Fusion expression Transporter Saccharomyces cerevisiae

Network Pharmacology-Based Exploration of the Mechanism of Guanxinning Tablet for the Treatment of Stable Coronary Artery Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2021年第4期7卷 456-466页

作者： song Sheng Qiao-ning Yang Hao-ning Zhu Yong-Yue Xian Department of Emergency Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijingChina

Objective:Network pharmacology was utilized to explore the mechanism of Guanxinning(GXN)tablet for the treatment of stable coronary artery disease(SCAD).Materials and Methods:First,active ingredients and therapeutic targets were predicted by databases and gene chip.Then,we constructed the compound-target(C-T)network and target-disease(T-D)network to screen hub compounds and therapeutic targets based on contribution index(CI),degree,closeness,betweenness,and coreness in the networks.Enrichment analysis was performed on hub therapeutic targets,and finally,the verification of hub ingredients and hub therapeutic targets was performed through molecular docking.Results:With"oral bioavailability≥30%,druglikeness≥0.18,and half-life≥4 h"as screening conditions,58 active ingredients were obtained.Seven hundred and seventeen compound targets and 636 SCAD targets were retrieved using databases and gene chip,and the intersection of both(139 targets)was defined as therapeutic targets.According to CI,degree,betweenness,closeness,and coreness,2 hub compounds and 13 hub therapeutic targets were chosen from the C-T network and T-D network,respectively.The Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis indicated that GXN treated SCAD from several aspects including inflammatory reaction,oxidative stress,nutritional metabolism,blood pressure regulation,ventricular remodeling,vascular smooth muscle proliferation,angiogenesis,and platelet aggregation.Tissue enrichment analysis revealed that the therapeutic targets were enriched in multiple organs and tissues.The excellent binding force between the hub compounds and hub therapeutic targets was verified by molecular docking.Conclusions:The treatment of SCAD by GXN has the characteristics of multiple ingredients,multiple targets,and multiple approaches.Consequently,it may theoretically treat SCAD from multiple angles and levels.

关键词： Gene chip Guanxinning tablet molecular docking network pharmacology stable coronary artery disease

维普期刊数据库

W-doped FeNi_(2)S_(4)/Ni_(3)S_(2)/NF with interfacial effect as efficient bifunctional electrocatalyst for overall water splitting

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第10期16卷 12116-12125页

作者： Jing Jiang Hui Su Shaojia song Weilong Liu ning Li Yangqin Gao Lei Ge State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum BeijingBeijing 102249China Department of Materials Science and Engineering College of New Energy and MaterialsChina University of Petroleum BeijingBeijing 102249China

Given the current shortage of resources and environmental pollution,rationally designing and developing low-cost and highefficiency bifunctional electrocatalysts is an urgent and challenging task.It is widely recognized that element doping can effectively improve the electrocatalytic activity by adjusting the microstructure,morphology,and electronic structure.Therefore,this work rationally designs and prepares three-dimensional flower-like structured W-doped FeNi_(2)S_(4)/Ni_(3)S_(2)/NF heterojunctions as efficient bifunctional electrocatalysts for overall water splitting.In 1 M KOH,the prepared W-FeNi_(2)S_(4)/Ni_(3)S_(2)/NF electrocatalyst can effectively drive both hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)processes,and only needs overpotentials of 93 and 210 mV to reach current densities of 10 and 50 mA·cm^(−2).In the double electrode cell composed by WFeNi_(2)S_(4)/Ni_(3)S_(2)/NF electrocatalyst,a low cell voltage of 1.52 V was required to reach a current density of 10 mA·cm^(−2),and 91.6%of this value was preserved after 24 h electrolysis operation.The performance of FeNi_(2)S_(4)/Ni_(3)S_(2)/NF electrocatalyst is superior to most of the current bifunctional electrocatalytic materials.Density functional theory(DFT)theoretical calculations also revealed a more intense electron transfer process that can be facilitated by constructing FeNi_(2)S_(4)and Ni_(3)S_(2)/NF interface,which may be the main reason for the archived excellent electrochemical performance.

关键词： bifunctional electrocatalysts water splitting density functional theory(DFT)calculation oxygen evolution reaction(OER)

Identify the contribution of vehicle non-exhaust emissions:a single particle aerosol mass spectrometer test case at typical road environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2023年第5期17卷 117-128页

作者： Qijun Zhang Jiayuan Liu ning Wei Congbo song Jianfei Peng Lin Wu Hongjun Mao Tianjin Key Laboratory of Urban Transport Emission Research&State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control College of Environmental Science and EngineeringNankai UniversityTianjin 300071China School of Geography Earth and Environment Sciences University of BirminghamBirmingham B152TTUK

A single particle aerosol mass spectrometer(SPAMS)was used to accurately quantify the contribution of vehicle non-exhaust emissions to particulate matter at typical road environment.The PM_(2.5),black carbon,meteorological parameters and traffic flow were recorded during the test period.The daily trend for traffic flow and speed on TEDA Street showed obvious“M”and“W”characteristics.6.3 million particles were captured via the SPAMS,including 1.3 million particles with positive and negative spectral map information.Heavy Metal,High molecular Organic Carbon,Organic Carbon,Mixed Carbon,Elemental Carbon,Rich Potassium,Levo-rotation Glucose,Rich Na,SiO_(3) and other categories were analyzed.The particle number concentration measured by SPAMS showed a good linear correlation with the mass concentrations of PM_(2.5) and BC,which indicates that the particulate matter captured by the SPAMS reflects the pollution level of fine particulate matter.EC,ECOC,OC,HM and crustal dust components were found to show high values from 7:00–9:00 AM,showing that these chemical components are directly or indirectly related to vehicle emissions.Based on the PMF model,7 major factors are resolved.The relative contributions of each factor were determined:vehicle exhaust emission(44.8%),coal-fired source(14.5%),biomass combustion(12.2%),crustal dust(9.4%),ship emission(9.0%),tires wear(6.6%)and brake pads wear(3.5%).The results show that the contribution of vehicle non-exhaust to particulate matter at roadside environment is approximately 10.1%.Vehicle non-exhaust emissions are the focus of future research in the vehicle pollutant emission control field.

关键词： Non-exhaust emissions SPAMS PMF Roadside environment