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Vibrations induced by tunnel boring machine in urban areas: In situ measurements and methodology of analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第1期15卷 130-145页

作者： Antoine Rallu nicolas Berthoz Simon Charlemagne Denis Branque University of Lyon ENTPELTDS-UMR CNRS 5513CeLyAVaulx-en-VelinFrance French Centre for Tunnel Studies(CETU) BronFrance

Excavation with tunnel boring machine(TBM)can generate vibrations,causing damages to neighbouring buildings and disturbing the residents or the *** problem is particularly challenging in urban areas,where TBMs are increasingly large in diameter and shallow in *** response to this problem,four experimental campaigns were carried out in different geotechnical contexts in *** vibration measurements were acquired on the surface and inside the *** measurements are also complemented by few data in the *** original methodology of signal processing is pro-posed to characterize the amplitude of the particle velocities,as well as the frequency content of the signals to highlight the most energetic *** levels of vibrations are also compared with the thresholds existing in various European regulations concerning the impact on neighbouring structures and the disturbance to local residents.

关键词： Ground-borne vibrations Tunnel boring machine(TBM) In situ measurement Dynamic characterization Vibration levels Site spectrum

Effect of Biostimulants Based on Natural Products on the Growth and Nutritional Value of Bean (Phaseolus vulgaris L.)

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American Journal of Plant Sciences 2024年第7期15卷 492-518页

作者： Aimé Giresse Tzeuton Flore Eliane Eyenga Arouna Meshuneke Gaston Mbang Elock Fabrice Damien Wassom Walter Jospin Timma Kom Marie Paule Djam Kengoum Erica Cabrelle Damtse Damtse Landry Silatsa Fotsing William Asah Che Marlyne Josephine Mananga nicolas Niemenak Cécile Annie Ewané Laboratory of Plant Physiology and Biochemistry Higher Teachers Training College University of Yaound 1 Yaound Cameroon Department of Biochemistry Faculty of Sciences University of Yaound 1 Yaound Cameroon Laboratory of Food Sciences and Metabolism University of Yaoundé 1 Yaoundé Cameroon Laboratory of Phytoprotection and Valorisation of Genetic Resources of the Biotechnology Centre University of Yaound 1 Yaound Cameroon Department of Biological Sciences Higher Teachers Training College University of Yaound 1 Yaound Cameroon

Beans (Phaseolus vulgaris L.) are widely grown in Cameroon and play a key role in the fight against food insecurity, malnutrition and poverty. However, its cultivation encounters problems due to abiotic and biotic stresses, which leads to the use of synthetic fertilizers and pesticides, which cause significant damage to the environment and human health due to the presence of synthetics residues in the seeds, pods and in the leaves that are eaten. Promoting the use of natural products is becoming a necessity for organic and eco-responsible agriculture that limits contamination problems and improves people’s purchasing power. This study aims to assess the effect of biostimulants based on natural products on the growth and nutritional value of common bean (Phaseolus vulgaris L.). Bean seedlings from white variety (MEX-142) and red variety (DOR-701) were treated every seven days in the field from their pre-emergence, emergence and growth to their maturation under a randomized block experimental design. Six treatments and three repetitions with the biostimulants based on natural products and controls were thus performed and the agromorphological parameters were measured. After 120 days, the contents of growth biomarkers and defense-related enzymes were evaluated in leaves, while the contents of macromolecules, minerals and antinutrients were evaluated in seeds. These biostimulants significantly increased (P P < 0.0001) of antinutrients including oxalates, phytates, tannins and saponins in seeds compared to controls (T+ and T−). Treatment with biostimulants, in particular BS4, improves the performance of bean plants in the field as well as the biofortification of seeds regardless of the variety.

关键词： Phaseolus vulgaris L. Biostimulants Biofortification Growth and Defense Biomarkers Nutritional Value

Control Evaluation of Antagonistic Series Elastic Actuation for a Robotic Endoscope Joint

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Journal of Bionic Engineering 2022年第4期19卷 965-974页

作者： Lorin Fasel nicolas Gerig Philippe C.Cattin Georg Rauter BIROMED-Lab Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland CIAN Department of Biomedical EngineeringUniversity of Basel4123AllschwilSwitzerland

Haptic feedback is typically missing during telemanipulation of surgical robots in minimally invasive surgeries,i.e.,surgeons cannot feel the interaction forces between the instruments and ***,surgeons have to solely rely on visual feedback,which increases complexity of guiding the instruments and poses the safety threat of unperceivable contacts outside the field of *** propose a novel series elastic actuation design for articulated robotic endoscopes to overcome these limitations and evaluate an according device with one *** to the actuation of human fingers,the joint is driven by antagonistic *** are integrated in the transmission between the tendons and the motors outside of the endoscope *** estimated the joint angle and thereby the endoscope shape,measured spring deflection,estimated tendon forces from that deflection,and implemented force control for the endoscope *** torque control and impedance control were evaluated under application of both a continuous force and an impact force to the endoscope *** springs reduced impact forces at the tip of the endoscope through their inherent *** the same time,feeding back the estimated force resulted in a stable tendon force control and a tunable endoscope joint control:Zero torque control effectively reduced the external forces,while the endoscope joint showed the expected stiffness in impedance *** results show that antagonistic series elastic actuation is a promising concept for endoscope joint actuation and that it can lead towards safer robot–tissue interactions in surgical robotics.

关键词： Minimally invasive surgery RAMIS Robot-assisted surgery Haptic feedback Force control Tendon-driven robotics

Blood–brain barrier dysfunction in intensive care unit

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Journal of Intensive Medicine 2023年第4期3卷 303-312页

作者： Loic Le Guennec nicolas Weiss Département de neurologie Sorbonne UniversitéAP-HP Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreUnitéde Médecine Intensive Réanimationàorientation neurologiqueParis 75013France Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université Paris 75013France Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et fibro-inflammatoire du foieInstitute of Cardiometabolism and Nutrition(ICAN)Paris 75013France

The central nervous system is characterized by a peculiar vascularization termed blood–brain barrier(BBB),which regulates the exchange of cells and molecules between the cerebral tissue and the whole *** dysfunction is a life-threatening condition since its presence corresponds to a marker of severity in most diseases encountered in the intensive care unit(ICU).During critical illness,inflammatory response,cytokine release,and other phenomena activating the brain endothelium contribute to alterations in the BBB and increase its permeability to solutes,cells,nutrients,and ***,patients in the ICU are often old,with underlying acute or chronic diseases,and overly medicated due to their critical condition;these factors could also contribute to the development of BBB *** accurate diagnostic approach is critical for the identification of the mechanisms underlying BBB alterations,which should be rapidly managed by *** methods were developed to investigate the BBB and assess its ***,in humans,exploration of the BBB requires the use of indirect *** and biochemical methods can be used to study the abnormal passage of molecules through the *** this review,we describe the structural and functional characteristics of the BBB,present tools and methods for probing this interface,and provide examples of the main diseases managed in the ICU that are related to BBB dysfunction.

关键词： Blood–brain barrier ICU hepatic encephalopathy Delirium Extracorporeal membrane oxygenation(ECMO) Acute bacterial meningitis

Stem cell therapy in retinal diseases

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Neural Regeneration Research 2023年第7期18卷 1478-1485页

作者： Audrey Voisin Amaury Pénaguin Afsaneh Gaillard nicolas Leveziel Laboratoire de Neurosciences Expérimentales et Cliniques Universitéde PoitiersINSERM 1084PoitiersFrance Department of Ophthalmology CHU PoitiersPoitiersFrance Laboratoires Thea Clermont-FerrandFrance

Alteration of the outer retina leads to various diseases such as age-related macular degeneration or retinitis pigmentosa characterized by decreased visual acuity and ultimately *** intensive research in the field of retinal disorders,there is currently no curative *** therapeutic approaches such as cell-based replacement and gene therapies are currently in *** the context of cell-based therapies,different cell sources such as embryonic stem cells,induced pluripotent stem cells,or multipotent stem cells can be used for *** the vast majority of human clinical trials,retinal pigment epithelial cells and photoreceptors are the cell types considered for replacement cell *** this review,we summarize the progress made in stem cell therapies ranging from the pre-clinical studies to clinical trials for retinal disease.

关键词： age-related macular degeneration cell transplantation clinical trial retinal disease retinal dystrophy stem cell

Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling

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Zoological Research 2023年第3期44卷 650-662页

作者： nicolas James Ho Xiao Chen Yong Lei Shen Gu School of Biomedical Sciences Faculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Dr.Li Dak Sum-Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejiang 310058China Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of MedicineHangzhouZhejiang 310058China Zhejiang University-University of Edinburgh Institute&School of Basic Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China Department of Sports Medicine Zhejiang University School of MedicineHangzhouZhejiang 310058China China Orthopedic Regenerative Medicine Group(CORMed) HangzhouZhejiang310058 China School of Medicine The Chinese University of Hong Kong(Shenzhen)ShenzhenGuangdong 518172China The Chinese University of Hong Kong(Shenzhen) Shenzhen Futian Biomedical Innovation R&D CenterShenzhenGuangdong 518172China Key Laboratory for Regenerative Medicine Ministry of EducationSchool of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics The Chinese University of Hong KongHong Kong SARChina

Hereditary spastic paraplegia(HSP)is a group of genetic motor neuron diseases resulting from length-dependent axonal degeneration of the corticospinal upper motor *** to the advancement of next-generation sequencing,more than 70 novel HSP disease-causing genes have been identified in the past *** this,our understanding of HSP physiopathology and the development of efficient management and treatment strategies remain *** major challenge in studying HSP pathogenicity is selective neuronal vulnerability,characterized by the manifestation of clinical symptoms that are restricted to specific neuronal populations,despite the presence of germline disease-causing variants in every cell of the ***,disease genes may exhibit ubiquitous expression patterns and involve a myriad of different pathways to cause motor neuron *** the current review,we explore the correlation between transcriptomic data and clinical manifestations,as well as the importance of interspecies models by comparing tissue-specific transcriptomic profiles of humans and mice,expression patterns of different genes in the brain during development,and single-cell transcriptomic data from related ***,we discuss the potential of emerging single-cell RNA sequencing technologies to resolve unanswered questions related to HSP pathogenicity.

关键词： degeneration transcript hereditary

Reproductive seasonality of Astyanax mexicanus cavefish

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Zoological Research 2023年第4期44卷 698-700页

作者： Luis Espinasa nicolas Rohner Sylvie Rétaux School of Science Marist CollegePoughkeepsieNY 12601USA Stowers Institute for Medical Research Kansas CityMO 64110USA Department of Molecular and Integrative Physiology University of Kansas Medical CenterKansas CityKS 66160USA Paris-Saclay Institute of Neuroscience CNRS and UniversitéParis-SaclaySaclay 91400France

DEAR EDITOR,The characiform fish Astyanax is a well-studied model system for understanding evolutionary development and genomics in cave ***,considerable gaps remain in our understanding of its field ***,we conducted a fouryear field study and found that while cavefish spawned yearround,reproductive peaks occurred in January to February.

关键词： cave ecology fish

Enzymatic debridement shall not modify the global strategy for mass burn events

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军事医学研究:英文版 2023年第4期10卷 554-555页

作者： nicolas Donat Thomas Leclerc Stian Kreken Almeland Burn Treatment Centre Percy Military Teaching Hospital92140 ClamartFrance Val-de-Grâce Military Medical Academy 75005 ParisFrance Norwegian National Burn Center Department of PlasticHand and Reconstructive SurgeryHaukeland University Hospital5021 BergenNorway

We read with interest the letter by Surowiecka et al.[1]about early burn wound excision in mass casualty *** couldn’t agree more with their statement about the benefit of early burn wound ***,we doubt whether applying this strategy to every patient during a mass burn event could be *** note,while there is an undisputed consensus that early burn wound excision is the gold standard of burn care,what‘early’actually means is still *** on the authors,the corresponding time limit typically varies from 24 h to a few days[2,3].

关键词： Enzymatic debridement(ED) Burn care Mass causality Burn surgery

The Impact of Meetings on the Network Governance and Mobility of UN Policy Programs on Environment and Education

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ECNU Review of Education 2023年第4期6卷 597-622页

作者： nicolas Stahelin Marcia McKenzie University of Saskatchewan University of Melbourne

Purpose:This paper adds to the understandings of how face-to-face meetings contribute to the network governance and global mobility of United Nations(UN)policy programs on environmental and sustainability education(ESE).Design/Approach/Methods:Data from interviews with 13 international ESE policy leaders were transcribed,coded,and analyzed for key themes related to the research ***:The findings indicate that meetings provide an arena for collaboration and influence on UN ESE policy programs,as well as facilitating the impact of the policy programs on UN member country *** addition,attending meetings enables the production of network relations that bind ESE policy communities together across distant *** are also a venue for the networking labor involved in forging new relationships and facilitating the social learning that supports global policy ***/Value:This pilot study enriches understanding of face-to-face meetings as a key vector of policy mobility and a significant factor in the overall network governance of UN organizations and their policy *** hope the study contributes to the fields of critical policy studies and ESE,as well as to informing policy actors on how important their participation in meetings can be for the network governance and mobility of UN policy programs.

关键词： Environmental education international organizations network ethnography network governance policy mobilities sustainability education