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Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

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Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： Marcos Antonio Costa de Albuquerque danielle Menezes dias Lucas Teixeira Vieira Carlos Anselmo Lima Angela Maria da silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

Renin-angiotensin system in the pathogenesis of liver fibrosis

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World Journal of Gastroenterology 2009年第21期15卷 2579-2586页

作者： Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa dias Mauro Martins Teixeira Ana Cristina Simoes e silva Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais Laboratory of Hypertension Department of Physiology and BiophysicsInstitute of Biological SciencesFederal University of Minas Gerais Laboratory of Immunopharmacology Department of Biochemistry and ImmunologyInstitute of Biological SciencesFederal University of Minas Gerais

Hepatic fibrosis is considered a common response to many chronic hepatic injuries. It is a multifunctional process that involves several cell types, cytokines, chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem. In spite of many studies regarding the development of fibrosis, the understanding of the pathogenesis remains obscure. The hepatic tissue remodeling process is highly complex, resulting from the balance between collagen degradation and synthesis. Among the many mediators that take part in this process, the components of the Renin angiotensin system （RAS） have progressively assumed an important role. Angiotensin （Ang） II acts as a profibrotic mediator and Ang-（1-7）, the newly recognized RAS component, appears to exert a counter-regulatory role in liver tissue. We briefly review the liver fibrosis process and current aspects of the RAS. This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis, focusing on the putative role of the ACE2-Ang-（1-7）- Mas receptor axis.

关键词： Hepatic fibrosis Renin angiotensin system Angiotensin II Angiotensin-(1-7) Receptor Mas Angiotensin converting enzyme 2

Impacted Lower Third Molar Fused with a Supernumerary Tooth—Diagnosis and Treatment Planning Using Cone-Beam Computed Tomography

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International Journal of Oral Science 2009年第4期1卷 224-228页

作者： Osny Ferreira-Junior Luciana Dorigatti de .＆.Aila Marcelo Bonifacio da silva Sampieri Eduardo dias- Ribeiro Wei-liang Chen Song Fan Department of Stomatology Dental School of Bauru University of Sao Paulo Bauru Sao Paulo Brazil Department of Stomatology the Second Affiliated Hospital Sun Yat-Sen University Guangzhou China

This paper reported a case of fusion between an impacted third molar and a supernumerary tooth, in which a surgical intervention was carried out, with the objective of removing the dental elements. The panoramic radiography was complemented by the Donovan＇s radiographic technique; but because of the proximity of the dental element to the mandibular ramus, it was not possible to have a final fusion diagnosis. Hence, the Cone-Beam Computed Tomography--which provides precise three- dimensional information--was used to determinate the fusion diagnosis and also to help in the surgical planning. In this case report we observed that the periapical, occlusal and panoramic were not able to show details which could only be examined through the cone-beam computed tomo- graphy.

关键词： third molar supernumerary tooth oral surgery,cone-beam computed tomography

Plant Breeding for Harmony between Modern Agriculture Production and the Environment

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Agricultural Sciences 2015年第1期6卷 87-116页

作者： Joao Carlos da silva dias Instituto Superior de Agronomia University of LisbonLisbonPortugal

The world population is estimated to be 9.2 billion in 2050. To sufficiently feed these people, the total food production will have to increase 60% - 70%. Climate models predict that warmer tem-peratures and increases in the frequency and duration of drought during the present century will have negative impact on agricultural productivity. These new global challenges require a more complex integrated agricultural and breeding agenda that focuses on livelihood improvement coupled with agro-ecosystem resilience, eco-efficiency and sustainability rather than just on crop productivity gains. Intensifying sustainability agro-ecosystems by producing more food with lower inputs, adapting agriculture to climate change, conserving agro-biodiversity through its use, and making markets to work for the small farmers are needed to address the main issues of our time. Plant breeding has played a vital role in the successful development of modern agriculture. Development of new cultivars will be required while reducing the impact of agriculture on the environment and maintaining sufficient production. Conventional plant breeding will remain the backbone of crop improvement strategies. Genetic engineering has the potential to address some of the most challenging biotic constraints faced by farmers, which are not easily addressed through conventional plant breeding alone. Protective measures and laws, especially patenting, must be moderated to eliminate coverage so broad that it stifles innovation. They must be made less restrictive to encourage research and free flow of materials and information. Small farmers have an important role in conserving and using crop biodiversity. Public sector breeding must remain vigorous, especially in areas where the private sector does not function. This will often require benevolent public/private partnerships as well as government support. Active and positive connections between the private and public breeding sectors and large-scale gene banks ar

关键词： Breeding Modern Agriculture Climate Changes Biodiversity Environment Ecosystems Transgenic Crops Small Farmers

Guiding strategies for breeding vegetable cultivars

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Agricultural Sciences 2014年第1期5卷 9-32页

作者： Joao Carlos da silva dias Technical University of Lisbon Instituto Superior de Agronomia Tapada da Ajuda Lisbon Portugal

Vegetables are considered essential for well-balanced diets. The production and marketing of vegetables crops are undergoing continuous change globally. This is mainly due to the growing demands of consumers for safe and healthy vegetables, increased urbanisation of societies, and the growth in scale and influence of supermarkets chains. Horticultural science can respond to many of these challenges through research, breeding and innovation that can seek to gain more efficient methods of crop production, refined post-harvest storage and handling methods, newer and higher value vegetable cultivars and demonstration of their health benefits. Vegetable breeding has to address and satisfy the needs of both the consumer and the producer. Innovation in vegetable breeding depends on specific knowledge, the development and application of new technologies, access to genetic resources, and capital to utilise them. The driving force behind this innovation is acquiring or increasing market share. Access to technology, as well as biodiversity, is essential for the development of new vegetable cultivars. A few multinational corporations, whose vast economic power has effectively marginalized the role of public sector breeding as well as local, small/medium-scale seed companies, dominate the global vegetable seed trade. For most vegetable crops, only a few multinational seed corporations are controlling large part of the world market. This situation makes a growing part of the global vegetable supply dependent on a few seed providers. The multinational seed corporations ensued from merging some small or medium vegetable breeding programs to reduce costs. There may be fewer vegetable breeders in the future and growers will rely on seeds with a narrow genetic base. In order to meet future needs of vegetable breeders it is important that educational programs incorporate rapidly changing new technologies with classical content and methods. Active and positive connections between the pr

关键词： Vegetables Horticulture Health Benefits Marketing Trading Breeding Year-Round Production Sustainability

Nutritional and Health Benefits of Carrots and Their Seed Extracts

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Food and Nutrition Sciences 2014年第22期5卷 2147-2156页

作者： Joao Carlos da silva dias Instituto Superior de Agronomia University of LisbonLisboaPortugal

Carrot is a root vegetable with carotenoids, flavonoids, polyacetylenes, vitamins, and minerals, all of which possess numerous nutritional and health benefits. Besides lending truth to the old adage that carrots are good for eyes, carotenoids, polyphenols and vitamins present in carrot act as antioxidants, anticarcinogens, and immunoenhancers. Anti-diabetic, cholesterol and cardiovascular disease lowering, anti-hypertensive, hepatoprotective, renoprotective, and wound healing benefits of carrot have also been reported. The cardio- and hepatoprotective, anti-bacterial, anti-fungal, anti-inflammatory, and analgesic effects of carrot seed extracts are also noteworthy. All are discussed in this review article.

关键词： daucus carota Chemical Composition Antioxidants Phytochemicals Disease Prevention

Repeated inoculations of Mycobacterium bovis Bacille Calmette-Guérin (BCG) are needed to induce a strong humoral immune response against antigens expressed by the bacteria

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Open Journal of Immunology 2013年第3期3卷 71-81页

作者： Monique C. da silva Elena B. Lasunskaia Wilmar dias da silva Laboratory of Biology of Recognition Universidade Estadual do Norte Fluminense Campos Rio de Janeiro Brazil Laboratory of Immunochemistry Institute Butantan S&atilde o Paulo Brazil

The cellular immune response elicited by Mycobacterium bovis Bacille Calmette-Guérin (BCG) has been carefully investigated, but the humoral immune response has been partially neglected. BALB/c mice were immunized with BCG strain used to immunize humans. Anti-BCG antibodies, as assayed by ELISA, began to appear in the sera after the third week of immunization and plateaued three weeks after the 8th immunization. The total immunoglobulins (Igs) were purified by caprylic acid method from pooled serum collected after the 8th immunization. Anti-BCG antigen antibodies were detected in the total Igs preparation as well as in IgG, IgM, IgA, IgG1, IgG2a, and IgG2b, but not in the IgG3. Distinct BCG proteins were recognized the IgGs in Western blot analysis. Opsonization of BCG bacilli by the purified Igs potentiated internalization of the bacteria by murine Raw 264.7 macrophages. The intracellular BCG elimination coincided with the induction of NO production, which was more pronounced in cells infected with opsonized BCG compared to those infected with the non-opsonized bacteria. Coincidently, the production of NO was also higher in macrophages infected with opsonized BCG (maximal NO production at 48 h of incubation). The obtained results demonstrate that repeated inoculations of BCG effectively activate the humoral immune response, justifying the use of BCG as a live recombinant vaccine vector to insert genes encoding virulence factors controlled by antibodies.

关键词： Mycobacterium bovis Bacille Calmette-Guérin BCG Antibodies Opsonization Bacterial Killing

Numerical Evaluation of Strength in the Interface during Indentation Spherical Testing in Thin Films

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Materials Sciences and Applications 2014年第3期5卷 149-157页

作者： Rodrigo Araújo Avelino Manuel da silva dias Federal University of Sao Joao Del-Rei(UFSJ) Sao Joao Del-ReiBrazil Federal University of Rio Grande do Norte(UFRN) NatalBrazil

The need for more components that are more resistant to wear and corrosion has promoted a growing interest in surface engineering. The search for improved tribological properties in materials contributes to the development of processes that extend the useful life of components and their applications in increasingly severe environments. In this respect, thin ceramic coatings have been used to enhance the tribological properties of components that operate under these conditions. However, new experimental assays are needed to assess the behaviour of these films and their surface as substrate. These experimental analyses require the use of sophisticated equipment and specialized personnel. On the other hand, with advances in computational mechanics, the application of numerical analysis to solve numerous technological problems has been increasingly frequent, owing to its low operational costs. This study aims to simulate an indentation assay with spherical penetrator in systems composed of thin ceramic film deposited on metallic substrate using a Finite Element commercial code. The main objective of this study was to evaluate the field behaviour of stresses in the contact region of the indenter with the sample, on the outline of the impression made by the penetrator and, primarily, on the film-substrate interface.

关键词： Finite Elements Indentation Test Thin Films

香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique silva Costa Thaís Jorge de Vasconcellos Claudio Sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho Cátia Henriques Callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(Cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡