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Drug therapy for heart failure in older patients —what do they want？

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Journal of Geriatric Cardiology 2015年第2期12卷 165-173页

作者： Donah Zachariah Jacqueline Taylor nigel rowell Clare Spooner Paul R Kalra Portsmouth Hospitals NHS Trust Portsmouth P06 3L Y UK Glasgow Royal Infirmary Glasgow G40SF UK South Tees Hospitals NHS Foundation Trust TS4 3BW UK Servier Laboratories Ltd SL3 6P J UK

长期的心失败(CHF ) 主要在更老的病人被看见，因此真实的生活药经常从在年轻得多的人口进行的试用要求调查结果的推测。规定模式和潜力受益在老被 polypharmacy 和 co 疾病的病理重重地影响。增加的长寿可以变得不太相关在脆弱老，而... 详细信息

长期的心失败(CHF ) 主要在更老的病人被看见，因此真实的生活药经常从在年轻得多的人口进行的试用要求调查结果的推测。规定模式和潜力受益在老被 polypharmacy 和 co 疾病的病理重重地影响。增加的长寿可以变得不太相关在脆弱老，而改善，生活(QoL ) 的质量经常成为优先级；在改进幸福上的义务，维持独立为更长，并且推迟 institutionalisation。与 CHF 评估老病人的特定的研究正在缺乏，很少关于 tolerability 和证据的副作用侧面被知道在这张人口的基于的药治疗。在有征兆的 CHF 的病人的心率的影响上有最近的兴趣。与降低能力的选择心率， Ivabradine 在湾穴节奏具有在有 CHF 和左室的收缩机能障碍的病人的利益，导致心失败 hospitalisation 和心血管的死亡的减小。这张手稿将集中于 CHF 和更老的病人并且将讨论心率，药治疗和 tolerability 的影响。它将也为集中于描述很治疗学的审判的集中病人的学习结束点而非死亡目标的特定的研究加亮未满足的需要。在介绍一个唯一的机会评估 tolerability 并且确定的治疗影响大量真实生活的 QoL 上评估 ivabradine 的影响的进行中的研究，有 CHF 的更老的病人将被讨论。

关键词：中老年人药物治疗心力衰竭患者心脏生活质量治疗试验 CHF

Ivabradine tolerability in heart failure

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Journal of Geriatric Cardiology 2018年第11期15卷 708-709页

作者： Sarah Birkhoelzer Daniel Stevens Donah Zachariah Jackie Taylor nigel rowell Paul R Kalra Portsmouth Hospitals NHS Trust UK Medical Affairs Department Servier Laboratories UK Glasgow Royal Infirmary UK South Tees Hospitals NHS Foundation Trust UK

The Systolic Heart failure treatment with the I( inhibitor ivabradine Trial (SHIFT, n = 6505) evaluated patients with symptomatic chronic heart failure (CHF), in sinus rhythm with resting heart rate ≥70 beats/min and... 详细信息

关键词： Heart failure Ivabradine Quality of life The elderly

Etiology and management of urethral calculi:A systematic review of contemporary series

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Asian Journal of Urology 2024年第1期11卷 10-18页

作者： Andrew Morton Arsalan Tariq nigel Dunglison Rachel Esler Matthew J.Roberts Faculty of Medicine The University of QueenslandBrisbaneQueenslandAustralia Department of Urology Ipswich HospitalQueenslandAustralia Department of Urology Royal Brisbane and Women's HospitalQueenslandAustralia The University of Queensland Centre for Clinical Research HerstonAustralia

Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management ***:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was ***,including case reports and case series on urethral calculi published between January 2000 and December 2019,were ***-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and *** were collated and analyzed with univariate ***:Seventy-four publications met inclusion criteria,reporting on 95 *** symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting *** calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment *** in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology.

关键词： Urinary calculi Urethra Urethral calculi Management algorithm

The variation of DOM during long distance water transport by the China South to North Water Diversion Scheme and impact on drinking water treatment

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 85-100页

作者： Hankun Yang Yujuan Li Hongyu Liu nigel J.D.Graham Xue Wu Jiawei Hou Mengjie Liu Wenyu Wang Wenzheng Yu State Key Laboratory of Environmental Aquatic Chemistry Key Laboratory of Drinking Water Science and TechnologyResearch Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China School of Environment and Municipal Engineering Qingdao Technological UniversityQingdao266033China Colleges of Forestry Northeast Forestry UniversityHarbin150006China Department of Civil and Environmental Engineering Imperial College LondonSouth Kensington CampusLondonSW7 2AZUK School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing100081China State Key Laboratory of Separation Membrane Processes School of Environment Science and EngineeringTiangong UniversityTianjin300387China

In this study,samples were taken from three locations,upstream to downstream,along the central route project of the China South to North Water Diversion(SNWD)scheme in summer and *** were used to reveal the variations of dissolved organic matter(DOM)during the water transfer process,and the effects of these variations on drinking water treatment and disinfection by-products formation potential(DBPs-FP).The results showed that polysaccharides accumulate in summer and reduce in winter with flow distance,which has an important effect on the overall properties of DOM,as well as on the performance of coagulation,ultrafiltration,and the formation of *** substances,and their hydrophilic content,also increased in summer and decreased in winter with flow *** contrast,the concentration of small organic substances(MW≤1000 Da)increased in both summer and winter with flow distance,which affected both nanofiltration(NF)membrane fouling and *** results provide a useful case study of spatial and temporal changes in raw water DOM during long distance water transfer and their impact on the treatment and quality of drinking water from the SNWD.

关键词： Long-distance water transfer The China South to North Water Diversion Scheme Coagulation Membrane filtration Disinfection by-products

From source to emplacement:The origin of leucogranites from the Sikkim-Darjeeling Himalayas,India

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Geoscience Frontiers 2024年第1期15卷 384-401页

作者： Tanya Srivastava nigel Harris Catherine Mottram Kumar Batuk Joshi Nishchal Wanjari Department of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK National Centre for Earth Science Studies ThiruvananthapuramKeralaIndia

Himalayan leucogranites are important for understanding the tectonic evolution of collision zones in general and the causes of crustal melting in the Himalayan orogen in *** paper aims to understand the melt source and emplacement age of the leucogranites from Sikkim in order to decipher the deep geodynamic processes of the eastern *** U-Pb analysis of the Higher Himalayan Sequence(HHS)metamorphic core reveals a prolonged period of crustal melting between>33 Ma and ca.14 *** and trace element abundances are presented for 27 leucogranites from North Sikkim that are classified into two-mica and tourmaline leucogranite *** are peraluminous in composition,characterized by high SiO2(70.91-74.9 wt.%),Al2O3(13.69-15.82 wt.%),and low MgO(0.13-0.74 wt.%).Elemental abundances suggest that Sikkim Himalayan leucogranites are derived from crustal *** two-mica leucogranites are derived from a metagreywacke source,whereas the tourmaline leucogranites are sourced from metapelitic sources,with inherited zircons indicating an HHS origin for both types.U-Pb zircon geochronology of the two mica leucogranites indicates ages of ca.19-15 Ma,consistent with crustal melting recorded in HHS gneisses from *** from both the two-mica and tourmaline leucogranites yield a crystallization age of ca.15-14 Ma,coeval with movement on the Main Central Thrust and South Tibetan Detachment System which further provides constraints on the timing and mechanism of petrogenesis of leucogranites in the Sikkim Himalayas.

关键词： Leucogranites Gneiss U-Pb geochronology Zircon Monazite Sikkim-Darjeeling Himalayas

Enhancing the clinical relevance of haemorrhage prediction models in trauma

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Military Medical Research 2024年第3期11卷 467-468页

作者： Sankalp Tandle Jared M.Wohlgemut Max E.R.Marsden Erhan Pisirir Evangelia Kyrimi Rebecca S.Stoner William Marsh Zane B.Perkins nigel R.M.Tai Centre for Trauma Sciences Blizard InstituteQueen Mary University of LondonLondon E12ATUK The Royal London Hospital Barts Health NHS TrustLondon E11FRUK Academic Department of Military Surgery and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK Department of Electronic Engineering and Computer Science Queen Mary University of LondonLondon E14NSUK

We read with interest the recent systematic reviewaArtificial intelligence and machine learning for hemorrhagic trauma careoby Peng et al.[1],which evaluated literature on machine learning(ML)in the management of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive transfusion Prediction Artificial intelligence Machine learning

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拉纳酒店及拉纳住宅公寓

世界建筑导报 2024年第3期39卷 123-126页

作者： nigel Young(摄) AHMED ALNAJI(摄) Cai Yunpu(摄) 福斯特建筑事务所

位于迪拜市中心和迪拜设计区(Dubai Design District)之间的马拉西码头(Marasi Marina)边缘的新滨海区域将成为这座城市的主要奢华生活方式目的地。新开发项目坐落在一条12公里长的海滨长廊的中心,长廊内设有浮动别墅和宽敞的游艇泊位... 详细信息

位于迪拜市中心和迪拜设计区(Dubai Design District)之间的马拉西码头(Marasi Marina)边缘的新滨海区域将成为这座城市的主要奢华生活方式目的地。新开发项目坐落在一条12公里长的海滨长廊的中心,长廊内设有浮动别墅和宽敞的游艇泊位。横穿开发项目的七个垂直花园是设计的环境和社会焦点。每个花园都创造了一种新的生活方式体验,丰富了客人和居民的生活。整座建筑被抬离地面,在码头和通往建筑的道路之间建立了视觉联系,同时在场地中间创造了一个景观公共空间。新长廊两侧林立着商店、餐馆和咖啡馆,被称为海滨花园,为海滨边缘增添了活力。

关键词：公共空间垂直花园住宅公寓咖啡馆滨海区域奢华生活拉纳酒店

Unraveling Membrane Fouling Induced by Chlorinated Water Versus Surface Water:Biofouling Properties and Microbiological Investigation

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Engineering 2022年第8期8卷 154-164页

作者： Li Zhang Lei Xu nigel Graham Wenzheng Yu State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Department of Civil and Environmental Engineering Imperial College LondonSouth Kensington CampusLondon SW72AZUK

Chlorine is usually applied in the urban water treatment process to deactivate pathogens and prevent waterborne *** a pre-treatment,it remains unclear whether chlorinated water can effectively alleviate membrane fouling during ultrafiltration(UF).In this study,tap water was investigated for its effect on biofilm formation and biofouling in a gravity-driven membrane(GDM)filtration *** comparison,biofilm/biofouling with untreated surface(lake)water was studied in *** was found that more severe membrane fouling occurred with the filtration of tap water than lake water,and larger quantities of polysaccharide and extracellular DNA(eDNA)were present in the tap-water biofilm than in the lake-water *** tap-water biofilm had a densely compact *** contrast,a porous,spider-like structure was observed for the lake-water biofilm,which was assumed to be associated with the bacteria in the *** hypothesis was verified by 16S ribosomal RNA(rRNA)sequencing,which demonstrated that Xanthobacter was the dominant taxon in the tap-water ***,membrane hydrophobicity/hydrophilicity played a minor role in affecting the membrane fouling properties and microbial *** study revealed the significant role of chlorine-resistant bacteria in biofouling formation and provides a deeper understanding of membrane fouling,which can potentially aid in searching for effective ways of controlling membrane fouling.

关键词： Membrane fouling Biofilm GDM filtration technology Ultrafiltration Chlorine-resistant bacteria Hydrophilicity

Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer’s disease

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Neural Regeneration Research 2023年第10期18卷 2127-2133页

作者： Aziz Unnisa nigel H.Greig Mohammad Amjad Kamal Department of Pharmaceutical Chemistry College of PharmacyUniversity of HailHailSaudi Arabia Drug Design&Development Section Translational Gerontology BranchIntramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMDUSA Institutes for Systems Genetics Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan ProvinceChina King Fahd Medical Research Center King Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhakaBangladesh Enzymoics Novel Global Community Educational FoundationHebershamNSWAustralia

Toxic aggregated amyloid-βaccumulation is a key pathogenic event in Alzheimer’s *** approaches have focused on the suppression,deferral,or dispersion of amyloid-βfibers and *** therapy has evolved as a potential therapeutic option for treating Alzheimer’s disease,owing to its rapid advancement over the recent *** interfering ribonucleic acid has recently garnered considerable attention in gene therapy owing to its ability to down-regulate genes with high sequence specificity and an almost limitless number of therapeutic targets,including those that were once considered ***,lackluster cellular uptake and the destabilization of small interfering ribonucleic acid in its biological environment restrict its therapeutic application,necessitating the development of a vector that can safeguard the genetic material from early destruction within the bloodstream while effectively delivering therapeutic genes across the bloodbrain *** has emerged as a possible solution,and several delivery systems utilizing nanoparticles have been shown to bypass key challenges regarding small interfering ribonucleic acid *** reducing the enzymatic breakdown of genetic components,nanomaterials as gene carriers have considerably enhanced the efficiency of gene ***,polymeric nanoparticles,magnetic nanoparticles,dendrimers,and micelles are examples of nanocarriers that have been designed,and each has its own set of ***,recent advances in the specific delivery of neurotrophic compounds via gene therapy have provided promising results in relation to augmenting cognitive *** this paper,we highlight the use of different nanocarriers in targeted gene delivery and small interfering ribonucleic acid-mediated gene silencing as a potential platform for treating Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β BACE1 gene silencing gene therapy nanoparticle neurotrophins small interfering ribonucleic acid