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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel S Dennahy nicole C Mountz Luisa Wilschrey Arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States Department of Surgery University of EssenEssen D-45122Germany Department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUND Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value of<0.05 was accepted as statistically *** Of the total 779 LT recipients,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all P<0.05).Baseline characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

Cascade Catalysts Based on Colloidal Engineering

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CCS Chemistry 2024年第9期6卷 2150-2161页

作者： Chen Chen Chin Ken Wong Hui Chen nicole Janoszka Giada Quintieri AndréH.Gröschel School of Chemistry and Chemical Engineering Shanghai Jiao Tong University200240 Shanghai School of Chemistry University of New South Wales(UNSW)SydneySydney NSW 2052 Physical Chemistry and Center for Soft Nanoscience University of MünsterCorrensstraße 28-3048149 Münster

We see significant progress in the preparation of nanoreactors that host incompatible catalysts for cascade reactions,yet their preparation typically requires specialized,multistep synthetic ***,we utilize core-satellite microparticles as a versatile strategy for the site isolation of catalysts in core and *** core-satellite clusters are prepared by mixing specific amounts of negatively charged core microparticles(e.g.,acid catalyst)with positively charged satellites(e.g.,base catalyst).Core and satellite are made from incompatible polymers allowing solvent-annealing of clusters into different morphologies(raspberry,patchy,and core-shell)while maintaining site isolation of the *** core-satellite microparticles show very good catalytic activity in a model one-pot acid/base cascade reaction with subtle differences regarding particle *** microparticles thereby demonstrated the highest reaction rate and yield,likely due to an alleviated diffusion pathway for the ***,we show that this colloidal engineering strategy can be extended to multifunctional microparticles suitable to perform multistep cascade reactions in one pot.

关键词： cascade catalysts compartmentalization colloidal engineering emulsion polymerization multifunctional particles

Effectiveness of chemical inactivation of infectious liquid biological waste:A randomized sample study of research laboratories in Switzerland

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Journal of Biosafety and Biosecurity 2024年第1期6卷 16-26页

作者： Alina CTeuscher Charlotte Ruhnau nicole Stöcklin Fabienne Wichmann Evelyn Ilg Hampe Claudia Bagutti State Laboratory Basel-City Biosafety LaboratoryBaselSwitzerland Novatis Lichtstrasse 354056 BaselSwitzerland1 IQVIA AG Kirschgartenstrasse 144051 BaselSwitzerland1 Becton Dickinson AG Binningerstrasse 944123 AllschwilSwitzerland1

Laboratory wastewater has been suggested as an important escape route for microorganisms from research *** reasons for the unintentional release of laboratory organisms are shortcomings in the handling of infectious liquid biological waste(LBW)and inadequate inactivation *** developed an analytical approach to investigate the use of chemical inactivation(CI)procedures in Swiss research laboratories by on-site random sampling of presumably inactivated infectious LBW and testing it for the presence of infectious lentiviruses(HIV-1)and adenoviruses(AdV).In addition,standard operating procedures(SOPs)for CI were collected and evaluated,and laboratorystaff knowledge of CI processes was assessed using a *** we found several deficiencies in the technical knowledge and training of laboratory staff on the CI of LBW,as documented by 27 returned questionnaires,no infectious viruses were detected in the eight LBW samples *** we acknowledge that the number of LBW samples and SOPs is small,we conclude that CI of LBW containing infectious lentiviruses and adenoviruses does not result in the systematic release of considerable amounts of infectious viruses into the environment from research laboratories in Switzerland.

关键词： Chemical inactivation Infectious liquid biological waste Lentivirus(HIV-1) Adenovirus

Evaluation of the Impact of Driver Behavior on Back of Queues Events in Work Zones Using the SHRP2 Naturalistic Driving Study Data

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Journal of Transportation Technologies 2024年第2期14卷 179-194页

作者： Shauna Hallmark Guillermo Basulto-Elias nicole Oneyear Omar Smadi Institute for Transportation 2711 S. Loop Drive Suite 4700 Ames Iowa Iowa Division Federal Highway Administration Ames Iowa

The SHRP2 Naturalistic Driving Study was used to evaluate the impact of various work zone and driver characteristics on back of queue safety critical events (crash, near-crash, or conflicts) The model included 43 SCE and 209 “normal” events which were used as controls. The traces included representing 209 unique drivers. A Mixed-Effects Logistic Regression model was developed with probability of a SCE as the response variable and driver and work zone characteristics as predictor variables. The final model indicated glances over 1 second away from the driving task and following closely increased risk of an SCE by 3.8 times and 2.9 times, respectively. Average speed was negatively correlated to crash risk. This is counterintuitive since in most cases, it is expected that higher speeds are related to back of queue crashes. However, most queues form under congested conditions. As a result, vehicles encountering a back of queue would be more likely to be traveling at lower speeds.

关键词： Safety Critical Events Speed Following Closely Glance Behavior

Vaginal Birth after Cesarean after Zavanelli Maneuver: A Woman’s Right to Choose

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1091-1095页

作者： nicole Jenkins Gregory Vurture Jonathan D. Baum Department of Obstetrics and Gynecology Jersey Shore University Medical Center Neptune NJ USA

Introduction: Vaginal birth after cesarean (VBAC) plays an essential role in lowering cesarean rates. Despite endorsement, trial of labor after cesarean (TOLAC) attempt rates remain low, in part due to fear of lawsuits. Zavanelli maneuver is a last resort procedure in the management of shoulder dystocia. We discuss a case of a woman determined to have a vaginal birth after her prior birth was complicated by shoulder dystocia requiring a Zavanelli maneuver. Her physicians were reluctant to allow her a TOLAC given her prior obstetric history. Case: A 34-year-old para 1 with prior cesarean delivery due to shoulder dystocia that required Zavanelli maneuver presents determined to pursue VBAC in her current pregnancy. She considered her delivery route options and addressed her modifiable risk factors. She consulted with multiple perinatologists who agreed that a TOLAC was reasonable, however she had to travel more than 70 miles (from Pennsylvania to New Jersey) to find an obstetrical practice and hospital willing to consider VBAC. She transferred care and the remainder of her prenatal course was uncomplicated. She went into labor at 41 weeks and had a successful VBAC without complication. In a thank you letter to her obstetrician, she described her birth experience as euphoric. Conclusion: This case illustrates how a woman’s choice of delivery route may be impacted by fear of litigation. Local providers focused on her prior delivery instead of her overall improved risk profile. Delivery route decisions should be based on a thorough evaluation of all risk factors and individualized to meet the reproductive goals of each woman. .

关键词： Vaginal Birth after Cesarean Zavanelli Autonomy Case Report

Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke Jennie E.Pryce nicole M.Steele Peter R.Amer Susanne Meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

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Doinb:镜子

电子竞技 2024年第3期 52-57页

作者： nicole 不详

在英雄联盟的地图上,中路或许是最特殊同时又最引人注目的分路,不仅仅因为它总是能位于镜头的中央,也因为中路的兵线最短,相对的对线空间最小。所以中路的对线不像上路那么刀刀见血,但总能够充分展示选手的个人操作和英雄主义。中路也... 详细信息

在英雄联盟的地图上,中路或许是最特殊同时又最引人注目的分路,不仅仅因为它总是能位于镜头的中央,也因为中路的兵线最短,相对的对线空间最小。所以中路的对线不像上路那么刀刀见血,但总能够充分展示选手的个人操作和英雄主义。中路也不像下路一样,尽管不激烈,但实力上的差距会被补刀、防御塔收益这些数据放大。

关键词：英雄主义英雄联盟充分展示中路

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2023电子竞技终身成就奖颁布

电子竞技 2024年第1期 86-93页

作者： nicole 不详

12月8日,在美国洛杉矶举办的TGA 2023颁奖典礼上,多项游戏与赛事奖项获得者被正式颁布。其中由比利时游戏开发商拉瑞安工作室推出的《博德之门3》斩获了包括年度游戏奖在内的五个奖项,《无畏契约》获得了最佳电竞游戏奖,英雄联盟全球总... 详细信息

12月8日,在美国洛杉矶举办的TGA 2023颁奖典礼上,多项游戏与赛事奖项获得者被正式颁布。其中由比利时游戏开发商拉瑞安工作室推出的《博德之门3》斩获了包括年度游戏奖在内的五个奖项,《无畏契约》获得了最佳电竞游戏奖,英雄联盟全球总决赛获得了最佳电竞赛事奖,Faker获得了最佳电竞选手奖。上个月,同样享有“电竞奥斯卡”之誉的Esports Awards颁布了2023电子竞技终身成就奖。八位从事不同项目,拥有不同身份的从业人员获得了该奖项。

关键词：终身成就奖电子竞技总决赛游戏开发商工作室电竞英雄联盟

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依然SofM

电子竞技 2024年第8期 87-89页

作者： nicole 不详

2024年4月7日,越南战队GAM在VCS赛区春季赛决赛上,以3∶1的比分战胜VKE,成功拿下了越南赛区的五连冠。而VKE在赛点局的逆转失败,也宣告着他们的老板兼主教练兼辅助的SofM再次无缘MSI。2022年年底,当SofM宣布离开LPL赛区,选择回归越南并... 详细信息

2024年4月7日,越南战队GAM在VCS赛区春季赛决赛上,以3∶1的比分战胜VKE,成功拿下了越南赛区的五连冠。而VKE在赛点局的逆转失败,也宣告着他们的老板兼主教练兼辅助的SofM再次无缘MSI。2022年年底,当SofM宣布离开LPL赛区,选择回归越南并创立自己的战队,同时退出职业赛场转型为主教练时,无数观众对此表示了惋惜,因为他们是如此喜欢这位总是在赛场上展现出神鬼莫测操作的选手。

关键词：五连冠赛点赛场主教练越南神鬼莫测