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Pros and cons of live kidney donation in prediabetics: A critical review and way forward

World Journal of Transplantation 2024年第1期14卷 12-31页

作者： Muhammad Abdul Mabood Khalil nihal mohammed sadagah Jackson Tan Furrukh Omair Syed Vui Heng Chong Salem H Al-Qurashi Center of Renal Diseases and Transplantation King Fahad Armed Forces Hospital JeddahJeddah 23311Saudi Arabia Department of Nephrology RIPAS Hospital Brunei DarussalamBrunei Muara BA1710Brunei Darussalam Division of Gastroenterology and Hepatology Department of MedicineRaja Isteri Pengiran Anak Saleha HospitalBandar Seri Begawan BA1710Brunei Darussalam

There is shortage of organs,including kidneys,*** with deceased kidney transplantation,there is a significant rise in live kidney *** prevalence of prediabetes(PD),including impaired fasting glucose and impaired glucose tolerance,is on the rise across the *** teams frequently come across prediabetic kidney donors for *** are at risk of diabetes,chronic kidney disease,cardiovascular events,stroke,neuropathy,retinopathy,dementia,depression and nonalcoholic liver disease along with increased risk of all-cause ***,most of the studies done in prediabetic kidney donors are retrospective in nature and have a short follow up *** is lack of prospective long-term studies to know about the real risk of complications after ***,there are variations in recommendations from various guidelines across the globe for donations in prediabetics,leading to more confusion among *** increases the responsibility of transplant teams to take appropriate decisions in the best interest of both donors and *** review focuses on pathophysiological changes of PD in kidneys,potential complications of PD,other risk factors for development of type 2 diabetes,a review of guidelines for kidney donation,the potential role of diabetes risk score and calculator in kidney donors and the way forward for the evaluation and selection of prediabetic kidney donors.

关键词： Live kidney donation Prediabetes Impaired fasting glucose Impaired glucose tolerance Review

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Outcomes of Pregnancy with Group B Streptococcal Infections in Najran, Saudi Arabia

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Open Journal of Obstetrics and Gynecology 2023年第3期13卷 395-402页

作者： Majed Saeed Alshahrani Ali H. Alhajri Fahad Thamer Almutairi Ashwag Hassan Abdelmajed Fatima Ibrahim Abdalla Yousra Bala Babkir Abdullah Mosab Mohamedelamineltaib Ahmed Faroug Ahmed Abdelaal Mohamed Ahmed Mukhtar Mowafag Bushra Galaleldin Elsayed Marwa Mohamed Ahmed Elkhidir Babikir nihal Altayeb Abdallah Selma mohammed Abdelgadir Elhabeeb Department of Obstetrics and Gynecology College of Medicine Najran University Najran Saudi Arabia Najran Armed Forces Hospital Najran Saudi Arabia

Background: The gram-positive, beta-hemolytic, and chain-forming Group B Streptococcus (GBS), commonly known as Streptococcus agalactiae, may asymptomatically invade the human gastrointestinal and vaginal tracts. However, GBS may become very invasive and pathogenic to the mother and baby during pregnancy, having negative effects. Study Aim: This study aims to investigate the pregnancy outcomes of women who tested positive for genitourinary GBS infection during pregnancy in Najran, Saudi Arabia. Methods: Data was collected retrospectively from patient files in Armed Forces Hospital, Najran, Saudi Arabia. Data collected were entered to a Microsoft Excel sheet, then imported and analysed using the Statistical Package for Social Sciences. Results: The study included 272 women of whom 66.5% were 31 to 45 years old. Gestational diabetes was diagnosed in 8.5% of the sample, 71.7% had a normal spontaneous vaginal delivery (NSVD), 1.8% had previous abortions, and 27.2% of new-borns were admitted to the NICU after delivery. There was a significant association between NICU admissions and women employment status (p = 0.001), gravidity (p = 0.001), parity (p = 0.001), history of abortions (p = 0.001), medical conditions (p = 0.049), and mode of delivery (p = 0.049). Conclusion: According to the findings of our study, GBS infection during pregnancy is associated to more NICU admissions. NICU admissions were significantly correlated with gestational diabetes, hypertension, and hypothyroidism in mothers but not with intrapartum antibiotic use.

关键词： Pregnancy Group B Streptococcal Outcomes

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Atypical hemolytic-uremic syndrome due to complement factor Ⅰ mutation

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World Journal of Nephrology 2017年第6期6卷 243-250页

作者： Abdullah H Almalki Laila F sadagah mohammed Qureshi Hatim Maghrabi Abdulrahman Algain Ahmed Alsaeed King Abdulaziz Medical City Ministry of National GuardJeddah 21423Saudi Arabia King Saud Bin Abdulaziz University for Health Sciences Ministry of National GuardJeddah 21423Saudi Arabia

Atypical hemolytic-uremic syndrome(a HUS) is a rare disease of complement dysregulation leading to thrombotic microangiopathy(TMA). Renal involvement and progression to end-stage renal disease are common in untreated patients. We report a 52-year-old female patient who presented with severe acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia. She was managed with steroid, plasma exchange, and dialysis. Kidney biopsy shows TMA and renal cortical necrosis. Genetic analysis reveals heterozygous complement factor Ⅰ(CFI) mutation. Eculizumab was initiated after 3 mo of presentation, continued for 9 mo, and stopped because of sustained hematologic remission, steady renal function, and cost issues. Despite this, the patient continued to be in hematologic remission and showed signs of renal recovery, and peritoneal dialysis was stopped 32 mo after initiation. We report a case of a HUS due to CFI mutation, which, to the best of our knowledge, has not been reported before in Saudi Arabia. Our case illustrates the challenges related to the diagnosis and management of this condition, in which a high index of suspicion and prompt treatment are usually necessary.

关键词：尿毒症疾病治疗方法临床分析

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