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Robotic transanal total mesorectal excision:Is the future now?

World Journal of Gastrointestinal Surgery 2021年第8期13卷 834-847页

作者： Juan Carlos Sebastián-Tomás Aleix Martínez-Pérez Elías Martínez-López nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero Department of Surgery Universidad de ValenciaValencia 46010Spain Department of General and Digestive Surgery Hospital Universitario Doctor PesetValencia 46017Spain Faculty of Health Sciences Valencian International UniversityValencia 46002Spain Minimally Invasive and Robotic Digestive Surgery Unit Miulli HospitalAcquaviva delle Fonti 70021Italy Department of General and Digestive Surgery Hospital Universitario Marqués de ValdecillaSantander 39008Spain Grupo de Investigación en Innovación Quirúrgica Instituto de Investigación Biomédica Valdecilla(IDIVAL)Santander 39008Spain Department of General and Digestive Surgery Hospital Universitarioy Politécnico la FeValencia 46026Spain

Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal *** invasive TME has been gaining ground favored by the continuous technological *** procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow *** earliest TaTME reports showed promising results when compared with the conventional laparoscopic ***,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national *** TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and *** short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional *** present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach.

关键词： Rectal cancer Minimally-invasive surgery Robotics Total mesorectal excision Transanal approach Natural orifice surgery

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PURIFICATION OF BLOOD ULTRAFILTRATE ON UNCOATED CHARCOAL

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中华医学杂志(英文版) 1988年第6期101卷 443-443页

作者： laura Politi nicola Cerullio Anna Rita D'Angeloo Roberto Scandurra Dipartitmento di Scienze Biochimiche and Istituto di Uroilogiao Universita "La Sapienza" Roma Italy

Dialysis is an insufficient depurative procedure since many substances are poorly removed. To improve the depuration, uremic patients were daily treated with 3-hour perfusion on uncoated granular charcoal (0.5 Kg) followed by 1-hour dialysis for 16 times for the removal of urea and electrolytes not absorbed by charcoal. The results showed that a granular uncoated charcoal removed from uremic ultrafiltrates many chemical species which were scarcely removed by dialysis. The conditions of the patients were improved and could be maintained for one-week charcoal treatment between two dialyses. This depurative procedure has been well documented by chromatography on Biogel P2.

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Synthesis and Characterization of A Dinuclear Europium Complex

Synthesis and Characterization of A Dinuclear Europium Compl...

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The Fifth International Conference on Rare Earth Development and Application

作者：周永慧郑佑轩 Gianluca Accorsi nicola Ammaroli State Key laboratory of Coordination Chemistry Nanjing University L’Istitutoper la Sintesi Organica e la Fotoreattività Il Consiglio Nazionale delle RicercheVia Gobetti10140129 BolognaItaly

A dinuclear Eu(Ⅲ) complex Eu(DBM)TPPD (Hexa(dibenzoyl-methanido)-(N,N,N;N-tetra(2-pyridyl)- 1,4-phenylenediamine)-dieuropium(Ⅲ)) was synthesized by employing DBM (dibenzoylmethane) and TPPD (N,N,N, N-Tetra(2-pyridyl)-1,4-phenyl-enediamine) as sensitizing ligands for the Eu(Ⅲ) ion and a bridging ligand,respective- *** analysis of the absorption,excitation,and emission spectra of the dinuclear complex along with a comparison with analogous mononuclear complex containing the same β-diketone ligands and 1,10-phenanthroline (phen) suggests that the dinuclear complex follows the luminescence mechanism of general Ln (Ⅲ) complexes.

关键词： dinuclear bridging ligand luminescence

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以生物标记为指导的神经退行性疾病分类表（英文）

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Journal of Sport and Health Science 2016年第4期5卷 383-387页

作者： Filippo Baldacci Simone Lista Francesco Garaci Ubaldo Bonuccelli nicola Toschi Harald Hampel Department of Clinical and Experimental Medicine University of Pisa Institute of Memory and Alzheimer’s Disease(IM2A) Brain and Spine Institute(ICM) UMR S 1127Department of NeurologyPitié-Salpêtrière Hospital Sorbonne Universities Pierre and Marie Curie University AXA Research Fund and Pierre and Marie Curie University Chair IHU-A-ICM-Paris Institute of Translational Neuroscience Pitié-Salpêtrière Hospital Department of Biomedicine and Prevention Faculty of MedicineUniversity of Rome Tor Vergata San Raffaele Cassino Nursing Home Department of Radiology Athinoula A. Martinos Center for Biomedical ImagingMassachusetts General Hospital and Harvard Medical School

*** complex spectrum of neurodegenerative diseases Epidemiologic data indicate that neurodegenerative diseases(NDDs)show high prevalence with a trend of a progressively growing incidence,especially in aging *** presents an increasing social and economic *** individuals>60years of age,the prevalence of Alzheimer’s disease(AD)is estimated to be 40 of 1000 persons with an annual incidence

关键词： FTD

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Prevalence of gallstone disease in first-degree relatives of patients with cholelithiasis

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World Journal of Gastroenterology 2005年第41期11卷 6508-6511页

作者： Adolfo Francesco Attili Adriano De Santis Fabia Attili Enrico Roda Davide Festi nicola Carulli GI Unit Department of Clinical Medicine University of Roma "La Sapienza"Italy Department of Internal Medicine University of Bologna Italy Department of Internal Medicine University of Modena Italy

AIM: To evaluate the influence of familiality on the prevalence of gallstone disease (GD) in ***: Families of 79 subjects with gallstones (cases) and of 79 subjects without gallstones (controls)were investigated for the presence of gallstones by ultrasonography. Index cases and index controls were matched for age, sex, and operative unit. Sixty-three and sixty-two husbands and wives of index cases and index controls, respectively, were also ***: Overall,the prevalence of GD was significantly higher (X2=14.52, P＜0.001) in the 202 first-degree relatives of subjects with gallstones than that in the 201 first-degree relatives of subjects without gallstones (28.6% vs 12.4%, relative risk (RR) 1.80, 95% confidence interval (CI) 1.29-2.63). In particular,prevalence of GD was significantly higher in mothers,fathers, and sisters of index cases than that in the respective family members of index controls. The highest RR was observed in mothers (RR=2.35, 95%CI 1.38-4.3).Prevalence of GD was not obviously different in brothers and also in husbands and wives of index cases and index controls. Family members of index cases did not differ from family members of control cases with respect to the most important risk factors for gallstones (age, diabetes,BMI, and number of pregnancies) with an exception of a higher prevalence of diabetes in fathers of index controls than in fathers of index ***: This study confirms that familiality plays a very important role in the pathogenesis of gallstones.

关键词：胆结石病理机制治疗临床表现

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High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross- sectional survey

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General Psychiatry 2021年第5期34卷 31-41,I0006-I0025页

作者： Natasha Smallwood Leila Karimi Marie Bismark Mark Putland Douglas Johnson Shyamali Chandrika Dharmage Elizabeth Barson nicola Atkin Claire Long Irene Ng Anne Holland Jane E Munro Irani Thevarajan Cara Moore Anthony McGillion Debra Sandford Karen Willis Department of Respiratory Medicine Alfred HospitalPrahranVictoriaAustralia Department of Allergy Immunology and Respiratory MedicineCentral Clinical SchoolAlfred HospitalMonash UniversityMelbourneVictoriaAustralia School of Psychology and Public Health La Trobe UniversityMelbourneVictoriaAustralia School of Medicine and Healthcare Management Caucasus UniversityTbilisiGeorgia Department of Psychiatry The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Public Health law Melbourne School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Emergency Services The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Critical Care Faculty of MedicineDentistry and Health SciencesThe University of MelbourneMelbourneVictoriaAustralia Departments of General Medicine and Infectious Diseases The Royal Melbourne HospitalParkvilleVictoriaAustralia Department of Medicine The Royal Melbourne HospitalThe University of MelbourneParkvilleVictoriaAustralia Allergy and Lung Health Unit School of Population and Global HealthThe University of MelbourneParkvilleVictoriaAustralia Department of Allied Health The Royal Melbourne HospitalParkvilleVictoriaAustralia Parkville Integrated Palliative Care Service The Royal Melbourne HospitalParkvilleVictoriaAustralia Sir Peter MacCallum Department of Oncology The University of MelbourneParkvilleVictoriaAustralia Department of Geriatric Medicine Western HealthFootscrayVictoriaAustralia Department of Anaesthesia and Pain Management The Royal Melbourne HospitalParkvilleVictoriaAustralia Centre for Integrated Critical Care Melbourne Medical SchoolThe University of MelbourneParkvilleVictoriaAustralia Department of Physiotherapy Alfred HealthMelbourneVictoriaAustralia Rheumatology Unit Royal Children's HospitalParkvilleVictoriaAustralia Arthritis and Rheumatology Murdoch Children's Research InstituteParkvilleVictoriaAustralia Department of Infectious Diseases T

Background The coronavirus disease 2019(COVID-19)pandemic has had a profound and prolonged impact on healthcare services and healthcare *** The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the severity and prevalence of mental health issues,as well as the social,workplace and financial disruptions experienced by Australian healthcare workers during the COVID-19 *** A nationwide,voluntary,anonymous,single timepoint,online survey was conducted between 27 August and 23 October *** self-identifying as frontline healthcare workers in secondary or primary care were invited to *** were recruited through health organisations,professional associations or colleges,universities,government contacts and national ***,home and work situation,health and psychological well-being data were *** A total of 9518 survey responses were received;of the 9518 participants,7846(82.4%)participants reported complete *** regard to age,4110(52.4%)participants were younger than 40 years;6344(80.9%)participants were *** were nurses(n=3088,39.4%),doctors(n=2436,31.1%),allied health staff(n=1314,16.7%)or in other roles(n=523,6.7%).In addition,1250(15.9%)participants worked in primary *** measured mental health symptoms were common:mild to severe anxiety(n=4694,59.8%),moderate to severe burnout(n=5458,70.9%)and mild to severe depression(n=4495,57.3%).Participants were highly resilient(mean(SD)=3.2(0.66)).Predictors for worse outcomes on all scales included female gender;younger age;pre-existing psychiatric condition;experiencing relationship problems;nursing,allied health or other roles;frontline area;being worried about being blamed by colleagues and working with patients with *** The COVID-19 pandemic is associated with significant mental health symptoms in frontline healthcare *** preparedness together with policies and pra

关键词： distress nurse workers

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法律起源的经济后果（下）

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理论经济学 2010年第12期

作者： Rafael la porta Lopez-de-Silanes Shleifer

过去10年里，经济学家发表的大量研究表明，一国法律的历史起源与它的法规、规范在多个方面高度关联，同时亦与其经济结果密切相关。本文总结了此领域的研究成果并试图给出一个统一的解析。对于“法律起源是重要的”这一经验性结论的反...

过去10年里，经济学家发表的大量研究表明，一国法律的历史起源与它的法规、规范在多个方面高度关联，同时亦与其经济结果密切相关。本文总结了此领域的研究成果并试图给出一个统一的解析。对于“法律起源是重要的”这一经验性结论的反对意见，我们也给予了评述。最后，我们对本研究在经济改革中的应用进行了评估。

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Sustained virological response: A milestone in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2013年第18期19卷 2793-2798页

作者： Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino laura Donnarumma laura Gaeta Ilaria Loperto Ivan Gentile Francesco Auriemma nicola Caporaso Dipartimento di Medicina Clinica e Chirurgia Gastroenterology Unit University of Naples "Federico Ⅱ" 80131 Naples Italy Dipartimento di Malattie Infettive e Tropicali University of Rome "La Sapienza" 00161 Rome Italy Dipartimento di Medicina Clinica e Chirurgia Infectious Diseases Unit University of Naples "Federico Ⅱ" 80131 Naples Italy

AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples "Federico Ⅱ". At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33

关键词： Antiviral therapy Cirrhosis Hepatitis C virus Sustained virological response Fibrosis

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Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850

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Research in Astronomy and Astrophysics 2023年第10期23卷 367-386页

作者： Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates nicola Scafetta Jan-Erik Solheim LászlóSzarka Víctor M.Velasco Herrera Hong Yan Weijia Zhang Center for Environmental Research and Earth Science(CERES) SalemMA 01970USA Independent scientists DublinIreland Institute of Earth Physics and Space Science(EPSS) SopronHungary Retired formerly Harvard-Smithsonian Center for AstrophysicsCambridgeMA 02138USA Independent researcher MalmöSweden Retired formerly Armagh ObservatoryCollege HillArmagh BT619DGNorthern IrelandUK Comisión de Investigaciones Científicas de la Provincia de Buenos Aires Argentina Grupo de Estudios Ambientales Universidad Tecnológica NacionalColón 332San Nicolás(2900)Buenos AiresArgentina laboratorio de Ionosfera Atmosfera Neutra y Magnetosfera(LIANM)Facultad de Ciencias Exactas y TecnologíaUniversidad Nacional de TucumánAv.Independencia 18004000 TucumánArgentina Instituto de Física del Noroeste Argentino(Consejo Nacional de Investigaciones Científicas y Técnicas—Universidad Nacional de Tucumán) 4000 TucumánArgentina Faculty of Geography Lomonosov Moscow State UniversityLeninskie Gory St.1Moscow 119991Russia Helmut-Schmidt-University HamburgGermany Center of Excellence in Information Systems Tennessee State UniversityNashvilleTN 37209 USA Independent scientist Berkeley SpringsWVUSA Emeritus Professor in Physical Geography Department of GeosciencesUniversity of OsloNorway Professor Emeritus College of EarthOceanand the EnvironmentUniversity of DelawareNewark DE 19716-2541USA Department of Earth Sciences Environment and GeoresourcesUniversity of Naples Federico IIComplesso Universitario di Monte S.Angelovia Cinthia21I-80126 NaplesItaly Retired formerly Department of Physics and TechnologyUiT The Arctic University of Norway9037 TromsøNorway Instituto de Geofisica Universidad Nacional Autónoma de MéxicoCiudad UniversitariaCoyoacán04510México D.F.México State Key laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Department of Mathematics and Physics Shaoxing UniversityShaoxing 312000China

Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly *** Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data *** compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear *** argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution *** also objected that many of the published TSI data sets were ***,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et *** confirmed for all five ST data ***,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both.

关键词： Sun:activity (Sun:)solar-terrestrial relations Earth

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Coronary artery calcium score on low-dose computed tomography for lung cancer screening

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World Journal of Radiology 2014年第6期6卷 381-387页

作者： Teresa Arcadi Erica Maffei nicola Sverzellati Cesare Mantini Andrea I Guaricci Carlo Tedeschi Chiara Martini Ludovico la Grutta Filippo Cademartiri Department of Radiology SDN Foundation IRCCS 80131 Naples Italy Cardio-vascular Imaging Unit Department of Radiology Giovanni XXIII Clinic Monas-tier di Treviso 31050 Treviso Italy Department of Radiology Erasmus Medical Center University Rotterdam 3015 CE Ro-tterdam The Netherlands Department of Radiology Azienda Ospeda-liero-Universitaria 43100 Parma Italy Department of Radiology Università di Chieti 66100 Chieti Italy Department of Cardiology Università di Foggia 71121 Foggia Italy Department of Cardiology San Gennaro Hospi-tal Naples 80136 Napoli Italy Department of Radiology University of Palermo Italy

AIM: To evaluate the feasibility of coronary artery calcium score(CACS) on low-dose non-gated chest CT(ngCCT).METHODS: Sixty consecutive individuals(30 males; 73 ± 7 years) scheduled for risk stratification by means of unenhanced ECG-triggered cardiac computed to-mography(gCCT) underwent additional unenhanced ngCCT. All CT scans were performed on a 64-slice CT scanner(Somatom Sensation 64 Cardiac, Siemens, Germany). CACS was calculated using conventional methods/scores(Volume, Mass, Agatston) as previ-ously described in literature. The CACS value obtained were compared. The Mayo Clinic classification was used to stratify cardiovascular risk based on Agatston CACS. Differences and correlations between the two methods were compared. A P-value lation between the two values was always very high(Volume: r = 0.95; Mass: r = 0.97; Agatston: r = 0.98). Of the 6 patients with 0 Agatston score on gCCT, 2(33%) showed an Agatston score > 0 in the ngCCT. Of the 3 patients with 1-10 Agatston score on gCCT, 1(33%) showed an Agatston score of 0 in the ngCCT. Overall, 23(38%) patients were reclassified in a different car-diovascular risk category, mostly(18/23; 78%) shifting to a lower risk in the ngCCT. The estimated radiation dose was significantly higher for gCCT(DLP 115.8 ± 50.7 vs 83.8 ± 16.3; Effective dose 1.6 ± 0.7 mSv vs 1.2 ± 0.2 mSv; P lar risk groups should be taken into account.

关键词：冠的动脉钙 20 屏蔽的肺癌症高分辨率的计算断层摄影术 Unenhanced 胸计算了断层摄影术心血管的风险层化

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