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Basal cisternostomy for traumatic brain injury: A case report of unexpected good recovery

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Chinese Journal of Traumatology 2022年第5期25卷 302-305页

作者： Manuel De Jesus Encarnacion Ramirez Rossi Evelyn Barrientos Castilo Anton vorobiev nikita Kiselev Amaya Alvarez Aquino Ibrahim E.Efe Department of Neurosurgery Russian People's Friendship University MoscowRussia Department of Neurosurgery Municipal HospitalPodolskRusia Department of Neurosurgery International Center for Neurological Restoration HavanaCuba Charite-Universitatsmedizin Berlin Corporate Member of Freie Universitat BerlinHumbold-Universitat zu BerlinAnd Berlin Institute of HealthBerlinGermany

In subarachnoid hemorrhage following traumatic brain injury (TBI), the high intracisternal pressure drives the cerebrospinal fluid into the brain parenchyma, causing cerebral edema. Basal cisternostomy involves opening the basal cisterns to atmospheric pressure and draining cerebrospinal fluid in an attempt to reverse the edema. We describe a case of basal cisternostomy combined with decompressive craniectomy. A 35-year-old man with severe TBI following a road vehicle accident presented with acute subdural hematoma, Glasgow coma scale score of 6, fixed pupils and no corneal response. Opening of the basal cisterns and placement of a temporary cisternal drain led to immediate relaxation of the brain. The patient had a Glasgow coma scale score of 15 on postoperative day 6 and was discharged on day 10. We think basal cisternostomy is a feasible and effective procedure that should be considered in the management of TBI.

关键词： Basal cisternostomy Cerebral edema Decompressive craniectomy Neurotrauma Traumatic brain injury

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沙虫

世界建筑导报 2014年第2期29卷 99-101页

作者：马可.卡萨格兰 nikita Wu

沙虫是坐落在比利时韦德市沿岸沙丘上的有机建构/空间/创造体。建筑有机的拱形外壳是用柳条编织而成的,总长45米,宽10米,高度则各不相同。沙虫弯曲的形态与比利时小镇上的沙丘融为一体。以作品和环境持续交互的＂当地知识＂为依据,这座... 详细信息

沙虫是坐落在比利时韦德市沿岸沙丘上的有机建构/空间/创造体。建筑有机的拱形外壳是用柳条编织而成的,总长45米,宽10米,高度则各不相同。沙虫弯曲的形态与比利时小镇上的沙丘融为一体。以作品和环境持续交互的＂当地知识＂为依据,这座高大的景观装置,是一件自由游走于建筑及环境艺术之间的作品。建筑师卡萨格兰及其年轻建筑师团队历I],-J4周，与当地专家共同研究柳条材料，并讨论出“弱建筑”的命题，意思是“通过灵活和有机性设计成为与自然相融合的人工建筑”。

关键词：室内面积环境艺术韦德萨格 artist 自然相 relaxation 有机性人工建筑 visitors

Infertility Management in Men with Cystic Fibrosis

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Journal of Reproduction and Contraception 2009年第1期20卷 57-62页

作者： nikita Rawal Rafit Gazvani Roger Mountford Department of Obstetrics and Gynaecology Liverpool Women's Hospita Crown Street Liverpool L8 7SS UK Department of Molecular Genetics Liverpool Women’s Hospital Crown Street Liverpool L8 7SS UK

Cystic fibrosis （CF） is a multisystem autosomal recessive disorder. CF has a reported incidence of 1 in 2 500 and a carrier frequency of 1 in 25. It is caused by mutations in a gene located on the long arm of chromosome 7. With almost 50% of patients with CF now in the adult population, and a very high interest in future parenting （78% of men wanting children）, there is an increasing need to be proactive in terms of advice about reproductive health. Discussion on reproduction should start in early adolescence and be regularly updated by medical staff. The recent advances in reproductive techniques have allowed the development of sperm aspiration coupled with intra-cytoplasmic sperm injection （ICSI）. Spermatozoa can be retrieved from either the epididymis or the testes. Genetic counselling is strongly recommended for both partners when congenital bilateral aplasia of vas deferens （CBAvD） is diagnosed as there is the inevitability of transmitting a mutated CFTR gene, and an increased risk of producing an affected child with serious long-term implications. Most treatment centres, with the introduction of ICSI, routinely screen all males with azoospermia caused by obstruction （other than that caused by vasectomy） or germ cell failure. Protocols usually involve screening for 28 relatively common CFTR mutations. Further advanced testing may be necessary up to a final detection level of approximately 98.5%. Before considering any assisted reproduction treatment, it is pertinent that CF patients receive medical and psychological counselling.

关键词： systic fibrosis (CF) ICSI infertility

Avian orientation: multi-cue integration and calibration of compass systems

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Chinese Birds 2012年第1期03卷 1-8页

作者：刘小峰尼基塔.切尼佐夫河海大学常州校区计算机与信息学院认知与机器人实验室常州213022 山东科技大学信息与电气工程学院青岛266510 俄罗斯科学院动物研究所雷巴奇生物研究站雷巴奇238535

Migratory birds are known to use a number of different orientation cues to determine and maintain the direction of their movements. They are able to use at least three different sources of compass information, including solar, stellar and geomagnetic cues. However, little is known about how these cues are calibrated into uniform reference direction information, while the hierarchy of these cues remains controversial. In recent studies, researchers suggest that avian migrants calibrate their geomagnetic compass on sunset cues, whereas others fail to find such patterns and insist on the prevalence of the magnetic compass. We carefully reviewed the existing literature and suggest that the conflicting results reported by different authors are due to genuine variation among species and propose hypotheses to explain this variation.

关键词： birds orientation compass system geomagnetic field solar cues

Modification in Atmospheric Refractivity and GPS Based TEC as Earthquake Precursors

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Positioning 2014年第2期5卷 46-52页

作者： Sheetal P. Karia Kamlesh N. Pathak Kunvar S. Yadav nikita P. Chaudhary Nilesh C. Patel. Ranjan Jana Applied Physics Department S. V. National Institute of Technology Surat India

The present paper reports the modification in GPS TEC (total electron content) and atmospheric refractivity prior to the Iran earthquake that had occurred on 16 April 2013 in Iran (28.10°N, 62.05°E). The analysis of GPS-based TEC from two GPS receivers, Surat (21.16°N, 72.78°E) and Lucknow (26.91°N, 80.95°E ) and results of atmospheric refractivity profile for radiosonde observation stations (Shiraz, Iran and Delhi, India) around the fault line are presented in this paper. It is seen that atmospheric refractivity gets modified from 8 to 6 days prior to the earthquake at Shiraz, Iran and Delhi, India. The GPS TEC showed variations a few days prior to the earthquake. We conclude that in search of precursory signatures for an earthquake, both GPS TEC and refractivity are important parameters.

关键词： Total Electron Content Refractivity Earthquake

Identification of the Decay Pathway of Photoexcited Nucleobases

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Ultrafast Science 2023年第2期3卷 31-38页

作者： Xiangxu Mu Ming Zhang Jiechao Feng Hanwei Yang nikita Medvedev Xinyang Liu Leyi Yang Zhenxiang Wu Haitan Xu Zheng Li State Key Laboratory for Mesoscopic Physics and Collaborative Innovation Center of Quantum Matter.School of Physics Peking UniversityBeijing 100871China institute of Physics Czech Academy of Science Na Slovance 218221 Prague 8Czech Republic School of Materials Science and Intelligent Engineering Nanjing UniversitySuzhou 215163China Shenzhen Institute for Quantum Science and Engineering Southern University of Science and TechnologyShenzhenChina School of Physical Sciences University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006 China Peking University Yangtze Delta Institute of Optoelectronics NantongJiangsu 226010China

The identification of the decay pathway of the nucleobase uracil after being photoexcited by ultraviolet light has been a long-standing *** theoretical models have been proposed but yet to be ***,we propose an experimental scheme to test the theoretical models of gas phase uracil decay mechanism by a combination of ultrafast x-ray spectroscopy,x-ray diffraction,and electron diffraction *** the signatures of multiple probing methods,we demonstrate an approach that can identify the dominant mechanism of the geometric and electronic relaxation of the photoexcited uracil molecule among several candidate models.

关键词： methods excited uracil

vlodulation of ABA Signaling by Altering vxGФL vlotif of PP2Cs in Oryza sativa

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Molecular Plant 2017年第9期10卷 1190-1205页

作者： Seungsu Han

The abscisic acid （ABA） signaling pathway is regulated by clade A type 2C protein phosphatases （PP2CAs） in plants. In the presence of ABA, PP2Cs release stress/ABA-activated protein kinases by binding to ABA-bound receptors （PYL/RCARs） for activation. Although the wedging tryptophan in PP2Cs is critical in the interaction with PYL/RCARs in Arabidopsis and rice, it remains elusive as to how other interface regions are involved in the interaction. Here, we report the identification of a conserved region on PP2Cs, termed the vxG4ФL motif, which modulates the interaction with PYL/RCARs through its second and fourth residues. The effects of the second and fourth residues on the interaction of OsPP2CS0 with several OsPYIJRCAR proteins were investigated by systematic mutagenesis. One OsPP2C50 mutant, vFGML （＂FM＂） mutant, lowered the affinity to OsPYL/RCAR3 by Ф15-fold in comparison with the wUd-type. Compar- ison of the crystal structures of wild-type OsPP2C50：ABA：OsPYI./RCAR3 with those composed of FM mutant revealed local conformational changes near the vxGФL motif, further supported by hydrogen-deute- rium exchange mass spectrometry. In rice protoplasts, ABA signaling was altered by mutations in the vxGФL motif. Transgenic Arabidopsis plants overexpressing OsPP2C50 and OsPP2C5OFM showed altered ABA sensitivity. Taken together, the vxGФL motif of PP2Cs appears to modulate the affinity of PP2Cs with PYL/RCARs and thus likely to alter the ABA signaling, leading to the differential sensitivity to ABA in planta.

关键词： ABA receptor type 2C protein phosphatase vxGФL motif Oryza sativa

俄罗斯艺术家nikita Nomerz创作的表情墙

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读写月报 2021年第32期 F0003-F0003页

作者： nikita Nomerz 不详

vaccination with the Live Attenuated FrancisellanovicidaMutant FTN0109Protects against Pulmonary Tularemia

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World Journal of vaccines 2015年第1期5卷 25-36页

作者： Aimee L. Cunningham M. Neal Guentzel Jieh-Juen Yu nikita Trivedi Karl E. Klose James P. Chambers Bernard P. Arulanandam South Texas Center for Emerging Infectious Disease and Center for Excellence in Infection Genomics University of Texas at San Antonio San Antonio TX USA Department of Microbiology and Immunology University of Texas Health Science Center at San Antonio San Antonio TX USA

Francisella tularensis is considered a potential bioterrorism agent due to its low infectious dose, high mortality rate, and ability to be spread via the aerosol route. We characterized the F. tularensis subspecies novicida mutant strain FTN0109 as a potential vaccine candidate against tularemia. This strain, which lacks an outer membrane lipoprotein, is attenuated in vitro and in vivo, as it exhibits reduced replication within murine J774 macrophages and has a pulmonary LD50 in BALB/c and C57BL/6 mice of >105 CFU (compared to WT parental strain U112, LD50 FTN0109 also conferred complete protection in BALB/c mice against subsequent pulmonary challenge with 10 LD50 (60,000 CFU) of the murine virulent Francisella strain LvS. We also have demonstrated partial protection (50%) against the highly human virulent subspecies tularensis strain SCHU S4 (25 LD50, 12,500 CFU) following intratracheal vaccination in the Fischer 344 rat, a second rodent model for tularemia. Overall, our results suggest that FTN0109 serves as a potential putative vaccine candidate against pulmonary tularemia.

关键词： Tularemia F. tularensis vaccines Live Attenuated