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World journal of Critical Care Medicine 2022年第4期11卷 236-245页

作者： Vincent Issac Lau jeffrey A johnson Sean M Bagshaw Oleksa G Rewa john Basmaji Kimberley A Lewis M Elizabeth Wilcox Kali Barrett Francois Lamontagne Francois Lauzier Niall D Ferguson Simon j W Oczkowski Kirsten M Fiest Daniel j Niven Henry T Stelfox Waleed Alhazzani Margaret Herridge Robert Fowler Deborah j.cook Bram Rochwerg Feng Xie Department of Critical Care Medicine University of AlbertaEdmonton T6G 2B7ABCanada School of Public Health Inst Hlth EconUniversity of AlbertaEdmonton T6G 2B7ABCanada Department of Medicine Division of Critical CareWestern UniversityLondon N6A 5W9Canada Division of Critical Care McMaster UniversityHamilton L8N 4A6Canada Interdepartmental Division of Critical Care University of TorontoToronto M5T 2S8Canada Department of Medicine University SherbrookeSherbrooke J1H 5N4Canada Departments of Medicine and Anesthesiology University LavalLaval G1V 4G2Canada Department Critical Care Medicine University of TorontoToronto M5G 2C4Canada Department of Medicine McMaster ClinHamilton Gen HospMcMaster UniversityHamilton L8N 4A6Canada Department of Community Health Sciences&Institute for Public Health University of CalgaryCalgary T2N 2T9Canada Department of Critical Care Medicine University CalgaryCalgary T2N 2T9Canada Department of Community Health Sciences University of CalgaryCalgary T2N 2T9Canada Department of Medicine McMaster UniversityHamilton L8N 4A6Canada Indepartmental Division of Critical Care University Health NetworkToronto M5G 2C4Canada Departments of Medicine and Critical Care Medicine Sunnybrook Health Sciences CenterInstitute of Health Policy Management and EvaluationUniversity of TorontoToronto M4N 3M5Canada Health Research Methods Evidence and ImpactMcMaster UniversityHamilton L8N 3Z5Canada

Mortality is a well-established patient-important outcome in critical care *** contrast,morbidity is less uniformly reported(given the myriad of critical care illnesses and complications of each)but may have a common end-impact on a patient’s functional capacity and health-related quality-of-life(HRQoL).Survival with a poor quality-of-life may not be acceptable depending on individual patient values and ***,as mortality decreases within critical care,it becomes increasingly important to measure intensive care unit(ICU)survivor *** measurements with a preference-based scoring algorithm can be converted into health utilities on a scale anchored at 0(representing death)and 1(representing full health).They can be combined with survival to calculate quality-adjusted life-years(QALY),which are one of the most widely used methods of combining morbidity and mortality into a composite *** QALYs have been use for health-technology assessment decision-making,an emerging and novel role would be to inform clinical decision-making for patients,families and healthcare providers about what expected HRQoL may be during and after ICU *** care randomized control trials(RCTs)have not routinely measured or reported HRQoL(until more recently),likely due to incapacity of some patients to participate in patient-reported outcome *** differences in HRQoL measurement tools can lead to non-comparable *** this end,we propose the validation of a gold-standard HRQoL tool in critical care,specifically the *** combined health-utility and mortality(disaggregated)and QALYs(aggregated)can be reported,with disaggregation allowing for determination of which components are the main drivers of the QALY *** use of HRQoL,health-utility,and QALYs in critical care RCTs has the potential to:(1)Increase the likelihood of finding important effects if they exist;(2)improve research efficiency;and(3)help inform optimal m

关键词： Critical care health-related quality of life Quality-adjusted life-years Health-utility Mortality Morbidity Kaplan-Meier curves

Call for emergency action to limit global temperature increases,restore biodiversity and protect health

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Stroke & Vascular Neurology 2021年第3期6卷 321-323页

作者： Lukoye Atwoli Abdullah H Baqui Thomas Benfield Raffaella Bosurgi Fiona Godlee Stephen Hancocks Richard Horton Laurie Laybourn-Langton Carlos Augusto Monteiro Ian Norman Kirsten Patrick nigel Praities Marcel GM Olde Rikkert Eric j Rubin Peush Sahni Richard Smith Nicholas j Talley Sue Turale Damián Vázquez East African Medical journal NairobiKenya journal of Health Population and NutritionBaltimoreMarylandUSA Danish Medical journal CopenhagenDenmark PLOS Medicine CambridgeUK The BMj LondonUK British Dental journal LondonUK The Lancet LondonUK UK Health Alliance on Climate Change LondonUK Revista de Saúde Pública S鉶PauloBrazil International journal of Nursing Studies LondonUK CMAj OttawaOntarioCanada Pharmaceutical journal LondonUK Dutch journal of Medicine NijmegenThe Netherlands NEjM BostonMassachusettsUSA National Medical journal of India New DelhiIndia Medical journal of Australia NewcastleNew South WalesAustralia International Nursing Review GenevaSwitzerland Pan American journal of Public Health WashingtonDCUSA

Wealthy nations must do much more,much *** United Nations General Assembly in September 2021 will bring countries together at a critical time for marshalling collective action to tackle the global environmental *** will meet again at the biodiversity summit in Kunming,China,and the climate conference(Conference of the Parties(COP)26)in Glasgow,*** of these pivotal meetings,we-the editors of health journals worldwide-call for urgent action to keep average global temperature increases below 1.5℃,halt the destruction of nature and protect health.

关键词： action collective faster

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中文版Activity Learning

THE MEASUREMENT OF URANIUM ISOTOPE RATIOS BY QUADRUPOLE ICP-MS

作者： (美)Diane j. cook (美)Narayanan C. Krishnan

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THE MEASUREMENT OF URANIUM ISOTOPE RATIOS BY QUADRUPOLE ICP-...

第六届国际地质和环境材料分析大会

作者： S R N Chenery K M Breward j M cook British Geological Survey Keyworth NottinghamNG12 5GGUK British Geological Survey Keyworth NottinghamNG12 5GGUK British Geological Survey Keyworth NottinghamNG12 5GGUK

＜正＞Sources of low-level radioactivity in the environment include products from both civil and military activities, with examples ranging from nuclear power generation to munitions containing depleted uranium. In any environmental assessment of their impact, studies of the sources, pathways and sinks of contaminants are required. Because the 238U/235U ratio in nature is constant and effectively 236U does not occur naturally, uranium isotope signatures can be a very sensitive indicator of the source term and its

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导向随钻扩眼技术及其在大斜率井内的应用

国外钻井技术 2000年第3期15卷 1-8页

作者： cook,j 胡湘炯

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跨文化管理

Food consistency influencing the growth and morphology of the mandibular condyle

作者： (Holden nigel j.)霍尔顿

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Food consistency influencing the growth and morphology of th...

Primary care providers should prescribe aspirin to prevent cardiovascular disease based on benefit−risk ratio,not age

中国解剖学会2012年年会

作者： G.j.Dias R.B.cook M.Mirhosseni Department of Anatomy University of OtagoDunedinNew Zealand. School of Engineering Sciences University of SouthamptonUnited Kingdom.

＜正＞The objective of this study was to determine if variation in the shape and mineralization of the mandibular condyle are the result of natural adaptation in response to different functional loading *** female Kun...

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Family Medicine and Community Health 2021年第4期9卷 1-4页

作者： Kyungmann Kim Charles H Hennekens Lisa Martinez j Michael Gaziano Marc A Pfeffer Bianca Biglione Alexander Gitin jeanne Bell McCabe Thomas D cook David L DeMets Sarah K Wood Biostatistics and Medical Informatics University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA Medicine and Population Health and Social Medicine Florida Atlantic UniversityCharles E Schmidt College of MedicineBoca RatonFloridaUSA Medicine Harvard Medical SchoolBostonMassachusettsUSA Medicine University of Florida College of MedicineGainesvilleFloridaUSA

Recent guidelines restricted aspirin(ASA)in primary prevention of cardiovascular disease(CVD)to patients10%,benefits of ASA will generally outweigh risks of significant *** should be considered only after implementation of therapeutic lifestyle changes and other drugs of proven benefit such as statins,which are,at the very least,additive to *** perspective is that individual clinical judgements by primary care providers about prescription of ASA in primary prevention of CVD should be based on our evidence-based solution of weighing all the absolute benefits and risks rather than *** strategy would do far more good for far more patients as well as far more good than harm in both developed and developing *** new and novel strategy for primary care providers to consider in prescribing ASA in primary prevention of CVD is the same as the general approach suggested by Professor Geoffrey Rose decades ago.

关键词： prevention aspirin absolute

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胆道纤维化的发生发展与治疗

中华消化外科杂志 2024年第7期23卷 989-1000页

作者：赵进玉林延延岳平姚佳米宁宁李麻图付文康高龙 Azumi Suzuki Peng F Wong Kiyohito Tanaka Rungsun Rerknimitr Henrik H junger Tan T Cheung Emmanuel Melloul Nicolas Demartines joseph W Leung 袁金秋 Hans j Schlitt 孟文勃兰州大学第一临床医学院兰州730030 兰州大学第一医院普通外科兰州730030 浜松医学中心消化科日本浜松432-8002 詹姆斯库克大学医院血管外科英国米德尔斯堡TS43BW 京都第二红十字医院消化科日本京都602-8031 朱拉隆功国王纪念医院胃肠内镜卓越中心泰国曼谷10330 雷根斯堡大学医学中心外科德国雷根斯堡93053 香港大学外科学系中国香港999077 洛桑大学医院内脏外科瑞士洛桑CH-1015 加州大学戴维斯分校医学中心和萨克拉门托退伍军人医学中心胃肠肝病科美国萨克拉门托95817 中山大学附属第七医院临床研究中心深圳518107

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生... 详细信息

胆道纤维化(BF)是病理性胆道损伤修复的结果,主要表现为胆管壁的增厚硬化和管腔的进行性狭窄,最终可能导致胆道梗阻、胆汁性肝硬化、肝衰竭、肝胆恶性肿瘤等严重不良结局。目前的研究将BF描述为某些胆管病的病理特征,对其病因、病理生理、分子机制和治疗缺乏系统总结。BF是胆道系统普遍存在但容易被忽略的疾病状态,可能通过病理性胆道损伤后的异常修复机制促进肝胆疾病的发生和进展,笔者结合国内外最新研究进展,综述BF的概念、临床表现、病因、发病机制和治疗策略,为临床医师提供参考。

关键词：胆道疾病纤维化胆管反应病因信号通路治疗