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Big data in healthcare:Conceptual network structure,key challenges and opportunities

数字通信与网络:英文版 2023年第4期9卷 856-868页

作者： Leonardo B.Furstenaua Pedro Leivas Michele Kremer Sott Michael S.Dohan Jose Ricardo Lopez-Robles Manuel J.Cobo nicola luigi bragazzi Kim-Kwang Raymond Choo Post-Graduate Program in Industrial Engineering Federal University of Rio Grande Do SulPorto Alegre90035-190Brazil University of Santa Cruz Do Sul Av.Independencia 2293Santa Cruz Do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Faculty of Business Administration Lakehead UniversityThunder BayOntarioCanada Autonomous University of Zacatecas Av.Ramon Lopez Velarde Col.CentroZacatecas98000Mexico Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain York University ON M3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Big data is a concept that deals with large or complex data sets by using data analysis tools(e.g.,data mining,machine learning)to analyze information extracted from several sources *** data has attracted wide attention from academia,for example,in supporting patients and health professionals by improving the accuracy of decision-making,diagnosis and disease *** research aimed to perform a Bibliometric Performance and Network Analysis(BPNA)supported by a Scoping Review(SR)to depict the strategic themes,thematic evolution structure,main challenges and opportunities related to the concept of big data applied in the healthcare *** this goal in mind,4857 documents from the Web of Science covering the period between 2009 to June 2020 were analyzed with the support of SciMAT *** bibliometric performance showed the number of publications and citations over time,scientific productivity and the geographic distribution of publications and research *** strategic diagram yielded 20 clusters and their relative importance in terms of centrality and *** thematic evolution structure presented the most important themes and how it changes over ***,we presented the main challenges and future opportunities of big data in healthcare.

关键词： Big data Healthcare digitalization Bibliometric Strategic intelligence Co-word analysis SciMAT

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Internet of things:Conceptual network structure,main challenges and future directions

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Digital Communications and Networks 2023年第3期9卷 677-687页

作者： Leonardo B.Furstenau Yan Pablo Reckziegel Rodrigues Michele Kremer Sott Pedro Leivas Michael S.Dohan José Ricardo López-Robles Manuel J.Cobo nicola luigi bragazzi Kim-Kwang Raymond Choo Department of Industrial Engineering Federal University of Rio Grande do SulPorto Alegre 90035-190Brazil University of Santa Cruz do Sul Av.Independencia2293Santa Cruz do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Lakehead University Thunder BayONP7B 5E1Canada Academic Unit of Accounting and Management Autonomous University of ZacatecasCalle Comercio y Administracion S/NFracc.ProgresoC.P.98066ZacatecasZacatecasMexico Department of Computer Science and Artificial Intelligence University of Granada18071 GranadaSpain York University ONM3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Internet of Things(IoT)is a key technology trend that supports our digitalized society in applications such as smart countries and smart *** this study,we investigate the existing strategic themes,thematic evolution structure,key challenges,and potential research opportunities associated with the *** this study,we conduct a Bibliometric Performance and Network Analysis(BPNA),supplemented by an exhaustive Systematic Literature Review(SLR).Specifically,in BPNA,the software SciMAT is used to analyze 14,385 documents and 30,381 keywords in the Web of Science(WoS)database,which was released between 2002 and *** results reveal that 31 clusters are classified according to their importance and development,and the conceptual structures of key clusters are presented,along with their performance analysis and the relationship with other *** thematic evolution structure describes the important cluster(s)over *** the SLR,23 documents are *** SLR reveals key challenges and limitations associated with the *** expect the results will form the basis of future research and guide decision-making in the IoT and other supporting industries.

关键词： Internet of things Strategic intelligence Industry 4.0 SciMAT Bibliometric analysis Science mapping

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Nanotechnology meets atopic dermatitis: Current solutions, challenges and future prospects. Insights and implications from a systematic review of the literature

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Bioactive Materials 2019年第1期4卷 380-386页

作者： Giovanni Damiani Roberto Eggenhöffner Paolo Daniele Maria Pigatto nicola luigi bragazzi Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilanItaly Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilanItaly Department of Dermatology Case Western Reserve UniversityClevelandOHUSA Young Dermatologists Italian Network Centro Studi GISEDBergamoItaly Department of Surgical Sciences and Integrated Diagnostics University of GenoaGenoaItaly Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoaItaly Laboratory for Industrial and Applied Mathematics(LIAM) Department of Mathematics and StatisticsYork UniversityTorontoOntarioCanada Department of Neuroscience RehabilitationOphthalmologyGenetics and Maternal/Child Sciences(DINOGMI)University of GenoaGenoaItaly

Atopic dermatitis is a chronic,relapsing,non-contiguous,exudative eczema/dermatitis,which represents a complex,multi-factorial disorder,due to an impairment of the stratum corneum *** available drugs have a low skin bioavailability and may give rise to severe adverse ***,including nanoparticles,liposomes,nano-gels,nano-mixtures,nano-emulsions and other nano-carriers,offer unprecedented solutions to these issues,enabling:i)the management of different clinical forms of atopic dermatitis,especially the recalcitrant ones,i)a better bio-availability and trans-dermal drug targeted delivery at the inflammation site,ii)dose control,iii)significant improvements both in clinical symptoms and immune responses,iv)with less adverse events being reported and a better safety ***,some nano-sized structures could amplify and even worsen symptoms in particularly susceptible ***,most studies included in the present systematic review have been conducted in-vitro or in-vivo,with few randomized controlled clinical trials(RCTs).Future investigations should adopt this design in order to enable scholars achieving robust findings and ***,given the above-mentioned shortcomings,further research in the field is urgently warranted.

关键词： Nanodermatology Nanobiotechnologies Atopic dermatitis

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Canada needs to rapidly escalate public health interventions for its COVID-19 mitigation strategies

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Infectious Disease Modelling 2020年第1期5卷 316-322页

作者： Francesca Scarabel Lorenzo Pellis nicola luigi bragazzi Jianhong Wu Laboratory for Industrial and Applied Mathematics Department of Mathematics and StatisticsYork UniversityTorontoOntarioM3J1P3Canada CDLab-Computational Dynamics Laboratory Department of MathematicsComputer Science and PhysicsUniversity of Udinevia delle scienze 20633100UdineItaly School of Mathematics University of ManchesterManchesterM139PLUK Fields-CQAM Laboratory of Mathematics for Public Health York UniversityTorontoOntarioCanadaM3J 1P3

Background:After the declaration of COVID-19 pandemic on March 11th,2020,local transmission chains starting in different countries including Canada are forcing governments to take decisions on public health interventions to mitigate the spread of the ***:We conduct data-driven and model-free estimations for the growth rates of the COVID-19 epidemics in Italy and Canada,by fitting an exponential curve to the daily reported *** use these estimates to predict epidemic trends in Canada under different scenarios of public health ***:In Italy,the initial growth rate(0.22)has reduced to 0.1 two weeks after the lockdown of the country on March 8th,*** corresponds to an increase of the doubling time from about 3.15 to almost 7 *** comparison,the growth rate in Canada has increased from 0.13 between March 1st and 13th,to 0.25 between March 13th to *** current growth rate corresponds to a doubling time of 2.7 days,and therefore,unless further public health interventions are escalated in Canada,we project 15,000 cases by March ***,the case number may be reduced to 4000 if escalated public health interventions could instantly reduce the growth rate to 0.1,the same level achieved in ***:Prompt and farsighted interventions are critical to counteract the very rapid initial growth of the COVID-19 epidemic in *** plans must take into account the delayed effect of interventions by up to 2-weeks and the short doubling time of 3e4 days.

关键词： Canada doubling starting

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An updated estimation of the risk of transmission of the novel coronavirus(2019-nCov)

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Infectious Disease Modelling 2020年第1期5卷 248-255页

作者： Biao Tang nicola luigi bragazzi Qian Li Sanyi Tang Yanni Xiao Jianhong Wu The Interdisplinary Research Center for Mathematics and Life Sciences Xi’an Jiaotong UniversityXi’an710049People’s Republic of China Laboratory for Industrial and Applied Mathematics Department of Mathematics and StatisticsYork UniversityTorontoOntarioM3J 1P3Canada School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an710049People’s Republic of China School of Mathematics and Information Science Shaanxi Normal UniversityXi’an710119People’s Republic of China Fields-CQAM Laboratory of Mathematics for Public Health York UniversityTorontoOntarioM3J 1P3Canada

The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period,in a naïve,uninfected *** is well-known that the estimation of this number may vary due to several methodological issues,including different assumptions and choice of parameters,utilized models,used datasets and estimation *** the spreading of the novel coronavirus(2019-nCoV)infection,the reproduction number has been found to vary,reflecting the dynamics of transmission of the coronavirus outbreak as well as the case reporting *** to significant variations in the control strategies,which have been changing over time,and thanks to the introduction of detection technologies that have been rapidly improved,enabling to shorten the time from infection/symptoms onset to diagnosis,leading to faster confirmation of the new coronavirus cases,our previous estimations on the transmission risk of the 2019-nCoV need to be *** using time-dependent contact and diagnose rates,we refit our previously proposed dynamics transmission model to the data available until January 29th,2020 and re-estimated the effective daily reproduction ratio that better quantifies the evolution of the *** estimated when the effective daily reproduction ratio has fallen below 1 and when the epidemics will *** updated findings suggest that the best measure is persistent and strict *** epidemics will continue to grow,and can peak soon with the peak time depending highly on the public health interventions practically implemented.

关键词： Novel coronavirus Emerging and reemerging pathogens Mathematical modeling Basic reproduction number Effective daily reproduction ratio

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Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes

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Infectious Diseases of Poverty 2015年第1期4卷 474-486页

作者： Cristiano Alicino nicola luigi bragazzi Valeria Faccio Daniela Amicizia Donatella Panatto Roberto Gasparini Giancarlo Icardi Andrea Orsi Department of Health Sciences(DISSAL) University of GenoaGenoa 16132Italy Hygiene Unit IRCCS AOU San Martino–IST of GenoaGenoa 16132Italy

Background:The 2014 Ebola epidemic in West Africa has attracted public interest worldwide,leading to millions of Ebola-related Internet searches being performed during the period of the *** study aimed to evaluate and interpret Google search queries for terms related to the Ebola outbreak both at the global level and in all countries where primary cases of Ebola *** study also endeavoured to look at the correlation between the number of overall and weekly web searches and the number of overall and weekly new cases of ***:Google Trends(GT)was used to explore Internet activity related to *** study period was from 29 December 2013 to 14 June ***’s correlation was performed to correlate Ebola-related relative search volumes(RSVs)with the number of weekly and overall Ebola *** regression was performed using Ebola-related RSV as a dependent variable,and the overall number of Ebola cases and the Human Development Index were used as predictor ***:The greatest RSV was registered in the three West African countries mainly affected by the Ebola *** queries varied in the different *** quantitative and qualitative differences between the affected African countries and other Western countries with primary cases were noted,in relation to the different flux volumes and different time *** the affected African countries,web query search volumes were mostly concentrated in the capital ***,in Western countries,web queries were uniformly distributed over the national *** terms of the three countries mainly affected by the Ebola epidemic,the correlation between the number of new weekly cases of Ebola and the weekly GT index varied from weak to *** correlation between the number of Ebola cases registered in all countries during the study period and the GT index was very ***:Google Trends showed a coarse-grained nature,strongly correlating with global

关键词： Ebola Google Trends Human Development Index Internet Relative search volume Web West Africa

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Gut microbiota and nutrient interactions with skin in psoriasis:A comprehensive review of animal and human studies

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World Journal of Clinical Cases 2020年第6期8卷 1002-1012页

作者： Giovanni Damiani nicola luigi bragazzi Thomas S McCormick Paolo Daniele Maria Pigatto Sebastiano Leone Alessia Pacifico Danica Tiodorovic Sveva Di Franco Aniello Alfieri Marco Fiore Department of Dermatology Case Western Reserve UniversityClevelandOH 44106United States Clinical Dermatology IRCCS Istituto Ortopedico GaleazziMilan 20122Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20122Italy Postgraduate School of Public Health Department of Health SciencesUniversity of GenoaGenoa 16132Italy Department of Medicine Division of Infectious diseases“San Giuseppe Moscati”HospitalAvellino 83100Italy San Gallicano Dermatological Institute IRCCSRome 00144Italy Dermatology Clinic Medical FacultyNis UniversityNis 18000Serbia Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy

The intestinal tract(i.e.,the gut),is where the body’s nutrients are absorbed,and is simultaneously inhabited by numerous *** increasing body of literature suggests a crucial role for the gut microbiome in modulating systemic inflammatory *** is a chronic systemic inflammatory disease and its pathogenesis is related to the interaction between genetic susceptibility,immune response and environmental *** omics era has allowed physicians to assess different aspects of psoriasis pathogenesis such as the microbiome,infectome,and ***,diet appears to play an important role in modulating disease activity,perhaps by influencing gut *** these observations,we aimed to summarize the current knowledge regarding skin-microbiome-gut-nutrients and psoriasis.

关键词： Gut Microbiota Nutrients Endotypes Exposome Psoriasis

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Prevalence of hepatitis C virus among street children in Iran

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Infectious Diseases of Poverty 2018年第1期7卷 897-902页

作者： Masoud Behzadifar Hasan Abolghasem Gorji Aziz Rezapour nicola luigi bragazzi Department of Health Services Management School of Health Management and Information SciencesIran University of Medical SciencesTehranIran Health Management and Economics Research Center Iran University of Medical SciencesTehranIran School of Public Health Department of Health Sciences(DISSAL)University of GenoaGenoaItaly

Background:Street children are forced to spend a lot of time away from their homes and some of them do not have homes at all,due to economic and family problems,which makes them exposed to many health problems,such as the hepatitis C virus(HCV)***,like many other countries in the world,experiences the burden of street children,however,the rate of HCV among street children is virtually *** study aimed to determine the prevalence of HCV among street children in *** body:This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** study protocol of this review was registered in PROSPERO under identification term CRD42018082336.A comprehensive literature search was conducted to identify published studies reporting on the prevalence of HCV among street children in *** international scholarly databases,including Web of Science,PubMed^(■)/MEDLINE^(■),Embase,Scopus®,Google Scholar and Directory of Open Access Journals,as well as Iranian databases such as MagIran and Barakathns were *** published between 1988 and December 2017 with any of the following keywords were selected:(street OR homeless OR labour)AND(children OR child OR infant)AND(hepatitis C OR hepatitis C virus OR HCV OR viral hepatitis OR hepatitis OR hepacivirus)AND ***,a grey literature search was performed in order to obtain other potentially relevant *** search was carried out without any language *** studies,surveying a total of 1691 street children,conducted between 2006 and 2017 were found to be eligible for inclusion in the review and therefore *** studies were conducted in Tehran and one in *** prevalence of HCV among street children in Iran was found to be high,at 2.4%(95%CI:1.8-3.3).Conclusions:Since the prevalence of HCV among street children in Iran is quite high,health decision-and policy-makers should pay more

关键词： Systematic review Meta-analysis Hepatitis C virus Street children Iran

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Transurethral prostate surgery in prostate cancer patients: A population-based comparative analysis of complication and mortality rates

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Asian Journal of Urology 2024年第1期11卷 48-54页

作者： Michele Marchioni Giulia Primiceri Alessandro Veccia Marta Di nicola Umberto Carbonara Fabio Crocerossa Ugo Falagario Ambra Rizzoli Riccardo Autorino luigi Schips Laboratory of Biostatistics Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly Urology Unit Department of MedicalOral and Biotechnological Sciences“G.d'Annunzio”University of ChietiChietiItaly Division of Urology VCU HealthRichmondVAUSA

Objective:Prostate cancer(PCa)patients might experience lower urinary tract symptoms as those diagnosed with benign prostatic hyperplasia(BPH).Some of them might be treated for their lower urinary tract symptoms instead of *** aimed to test the effect of PCa versus BPH on surgical outcomes after transurethral prostate surgery,namely complication and mortality ***:Within the American College of Surgeons National Surgical Quality Improvement Program database(2011-2016),we identified patients who underwent transurethral resection of the prostate,photoselective vaporization,or laser *** were stratified according to postoperative diagnosis(PCa ***).Univariable and multivariable logistic regression models evaluated the predictors of perioperative morbidity and mortality.A formal test of interaction between diagnosis and surgical technique used was ***:Overall,34542 patients were *** all,2008(5.8%)had a diagnosis of *** multivariable logistic regression model failed to show statistically significant higher rates of postoperative complications in PCa patients(odds ratio:0.9,95%confidence interval:0.7-1.1;p=0.252).Moreover,similar rates of perioperative mortality(p=0.255),major acute cardiovascular events(p=0.581),transfusions(p=0.933),and length of stay of more than or equal to 30 days(p=0.174)were ***,all tests failed to show an interaction between post-operative diagnosis and surgical technique ***:Patients diagnosed with PCa do not experience higher perioperative morbidity or mortality after transurethral prostate surgery when compared to their BPH ***,the diagnosis seems to not influence surgical technique outcomes.

关键词： Prostatecancer Transurethral surgery of the prostate Prostate surgery Population-based analysis Benign prostatic hyperplasia Lasersurgery

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新型冠状病毒肺炎疫情数据挖掘与离散随机传播动力学模型分析

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中国科学：数学 2020年第8期50卷 1071-1086页

作者：唐三一唐彪 nicola luigi bragazzi 夏凡李堂娟何莎任鹏宇王霞向长城彭志行吴建宏肖燕妮陕西师范大学数学与信息科学学院西安710062 Department of Mathematics and Statistics York UniversityToronto M3J 1P3Canada 西安交通大学数学与统计学院数学与生命科学交叉中心西安710049 西安交通大学第二附属医院西安710004 湖北民族大学数学与统计学院恩施440015 南京医科大学公共卫生学院南京211166

新型冠状病毒肺炎(COVID-19)疫情已经蔓延至全国各地,包括陕西省在内很多省份的早期疫情均以输入病例为主,后期的疫情在严格的防控措施下也已呈下降趋势.评价防控措施的有效性、分析人口流动对疫情的影响对于研究陕西省(或其他以输入病... 详细信息

新型冠状病毒肺炎(COVID-19)疫情已经蔓延至全国各地,包括陕西省在内很多省份的早期疫情均以输入病例为主,后期的疫情在严格的防控措施下也已呈下降趋势.评价防控措施的有效性、分析人口流动对疫情的影响对于研究陕西省(或其他以输入病例为主的地区)疫情和未来应对突发性传染病有着重要的意义.根据陕西省卫生健康委员会(简称卫健委)公布的详实数据信息可以挖掘传播链(感染树),得到从发病到首诊、入院、确诊的中位持续时间,每日潜伏者类、感染者类、治疗者类的具体人数和感染者状态转移的空间分布.本文计算确定COVID-19疫情的控制再生数(1.48–1.69),并发展新的统计推断方法获得陕西省严控措施下的有效再生数;进而提出一个全新的融入了公共卫生干预和输入病例的离散随机COVID-19疫情传播模型,通过多源数据实现了模型的参数化,分析不同的流动模式、输入人口中感染者的比例对二次暴发风险的影响.主要结论显示,间歇性的人口流动、密切关注和有效隔离流动人口中的感染者能有效降低二次暴发的风险,为有序组织复工、复学提供决策支持.

关键词：新型冠状病毒肺炎输入病例离散随机模型有效再生数人口流动

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