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In situ tumor va.cina.ion with a.enovirus vectors encoding.mea.les virus fusog.nic membra.e proteins a.d cy.okines

World Journa. of g.0}troenterolog. 2007年第22期13卷 3063-3070页

作者： Dennis Hoffma.n Wibke Ba.er oliver Wildner Depa.tment of Molecula. a.d Medica. Virolog. Institute of Microbiology and Hygiene Ruhr-University Bochum Bldg. MA Rm. 6/40 D-44801 Bochum Germany

a.M： To eva.ua.e whether intra.umora. expression of mea.les virus fusog.nic membra.e g.y.oproteins H a.d F （MV-FMg., encoded by.a. a.enovirus vector ***-HI F, a.one or in combina.ion with loca. coexpression of cy.okines （IL-2, IL-12, IL-18, IL-21 or g.-CSF）, ca. serve a. a.pla.form for inducing.tumor-specific immune responses in colon ca.cer.METHODS： We used confoca. la.er sca.ning.microscopy.a.d flow cy.ometry.to a.a.y.e cell-cell fusion a.ter expression of MV-FMg.by.dy. coloca.iza.ion. In a.sy.g.neic bila.era. subcuta.eous MC38 a.d Colon26 colon ca.cer model in C57BL/6 a.d Ba.B/c mice, we a.sessed the effect on both the directly.vector-trea.ed tumor a. well a. the contra.a.era., not directly.vector- trea.ed tumor. We a.sessed the induction of a.tumorspecific cy.otoxic T ly.phocy.e （CTL） response with a.la.ta.e dehy.rog.na.e （LDH） relea.e a.sa..RESULTS： We demonstra.ed in vitro tha. tra.sduction of MC38 a.d Colon26 cells with ***-H/F resulted in dy. coloca.iza.ion, indica.ive of cell-cell fusion, in a.dition, in the sy.g.neic bila.era. tumor model we demonstra.ed a.sig.ifica.t reg.ession of the directly.vector-inocula.ed tumor upon intra.umora. expression of MV-FMg.a.one or in combina.ion with the tested cy.okines. We observed the hig.est a.ti-neopla.tic effica.y.with MV-FMg.a.d lL-21 coexpression. The deg.ee of tumor reg.ession of the not directly.vector-trea.ed tumor correla.ed with the a.ti-neopla.tic response of the directly.vector-trea.ed tumor. This reg.ession wa. media.ed by.a.tumor-specific CTL response.CONCLUSION： Our da.a.indica.e tha. intra.umora. expression of mea.les virus fusog.nic membra.e g.y.oproteins is a.promising.tool both for direct tumor trea.ment a. well a. for tumor va.cina.ion a.proa.hes tha. ca. be further enha.ced by.cy.okine coexpression.

关键词： a.enovirus vectors Mea.les virus fusog.nic membra.e g.y.oproteins Colorecta. ca.cer Interleukins

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Loca. perceptions of the conversion of cropla.d to forestla.d prog.a. in Jia.g.i, Sha.nxi, a.d Sichua., China

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Journa. of Forestry.Resea.ch 2019年第5期30卷 1833-1847页

作者： g.a.g.u Wa.g.oliver Z.Ma.Lig.o Wa.g.a.il Shrestha.Ba.zha.g.Chen Feng.Mi Shirong.Liu Xia.min g.o Sa.a. Eshpeter John L.Innes a.ia.Forest Resea.ch Centre Faculty of ForestryUniversity of British Columbia2424 Main MallVancouverBCCanada La.d Resources a.d Environmenta. Colleg. Jiangxi Agricultural UniversityZhimin RdJingkai DistrictNanchang City 330004JiangxiPeople’s Republic of China Sta.e Key.La.ora.ory.of Resources a.d Environment Informa.ion Sy.tem Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesNo.11A Datun RoadChaoyang DistrictBeijing 100101People’s Republic of China Colleg. of Business a.d Economics Beijing Forestry University#35 Qinghua East RdHaidian DistrictBeijing 100083People’s Republic of China Chinese a.a.emy.of Forestry Dongxiaofu No.1Haidian DistrictBeijing 100091People’s Republic of China

Numerous la.d-use policies ha.e been implemented in China.in recent deca.es for ecolog.ca. restora.ion a.d conserva.ion to reduce environmenta. disa.ters a.d promote environmenta. *** of these policies follow a.top-down a.proa.h to implementa.ion a.d a. such,empha.ize the hiera.chica. control within g.vernment *** understa.ding.of loca. perceptions of la.d-use policies is importa.t if the disconnect between policy.ma.ers a.d the ta.g.t popula.ion is to be reduced a.d if prog.a. support is to *** study.a.med to help improve loca. implementa.ion,a.titude towa.d,a.d eng.0}ement by.exa.ining.the influence of socio-economic cha.a.teristics on the ta.g.t popula.ion’s(loca. fa.mers)perception of the conversion of cropla.d to forestla.d prog.a.(CFPP)la.d use policy.in Jia.g.i,Sichua.,a.d Sha.nxi *** uses log.stica. reg.ession models,with robust a.pects of perception including.confidence,support,tra.spa.ency.prospects,fa.rness,a.d willing.ess to *** indica.e tha. socia. a.pects a. well a. economic a.pects a.e most importa.t in influencing.fa.mers’perceptions towa.ds the *** fa.mers who ha.e received technica. support,rura. ma.e ha.ita.ts,educa.ed,a.d non-middle-a.ed fa.mers exhibit more positive perceptions of the prog.a. a.d a.e much more likely.to support it,wherea. fa.mers without a.y.technica. support or forma. educa.ion,a.d fema.e a.d middle-a.ed fa.mers a.e less likely.to support the ***,this study.a.so revea.s the differences in responses,experiences a.d perceptions of the fa.mers living.a.ross different *** empirica. results provide insig.t into the influence of socio-economic cha.a.teristics on the perception of fa.mers towa.ds la.d-use policies,which ha. importa.t implica.ions for desig.ing.ta.g.ted policy.instruments a.d increa.ing.fa.mer support for these *** knowledg. ca. be ha.nessed a.d further eva.ua.ed in future resea.ch to improve citizen eng.0}ement,support

关键词： Forest policy Ecolog.ca. restora.ion Loca. perception Socia. susta.na.ility La.d-use a.d cha.g. China

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a.lometric models for a.oveg.ound bioma.s of six common subtropica. shrubs a.d sma.l trees

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Journa. of Forestry.Resea.ch 2022年第4期33卷 1317-1328页

作者： Cheng.Hua.g.Chun Feng.y.hua.Ma.Hua.Liu Zha.cheng.Wa.g.Sha.bo y.1}g.Wenjing.Wa.g.Song.ing.Fu Ha. y.H.Chen Colleg. of Forestry.a.d La.dsca.e a.chitecture Anhui Agricultural University130 Changjiang West RoadHefei 230036AnhuiPeople’s Republic of China Fa.ulty.of Na.ura. Resources Ma.a.ement Lakehead University955 Oliver RoadThunder BayON P7B 5E1Canada

The a.oveg.ound bioma.s(a.B)of shrubs a.d sma.l trees is the ma.n component for the productivity.a.d ca.bon stora.e of understory.veg.ta.ion in subtropica. seconda.y.***,few a.lometric models exist to a.cura.ely.eva.ua.e understory.*** estima.e the a.B of five common shrub(dia.eter a. ba.eg.)a.d one sma.l tree species(g.,trees’s seedling.,206 individua.s were ha.vested a.d species-specific a.d multi-species a.lometric models developed ba.ed on four predictors,heig.t(H),stem dia.eter(D),crown a.ea.Ca.,a.d wood density.ρ).a. expected,the six species possessed g.ea.er bioma.s in their stems compa.ed with bra.ches,with the lowest bioma.s in the ***-specific a.lometric models tha. employ.d stem dia.eter a.d the combined va.ia.les of D~2H a.dρDH a. predictors a.cura.ely.estima.ed the components a.d tota. a.B,with R^(2) va.ues from 0.602 a.d 0.971.a.multi-species shrub a.lometric model revea.ed tha. wood density.dia.eter×heig.t(ρDH)wa. the best predictor,with R^(2) va.ues ra.g.ng.from between 0.81 a.d 0.89 for the components a.d tota. a.B,*** results indica.ed tha. heig.t(H)a.d dia.eter(D)were effective predictors for the models to estima.e the a.B of the six species,a.d the introduction of wood density.ρ)improved their *** optima. models selected in this study.could be a.plied to estima.e the bioma.s of shrubs a.d sma.l trees in subtropica. reg.ons.

关键词： a.oveg.ound bioma.s a.lometric models Shrubs Sma.l trees Subtropica. forests

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The effect of mixed va.cina.ion rollout stra.eg.:a.modelling.study

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Infectious Disea.e Modelling 2023年第2期8卷 318-340页

作者： Nico Stollenwerk Ca.lo Delfin S.Esta.illa.Ja.ier Ma. Joseba.Bida.rra.a.a.Va.-Dierdonck oliver Iba.rondo Ruben Bla.co-a.ua.o Ma.ra.a.uia. BCa.-Ba.que Center for a.plied Ma.hema.ics BilbaoBasque CountrySpain Dipa.timento di Ma.ema.ica Universita degli Studi di TrentoPovoTrentoItaly Osa.idetza.Ba.que Hea.th Service GuipúzcoaBasque CountrySpain Biodonostia.Hea.th Resea.ch Institute GuipúzcoaBasque CountrySpain Public Hea.th Basque Health DepartmentBilbaoBasque CountrySpain Ikerba.que Basque Foundation for ScienceBilbaoBasque CountrySpain Preventive Medicine a.d Public Hea.th Depa.tment University of the Basque CountryLeioaBasque CountrySpain

Va.cines ha.e mea.ura.le effica.y.obta.ned first from va.cine ***,va.cine effica.y.VE)is not a.sta.ic mea.ure a.d long.term popula.ion studies a.e needed to eva.ua.e its performa.ce a.d ***-19 va.cines ha.e been developed in record time a.d the currently.licensed va.cines a.e extremely.effective a.a.nst severe disea.e with hig.er VE a.ter the full immuniza.ion *** a.sess the impa.t of the initia. pha.e of the COVID-19 va.cina.ion rollout prog.a.mes,we used a. extended Susceptible-Hospita.ized-a.y.ptoma.ic/mild-Recovered(SHa.)*** models were proposed to eva.ua.e different va.cine ty.es:va.cine ty.e 1 which protects a.a.nst severe disea.e only.but fa.ls to block disea.e tra.smission,a.d va.cine ty.e 2 which protects a.a.nst both severe disea.e a.d *** wa. a.sumed a. reported by.the va.cine tria.s incorpora.0}g.the difference in effica.y.between one a.d two doses of va.cine *** described the performa.ce of the va.cine in reducing.hospita.iza.ions during.a.momenta.y.scena.io in the Ba.que Country.*** a.popula.ion in a.mixed va.cina.ion setting.our results ha.e shown tha. reductions in hospita.ized COVID-19 ca.es were observed five months a.ter the va.cina.ion rollout sta.ted,from Ma. to June *** in June,a.g.od a.reement between modelling.simula.ion a.d empirica. da.a.wa. well pronounced.

关键词： COVID-19 Va.cine effica.y Ba.esia. a.proa.h Herd immunity

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Immune-media.ed a.ti-neopla.tic effect of intra.umora. RSV envelope g.y.oprotein expression is rela.ed to a.optotic dea.h of tumor cells but not to the size of sy.cy.ia

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World Journa. of g.0}troenterolog. 2008年第12期14卷 1842-1850页

作者： Dennis Hoffma.n Thoma. g.unwa.d Wibke Ba.er oliver Wildner Ruhr-University.Bochum Institute of Microbiology and Hygiene Department of Molecular and Medical Virology Bldg. MA Rm. 6/40 Bochum 44801 Germany

a.M： To promote the development of improved tumor va.cina.ion stra.eg.es rely.ng.on the intra.umora. expression of vira. fusog.nic membra.e proteins, we elucida.ed whether the size of sy.cy.ia.or the wa. tumor cells die ha. a. effect on the thera.eutic outcome. METHODS： In two sy.g.neic subcuta.eous murine colon ca.cer models we a.sessed the a.ti-neopla.tic effect on vector-trea.ed a.d contra.a.era. untrea.ed tumors. RESULTS： Intra.umora. injection of a.replica.ion-defective a.enovirus encoding.respira.ory.sy.cy.ia. virus fusion protein （RSV-F） a.one （***-F） or tog.ther with the a.ta.hment g.y.oprotein RSV-g.（***-F/g. led to a.sig.ifica.t g.owth reduction of the vector-trea.ed a.d contra.a.era. untrea.ed tumors. The trea.ment response wa. a.socia.ed with a.strong.tumor-specific CTL response a.d sig.ifica.tly.improved surviva. with media.s of 46 d a.d 44 d, respectively. Intra.umora. injection of a.,RSV-g.or a.soluble RSV-F encoding.a.enovirus （***-Fsol） ha. no sig.ifica.t a.ti-neopla.tic effect. The media. surviva. of these trea.nent g.oups a.d of ***-trea.ed control a.ima.s wa. a.out 30 d. CONCLUSION： a.thoug. in vitro tra.sduction of colon ca.cer cell lines with ***-F/g.resulted in a.out 8-fold la.g.r sy.cy.ia.tha. with ***-F, the in vivo outcome wa. not sig.nifica.tly.different, Tra.sduction of murinecolon ca.cer cell lines with *** or ***-F/g.ca.sed a.optotic cell dea.h, in contra.t to tra.sduction with ***-g.or ***-Fsol, sug.esting.a. importa.ce of the mode of cell dea.h. Overa.l, these finding. provide insig.t into improved tumor va.cina.ion stra.eg.es rely.ng.on the intra.umora. expression of vira. fusog.nic membra.e proteins.

关键词： a.enovira. vectors Tumor va.cina.ion Fuso-g.nic membra.e protein Colorecta. ca.cer Sy.g.neictumor model

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Viola.0}g.the a.fba. principle: a. efficient wa. to improve the sta.ility.of luminescent ra.ica.s

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Science China.Chemistry 2019年第12期62卷 1551-1552页

作者： y.g.a.g.ma Institute of Poly.er Optoelectronic Ma.eria.s a.d Devices State Key Laboratory of Luminescent Materials and Devices South China University of Technology

The a.fba. principle,a.so known a.“building.up”principle,is a.method of expla.ning.the a.ra.g.ments of electrons within a.oms of different chemica. *** principle wa. initia.ly.introduced by.Da.ish phy.icist niels Bohr a.d the ba.ic sta.ements include“Electrons will fill orbita.s in increa.ing.order of energ.,a.d ea.h orbita. ca. conta.n a.ma.imum of two electrons,a.d these must ha.e opposite spins”[1].The principle is not perfect,a.d there a.e a.few exceptions,but it is a.very.useful tool for lea.ning.a.out a.omic a.d molecula. structure.

关键词： structure. sta.ility a.ra.g.ment

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Multi-ca.era.sy.tems for reha.ilita.ion thera.ies:a.study.of the precision of Microsoft Kinect sensors

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Frontiers of Informa.ion Technolog. & Electronic Eng.neering 2016年第4期17卷 348-364页

作者： Mig.el oliver Fra.cisco MONTERO Jose Pa.cua. MOLINa.Pa.cua. g.NZa.EZ a.tonio FERNa.DEZ-Ca.a.LERO Instituto de Investig.0}idn en Informdtica.de a.ba.ete Universidad de Castilla-La ManchaAlbacete 02071Spain Depa.ta.ento de Sistema. Informa.icos Universidad de Castilla-La ManchaAlbacete 02071Spain

This pa.er seeks to determine how the overla. of severa. infra.ed bea.s a.fects the tra.ked position of the user, depending.on the a.g.e of incidence of lig.t, dista.ce to the ta.g.t, dista.ce between sensors, a.d the number of ca.ture devices used. We a.so try.to show tha. under idea. conditions using.severa. Kinect sensors increa.es the precision of the da.a.collected. The results obta.ned ca. be used in the desig. of telereha.ilita.ion environments in which severa. Rg.-D ca.era. a.e needed to improve precision or increa.e the tra.king.ra.g.. a.numerica. a.a.y.is of the results is included a.d compa.isons a.e ma.e with the results of other studies. Fina.ly. we describe a.sy.tem tha. implements intellig.nt methods for the reha.ilita.ion of pa.ients ba.ed on the results of the tests ca.ried out.

关键词： Kinect sensor Reha.ilita.ion sy.tem Ca.ture precision Multi-ca.era.sy.tem

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a.ra.e dia.nosis:testicula. dy.g.nesis with ca.cinoma.in situ detected in a.pa.ient with ultra.onic microlithia.is

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a.ia. Journa. of a.drolog. 2005年第4期7卷 445-447,页

作者： Christina.E.Hoei-Ha.sen Peter Sommer Ewa.Ra.pert-De Mey.s niels E.Ska.keba.k Depa.tment of g.owth a.d Reproduction Depa.tment of Urolog. University Hospital of Rigshospitalet2100 Copenhagen Denmark

a.ra.e ca.e is presented where a.dy.g.netic testis with microinva.ive ca.cinoma.in situ （CIS, a.so known a. intra.ubula. g.rm cell neopla.m of uncla.sified ty.e [Ig.NU] a.d testicula. intra.pithelia. neopla.ia.[tin]） with microinva.ion to rete testis a.d the interstitia. tissue wa. found in a.32-y.a.-old ma. presenting.with mild scrota. pa.n a.d ultra.onic testicula. microlithia.is. Knowledg. of the a.socia.ion of ultra.ound a.d CIS is importa.t to dia.nose pa.ients a. the sta.e prior to development of a. overt g.rm cell tumor. The pa.ient ha. three of four disorders considered sy.ptoms of the testicula. dy.g.nesis sy.drome （TDS）： a.dy.g.netic left testicle with CIS, a.mild left-sided cry.torchidism （hig. positioned scrota. hy.otrophic testis） a.d a.slig.tly.reduced semen qua.ity. Therefore, it should be kept in mind tha. a.pa.ient with one TDS sy.ptom ma. ha.bour the other, even CIS or testicula. ca.cer. a.cording.y. pa.ients with one TDS sy.ptom oug.t to be exa.ined for the presence of the others, a.d if more tha. one is present, extra.concern is wa.ra.ted.

关键词： testicula. ca.cer ca.cinoma.in situ testis microlithia.is testicula. dy.g.nesis sy.drome

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Ma.netostra.ig.a.hy.of the Za.da.ba.in in southwest Tibet Pla.ea. a.d its tectonic implica.ions

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Chinese Science Bulletin 2008年第9期53卷 1393-1400页

作者： Wa.g.ShiFeng.ZHa.g.WeiLin Fa.g.Xia.Min Da. Shua.g.oliver KEMPF Institute of Tibeta. Pla.ea. Resea.ch Chinese Academy Sciences Beijing 100085 China Key.La.ora.ory.of Western China.s Environmenta. Sy.tems Ministry of Education of China & College of Resources and Environ- ment Lanzhou University Lanzhou730000 China Institut fer Umweltg.olog.e Technische University Braunschweig Braunschweig 38106 Germany

The Za.da.ba.in is one of the very.importa.t ba.ins a. the north slope of the Hima.a.a.Ra.g.. Thus the study.of the ba.in stra.a.will provide critica. informa.ion a.out the tectonic evolution of the Hima.a.a. Orog.nic Belt. 268 oriented block sa.ples were collected in the 750-m-thick sections of the Za.da.ba. sin. The cha.a.teristic rema.ent ma.netiza.ion (ChRM) wa. isola.ed tha. deca.s linea.ly.to the orig.n between 500oC a.d 690oC for most studied sa.ples. a. a.e ra.g. of 9.5―2.6 Ma.wa. estima.ed from the correla.ion between our observed pola.ity.column a.d the g.oma.netic Pola.ity.Time Sca.e (g.TS). The a.e of the Za.da.ba.in does not support the models tha. the South Tibeta. Deta.h sy.tem (STDS) is one of the ba.in controlling.fa.lts. g.ven the sedimentolog.ca. fea.ures in the ba.in a.d the tectonic fea.ures a. the north edg. of the ba.in, the Za.da.ba.in wa. a.ha.f g.a.en tha. wa. possibly.controlled by.the Ka.a.orum fa.lt on the northea.t.

关键词：盆地磁性地层学断层西藏南部

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铝颗粒粉尘对冲火焰数值模拟研究

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物理学报 2022年第7期71卷 229-240页

作者：张家瑞夏智勋方传波马立坤冯运超 oliver Stein a.drea. Kronenburg 国防科技大学空天科学学院长沙410073 清河大楼丁–3 北京100085 斯图加特大学燃烧技术研究所斯图加特70569

铝颗粒由于具有能量密度高、易储存、燃烧过程不产生温室气体等优势,有望成为未来化石燃料替代的解决方案.本文建立了铝颗粒粉尘火焰的燃烧模型,其中考虑了相间传热、相变、表面化学反应、气相详细化学反应及辐射传热等过程,并针对铝颗... 详细信息

铝颗粒由于具有能量密度高、易储存、燃烧过程不产生温室气体等优势,有望成为未来化石燃料替代的解决方案.本文建立了铝颗粒粉尘火焰的燃烧模型,其中考虑了相间传热、相变、表面化学反应、气相详细化学反应及辐射传热等过程,并针对铝颗粒粉尘对冲火焰开展了数值模拟研究.首先,通过仿真Mcg.ll大学的铝颗粒粉尘对冲火焰实验进行模型验证,并分析了实验中使用铝颗粒本身作为示踪粒子引起的气相速度测量误差,结果表明,数值模拟得到的离散相速度分布与实验结果基本一致,火焰传播速度的预测值也同实验数据吻合较好.当颗粒粒径小于10μm时,连续介质假设不再成立,相间传热模型必须考虑过度区机制,随着颗粒粒径的增加,火焰传播速度不断降低.随着对冲火焰拉伸率的增加,颗粒在火焰区的停留时间减少,并出现燃烧不完全的现象,粉尘火焰由双峰变为单峰结构.火焰传播速度随着拉伸率的增加而增大,通过线性外推可得到未拉伸的火焰传播速率约为29 cm/s.辐射引起的热损失会导致气相温度大幅降低,但辐射传热对颗粒的加热作用相对较小.

关键词：铝燃烧对冲火焰颗粒粉尘火焰传播速度

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