检索结果-南通市图书馆

Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of cisplatin-induced toxicity in cynomolgus macaq...

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI Lew KINTER nigel BARRASS Global Safety Assessment Centre for Drug Safety Evaduation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans. Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1/sex/group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg~(-1)) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3/sex/group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg~(-1)) and then they were terminated for necropsy on days 2,5,10 or 21,respectively, *** following endpoints were assessed in both studies:clinical observations,body weight,food consumption, haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration/toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1:A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity, reduced food consumption and minor body weight loss at the highest dose(5 mg·kg~(-1)).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the urine. The high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg~(-1) and there were progressive renal histopathological *** to cisplatin〔C_(max) and AUC_((0-24))〕increased slightly more than in proportion to the dose of cisplatin across the dose *** #2:One male dosed at 2.5 mg·kg~(-1) cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderatel

关键词：

Evaluation of paracetamol toxicity in the cynomolgus monkey

在线全文

cnki会议

学校读者我要写书评

暂无评论

Evaluation of paracetamol toxicity in the cynomolgus monkey

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： YU Hong nigel BARRASS Sonya GALES Eva LENZ Dan WESTON lan WILSONB Tony PARRY Helen POWELL Dale THURMAN QIAO Jun-wen QIN Qiu-ping REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica Global Safety Assessment AstraZeneca R&D Boston

Paracetamol(acetominophen,APAP) was administered orally in a rising dose protocol to 2 male and 2 female Cynomolgus monkeys to determine the Maximum Tolerated dose(MTD) for subsequent toxicology *** the subsequent repeat dose study involving 6 monkeys,no dose-limiting toxicity was seen at up to 900 mg·kg·d APAP for 14 *** analysis showed that plasma exposure rose,albeit less than proportionally,with increasing *** were some fluctuations in clinical chemistry and haematology parameters,but these were not dose-related, and there were no compound-related findings observed *** monkeys at 900 mg·kg·d had a 5 cm, gas filled segment in their large intestine that was considered *** profiling of the urine showed parent and glucuronidated APAP,but the cysteinyl conjugate which would be anticipated if the monkey has similar metabolism to rats and man was notably *** opens the possibility that metabolism in the cynomolgus monkey differs from that in the other species,and shows that the cynomolgus monkey is a poor model for investigating paracetamol-mediated toxicity in humans.

关键词： acetominophen toxicity

带开洞的部分灌芯混凝土空心砌块砌体在拟静力往复荷载作用下的力学行为研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

建筑砌块与砌块建筑 2017年第3期 11-17页

作者： Fortes Ernesto S. Parsekian Guilherme A. Fonseca Fernando S. Shrive nigel G. 杨旭巴西圣卡格斯联邦大学土木工程系美国杨白翰大学加拿大卡尔加里大学哈尔滨工业大学

在墙体上开洞,会改变墙体结构的力学性能,使得对其进行研究与设计时更加复杂。墙体的承载力和刚度,会受到墙体上开洞、以及附近有关构件的影响。曾经有研究人员对混凝土砌体剪力墙上开洞,对墙体性能产生的影响进行过一些研究,但大多数... 详细信息

在墙体上开洞,会改变墙体结构的力学性能,使得对其进行研究与设计时更加复杂。墙体的承载力和刚度,会受到墙体上开洞、以及附近有关构件的影响。曾经有研究人员对混凝土砌体剪力墙上开洞,对墙体性能产生的影响进行过一些研究,但大多数试验对象都只有一层。本文使用混凝土空心砌块砌筑了六片三层高、分别带有门洞口和窗洞口的1/2比例缩小墙体试件模型,以此为研究对象,探讨开洞对墙体性能产生的影响,并介绍所取得的初步研究成果。本文所述试验的主要目的:研究在循环荷载作用下,在部分灌芯配筋砌块砌体墙上开洞,对墙体性能所产生的影响。共在试验室制作了六片墙体试件,其中三片为带门洞口的墙片,另三片为带窗洞口的墙片。试验中发现:这些墙体试件的承载能力逐渐下降,最后会发生受剪破坏。本文认为,使得试件能够呈现类似框架结构的力学行为,得益于在墙体试件顶部所设置的砌块系梁构造。试验过程中出现砂浆水平裂缝、对角型破坏,均表明试件是受剪破坏。

关键词：混凝土砌块砌体承重墙循环荷载混凝土框架系梁砌块多层模型

Evaluation of paracetamol toxicity in the cynomolgus monkey

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of paracetamol toxicity in the cynomolgus monkey

Paracetamol(acetaminophen,APAP) was administered orally in a rising dose protocol to 2 male and 2 female Cynomolgus monkeys to determine the Maximum Tolerated dose(MTD) for subsequent toxicology *** the subsequent repeat dose study involving 6 monkeys,no dose-limiting toxicity was seen at up to 900 mg·kg~(-1)·d~(-1) APAP for 14 *** analysis showed that plasma exposure rose,albeit less than proportionally,with increasing *** were some fluctuations in clinical chemistry and haematology parameters,but these were not dose-related, and there were no compound-related findings observed *** monkeys at 900 mg·kg~(-1)·d~(-1) had a 5 cm, gas filled segment in their large intestine that was considered *** profiling of the urine showed parent and glucuronidated APAP,but the cysteinyl conjugate which would be anticipated if the monkey has similar metabolism to rats and man was notably *** opens the possibility that metabolism in the cynomolgus monkey differs from that in the other species,and shows that the cynomolgus monkey is a poor model for investigating paracetamol-mediated toxicity in humans.

关键词：

睡前折腾到很晚（上）——《宝贝家规》节选连载

在线全文

cnki会议

学校读者我要写书评

暂无评论

母婴世界 2013年第7期 120-123页

作者：奈杰尔·拉塔(nigel Latta)

案例分享不折腾到很晚，她不罢休今年4岁的珊是一个讨厌床和睡觉,喜欢蔓越莓果汁和汤匙的小女孩。在外人看来．她活泼可爱；但对于父母而言，她整天蹦蹦跳跳和迷恋汤匙问题．令人头疼。

关键词：连载节选家规宝贝不折腾睡觉女孩

Evaluation of cisplatin-induced toxicity in cynomolgus macaques including assessment of potential biomarkers of renal toxicity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of cisplatin-induced toxicity in cynomolgus macaq...

2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

作者： YU Hong Sonya GALES ZHENG Wei-jun QIN Qiu-ping Dale THURMAN QIAO Jun-wen REN Jin CHEN Ya-fei Russell BIALECKI Lew KINTER nigel BARRASS Centre for Drug Safety Evaduation and Research Shanghai Institute of Materia Medica

OBJECTIVE Cisplatin-induced nephrotoxicity has been characterized previously in animals and humans. Two studies were conducted in cynomolgus macaques to assess the nephrotoxicity of cisplatin and to correlate the pathogenesis of lesions in the kidneys with expression of a panel of potential urinary biomarkers of kidney *** In study #1,6 monkeys(1/sex/group) were given a single *** of cisplatin(1.25,2.5 and 5 mg·kg) and were terminated for necropsy on day 7 *** Study #2,36 monkeys(3/sex/group) were given a single iv infusion of vehicle or cisplatin(2.5 mg·kg) and then they were terminated for necropsy on days 2,5,10 or 21,respectively, post - *** following endpoints were assessed in both studies:clinical observations,body weight,food consumption, haematology,coagulation,blood chemistry,urine analysis,cisplatin concentration/toxicokinetics(TK) and gross and microscopic *** of biomarkers for drug-induced kidney injury(DIKI) was confined to Study #*** Study #1:A single intravenous administration of cisplatin induced occasional vomiting,decreased motor activity, reduced food consumption and minor body weight loss at the highest dose(5 mg·kg).Urea and creatinine were markedly increased,plasma electrolytes showed dose-related alterations and blood and proteins were found in the urine. The high dose animals had reduced urine *** weights were increased following 2.5 and 5 mg·kg and there were progressive renal histopathological *** to cisplatin[C and AUC(04))]increased slightly more than in proportion to the dose of cisplatin across the dose *** #2:One male dosed at 2.5 mg·kg cisplatin was prematurely terminated on day *** other animals survived to their scheduled *** evaluation demonstrated that kidney lesions progressed with *** chemistry results indicated that 7 out of 24 animals treated with cisplatin had moderately to markedly increased urea and

关键词： cisplatin renal toxicity biomarkers

护理--未来的潮流 nigel Crisp指出未来护士承担更多责任,医学将更加坚实

在线全文

cnki会议

学校读者我要写书评

暂无评论

英国医学杂志中文版 2022年第3期25卷 175-176页

作者： nigel Crisp 邹镒严(译) 郭娜(校) All Party Parliamentary Group on Global Health 中国医学科学院北京协和医院

现在护士已经比医生更被公众信任。未来会如何呢?最近一项议会党团的报告描述了通过发展全球护理,不仅可以促进健康,还能够更接近联合国另外两个可持续发展目标:促进性别平等和经济发展。

关键词：可持续发展目标促进健康公众信任护士护理性别平等联合国

攀枝花层状侵入体中矿物微量元素和纳米结构对多阶段成岩成矿的指示

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

攀枝花层状侵入体中矿物微量元素和纳米结构对多阶段成岩成矿的指...

第九届全国成矿理论与找矿方法学术讨论会

作者：高文元黄菲 Cristiana L.Ciobanu nigel J.Cook 东北大学资源与土木工程学院深部金属矿山安全开采教育部重点实验室 School of Chemical Engineering and Advanced Materials The University of Adelaide

峨眉山大火成岩省中部的二叠纪镁铁–超镁铁质层状侵入体中赋存了攀枝花式钒钛磁铁矿,是研究岩浆演化过程的重要窗口,也是揭示岩浆分异过程中Fe–Ti–V元素富集过程的重要研究对象。该地区是中国乃至世界钒钛磁铁矿资源最富集的地区之一...

峨眉山大火成岩省中部的二叠纪镁铁–超镁铁质层状侵入体中赋存了攀枝花式钒钛磁铁矿,是研究岩浆演化过程的重要窗口,也是揭示岩浆分异过程中Fe–Ti–V元素富集过程的重要研究对象。该地区是中国乃至世界钒钛磁铁矿资源最富集的地区之一,同时还伴生钴、铬、镍、镓、钪等10多种稀有贵重矿产资源,综合利用价值极高。在攀枝花层状侵入体的兰家火山矿段采集了一套代表其下部含矿岩体的地质样品。通过电子探针原位获得矿物的微区主量元素成分特征,并运用激光剥蚀等离子体质谱仪原位获得矿物微区微量元素成分特征。

关键词：

在线全文

cnki会议

学校读者我要写书评

暂无评论

制定管理决策教程第2版