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SEISMIC RANDOM VIBRATION ANALYSIS OF STOCHASTIC STRUCTURES USING RANDOM FACTOR METHOD

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Chinese Journal of Mechanical Engineering 2006年第1期19卷 1-8页

作者： KESSISSOGLOU nicole J School of Mechanical and Manufacturing Engineering

Seismic random vibration analysis of stochastic truss structures is presented. A new method called random factor method is used for dynamic analysis of structures with uncertain parameters, due to variability in their material properties and geometry. Using the random factor method, the natural frequencies and modeshapes of a stochastic structure can be respectively described by the product of two parts, corresponding to the random factors of the structural parameters with uncertainty, and deterministic values of the natural frequencies and modeshapes obtained by conventional finite element analysis. The stochastic truss structure is subjected to stationary or non-stationary random earthquake excitation. Computational expressions for the mean and standard deviation of the mean square displacement and mean square stress are developed by means of the random variable＇s functional moment method and the algebra synthesis method. An antenna and a truss bridge are used as practical engineering examples to illustrate the application of the random factor method in the seismic response analysis of random structures under stationary or non-stationary random earthquake excitation.

关键词： Seismic random vibration Uncertainty structures Random factor methodNon-stationary ground motion

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煮字人生——林青霞、黄心村二人谈

扬子江文学评论 2024年第4期 48-54页

作者：林青霞黄心村张真瑞(整理) 宋宝平(整理) 不详香港大学比较文学系中国

二○二三年二月十日,中国香港大学文学院和比较文学系合办的“煮字人生:林青霞、黄心村二人谈”讲座,在中国香港大学百周年校园李兆基会议中心大会堂(The Grand Hall)隆重举行,场内超过八百位的听众、坐满三个直播室的观众以及场外众多... 详细信息

二○二三年二月十日,中国香港大学文学院和比较文学系合办的“煮字人生:林青霞、黄心村二人谈”讲座,在中国香港大学百周年校园李兆基会议中心大会堂(The Grand Hall)隆重举行,场内超过八百位的听众、坐满三个直播室的观众以及场外众多的等候观众,将现场挤得水泄不通。对谈伊始,黄心村播放了一段珍贵录像,记录了1998年林青霞和张国荣走上港大比较文学系的讲堂,与当年比较文学系系主任阿巴斯(Ackbar Abbas)对谈的盛况。时隔25年之后,林青霞再次应黄心村之邀来到了港大的讲坛,所以黄心村说“青霞和港大文学院的因缘是前定的,25年前就定下的,然后我和她认识只是一个时间的问题,是命中注定要认识的”,由此开始了她们的对谈。

关键词：林青霞挤得水泄不通李兆基张国荣阿巴斯直播室香港大学比较文学系

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Metformin treatment of high-fat diet-fed obese male mice restores sperm function and fetal growth,without requiring weight loss

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Asian Journal of Andrology 2020年第6期22卷 560-568页

作者： nicole O McPherson Michelle Lane Robinson Research Institute School of MedicineUniversity of AdelaideAdelaide 5005Australia Freemasons Foundation Centre for Men's Health University of AdelaideAdelaide 5005Australia Repromed Dulwich 5065Australia Monash IVF Group Melbourne 3000Australia.

Male obesity is associated with subfertility and increased disease risk of *** is unknown if effects can be reversed through pharmacological ***-to 6-week-old C57BL6 male mice were fed control diet(n=10,CD)or high-fat diet(n=20,HFD)for 16 *** fed with a HFD were then allocated to continuation of HFD(n=8)or HFD with metformin 28 mg kg1 day-1(n=8)for 6 *** fed with CD continued on a CD(n=9).Males were mated with fertile C57BL6 females for the assessment of pregnancy and fetal *** motility,spermatozoa and testicular morphology,sperm-zona pellucida binding,sperm reactive oxygen species(ROS)(intracellular[DCFDA],superoxide[MSR],and oxidative DNA lesions[8OHdG]),and mitochondrial membrane potential(JC1)were *** treatment of HFD males improved glucose toleranee(+12%,P<0.05)and reduced Homeostatic Model Assessment of Insulin Resistance(HOMA-IR;-36%,P<0.05).This occurred in the absenee of a change in body weight or *** treatment of HFD-fed males restored testicular morphology(+33%,P<0.05),sperm motility(+66%,P<0.05),sperm-zona pellucida binding(+25%,P<0.05),sperm intracellular ROS concentrations(-32%,P<0.05),and oxidative DNA lesions(-45%,P<0.05)to the levels of the CD *** treatment of HFD fathers increased fetal weights and lengths compared with those born to HFD fathers(+8%,P<0.05),with fetal lengths restored to those of fetuses of CD ***-term metformin treatment in men who are obese could be a potential intervention for the treatment of subfertility,without the need for a reduction in body weight/adiposity.

关键词： fertility glucose metabolic syndrome overweight subfertility

The “PAWPER-on-a-page”: Increasing global access to a low-cost weight estimation system

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World Journal of Emergency Medicine 2019年第2期10卷 101-108页

作者： Mike Wells Lara nicole Goldstein Division of Emergency Medicine Faculty of Health Sciences University of the Witwatersrand

BACKGROUND: The PAWPER tape is one of the most accurate weight estimation systems available today, but international access to the tape is limited because it has no commercial distribution. For this reason, the "PAWPER-on-a-page" concept was devised: downloadable image fi les that allow users to print and assemble their own tapes. However, the feasibility of this method is dependent on users being able to produce accurate tapes. This study was devised to determine whether untrained participants could print and assemble the "PAWPER-on-a-page" easily and ***: Doctor and nurse volunteers downloaded the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" image files and printed copies on a home-printer and also at a commercial printer. One copy of each tape was then assembled according to instructions from an online video. The accuracy of printing and assembly, the time taken for assembly and the cost were then ***: There were 32 participants. The median time for assembly was 8 minutes 19 seconds and 7 minutes 31 seconds for the "PAWPER-on-a-page" and "PAWPER XL-on-a-page" respectively, with a median cost of USD 0.09 and USD 1.00 respectively. For the assembled tapes, 71.9% of the "PAWPER-on-a-page" tapes and 65.6% of the "PAWPER XL-on-a-page" achieved the required accuracy of 0.2%. Printing errors, related to scaling, were common, but easily ***: The "PAWPER-on-a-page" system can be easily, quickly, affordably and accurately printed and assembled by end users. Stringent double checking of the printed and fully assembled tapes is essential to ensure accuracy.

关键词： PAWPER tape Weight estimation Paediatric emergency care

Excitatory synapse impairment and mitochondrial dysfunction in Huntington’s disease: heat shock factor 1 (HSF1) converging mechanisms

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Neural Regeneration Research 2020年第1期15卷 69-70页

作者： nicole Zarate Rocio Gomez-Pastor Department of Neuroscience School of Medicine University of Minnesota

Heat shock factor 1(HSF1)is abnormally degraded in Huntington’s disease(HD):HD is a neurodegenerative disorder characterized by severe cognitive and motor *** is caused by a CAG repeat expansion within exon 1 of the huntingtin(HTT)gene(The Huntington’s Disease Collaborative Research Group,1993).These expansions lead to the production of an aberrant mutant huntingtin protein(mHTT)that is prone to misfolding and *** and aggregation of mHTT is present in virtually all cell types in the body but preferentially affects medium spiny neurons of the striatum,a brain region that controls movement and some forms of *** of mHTT leads to,but not only,transcriptional dysregulation,DNA damage,mitochondrial dysfunction and excitatory synaptic failure ultimately causing neuronal ***,the molecular mechanisms by which mHTT exerts these defects are still unclear.

关键词： Huntington impairment shock

LiDAR mapping of ground damage in a heading re-orientation case study

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International Journal of Mining Science and Technology 2021年第1期31卷 67-74页

作者： nicole Evanek Brent Slaker Anthony Iannacchione Tim Miller National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA University of Pittsburgh PittsburghPA 15260USA East Fairfield Coal Company North LimaOH 44452USA

The Subtropolis Mine is a room-and-pillar mine extracting the Vanport limestone near Petersburg,Ohio,*** February of 2018,mine management began implementing a heading re-orientation to better control the negative effects of excessive levels of horizontal *** conditions in the headings improved,but as expected,stress-related damage concentrated within *** mine operator has worked to lessen the impact of the instabilities in the outby crosscuts by implementing several engineering *** the implementation of each control,conditions were monitored and analyzed using observational and measurement techniques including 3D LiDAR *** the heading re-orientation,several 3D LiDAR surveys have been conducted and analyzed by researchers from the National Institute for Occupational Safety and Health(NIOSH).This study examines(1)the characteristics of each 3D LiDAR survey,(2)the change in the detailed strata conditions in response to stress concentrations,and(3)the change detection techniques between 3D LiDAR surveys to assess entry ***,the 3D LiDAR surveys proved to be a useful tool for characterizing ground instability and assessing the effectiveness of the engineering controls used in the heading re-orientation at the Subtropolis Mine.

关键词： Ground control Limestone Horizontal stress Stress control layout Crosscut Windows

最狭长山脉造就最狭长国度散落在智利与秘鲁的异度空间之谜

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环球人文地理 2024年第5期 38-49页

作者：丸子 Mark.C 胡子捷森郭卓然徐霄宇惺辰 MitchellFrye nicole videobuzzing Nataliya atosan Leckerstudio

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪...

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪勒拉。其中最引人关注的是中安第斯，这里仿佛是被神明选中的圣地，狭长的智利拥有世界上最孤独的岛屿；神秘的秘鲁掌握着印加帝国古老的文明。

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Embolic protection device, the next advancement in TAVR?

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Journal of Geriatric Cardiology 2020年第3期17卷 160-163页

作者： David Li nicole Shirakawa Hong Liu Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoCAUSA

The approval of commercial application transcatheter aortic valve replacement(TAVR)by the FDA in 2011 has revolutionized the management of high-risk surgical patients with severe aortic stenosis(AS).With TAVR being expanded to intermediate surgical risk patients in 2016,the number of patients undergoing TAVR has been increasing *** fact,since the very first human TAVR procedure in 2002,more than 300,000 TAVRs have been performed worldwide.[1,2]The technological advancements in the TAVR since its early days of clinical adaptation has made this procedure a routine practice in many institutions ***,one of the most feared complications,ischemic stroke,remains a major concern for clinicians and patients despite all the advancements in the procedure.

关键词： Embolic protection Stroke Transcatheter aortic valve replacement

Plant peroxisomal solute transporter proteins

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Journal of Integrative Plant Biology 2019年第7期61卷 817-835页

作者： Lennart Charton Anastasija Plett nicole Linka Institute for Plant Biochemistry and Cluster of Excellence on Plant Sciences (CEPLAS) Heinrich Heine University

Plant peroxisomes are unique subcellular organelles which play an indispensable role in several key metabolic pathways, including fatty acid b-oxidation,photorespiration, and degradation of reactive oxygen species. The compartmentalization of metabolic pathways into peroxisomes is a strategy for organizing the metabolic network and improving pathway efficiency. An important prerequisite, however, is the exchange of metabolites between peroxisomes and other cell compartments. Since the first studies in the 1970s scientists contributed to understanding how solutes enter or leave this *** review gives an overview about our current knowledge of the solute permeability of peroxisomal membranes described in plants, yeast, mammals and other eukaryotes. In general, peroxisomes contain in their bilayer membrane specific transporters for hydrophobic fatty acids(ABC transporter) and large cofactor molecules(carrier for ATP, NAD and CoA). Smaller solutes with molecular masses below 300–400 Da, like the organic acids malate, oxaloacetate, and 2-oxoglutarate, are shuttled via non-selective channels across the peroxisomal *** comparison to yeast, human, mammals and other eukaryotes, the function of these known peroxisomal transporters and channels in plants are discussed in this review.

关键词： Plant peroxisomal solute transporter proteins