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Fatal gastrointestinal histoplasmosis 15 years after orthotopic liver transplantation

World Journal of Gastroenterology 2017年第43期23卷 7807-7812页

作者： nikita Agrawal David EJ Jones Jessica K Dyson Tim Hoare Sharon A Melmore Stephanie Needham Nick P Thompson Department of Gastro-enterology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Faculty of Medical Sciences Newcastle UniversityNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Radiology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Department of Histopathology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom

We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver transplant(OLT) for primary biliary cholangitis 15 years earlier. The recipient lived in the United Kingdom,a non-endemic region for Histoplasmosis. However,she had previously lived in rural southern Africa prior to her OLT. The patient presented with iron deficiency anaemia,diarrhoea,abdominal pain and progressive weight loss. She reported no previous foreign travel,however,it later became known that following her OLT she had been on holiday to rural southern Africa. On investigation,a mild granulomatous colitis primarily affecting the right colon was identified,that initially improved with mesalazine. Her symptoms worsened after 18 mo with progressive ulceration of her distal small bowel and right colon. Mycobacterial,Yersinia,cytomegalovirus and human immunodeficiency virus infections were excluded and the patient was treated with prednisolone for a working diagnosis of Crohn's disease. Despite some early symptom improvement following steroids,there was subsequent deterioration with the patient developing gram-negative sepsis and multi-organ failure,leading to her death. Post-mortem examination revealed that her ileo-colonic inflammation was caused by Histoplasmosis.

关键词： Histoplasmosis Orthotopic liver transplant Primary biliary cholangitis Primary biliary cholangitis

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Evaluation of cardiolipin nanodisks as lipid replacement therapy for Barth syndrome

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The Journal of Biomedical Research 2018年第2期32卷 107-112页

作者： nikita Ikon Fong-Fu Hsu Jennifer Shearer Trudy M.Forte Robert O.Ryan Children's Hospital Oakland Research Institute Oakland CA 94609 USA Department of Medicine School of Medicine Washington University St. Louis MO 63110 USA Department of Biochemistry University of Nevada Reno NV 89557 USA.

Barth syndrome（BTHS） is a mitochondrial disorder characterized by cardiomyopathy and skeletal muscle weakness. Disease results from mutations in the tafazzin（TAZ） gene, encoding a phospholipid transacylase. Defective tafazzin activity results in an aberrant cardiolipin（CL） profile. The feasibility of restoring the intracellular CL profile was tested by in vivo administration of exogenous CL in nanodisk（ND） delivery particles. Ninety mg/kg CL（as ND）was administered to doxycycline-inducible taz shRNA knockdown（KD） mice once a week. After 10 weeks of CLND treatment, the mice were sacrificed and tissues harvested. Liquid chromatography-mass spectrometry of extracted lipids revealed that CL-ND administration failed to alter the CL profile of taz KD or WT mice. Thus, although CL-ND were previously shown to be an effective means of delivering CL to cultured cells, this effect does not extend to an in vivo setting. We conclude that CL-ND administration is not a suitable therapy option for BTHS.

关键词： mitochondria cardiomyopathy nanoparticles drug delivery

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Whispering-gallery microlasers for cell tagging and barcoding:the prospects for in vivo biosensing

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Light(Science & Applications) 2021年第5期10卷 710-712页

作者： nikita Toropovo Frank vollmer Department of Physics and Astronomy Living Systems InstituteUniversity of ExeterExeter EX44QDUK

Researchers in the field of whispering-gallery-mode(WGM)microresonators have proposed biointegrated low-threshold WGM lasers,to enable large-scale parallel single-cell tracking and *** the reported devices have so far been primarily investigated in model applications,most recent results represent important steps towards the development of in vivo tags and sensors that utilize the unique and narrow spectral features of miniature WGM lasers.

关键词： lasers vivo utilize

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Optical in vivo and ex vivo imaging of glioma cells migration via the cerebral vessels:Prospective clinical application of the beta2-adrenoreceptors blockade for glioma treatment

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 98-107页

作者： Olga Pavlova Alexander Shirokov Alexander Fomin nikita Navolokin Andrey Terskov Alexander Khorovodov Anton Namykin Alexey Pavlov valery Tuchin Oxana Semyachkina-Glushkovskaya Interdisciplinary Center of Critical Technologies in Medicine Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of Sciences13 Entuziastov Ave.Saratov 410049Russia Saratov State Medical University 112 Bolshaya Kazachia Str. Saratov 410012Russia Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya Str.Saratov 410012Russia Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Str. Saratov 410054Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precision Mechanics and Control of RAS 24 Rabochaya Str.Saratov 410028Russia Laboratory of Biophotonics Tomsk State University 36 Lenin's Ave.Tomsk 634050Russia

Malignant gliomas are highly invasive tumors that 1use the cerebral vessels for invasion due to high vascular fragility of the blood--brain barrier(BBB).On one hand,glioma is characterized by the BBB disruption,on the other hand,drug brain delivery via the BBB is a big challenge in glioma *** limited information about vascular changes associated with glioma growth is a reason of slow progress in prevention of glioma ***,we present in vrivo and er vrivo study of the BBB disruption and glioma cells(GCs)migration in rats using fuorescence and confocal *** uncovered a local breach in the BBB in the main tumor mass but not within the border of normal and malignant cells,where the BBB was impermeable for high weight *** migr ation of GCs were observed via the cerebral vessels with the intact BBB that was associated with macrophages *** mechanisms underlying glioma progression remain umknown but there is an evidence that the sympathetic nervous system(SNS)via activation of vascular beta2-adrenoreceptors(B2-ADRs)can play an important role in tumor *** results clearly show an increase in the expression of vascular B2-ADRs and production of the beta arrestin-1-co-factor of B2-ADRs signaling pathway in rats with *** blockade of B2-ADRs reduces the BBB disruption,macrophages infiltration,GCs migration and increases survival *** data suggest that the blockade of B2-ADRs may be a novel adjuvant therapeutic strategy to reduce glioma progression and prevent metastasis。

关键词： Glioma macrophages blood-brain barrier beta-2 adrenoreceptors bet a arrestin-1

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主题模型在基于社交媒体的灾害分类中的应用及比较

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地球信息科学学报 2019年第8期21卷 1152-1160页

作者：苏凯程昌秀 nikita Murzintcev 张婷北京师范大学地理科学学部地理数据与应用分析中心北京100875 中国科学院地理科学与资源研究所北京100101

“一带一路”沿线为自然灾害高发地区,且多为经济欠发达、抗灾能力弱的发展中国家。灾害发生时,挖掘和分析相关推特数据有助于开展应急救援、灾情评估、减灾防灾等工作,为中国国际救援与救助工作提供重要支撑。主题模型能在没有经验语... 详细信息

“一带一路”沿线为自然灾害高发地区,且多为经济欠发达、抗灾能力弱的发展中国家。灾害发生时,挖掘和分析相关推特数据有助于开展应急救援、灾情评估、减灾防灾等工作,为中国国际救援与救助工作提供重要支撑。主题模型能在没有经验语料库的情况下,从海量灾害相关推文中快速聚合出对灾害救援、评估有价值的信息。本文采用BTM模型和LDA模型,对2013年海燕台风相关推文进行细粒度的主题聚类,分析2个模型的精度并测试它们对近似灾害主题的区分能力,并基于“需求相关”主题类的推文,通过地名匹配,分析了海燕台风发生过程中菲律宾物资、医疗等需求程度的空间分布。结果表明:①在区分主题近似的短文本时,BTM总体精度为***的总体精度仅为0.321,说明在海燕台风灾害推文的主题识别中,BTM模型的精度高于LDA模型;②BTM能够较好识别出“灾害地点相关”、“祈福相关”等较为精细的灾害主题;③经初步验证,基于“需求相关”主题文本生成的物资、医疗等需求的需求程度空间分布与实际需求情况基本相符。

关键词：主题模型 BTM LDA 推文主题分类自然灾害应急管理

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Dissociative disorder presenting as foreign accent syndrome

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World Journal of Psychiatry 2013年第4期3卷 103-106页

作者： nikita Rajpal Subho Chakrabarti Department of Psychiatry Postgraduate Institute of Medical Education and ResearchChandigarh 160012 India

The foreign accent syndrome(FAS) is a rare speech disorder, characterised by the appearance of a new accent, different from the speaker's native language and perceived as foreign by others. In the majority of patients, FAS is secondary to focal brain damage caused by stroke or other neurological disorders. Infrequently, FAS has been reported in association with psychiatric disorders, including dissociative or conversion disorders. The case of a young woman with recurrent episodes of speaking with a foreign accent is described. Repeated neurological examinations, imaging and electroencephalography did not reveal any brain abnormality. However, there was a history of a difficult childhood, alcohol dependence in the father, parental discord, alleged sexual abuse in the past, interpersonal difficulties and parental death. Episodes were precipitated by stressful life circumstances and resolved spontaneously, or with supportive treatment. She had additional "suspect" symptoms such as non-epileptic seizures, aphonia and motor paralysis. All these features indicated that a dissociative disorder was involved in the genesis of her FAS. The influence of external factors such as the media was unclear. Generally biological factors have been implicated in the onset of FAS, but the presentation in this young woman suggests that psychological factors such as personality, trauma, stressful life events and psychiatric disorder; familial factors such as parental discord and parental death and family conflicts; and, social factors such the possible influence of the media may also be involved in the production of foreign accents by patients.

关键词： Foreign accent syndrome Dissociative disorder Conversion disorder Psychosocial

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Corrigendum:Edible seaweed-derived constituents:an undisclosed source of neuroprotective compounds

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Neural Regeneration Research 2021年第12期16卷 2564-2568页

作者： Melissa Schepers nikita Martens Assia Tiane Kenneth vanbrabant Hong-Bing Liu Dieter Lütjohann Monique Mulder Tim vanmierlo Department of Neuroimmunology Biomedical Research InstituteHasselt UniversityEuropean Graduate School of Neuroscience(EURON)HasseltBelgium Department of Psychiatry&Neuropsychology Division of Translational NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityEuropean Graduate School of Neuroscience(EURON)MaastrichtThe Netherlands Department of Internal Medicine Laboratory of Vascular MedicineErasmus MC University Medical CenterRotterdamthe Netherlands Institue for Clinical Chemistry and Clinical Pharmacology BonnGermany Key Laboratory of Marine Drugs Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdaoShandong ProvinceChina

Edible marine algae,or seaweeds,are a rich source of several bioactive compounds including phytosterols,carotenoids,and *** the last decades,seaweedderived constituents turned out to not only reside in the systemic circulation,but are able to cross the blood-brain barrier to exert neuro-active functions both in homeostatic and pathological ***,seaweed-derived constituents have gained increasing interest for their neuro-immunomodulatory and neuroprotective properties,rendering them interesting candidates for the management of several neurodegenerative *** particular seaweed-derived phytosterols gained interest for the treatment of neurodegenerative disorders as they potentiate neuroplasticity,enhance phagocytic clearance of neurotoxic peptides and have anti-inflammatory ***,the antiinflammatory and anti-oxidative properties of other constituents including carotenoids,phenols and polysaccharides have recently gained more *** this review,we provide an overview of a selection of the described neuro-active properties of seaweed-derived constituents with a focus on phytosterols.

关键词： algae carotenoids neuro-active phenols phytosterols polysaccharides seaweed

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A Comparison of SWAT Model Calibration Techniques for Hydrological Modeling in the Ganga River Watershed

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Engineering 2018年第5期4卷 643-652页

作者： nikita Shivhare Prabhat Kumar Singh Dikshir Shyam Bihari Dwivedi Indian Institute of Technology Banaras Hindu University Varanasi 221005 India

The Ganga River, the longest river in India, is stressed by extreme anthropogenic activity and climate change, particularly in the varanasi region. Anticipated climate changes and an expanding populace are expected to further impede the efficient use of water. In this study, hydrological modeling was applied to Soil and Water Assessment Tool （SWAT） modeling in the Ganga catchment, over a region of 15 621.612 km2 in the southern part of Uttar Pradesh. The primary goals of this study are： ① To test the execution and applicability of the SWAT model in anticipating runoff and sediment yield; and ② to compare and determine the best calibration algorithm among three popular algorithms-sequential uncertainty fitting version 2 （SUFI-2）, the generalized likelihood uncertainty estimation （GLUE）, and par-allel solution （ParaSol）. The input data used in the SWAT were the Shuttle Radar Topography Mission （SRTM） digital elevation model （DEM）, Landsat-8 satellite imagery, soil data, and daily meteorological data. The watershed of the study area was delineated into 46 sub-watersheds, and a land use/land cover （LULC） map and soil map were used to create hydrological response units （HRUs）. Models utilizing SUFI- 2, GLUE, and ParaSol methods were constructed, and these algorithms were compared based on five cat-egories： their objective functions, the concepts used, their performances, the values of P-factors, and the values of R-factors. As a result, it was observed that SUFI-2 is a better performer than the other two algo-rithms for use in calibrating Indian watersheds, as this method requires fewer runs for a computational model and yields the best results among the three algorithms. ParaSol is the worst performer among the three algorithms. After calibrating using SUFI-2, five parameters including the effective channel hydraulic conductivity （CH_K2）, the universal soil-loss equation （USLE） support parameter （USLE_P）, Manning＇s n value for the main channel （CH_N2）, the surface runof

关键词： Remote sensing Geographic information system Soil and Water Assessment Tool Hydrological modeling SUFI-2 GLUE ParaSol Sediment yield

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The influence on biotissue laser resection of a strongly absorbing layer at the optical fiber tip

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 15-21页

作者： Daria Kuznetsova vadim Elagin Maria Karabut Maria Shakhova vladimir Bredikhin Liudmila Snopova Andrei Shakhov Natalia Sapogova nikita Bityurin victor Bagratashvili vladislav Kamensky Institute of Biomedical Technologies Nizhny Novgorod State Medical Academy 10/1 Minin and Pozharsky Sq. Nizhny Novgorod 603005Russia Lobachevsky State University of Nizhni Novgorod 23 Gagarin Avenue BLDG 2 Nizhny Novgorod 603950Russia Nizhny Novgorod State Medical Academy 10/1 Minin and Pozharsky Sq. Nizhny Novgorod 603005Russia Institute of Applied Physics Russian Academy of Sciences 46 Ul'yanov StreetNizhny Novgorod 603950Russia Institute on Laser and Information Technologies Russian Academy of Sciences 2 Pionerskaya St. Troitsk 142092Russia

In this paper,we consider a method of laser resection using the silica glass core from which the cladding layer has been removed as the cutting part of a laser *** absorbing layer coating the silica fiber tip markedly alters its biotissue cutting character *** results of histological studies of skin after exposure to a laser scalpel with and without a strongly absorbing coating(SAC)at a wavelength of 097μm show that resection using a coated scalpel is more *** an uncoated scalpel was used,skin injury was more apparent in both its surface spread and the depth of structural damage,resulting in poorer tissue regeneration.

关键词： Laser surgery silica fibers strongly absorbing coating histology

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MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter:In vitro and in vivo study

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2609-2618页

作者： Zhuo-Xun Wu Qiu-Xu Teng Yuqi Yang nikita Acharekar Jing-Quan Wang Min He Sabesan Yoganathan Jun Lin Jian Wang Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Anesthesiology Stony Brook University Health Sciences CenterStony BrookNY 11794USA Department of Radiotherapy the Afﬁliated Jiangyin People’s Hospital of Nantong UniversityJiangyin 214400China

Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance(MDR), an obstacle to cancer therapy. Our recent study uncovered that the MET inhibitor,tepotinib, is a potent reversal agent for ABCB1-mediated MDR. In the present study, we reported for the first time that the MET inhibitor tepotinib can also reverse ABCG2-mediated MDR in vitro and in vivo by directly binding to the drug-binding site of ABCG2 and reversibly inhibiting ABCG2 drug efflux activity, therefore enhancing the cytotoxicity of substrate drugs in drug-resistant cancer cells. Furthermore, the ABCB1/ABCG2 double-transfected cell model and ABCG2 gene knockout cell model demonstrated that tepotinib specifically inhibits the two MDR transporters. In mice bearing drug-resistant tumors, tepotinib increased the intratumoral accumulation of ABCG2 substrate drug topotecan and enhanced its antitumor effect. Therefore, our study provides a new potential of repositioning tepotinib as an ABCG2 inhibitor and combining tepotinib with substrate drugs to antagonize ABCG2-mediated MDR.

关键词： MET inhibitor Tepotinib Multidrug resistance ABCG2 transporter Reversal agent Combination treatment Chemotherapy In vivo study

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