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A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

Oncology Research 2024年第5期32卷 849-875页

作者： nilam bhusare MAUSHMI KUMAR Somaiya Institute for Research&Consultancy Somaiya Vidyavihar UniversityVidyavihar(East)Mumbai400077India

Glioblastoma,the most aggressive form of brain tumor,poses significant challenges in terms of treatment success and patient *** treatment modalities for glioblastoma include radiation therapy,surgical intervention,and ***,the median survival rate remains dishearteningly low at 12–15 *** of the major obstacles in treating glioblastoma is the recurrence of tumors,making chemotherapy the primary approach for secondary glioma ***,the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance ***,considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing targeted *** tackle glioma,numerous studies have examined kinase-downstream signaling pathways such as *** targeting specific signaling pathways,heterocyclic compounds have demonstrated efficacy in glioma ***,key kinases including phosphatidylinositol 3-kinase(PI3K),serine/threonine kinase,cytoplasmic tyrosine kinase(CTK),receptor tyrosine kinase(RTK)and lipid kinase(LK)have been considered for *** pathways play crucial roles in drug effectiveness in glioma *** compounds,encompassing pyrimidine,thiazole,quinazoline,imidazole,indole,acridone,triazine,and other derivatives,have shown promising results in targeting these *** part of this review,we propose exploring novel structures with low toxicity and high potency for glioma *** development of these compounds should strive to overcome multidrug resistance mechanisms and efficiently penetrate the blood-brain *** optimizing the chemical properties and designing compounds with enhanced drug-like characteristics,we can maximize their therapeutic value and minimize adverse *** the complex nature of glioblastoma,these novel structures should be rigorously tested and e

关键词： Glioblastoma Kinase pathway Pyrimidine Quinazoline Heterocycles

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