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Acta Oceanologica Sinica 2024年第1期43卷 35-47页

作者： ning jiang Zhaoru Zhang Ruifeng Zhang Chuning Wang Meng Zhou School of Oceanography Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Polar Science Polar Research Institute of ChinaMinistry of Natural ResourcesShanghai 200136China

Antarctic coastal polynyas are biological hotspots in the Southern Ocean that support the abundance of hightrophic-level predators and are important for carbon cycling in the high-latitude *** this study,we examined the interannual variation of summertime phytoplankton biomass in the Marguerite Bay polynya(MBP)in the western Antarctic Peninsula area,and linked such variability to the Southern Annular Mode(SAM)that dominated the southern hemisphere extratropical climate *** satellite data,atmosphere reanalysis products and numerical simulations,we found that the interannual variation of summer chlorophyll-a(Chl-a)concentration in the MBP is significantly and negatively correlated with the spring SAM index,and weakly correlated with the summer SAM *** negative relation between summer Chl-a and spring SAM is due to weaker spring vertical mixing under a more positive SAM condition,which would inhibit the supply of iron from deep layers into the surface euphotic *** negative relation between spring mixing and spring SAM results from greater precipitation rate over the MBP region in positive SAM phase,which leads to lower salinity in the ocean surface *** coupled physical-biological mechanisms between SAM and phytoplankton biomass revealed in this study is important for us to predict the future variations of phytoplankton biomasses in Antarctic polynyas under climate change.

关键词： Marguerite Bay polynya phytoplankton biomass Southern Annular Mode mixed layer depth interannual variation

Ballistic performance of spherical fragments penetrating PCrNi3MoV target plates

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Defence Technology（防务技术） 2024年第3期33卷 295-307页

作者： Dou Hong Wenbin Li Yu Zheng Yiming Li ning jiang Kebin Zhang Ministerial Key Laboratory of ZNDY Nanjing University of Science and TechnologyNanjingChina

PCrNi3MoV steel is a medium-carbon,low-alloy quenched and tempered steel that finds its applications in military gun barrels due to the high wear resistance and ablation *** study the penetration and failure modes of PCrNi3MoV plates impacted by tungsten spheres,tungsten spheres of various diameters(5 mm,8 mm,and 10 mm)were used to impact PCrNi3MoV steel plates with thicknesses of 6 mm,9 mm,and 14 *** penetration performance of the spheres was analyzed for different velocities,and the ultimate penetration velocity of the plate was *** was found that the primary failure modes of the PCrNi3MoV plate were compression pitting failure and shear *** the dimensional analysis method,a relationship between the bulge height of the steel plate and the fragment velocity,an equation for the ultimate penetration velocity,and a relationship between the target penetration energy and the fragment velocity were ***,a projectile-target action index was proposed to describe the process of tungsten spheres with different velocities impacting target *** results suggested that under the same thickness of the target plate,a larger-diameter fragment required more kinetic energy to obtain the same ultimate penetration effect as a smaller-diameter *** equations obtained through dimensional analysis predicted values that agreed well with experimental values,indicating that these equations can be applied to engineering applications.

关键词： Impact damage Ultimate penetration velocity Bulge height Target penetration energy Failure modes

On-chip spiking neural networks based on add-drop ring microresonators and electrically reconfigurable phase-change material photonic switches

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Photonics Research 2024年第4期12卷 755-766页

作者： QIANG ZHANG ning jiang YIQUN ZHANG ANRAN LI HUANHUAN XIONG GANG HU YONGSHENG CAO KUN QIU School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

We propose and numerically demonstrate a photonic computing primitive designed for integrated spiking neural networks (SNNs) based on add-drop ring microresonators (ADRMRs) and electrically reconfigurable phasechange material (PCM) photonic switches. In this neuromorphic system, the passive silicon-based ADRMR,equipped with a power-tunable auxiliary light, effectively demonstrates nonlinearity-induced dual neural dynamics encompassing spiking response and synaptic plasticity that can generate single-wavelength optical neural spikes with synaptic weight. By cascading these ADRMRs with different resonant wavelengths, weighted multiple-wavelength spikes can be feasibly output from the ADRMR-based hardware arrays when external wavelengthaddressable optical pulses are injected;subsequently, the cumulative power of these weighted output spikes is utilized to ascertain the activation status of the reconfigurable PCM photonic switches. Moreover, the reconfigurable mechanism driving the interconversion of the PCMs between the resonant-bonded crystalline states and the covalent-bonded amorphous states is achieved through precise thermal modulation. Drawing from the thermal properties, an innovative thermodynamic leaky integrate-and-firing (TLIF) neuron system is proposed. With the TLIF neuron system as the fundamental unit, a fully connected SNN is constructed to complete a classic deep learning task:the recognition of handwritten digit patterns. The simulation results reveal that the exemplary SNN can effectively recognize 10 numbers directly in the optical domain by employing the surrogate gradient algorithm. The theoretical verification of our architecture paves a whole new path for integrated photonic SNNs, with the potential to advance the field of neuromorphic photonic systems and enable more efficient spiking information processing.

关键词： neural networks precise

A vicinal oxygen chelate protein facilitates viral infection by triggering the unfolded protein response in Nicotiana benthamiana

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Journal of Integrative Plant Biology 2024年第7期66卷 1481-1499页

作者： Zhihong Guo ning jiang Menglin Li Hongfang Guo Qi Liu Xinyu Qin Zongying Zhang Chenggui Han Ying Wang Ministry of Agriculture and Rural Affairs Key Laboratory of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

Vicinal oxygen chelate(VOC)proteins are members of an enzyme superfamily with dioxygenase or non-dioxygenase ***,the biological functions of VOC proteins in plants are poorly ***,we show that a VOC in Nicotiana benthamiana(NbVOC1)facilitates viral ***1 was significantly induced by infection by beet necrotic yellow vein virus(BNYVV).Transient overexpression of NbVOC1 or its homolog from Beta vulgaris(BvVOC1)enhanced BNYVV infection in ***,which required the nuclear localization of *** with this result,overexpressing NbVOC1 facilitated BNYVV infection,whereas,knockdown and knockout of NbVOC1 inhibited BNYVV infection in transgenic *** ***1 interacts with the basic leucine zipper transcription factors bZIP17/28,which enhances their self-interaction and DNA binding to the promoters of unfolded protein response(UPR)-related *** propose that bZIP17/28 directly binds to the NbVOC1 promoter and induces its transcription,forming a positive feedback loop to induce the UPR and facilitating BNYVV ***,our results demonstrate that NbVOC1 positively regulates the UPR that enhances viral infection in plants.

关键词： beet necrotic yellow vein virus bZIP17/28 Nicotiana benthamiana unfolded protein response VOC1

Post-transcriptional regulation of grain weight and shape by the RBP-A-J-K complex in rice

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Journal of Integrative Plant Biology 2024年第1期66卷 66-85页

作者： Ding Ren Hui Liu Xuejun Sun Fan Zhang Ling jiang Ying Wang ning jiang Peiwen Yan Jinhao Cui Jinshui Yang Zhikang Li Pingli Lu Xiaojin Luo State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology School of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China MOE Key Laboratory of Crop Physiology Ecology and Genetic Breeding College of AgronomyJiangxi Agricultural UniversityNanchang 330045China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China College of Agronomy Anhui Agricultural UniversityHefei 230036China

RNA-binding proteins(RBPs)are components of the post-transcriptional regulatory system,but their regulatory effects on complex traits remain *** an integrated strategy involving map-based cloning,functional characterizations,and transcriptomic and population genomic analyses,we revealed that RBP-K(LOC_Os08g23120),RBP-A(LOC_Os11g41890),and RBP-J(LOC_Os10g33230)encode proteins that form an RBP-A-J-K complex that negatively regulates rice yield-related *** of the RBP-A-J-K complex indicated RBP-K functions as a relatively non-specific RBP chaperone that enables RBP-A and RBP-J to function ***,RBP-J most likely affects GA pathways,resulting in considerable increases in grain and panicle lengths,but decreases in grain width and *** contrast,RBP-A negatively regulates the expression of genes most likely involved in auxin-regulated pathways controlling cell wall elongation and carbohydrate transport,with substantial effects on the rice grain filling process as well as grain length and ***,RBP-K is relatively ancient and highly conserved,whereas RBP-J and RBP-A are more ***,the RBP-A-J-K complex may represent a typical functional model for many RBPs and protein complexes that function at transcriptional and post-transcriptional levels in plants and animals for increased functional consistency,efficiency,and versatility,as well as increased evolutionary *** results clearly demonstrate the importance of RBP-mediated post-transcriptional regulation for the diversity of complex ***,rice grain yield and quality may be enhanced by introducing various complete or partial loss-of-function mutations to specific RBP genes using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 technology and by exploiting desirable natural tri-genic allelic combinations at the loci encoding the components of the RBP-A-J-K complex through marker-assisted select

关键词： GL11 grain weight and shape post-transcriptional regulation RNA-binding proteins

Genome-Wide Exploration of the Grape GLR Gene Family and Differential Responses of VvGLR3.1 and VvGLR3.2 to Low Temperature and Salt Stress

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 533-549页

作者： Honghui Sun Ruichao Liu Yueting Qi Hongsheng Gao Xueting Wang ning jiang Xiaotong Guo Hongxia Zhang Chunyan Yu The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai264025China College of Agriculture Ludong UniversityYantai264025China

Grapes,one of the oldest tree species globally,are rich in ***,environmental conditions such as low temperature and soil salinization signiﬁcantly affect grape yield and *** glutamate receptor(GLR)family,comprising highly conserved ligand-gated ion channels,regulates plant growth and development in response to *** this study,11 members of the VvGLR gene family in grapes were identiﬁed using whole-genome sequence *** methods were employed to analyze the basic physical and chemical properties,phylogenetic trees,conserved domains,motifs,expression patterns,and evolutionary *** and collinear analyses revealed that the VvGLRs were divided into three subgroups,showing the high conservation of the grape GLR *** members exhibited 2 glutamate receptor binding regions(GABAb and GluR)and 3-4 transmembrane regions(M1,M2,M3,and M4).Real-time quantitative PCR analysis demonstrated the sensitivity of all VvGLRs to low temperature and salt *** localization studies in Nicotiana tabacum veriﬁed that VvGLR3.1 and VvGLR3.2 proteins were located on the cell membrane and cell ***,yeast transformation experiments conﬁrmed the functionality of VvGLR3.1 and VvGLR3.2 in response to low temperature and salt ***ﬁndings highlight the signiﬁcant role of the GLR family,a highly conserved group of ion channels,in enhancing grape stress *** study offers new insights into the grape GLR gene family,providing fundamental knowledge for further functional analysis and breeding of stress-resistant grapevines.

关键词： Genome-wide identiﬁcation glutamate receptor(GLR)family low temperature stress salt stress grape

Intermediate-mass black holes in Green pea galaxies (IMBH-GP) I:A candidate sample from LAMOST and SDSS

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Ruqiu Lin Zhen-Ya Zheng Fang-Ting Yuan Jun-Xian Wang Chunyan jiang ning jiang Lingzhi Wang Linhua jiang Xiang Ji Shuairu Zhu Xiaodan Fu Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical Observatory Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences CAS Key Laboratory for Research in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China Chinese Academy of Sciences South America Center for Astronomy (CASSACA) National Astronomical ObservatoriesChinese Academy of Sciences CAS Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Kavli Institute for Astronomy and Astrophysics Peking University Department of Astronomy School of Physics Peking University

The scaling relation of central massive black holes (MBHs) and their host galaxies is well-studied for supermassive BHs (SMBHs,MBH≥10～6M⊙).However,this relation has large uncertainties in the mass range of the intermediate-mass BHs (IMBHs,MBH～10～3-10～6M⊙).Since Green pea （GP） galaxies are luminous compact dwarf galaxies,which may be likely to host less massive SMBHs or even IMBHs,we systematically search for MBHs in a large sample of 2190 GP galaxies at z<0.4,selected from LAMOST and SDSS spectroscopic ***,we report a newly discovered sample of 59 MBHcandidates with broad Hα *** sample has a median stellar mass of 108.83±0.11M⊙and hosts MBHs with single-epoch virial masses ranging from MBH～104.7to 108.5M⊙(median 105.85±0.64M⊙).Among the 59 MBHcandidates,36 have black hole masses MBH≤10～6M⊙(IMBHcandidates),one of which even has MBH10～5M⊙.We find that the MBH-M*relation of our MBHsample is consistent with the MBH-Mbulgerelation for SMBHs,while is above the MBH-M*relation for MBHs in dwarf galaxies in the same mass ***,we show that 25 MBHcandidates,including 4 IMBHcandidates,have additional evidence of black hole activities,assessed through various methods such as the broad-line width,BPT diagram,mid-infrared color,X-ray luminosity,and radio *** studies show that it is very promising to find IMBHs in GP galaxies,and the BH sample so obtained enables us to probe the connection between the MBHs and compact dwarf galaxies in the low-redshift Universe.

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南极冰间湖浮游植物生物量和生物生产力时空特征及影响因素研究进展

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极地研究 2024年第2期36卷 266-285页

作者：江宁张召儒上海交通大学海洋学院上海200240 自然资源部极地科学重点实验室中国极地研究中心(中国极地研究所)上海200136

南极冰间湖在气候变化中和生态系统环境中扮演着重要角色。本文通过回顾南极罗斯海、阿蒙森海、松岛和默茨等4个冰间湖浮游植物生物量和生产力的时空分布特征和变化规律、物理环境参数和气候模态对冰间湖中叶绿素a和浮游植物水华开始及... 详细信息

南极冰间湖在气候变化中和生态系统环境中扮演着重要角色。本文通过回顾南极罗斯海、阿蒙森海、松岛和默茨等4个冰间湖浮游植物生物量和生产力的时空分布特征和变化规律、物理环境参数和气候模态对冰间湖中叶绿素a和浮游植物水华开始及持续时间的影响,得出以下几点结论:(1)罗斯海冰间湖是南极近海生物生产力最高的区域,占南大洋总生产力的28%;阿蒙森海和松岛冰间湖在37个南极冰间湖生态系统中单位面积的生产力最高;默茨冰间湖浮游植物生物量年际变化明显。(2)海冰密集度、风速和云量等物理参数与浮游植物生物量变化密切相关,其相关关系的季节性和地域特征明显。海冰密集度主要通过改变冰间湖开放水域的面积来影响可到达海表的光合有效辐射;风速通过影响水体的垂直混合强度来改变营养盐及浮游植物的垂向输运;云量对冰间湖生态系统的影响是可见光强度及紫外线辐射量之间平衡的结果。(3)在部分冰间湖,浮游植物生物量的年际变化同调控南半球高纬度气候的主要模态,如南半球环状模和半年振荡等存在显著相关性。未来工作可结合长期卫星遥感观测、现场观测和数值模拟,进一步开展气候模态对冰间湖浮游植物生物量年际变化的物理-生态耦合机制、冰间湖生态系统生产力各个尺度变异规律和机制等的深入探究,从而更好地认知极地关键海区的生物地球化学循环过程及其气候效应。

关键词：南极冰间湖浮游植物生物量时空特征环境变量气候模态

Damage effect and mechanisms of cyclophosphamide to human neuroblastoma SH-SY5Y cells

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中国药理学与毒理学杂志 2024年第8期38卷 561-574页

作者： LI Jiajia WANG Jiao XIAO Wenyi WEI Donghui ZHANG Yongxiang jiang ning ZHOU Wenxia State Key Laboratory of National Security Specially Needed Medicines Academy of Military Medical SciencesBeijing 100850China

OBJECTIVE To investigate the damage effect and mechanisms of cyclophosphamide(CTX)and its active metabolite derivative 4-hydroperoxycyclophosphamide(4-HC)to human neuroblas⁃toma SH-SY5Y *** SH-SY5Y cells were treated with CTX[0(cell control),0.01,0.1,1,5,10,20,40 and 80 mmol·L^(-1)]and 4-HC[0(cell control),0.01,0.1,1,5,10,20,40 and 80μmol·L^(-1)]for 48 *** confluence and morphology were observed by the IncuCyte ZOOM *** viability was assessed by CCK-8 *** dehydrogenase(LDH)release was measured by LDH assay ***-SY5Y cells were treated with CTX(0,1,5,10 and 20 mmol·L^(-1))and 4-HC(0,1,5,10 and 20μmol·L^(-1))for 48 h before cell proliferation was analyzed by 5-ethynyl-2′-deoxyuridine(EdU)staining *** was employed to assess the levels of the DNA double-strand break markerγ-H2AX and to evaluate changes in mitochondrial membrane ***-SY5Y cells were treated with CTX(0,1,5 and 10 mmol·L^(-1))and 4-HC(0,1,5 and 10μmol·L^(-1))for 48 h,and the alterations in glycolysis and oxidative phosphorylation levels were analyzed using the Seahorse XFe96 *** Compared with the cell control group,cell confluence and cell viability were significantly reduced in the CTX and 4-HC groups(P<0.01),and the half-maximal inhibitory concentrations(IC50)for CTX and 4-HC were 4.44 mmol·L^(-1) and 4.78μmol·L^(-1),*** release rate of LDH was signif⁃icantly increased while the percentage of EdU+cells was significantly reduced in the CTX and 4-HC groups(P<0.01).The percentage ofγ-H2AX+cells was significantly increased and mitochondrial membrane potential significantly decreased in the CTX and 4-HC group(P<0.05).Treatment with CTX and 4-HC resulted in reduced levels of maximum glycolytic capacity,glycolytic reserve,maximal respi⁃ration,and ATP production(P<0.05).CONCLUSION CTX and 4-HC exert significant cytotoxic effects on SH-SY5Y cells by disrupting cell membrane structure,impeding cell proliferation,and reducing ce

关键词： cyclophosphamide 4-hydroperoxycyclophosphamide neurotoxicity energy metabolism

Targeting NRP1 axis as a strategy for treating energy metabolism impairment induced by SARS-CoV-2 spike

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Science China Life Sciences 2024年

作者： Lihui Zhang Wanting Hu Jingxuan Li Yuehan Li Feng Liu Wenyi Xiao ning jiang Zhiyong Xiao Lu Han Wenxia Zhou Beijing Institute of Pharmacology & Toxicology State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology & Toxicology School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine

Dear Editor,Free spike protein of SARS-CoV-2 alone can cause abnormal energy metabolism(Table S1 in Supporting Information), and limited research suggested a potential correlation between spike-induced mitochondrial damage and the ACE2 receptor(Lei et al., 2021; Yang et al., 2023). In order to further explore the mechanisms involved, we observed that the wild-type S1 protein of SARS-CoV-2 exerts a more potent inhibitory effect on host cell ATP compared to the wild-type S protein, S2protein, the Omicron variant S1 protein and HCoV-NL63 S1protein in HLMVEC and 293T cell lines(Figure 1A and B),indicating the importance of exploring the mechanism by which the S1 protein causes ATP decrease. Meanwhile, the S1protein did not lead to significant changes in cellular lactate levels, indicating that its primary mechanism involves impairing oxidative phosphorylation and mitochondrial damage(Figure 1C and D).

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