检索结果-南通市图书馆

Persistent inflammation and neuronal loss in the mouse brain induced by a modified form of attenuated herpes simplex virus type I

引用

Virologica Sinica 2023年第1期38卷 108-118页

作者： Erlin wang Xinwei Huang Yunshuang Ye Shiqing Zou Guijun Chen Liping Yang nigel w.fraser Fukai Bao Jumin Zhou Xia Cao Key Laboratory of Second Affiliated Hospital of Kunming Medical University Kunming650000China Key Laboratory of Animal Models and Human Disease Mechanism of the Chinese Academy of Science/Key Laboratory of Healthy Aging Research of Yunnan Province Kunming Institute of ZoologyThe Chinese Academy of SciencesKunming650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming650204China Department of Microbiology Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19104USA Department of Biology and Immunology Kunming Medical UniversityKunming650101China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming650223China

Herpes simplex virus-1(HSV-1)is a widespread neurotropic virus that can reach the brain and cause a rare but acute herpes simplex encephalitis(HSE)with a high mortality *** patients present with changes in neurological and behavioral status,and survivors suffer long-term neurological *** date,the pathogenesis leading to brain damage is still not well ***-1 induced encephalitis in the central nervous system(CNS)in animals are usually very diffuse and progressing rapidly,and mostly fatal,making the analysis ***,we established a mouse model of HSE via intracerebral inoculation of modified version of neuralattenuated strains of HSV-1(deletion of ICP34.5 and inserting a strong promoter into the latency-associated transcript region),in which the LMR-αΔpA strain initiated moderate productive infection,leading to strong host immune and inflammatory response characterized by persistent microglia *** viral replication activity and prolonged inflammatory response activated signaling pathways in neuronal damage,amyloidosis,Alzheimer's disease,and neurodegeneration,eventually leading to neuronal loss and behavioral changes characterized by *** study reveals detailed pathogenic processes and persistent inflammatory responses in the CNS and provides a controlled,mild and non-lethal HSE model for studying long-term neuronal injury and increased risk of neurodegenerative diseases due to HSV-1 infection.

关键词： Herpes simplex virus-1(HSV-1) Herpes simplex encephalitis(HSE) ICP34.5 Neuroinflammation Neuronal loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：