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Extrahepatic right portal vein ligation allows parenchyma-sparing en bloc resection of segments 7, 8 and 4a for liver tumors engaging the right and middle hepatic veins

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Hepatobiliary & Pancreatic Diseases International 2015年第5期14卷 539-542页

作者： Charalampos Farantos nikolaos Arkadopoulos Pantelis Vassiliu Panagiotis Kokoropoulos nikolaos Economopoulos Aggeliki Pandazi Vassilis Smyrniotis Fourth Department of Surgery Athens University Medical School Attikon University Hospital Second Department of Radiology Athens University Medical School Attikon University Hospital Second Department of Anesthesiology Athens University Medical School Attikon University Hospital

Right trisectionectomy for posterior liver tumors engaging the right and middle hepatic veins may lead to post-hepatectomy liver failure if the anticipated liver remnant is small. In such patients we developed a parenchymasparing one-step approach, that includes extrahepatic right portal vein ligation accompanied by en bloc resection only of segments 7, 8 and 4a and resection of the right and middle hepatic veins. The technique was applied in 3 patients with normal liver function, where according to the preoperative computed tomography the volume of segments 1, 2 and 3 ranged between 17% and 20% of the total liver volume. In all patients liver biochemistry improved rapidly postoperatively and a doubling of volume of segments 1, 2 and 3 was achieved by the third postoperative week, as extrahepatic right portal vein ligation ameliorated reperfusion injury of the remaining segments 5 and 6 and induced hypertrophy of segments 1, 2, 3 and 4b. There was no mortality or long-term *** are alive and free of disease 74, 50 and 17 months after the operation, respectively. We propose that the term ＂extended upper right sectionectomy＂ may be considered for the en bloc resection of segments 7, 8 and 4a, in future revisions ofthe Brisbane 2000 terminology of hepatic anatomy and resections.

关键词： liver trisectionectomy extrahepatic right portal vein ligation parenchyma-sparing hepatectomy

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Use of isolated Roux loop for pancreaticojejunostomy reconstruction after pancreaticoduodenectomy

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World Journal of Gastroenterology 2010年第25期16卷 3178-3182页

作者： Konstantinos Ballas nikolaos Symeonidis Savvas Rafailidis Theodoros Pavlidis Georgios Marakis nikolaos Mavroudis Athanasios Sakantamis Second Propedeutical Department of Surgery Ippokratio General Hospital Aristotle University of Thessaloniki 49 Konstantinoupoleos str Thessaloniki 54642 Thessaloniki Greece

AIM: To evaluate the efficacy of the isolated Roux loop technique in decreasing the frequency of pancreaticojejunal anastomosis failure. METHODS: We retrospectively reviewed 88 consecutive patients who underwent pancreaticoduodenectomy (standard or pylorus-preserving). Single jejunal loop was used in 42 patients (SL group) while isolated Roux loop was used in 46 patients (RL group). Demographic characteristics (age, gender) and perioperative results (major/minor complications, mortality, hospital stay) were compared between the two groups. RESULTS: Mortality was almost equal in both groups and overall mortality was 2.27%. Leak rate from the pancreaticojejunal anastomosis and hospital stay were lower in the RL group without significant difference. Morbidity was 39.1% in the RL group, insignificantly higherthan the SL group. Operative time was almost 30 min longer in the RL group. CONCLUSION: The isolated Roux loop, although an equally safe alternative, does not present advantages over the traditional use of a single jejunal loop. Randomized controlled studies are required to further clarify its efficacy.

关键词： Pancreaticojejunal anastomosis Isolated Roux loop Whipple pancreaticoduodenectomy Pancreatic leak

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Biomarkers, erectile dysfunction, and cardiovascular risk prediction： the latest of an evolving concept

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Asian Journal of Andrology 2015年第1期17卷 17-20,I0006页

作者： Charalambos Vlachopoulos nikolaos Ioakeimidis Christodoulos Stefanadis Department of Cardiology Cardiovascular Diseases and Sexual Health Unit Athens Medical School Hippokration Hospital Athens Greece.

A number of circulating and imaging biomarkers are robustly associated with cardiovascular （CV） risk. The overall expectation from a biomarker in the erectile dysfunction （ED） setting is to enhance the optimal management of a man with this disorder but no clinical atherosclerosis. Evidence demonstrating that these biomarkers enhance risk prediction for individuals with ED is at this stage still limited for most of them. A better identification of the subsets of the ED population that require further risk stratification, as well as the initiation of randomized trials that will formally test the ability of biomarkers to predict CV risk, could make biomarker-guided prevention an attainable goal.

关键词： biomarkers erectile dysfunction risk prediction

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A numerical case study on the long-term seismic assessment of reinforced concrete tunnels in corrosive environments

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 551-572页

作者： Maria Antoniou Antonios Mantakas nikolaos Nikitas Raul Fuentes ETH Zurich ZurichSwitzerland National Technical University of Athens AthensGreece University of Leeds LeedsUK RWTH Aachen University AachenGermany

The paper investigates the long-term seismic behaviour of an underground reinforced concrete(RC)metro tunnel in Santiago,Chile,considering the combined effects of chloride-induced corrosion and cumulative,low-amplitude seismic shaking on the structure’s *** soil-tunnel response is evaluated with the aid of transient,nonlinear finite element analysis using a two-dimensional(2D)plane strain numerical model that adopts advanced nonlinear models for the simulation of soil and concrete plasticity and the dynamic stiffness *** effects of corrosion deterioration are demonstrated in terms of time-dependent loss of rebar area and cover concrete stiffness and *** study illustrates the influence of ageing and repeated seismic shaking on lining deformation,crack development,and the modal characteristics of the intact and degrading *** results indicate that multiple lowamplitude events drive the non-degrading RC tunnel beyond its elastic regime without significant structural response consequences.A noticeable impact of corrosion deterioration on the structure’s seismic performance is revealed,increasing with the number and intensity of earthquake *** different tunnel embedment depths are comparatively *** analyses demonstrate larger coseismic section convergence in the case of the deeper tunnel,yet a less pronounced effect of ageing and successive seismic loading compared to the shallow section,which is evident in the RC lining cracks at the end of shaking.

关键词： Tunnels Reinforcement corrosion Ageing Earthquakes Numerical modelling Long-term performance Concrete cracking behaviour

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Multifunctional HDPE/Cu biocidal nanocomposites for MEX additive manufactured parts: Perspectives for the defense industry

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Defence technology 2024年第8期 16页

作者： Nectarios Vidakis nikolaos Michailidis Markos Petousis Nektarios K.Nasikas Vassilios Saltas Vassilis Papadakis nikolaos Mountakis Apostolos Argyros Mariza Spiridaki Ioannis Valsamos

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Contribution of Global Warming and Atmospheric Circulation to the Hottest Spring in Eastern China in 2018

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Advances in Atmospheric Sciences 2020年第11期37卷 1285-1294页

作者： Chunhui LU Ying SUN nikolaos CHRISTIDIS Peter ASTOTT National Climate Center Laboratory for Climate StudiesChina Meteorological AdministrationBeijing 100081China Met Office Hadley Centre Met OfficeExeter EX13PBUK Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China

The spring of 2018 was the hottest on record since 1951 over eastern China based on station observations,being 2.5°C higher than the 1961−90 mean and with more than 900 stations reaching the record spring mean *** event exerted serious impacts in the region on agriculture,plant phenology,electricity transmission systems,and human *** this paper,the contributions of human-induced climate change and anomalous anticyclonic circulation to this event are investigated using the newly homogenized observations and updated Met Office Hadley Centre system for attribution of extreme events,as well as CanESM2(Second Generation Canadian Earth System Model)*** indicate that both anthropogenic influences and anomalous anticyclonic circulation played significant roles in increasing the probability of the 2018 hottest *** estimates of the probability ratio show that anthropogenic forcing may have increased the chance of this event by ten-fold,while the anomalous circulation increased it by approximately *** persistent anomalous anticyclonic circulation located on the north side of China blocked the air with lower temperature from high latitudes into eastern *** anthropogenic forcing or without the anomalous circulation in northern China,the occurrence probability of the extreme warm spring is significantly reduced.

关键词： extreme warm spring extreme event attribution anthropogenic influence circulation effect

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Risk dynamics for marine systems:towards a bio-inspired framework for dynamic risk assessment

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Transportation Safety and Environment 2022年第3期4卷 1-17页

作者： nikolaos P.Ventikos Konstantinos Louzis School of Naval Architecture and Marine Engineering National Technical University of Athens9 Iroon Politechneiou St15773ZografouGreece.

The development of innovative, complex marine systems, such as autonomous ship concepts, has led to risk-based approaches indesign and operation that provide safety level quantification and continuous risk assessment. The existing approaches to dynamicrisk assessmentmainly aim at updating accident probabilities for specific risk scenarios, based on knowledge of system operation andfailure, aswell as on past accident and failure information. However, for innovative marine systems that include complex interactions,our ability to identify anything that might go wrong is very limited, which may lead to unidentified risks, and failure data may not beavailable. This paper presents the foundations of a framework for dynamic risk assessment, which is equally applicable to mannedand autonomous ships and mainly relies on information about the safe operational envelope and real-time information regardingdeviations from safety. Inspiration is drawn from how the biological immune system identifies the risk of infection in a dynamicenvironment. The objective is to show the feasibility and benefits of our approach for quantifying the operational risk of marinesystems. This paper provides the conceptual basis for developing ship specific applications and describes a process for dynamic riskassessment that is methodologically based on artificial immune systems. To demonstrate the implementation of our framework, wedescribed, an illustrative example that involves a ship in a grounding scenario. The results show that the bio-inspired assessmentprocess and risk description can reflect the changes of the risk level of a marine system.

关键词： Dynamic risk assessment artificial immune systems risk description system risk autonomous ships

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Fully integrated and broadband Si-rich silicon nitride wavelength converter based on Bragg scattering intermodal four-wave mixing

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Photonics Research 2024年第3期12卷 I0001-I0010页

作者： VALERIO VITALI THALÍA DOMÍNGUEZ BUCIO HAO LIU JOSÉMANUEL LUQUE GONZÁLEZ FRANCISCO JURADO-ROMERO ALEJANDRO ORTEGA-MOÑUX GLENN CHURCHILL JAMES C.GATES JAMES HILLIER nikolaos KALFAGIANNIS DANIELE MELATI JENS H.SCHMID ILARIA CRISTIANI PAVEL CHEBEN J.GONZALO WANGÜEMERT-PÉREZ ÑIGO MOLINA-FERNÁNDEZ FREDERIC GARDES COSIMO LACAVA PERIKLIS PETROPOULOS Optoelectronics Research Centre University of SouthamptonSouthampton SO171BJUK Electrical Computer and Biomedical Engineering DepartmentUniversity of PaviaPavia 27100Italy Telecommunication Research Institute(TELMA) Universidad de MálagaCEI Andalucı´a TECHE.T.S.I.Telecomunicación29010 MálagaSpain School of Science and Technology Nottingham Trent UniversityNottingham NG118NSUK Department of Electrical Engineering Eindhoven University of TechnologyEindhoven 5600 MBThe Netherlands Department of Materials Science and Engineering University of IoanninaIoannina 45110Greece Centre de Nanosciences et de Nanotechnologies UniversitéParis-SaclayCNRS91120 PalaiseauFrance Advanced Electronics and Photonics Research Center National Research Council CanadaOttawaOntario K1A 0R6Canada

Intermodal four-wave mixing(FWM)processes have recently attracted significant interest for all-optical signal processing applications thanks to the possibility to control the propagation properties of waves exciting distinct spatial modes of the same *** allows,in principle,to place signals in different spectral regions and satisfy the phase matching condition over considerably larger bandwidths compared to intramodal ***,the demonstrations reported so far have shown a limited bandwidth and suffered from the lack of on-chip components designed for broadband manipulation of different *** demonstrate here a silicon-rich silicon nitride wavelength converter based on Bragg scattering intermodal FWM,which integrates mode conversion,multiplexing and de-multiplexing functionalities *** system enables wavelength conversion between pump waves and a signal located in different telecommunication bands(separated by 60 nm)with a 3 dB bandwidth exceeding 70 nm,which represents,to our knowledge,the widest bandwidth ever achieved in an intermodal FWM-based system.

关键词： scattering pump modal

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Remission of type 2 diabetes depends on prompt comprehensive lifestyle changes upon diagnosis: How can this“Road to Damascus” experience be supported?

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Journal of Integrative Medicine 2022年第4期20卷 288-291页

作者： Theocharis Koufakis Kalliopi Kotsa nikolaos Papanas Division of Endocrinology and Metabolism and Diabetes Centre First Department of Internal MedicineMedical SchoolAristotle University of ThessalonikiAHEPA University Hospital54636 ThessalonikiGreece Diabetes Centre Second Department of Internal MedicineDemocritus University of Thrace68100 AlexandroupolisGreece

Theoretically, a new diagnosis of type 2 diabetes mellitus(T2DM) requires a dramatic change in an individual’s way of life. Weight loss and physical activity can lead to remission of diabetes, which has been associated with a lower risk of developing complications. Today, the importance of a healthy lifestyle is further highlighted by data showing that obesity and diabetes increase the risk of severe complications from coronavirus disease 2019. However, remission rarely occurs in reality, probably due to the inability of people with T2DM to adhere to the intensive lifestyle interventions that are necessary. The complexity of contributing factors may explain why making these changes is so challenging and underscore the fact that there is no magical solution for T2DM. Instead, hard work from both patients and health care providers is needed for the conversion to be achieved. This article calls for more research on the underlying reasons why adhering to a healthy way of life is so difficult for people with diabetes and obesity. Clearly defining these barriers would facilitate the planning of effective policies to promote the adoption of appropriate lifestyle changes early in the course of the disease.

关键词： Type 2 diabetes Remission Exercise Diet Lifestyle change

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Bacterial Infections in Cirrhotic Patients in a Tertiary Care Hospital

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Journal of Clinical and Translational Hepatology 2021年第1期9卷 32-39页

作者： Vivek A.Lingiah nikolaos T.Pyrsopoulos Department of Medicine Division of Gastroenterology and HepatologyRutgers UniversityNew Jersey Medical SchoolNewarkNJUSA

Background and Aims:Patients with cirrhosis are immunocompromised and at higher risk of developing infections compared to the general *** aim of this study was to assess the incidence of infections in cirrhotic patients in a large academic liver center and investigate potential associations between infections,bacteria isolated,therapeutic regimens used,and ***:This was a retrospective chart review study,including 192 *** patients had a diagnosis of cirrhosis and were admitted to University *** collected included demographics,etiology of cirrhosis,identification of bacteria from cultures,multidrug-resistant(MDR)status,antibiotics administered,intensive care unit(ICU)admission,and patient ***:Infections were present in 105(54.6%)patients,and 60(31.2%)patients had multiple infections during a hospitalization(s)for infections.A total of 201 infections were *** tract infections(UTIs)were the most common infection(37.8%),followed by bacteremia(20.4%),pneumonia(12.9%),spontaneous bacterial peritonitis(SBP)(11.9%),abscess/cellulitis(6.0%),infectious diarrhea(6.0%),and other(5.0%).Escherichia coli was the most common bacteria isolated(13.4%),both among sensitive and MDR *** bacteria were the cause for 41.3%of all infections *** accounted for 9.5%of infections.21.9%of patients had decompensation from their infection(s)that required ICU care,and 14.6%of patients died during hospitalization or soon after ***:The incidence of infections in cirrhotic patients is much higher than in their non-cirrhotic counterparts(54.6%),even higher than prior studies *** many of these infections are caused by MDR bacteria and fungal organisms,stronger empiric antibiotics and antifungals should be considered when initially treating this immunocompromised ***,once organism sensitivities are discovered,narrowing of antibiotic regimens must occur to maintain g

关键词： Cirrhosis Bacterial infections Multidrug resistance Fungal infections

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