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A Comparison of SWAT Model Calibration Techniques for Hydrological Modeling in the Ganga River Watershed

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Engineering 2018年第5期4卷 643-652页

作者： nikita Shivhare Prabhat Kumar Singh Dikshir Shyam Bihari Dwivedi Indian Institute of Technology Banaras Hindu University Varanasi 221005 India

The Ganga River, the longest river in India, is stressed by extreme anthropogenic activity and climate change, particularly in the varanasi region. Anticipated climate changes and an expanding populace are expected to further impede the efficient use of water. In this study, hydrological modeling was applied to Soil and Water Assessment Tool （SWAT） modeling in the Ganga catchment, over a region of 15 621.612 km2 in the southern part of Uttar Pradesh. The primary goals of this study are： ① To test the execution and applicability of the SWAT model in anticipating runoff and sediment yield; and ② to compare and determine the best calibration algorithm among three popular algorithms-sequential uncertainty fitting version 2 （SUFI-2）, the generalized likelihood uncertainty estimation （GLUE）, and par-allel solution （ParaSol）. The input data used in the SWAT were the Shuttle Radar Topography Mission （SRTM） digital elevation model （DEM）, Landsat-8 satellite imagery, soil data, and daily meteorological data. The watershed of the study area was delineated into 46 sub-watersheds, and a land use/land cover （LULC） map and soil map were used to create hydrological response units （HRUs）. Models utilizing SUFI- 2, GLUE, and ParaSol methods were constructed, and these algorithms were compared based on five cat-egories： their objective functions, the concepts used, their performances, the values of P-factors, and the values of R-factors. As a result, it was observed that SUFI-2 is a better performer than the other two algo-rithms for use in calibrating Indian watersheds, as this method requires fewer runs for a computational model and yields the best results among the three algorithms. ParaSol is the worst performer among the three algorithms. After calibrating using SUFI-2, five parameters including the effective channel hydraulic conductivity （CH_K2）, the universal soil-loss equation （USLE） support parameter （USLE_P）, Manning＇s n value for the main channel （CH_N2）, the surface runof

关键词： Remote sensing Geographic information system Soil and Water Assessment Tool Hydrological modeling SUFI-2 GLUE ParaSol Sediment yield

MET inhibitor tepotinib antagonizes multidrug resistance mediated by ABCG2 transporter:In vitro and in vivo study

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2609-2618页

作者： Zhuo-Xun Wu Qiu-Xu Teng Yuqi Yang nikita Acharekar Jing-Quan Wang Min He Sabesan Yoganathan Jun Lin Jian Wang Zhe-Sheng Chen Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA Department of Anesthesiology Stony Brook University Health Sciences CenterStony BrookNY 11794USA Department of Radiotherapy the Afﬁliated Jiangyin People’s Hospital of Nantong UniversityJiangyin 214400China

Overexpression of ABCG2 transporter in cancer cells has been linked to the development of multidrug resistance(MDR), an obstacle to cancer therapy. Our recent study uncovered that the MET inhibitor,tepotinib, is a potent reversal agent for ABCB1-mediated MDR. In the present study, we reported for the first time that the MET inhibitor tepotinib can also reverse ABCG2-mediated MDR in vitro and in vivo by directly binding to the drug-binding site of ABCG2 and reversibly inhibiting ABCG2 drug efflux activity, therefore enhancing the cytotoxicity of substrate drugs in drug-resistant cancer cells. Furthermore, the ABCB1/ABCG2 double-transfected cell model and ABCG2 gene knockout cell model demonstrated that tepotinib specifically inhibits the two MDR transporters. In mice bearing drug-resistant tumors, tepotinib increased the intratumoral accumulation of ABCG2 substrate drug topotecan and enhanced its antitumor effect. Therefore, our study provides a new potential of repositioning tepotinib as an ABCG2 inhibitor and combining tepotinib with substrate drugs to antagonize ABCG2-mediated MDR.

关键词： MET inhibitor Tepotinib Multidrug resistance ABCG2 transporter Reversal agent Combination treatment Chemotherapy In vivo study

Sparse representation for machine learning the properties of defects in 2D materials

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npj Computational Materials 2023年第1期9卷 1186-1195页

作者： nikita Kazeev Abdalaziz Rashid Al-Maeeni Ignat Romanov Maxim Faleev Ruslan Lukin Alexander Tormasov A.H.Castro Neto Kostya S.Novoselov Pengru Huang Andrey Ustyuzhanin Institute for Functional Intelligent Materials National University of Singapore4 Science Drive 2117544 SingaporeSingapore Constructor University Bremen gGmbH Campus Ring 1Bremen 28759Germany HSE University Myasnitskaya Ulitsa20101000 MoscowRussia Innopolis University Universitetskaya St1InnopolisRepublic of Tatarstan 420500Russia Centre for Advanced 2D Materials National University of Singapore6 Science Drive 2117546 SingaporeSingapore

Two-dimensional materials offer a promising platform for the next generation of(opto-)electronic devices and other high technology *** of the most exciting characteristics of 2D crystals is the ability to tune their properties via controllable introduction of ***,the search space for such structures is enormous,and ab-initio computations prohibitively *** propose a machine learning approach for rapid estimation of the properties of 2D material given the lattice structure and defect *** method suggests a way to represent configuration of 2D materials with defects that allows a neural network to train quickly and *** compare our methodology with the state-of-the-art approaches and demonstrate at least 3.7 times energy prediction error ***,our approach is an order of magnitude more resource-efficient than its contenders both for the training and inference part.

关键词： properties defects prediction

考虑AA-CAES季节效率优化的建筑微网群多能协同优化策略

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电力建设 2023年第9期44卷 94-107页

作者：韩雪茹杨德昌 Payman Dehghanian nikita Tomin 中国农业大学信息与电气工程学院北京市100083 乔治华盛顿大学电气与计算机工程系华盛顿20052 俄罗斯科学院西伯利亚分院能源研究所新西伯利亚630090

先进绝热压缩空气储能(advanced adiabatic compressed air energy storage,AA-CAES)装置因具有大容量、寿命长、污染少、成本低等优点而日渐受到关注,其大容量多能联供联储特点与建筑能耗特征相匹配,接入由多建筑微网构成的区域综合能... 详细信息

先进绝热压缩空气储能(advanced adiabatic compressed air energy storage,AA-CAES)装置因具有大容量、寿命长、污染少、成本低等优点而日渐受到关注,其大容量多能联供联储特点与建筑能耗特征相匹配,接入由多建筑微网构成的区域综合能源系统(regional integrated energy system,RIES),两者相得益彰。文章建立了一种含AA-CAES的由多个建筑微网组成的区域综合能源系统模型,考虑压缩空气储能设备储气、储热双荷能状态以建立季节性效率优化模型,对AA-CAES的运行模式进行季节性优化,在区域内多能流平衡约束分析的基础上构建关于系统综合效益最优的二次约束问题,利用Gurobi求解器求解。仿真表明,改进的AA-CAES可协调区域内多个建筑微网的多能优化,提高系统经济性、节能性、环保性,促进可再生能源就地消纳与能源梯级利用。

关键词：先进绝热压缩空气储能(AA-CAES) 建筑微网群双荷能状态冷热电联供(CCHP)

俄罗斯医疗器械市场的进入策略 ——以中国公司为例

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俄罗斯医疗器械市场的进入策略 ——以中国公司为例

作者： nikita Martov 北京外国语大学

学位级别：硕士

目前,俄罗斯的经济正处于下降的状态,被西方制裁和限制,然而市场仍然是最有利可图的,国际企业有新的机会。俄罗斯是不同组织的成员,比如金砖国家(BRICS),这意味着该国的稳定和它的潜力是巨大的,俄国也成为了一种政治力量,并开始影响其... 详细信息

目前,俄罗斯的经济正处于下降的状态,被西方制裁和限制,然而市场仍然是最有利可图的,国际企业有新的机会。俄罗斯是不同组织的成员,比如金砖国家(BRICS),这意味着该国的稳定和它的潜力是巨大的,俄国也成为了一种政治力量,并开始影响其他国家。这些行为导致与欧盟和美国的敌对关系。因此,西方公司可能会面临许多挑战和法规,政府已出台政策支持当地的产品,并邀请东方公司。所以,中国企业在俄罗斯市场潜力巨大,并且仍然可以受到官僚机构和立法的影响。本篇论文有几个目标。本篇论文有几个论点。首先,要了解俄罗斯市场是一个整体,这就是问题所在,什么进入策略可以在局势被应用。其次,要找到并讨论相应的退出策略,在俄罗斯市场的具体中国公司,找出存在的主要问题,以及如何避免它们。该市场被定义为医疗设备市场,这在医学上最大领域之一使用——"泌尿外科"使用。该项目还考察了医疗设备,定制,网络关系,官僚机构认证的重要性,并拒绝腐败。该方法是基于螺旋式中国公司的实际案例来研究的,该公司于20]6年底进入市场,主要经验来自数据收集和与中国方面的代表面谈。此外,为了了解医疗器械企业在俄罗斯的经营情况,还与这个领域最大的参与者进行了面谈。这些巨头在加入战略提出,将与境外企业建立与俄罗斯的合作伙伴关系。本文的考察对象主要是那些参与到卫生保健系统的中国医疗公司或相关企业,并期望为其进入俄罗斯市场带来帮助。这项研究需要了解、分析中俄两国的基本国情、医疗市场、企业运营等,并尝试分析俄罗斯医疗器械市场的介入、退出策略,和当下俄罗斯卫生部门的优势与竞争何在。特别是中国公司在全球视野下不断发展,其又将如何面对俄罗斯的医疗器械市场(特别是在泌尿外科领域),以及会有哪些发展趋势,本文都将给予解答。

关键词：进入策略市场分析俄罗斯的市场卫生保健医疗器械泌尿科

利用引力模型分析非洲国家参与“一带一路”倡议的效果

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利用引力模型分析非洲国家参与“一带一路”倡议的效果

作者： Glaznev nikita 华东师范大学

学位级别：硕士

“一带一路”倡议已成为中国外交政策的重要组成部分,旨在加强全球互联互通和促进贸易。非洲国家已经成为“一带一路”的重要参与者,从中国获得了大量投资用于各种基础设施项目。本论文使用国际贸易引力模型和差分法(DID)框架分析了中... 详细信息

“一带一路”倡议已成为中国外交政策的重要组成部分,旨在加强全球互联互通和促进贸易。非洲国家已经成为“一带一路”的重要参与者,从中国获得了大量投资用于各种基础设施项目。本论文使用国际贸易引力模型和差分法(DID)框架分析了中国和非洲国家之间的贸易模式。引力模型被用来分析中国和非洲国家之间双边贸易的决定因素,包括影响贸易流动的经济、地理和制度因素。DID框架被用来考察BRI参与对中国和非洲国家之间双边贸易流动的影响。研究发现,BRI的参与积极影响了中国和非洲国家之间的贸易流动,DID结果显示,BRI参与国与未参与国相比,贸易增长超过13%。本文探讨了中国和非洲大陆多个国家之间的贸易和经济关系,将“一带一路”倡议下的项目作为过去十年中非关系的前沿,并分析了这种合作的效果和潜力。本文选择了中国及其贸易伙伴的GDP、地理距离、双边贸易额和人口作为解释变量,在国际贸易引力模型中对中国和非洲国家之间的进出口额做了多重测算,并采用DID框架观察它们加入BRI后与选择不加入的国家相比的积极效果。对这两个地区之间的经济关系和倡议本身进行了多项研究,然而本研究的重点是将这两个主题联系起来,以便更清楚地了解目前的状况以及未来的多种可能性,包括中国、其政府和私人投资者的商业机会。本研究使用了从联合国统计司、国际货币基金组织和世贸组织等公开渠道收集的二手面板数据,所有的描述性统计、回归和检查都是使用STATA 14软件完成的。

关键词：一带一路倡议非中贸易引力模型进口出口差分框架

The Trend of Homicides in South Kerala from 2002-2016:A Retrospective Forensic Autopsy-Based Study

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Journal of Forensic Science and Medicine 2021年第4期7卷 111-116页

作者： Nikhil Dileeph S.Sharija Antony Stanley K.valsala S.S.Sujisha nikita Prabhakaran Department of Forensic Medicine De SMCSI Medical CollegeThiruvananthapuramKeralaIndia Department of Forensic Medicine Government Medical CollegeThiruvananthapuramKeralaIndia Achutha Menon Centre for Health Science Studies Sree Chitra Tirunal Institute for Medical Sciences and TechnologyThiruvananthapuramKeralaIndia

Aims:The aim was to analyze the homicide pattern in South Kerala from autopsies conducted between 2002 and ***:Exploring the age and gender distribution of death due to homicide,the type and distribution of injuries according to the region of the body,and trends of *** also tried to study the pattern of defense wounds in homicidal cases and characteristics in dyadic deaths(homicide-suicide).Materials and Methods:It was a retrospective descriptive *** setting was the Department of Forensic Medicine,State Medico-Legal Institute,Government Medical College(GMC),*** cases of autopsies with an alleged history of homicide,between 2002 and 2016,done at Mortuary of GMC,Thiruvananthapuram,were included in the *** of all cases of an alleged history of homicide from January 1,2002 to December 31,2016 were ***:957 cases were *** annual incidence of homicide is declining after *** adult males(31T0 years)are the most common group involved(24.97%).Head injury was the most common cause of death(43.68%).The head was the most common area to be affected in fatal blunt force injuries(49%)while the chest was involved commonly in fatal sharp force injuries(36%).Females were more often the homicide victims in ***-wife and fatherchild combination was the most common pairs in dyadic ***:The characteristics which were associated with the homicides were generally in agreement with the existing forensic *** findings encourage examining the motives of homicide and potential sociocultural factors affecting the victims and possibly the *** also found that the murder-suicide cases differed from the homicides requiring a separate domain of understanding and subsequent investigations.

关键词： Death homicide homicide-suicide Kerala murder Thiruvananthapuram

Recent advances in laser self-injection locking to high-Q microresonators

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Frontiers of physics 2023年第2期18卷 89-130页

作者： nikita M.Kondratiev valery E.Lobanov Artem E.Shitikov Ramzil R.Galiev Dmitry A.Chermoshentsev nikita Yu.Dmitriev Andrey N.Danilin Evgeny A.Lonshakov Kirill N.Min’kov Daria M.Sokol Steevy J.Cordette Yi-Han Luo Wei Liang Junqiu Liu Igor A.Bilenko Directed Energy Research Centre Technology Innovation InstituteAbu DhabiUnited Arab Emirates Russian Quantum Center MoscowRussia Skolkovo Institute of Science and Technology SkolkovoRussia Moscow Institute of Physics and Technology DolgoprudnyMoscow RegionRussia Faculty of Physics Lomonosov Moscow State UniversityMoscowRussia Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhen 518055China International Quantum Academy Shenzhen 518048China Key Laboratory of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China

The stabilization and manipulation of laser frequency by means of an external cavity are nearly ubiquitously used in fundamental research and laser applications. While most of the laser light transmits through the cavity, in the presence of some back-scattered light from the cavity to the laser, the self-injection locking effect can take place, which locks the laser emission frequency to the cavity mode of similar frequency. The self-injection locking leads to dramatic reduction of laser linewidth and noise. Using this approach, a common semiconductor laser locked to an ultrahigh-Q microresonator can obtain sub-Hertz linewidth, on par with state-of-the-art fiber lasers. Therefore it paves the way to manufacture high-performance semiconductor lasers with reduced footprint and cost. Moreover, with high laser power, the optical nonlinearity of the microresonator drastically changes the laser dynamics, offering routes for simultaneous pulse and frequency comb generation in the same microresonator. Particularly, integrated photonics technology, enabling components fabricated via semiconductor CMOS process, has brought increasing and extending interest to laser manufacturing using this method. In this article, we present a comprehensive tutorial on analytical and numerical methods of laser self-injection locking, as well a review of most recent theoretical and experimental achievements.

关键词： self-injection locking laser stabilization microresonator nonlinearity single-frequency lasing multi-frequency lasing

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中俄天然气贸易合作发展研究

中俄天然气贸易合作发展研究

作者： ZOTOv，nikita 青岛科技大学

学位级别：硕士

自2001年《中俄睦邻友好合作条约》签署以来,中俄战略协作伙伴关系不断加深,双边合作在各个领域全面展开,而能源合作当中天然气是其重要组成部分。未来天然气将成为最佳替代能源,它除了是一种物美价廉的燃料来源之外,还是一种对环境友... 详细信息

自2001年《中俄睦邻友好合作条约》签署以来,中俄战略协作伙伴关系不断加深,双边合作在各个领域全面展开,而能源合作当中天然气是其重要组成部分。未来天然气将成为最佳替代能源,它除了是一种物美价廉的燃料来源之外,还是一种对环境友好、优质高效的能源,其二氧化碳排放量约为煤炭的一半,所以天然气是解决中国环境污染的问题具有重要意义的能源因素。中国对能源资源的需求很大,中国需要更加重视天然气的利用,转变能源消费方式和经济发展模式,保障国家经济社会发展。由于国内天然气生产不能满足国家能源需求,中国需要加强天然气领域的国际合作。俄罗斯是中国在天然气领域最好的合作伙伴,第一,俄罗斯与中国接壤,因此有最快的供气方式;第二,俄罗斯拥有最大的天然气储量;第三,中俄关系处于历史最好时期。这种伙伴关系无疑会积极利好的合作:俄罗斯是天然气的主要出口国,而中国是其最大的消费国。2019年12月“西伯利亚力量-1”天然气管道首次开始供应,合同总金额为4000亿美元,2022年2月,签订远东管道“SHv”供气合同及正在设计另一条通过蒙古的管道-“西伯利亚力量-2”。本文旨在总结新时期中俄天然气合作的特征,探讨中俄天然气合作问题,如没有创建成熟的天然气交易中心,两国在协议中的立场不平衡等,分析中俄天然气合作发展的影响政治,经济,社会等因素。使用预测来确定天然气合作前景。同时提出中俄天然气合作发展的路径。

关键词：中俄合作发展贸易天然气合作路径