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Wearable devices and IoT applications for symptom detection, infection tracking, and diffusion containment of the COVID-19 pandemic: a survey

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Frontiers of Information Technology & Electronic Engineering 2021年第11期22卷 1413-1442页

作者： Roberto DEFAZIO nicola ivan giannoccaro Miguel CARRASCO Ramiro VELAZQUEZ Paolo VISCONTI Department of Innovation Engineering University of SalentoLecce73100Italy Facultad de Ingeniería y Ciencias Universidad Adolfo IbáñezPeñalolénSantiago7941169Chile Facultad de Ingeniería Universidad PanamericanaAguascalientes20290Mexico

Until a safe and effective vaccine to fight the SARS-CoV-2 virus is developed and available for the global population, preventive measures, such as wearable tracking and monitoring systems supported by Internet of Things(IoT) infrastructures, are valuable tools for containing the pandemic. In this review paper we analyze innovative wearable systems for limiting the virus spread, early detection of the first symptoms of the coronavirus disease COVID-19 infection, and remote monitoring of the health conditions of infected patients during the quarantine. The attention is focused on systems allowing quick user screening through ready-to-use hardware and software components. Such sensor-based systems monitor the principal vital signs, detect symptoms related to COVID-19 early, and alert patients and medical staff. Novel wearable devices for complying with social distancing rules and limiting interpersonal contagion(such as smart masks) are investigated and analyzed. In addition, an overview of implantable devices for monitoring the effects of COVID-19 on the cardiovascular system is presented. Then we report an overview of tracing strategies and technologies for containing the COVID-19 pandemic based on IoT technologies, wearable devices, and cloud computing. In detail, we demonstrate the potential of radio frequency based signal technology, including Bluetooth Low Energy(BLE), Wi-Fi, and radio frequency identification(RFID), often combined with Apps and cloud technology. Finally, critical analysis and comparisons of the different discussed solutions are presented, highlighting their potential and providing new insights for developing innovative tools for facing future pandemics.

关键词： Wearable devices IoT health-monitoring applications Medical sensors COVID-19 pandemic Symptom detection

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Osteosarcopenia in autoimmune cholestatic liver diseases:Causes,management,and challenges

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World Journal of Gastroenterology 2022年第14期28卷 1430-1443页

作者： nicola Pugliese ivan Arcari Alessio Aghemo Andrea G Lania Ana Lleo Gherardo Mazziotti Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20090MilanItaly Division of Internal Medicine and Hepatology Department of GastroenterologyIRCCS Humanitas Research HospitalRozzano 20089MIItaly Department of Endocrinology Diabetology and Medical Andrology UnitIRCCS Humanitas Research HospitalRozzano 20089MIItaly

Primary biliary cholangitis and primary sclerosing cholangitis(PSC)are the most common cholestatic liver diseases(CLD)in adults and are both characterized by an immune *** primary biliary cholangitis is a model autoimmune disease,with over 90%of patients presenting very specific autoantibodies against mitochondrial antigens,PSC is considered an immune mediated *** is the most common bone disease in CLD,resulting in frequent fractures and leading to significant ***,sarcopenia is emerging as a frequent complication of chronic liver diseases with a significant prognostic impact and severe implications on the quality of life of *** mechanisms underlying osteoporosis and sarcopenia in CLD are still largely unknown and the association between these clinical conditions remains to be *** timely diagnosis,prevention,and management of osteosarcopenia are crucial to limit the consequences,there are no specific guidelines for management of osteoporosis and sarcopenia in patients with *** guidelines recommend screening for bone disease at the time of diagnosis of ***,the optimal monitoring strategies and treatments have not been defined yet and vary among *** herein aim to comprehensively outline the pathogenic mechanisms and clinical implications of osteosarcopenia in CLD,and to summarize expert recommendations for appropriate diagnostic and therapeutic approaches.

关键词： Cholestatic liver diseases Primary biliary cholangitis Primary sclerosing cholangitis Osteoporosis Sarcopenia

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Sustained virological response: A milestone in the treatment of chronic hepatitis C

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World Journal of Gastroenterology 2013年第18期19卷 2793-2798页

作者： Filomena Morisco Rocco Granata Tommaso Stroffolini Maria Guarino Laura Donnarumma Laura Gaeta Ilaria Loperto ivan Gentile Francesco Auriemma nicola Caporaso Dipartimento di Medicina Clinica e Chirurgia Gastroenterology Unit University of Naples "Federico Ⅱ" 80131 Naples Italy Dipartimento di Malattie Infettive e Tropicali University of Rome "La Sapienza" 00161 Rome Italy Dipartimento di Medicina Clinica e Chirurgia Infectious Diseases Unit University of Naples "Federico Ⅱ" 80131 Naples Italy

AIM: To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response. METHODS: One hundred and fifty subjects with chronic hepatitis C (CHC) or cirrhosis and sustained virological response (SVR) between the years of 1989 and 2008 were enrolled in a long-term clinical follow-up study at the Gastrointestinal and Liver Unit of the University Hospital of Naples "Federico Ⅱ". At the beginning of the study, the diagnosis of HCV infection was made on the basis of serum positivity for antibodies to HCV and detection of HCV RNA transcripts, while a diagnosis of chronic hepatitis was formulated using imaging techniques and/or a liver biopsy. SVR was achieved by interferon-based therapy, both conventional and pegylated, with and without ribavirin treatment. The patients were evaluated for follow-up at a median length of 8.6 years, but ranged from 2-19.9 years. Among them, 137 patients had pre-treatment CHC and 13 had cirrhosis. The patients were followed with clinical, biochemical, virological, and ultrasound assessments on a given schedule. Finally, a group of 27 patients underwent a liver biopsy at the beginning of the study and transient elastography at their final visit to evaluate changes in liver fibrosis. RESULTS: The median follow-up was 8.6 years (range 2-19.9 years). HCV RNA remained undetectable in all patients, even in patients who eventually developed liver-related complications, indicating no risk of HCV recurrence. Three liver-related complications were observed: two cases of hepatocellular carcinoma and one case of bleeding from esophageal varices resulting in an incidence rate of 0.23%/person per year. Further, all three complications took place in patients diagnosed with cirrhosis before treatment began. Only one death due to liver-related causes occurred, resulting in a mortality rate of 0.077% person per year. This amounts to a 99.33

关键词： Antiviral therapy Cirrhosis Hepatitis C virus Sustained virological response Fibrosis

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Comparison of Proton Shower Developments in the BGO Calorimeter of the Dark Matter Particle Explorer between GEANT4 and FLUKA Simulations

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Chinese Physics Letters 2020年第11期37卷 114-120页

作者：蒋维岳川崔明阳李翔袁强 Francesca Alemanno Paolo Bernardini Giovanni Catanzani 陈占方 ivan De Mitri 董铁矿 Giacinto Donvito David Francois Droz Piergiorgio Fusco Fabio Gargano 郭东亚 Dimitrios Kyratzis 雷仕俊刘杨 Francesco Loparco 马鹏雄 Giovanni Marsella Mario nicola Mazziotta 潘旭彭文溪 Antonio Surdo Andrii Tykhonov 魏逸丰余玉洪藏京京张亚鹏张永杰张云龙 Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Gran Sasso Science Institute(GSSI) Viale F.Crispi 7I-67100L'AquilaItaly Istituto Nazionale di Fisica Nucleare Laboratori Nazionali del Gran SassoVia G.Acitelli 22I-67100AssergiL'AquilaItaly Dipartimento di Matematica e Fisica E.De Giorgi Universitàdel SalentoI-73100 LecceItaly Istituto Nazionale di Fisica Nucleare(INFN)-Sezione di Lecce I-73100 LecceItaly INFN Section of Perugia I-06100 PerugiaItaly University of Perugia I-06100 PerugiaItaly Istituto Nazionale di Fisica Nucleare(INFN)-Sezione di Bari I-70125BariItaly Department of Nuclear and Particle Physics University of GenevaCH-1211Switzerland Dipartimento Interateneo“M.Merlin”dell'Universitàdegli Studi di Bari e del Politecnico di Bari I-70125BariItaly Dipartimento di Fisica e Chimica“E.Segrè” via delle Scienze Edificio 17UniversitàDegli Studi di PalermoI-90128PalermoItaly Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China

The DArk Matter Particle Explorer(DAMPE)is a satellite-borne detector for high-energy cosmic rays and *** fully understand the detector performance and obtain reliable physical results,extensive simulations of the detector are *** simulations are particularly important for the data analysis of cosmic ray nuclei,which relies closely on the hadronic and nuclear interactions of particles in the detector *** adopted simulation softwares include the GEANT4 and FLUKA,both of which have been implemented for the DAMPE simulation *** we describe the simulation tool of DAMPE and compare the results of proton shower properties in the calorimeter from the two simulation *** a comparison gives an estimate of the most significant uncertainties of our proton spectral analysis.

关键词： material. GEANT4 calorimeter

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Determinants of percutaneous coronary intervention success in repeat chronic total occlusion procedures following an initial failed attempt

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World Journal of Cardiology 2017年第4期9卷 355-362页

作者： Cecilia Cuevas nicola Ryan Alicia Quirós Juan Gustavo Del Angel Nieves Gonzalo Pablo Salinas Pilar Jiménez-Quevedo Luis Nombela-Franco ivan Nunez-Gil Antonio Fernandez-Ortiz Carlos Macaya Javier Escaned Cardiovascular Institute Hospital Clinico San Carlos28040 MadridSpain

AIM To investigate the rates and determinants of success of repeat percutaneous coronary intervention(PCI) following an initial failed attempt at recanalising the chronic total occlusions(CTO) *** In 445 consecutive first attempt CTO-PCI procedures in our institution,procedural failure occurred in 149(33.5%). Sixty-four re-PCI procedures were performed in 58 patients(39%) all had a single CTO. Procedural and outcome data in the re-PCI population was entered into the institutional database. A retrospective analysis of clinical,angiographic and procedural data was performed. RESULTS Procedural success was achieved in 41(64%) procedures. Univariate analysis of clinical and angiographic characteristics showed that re-PCI success was associated with intravascular ultrasound(IVUS) guidance(19.5% vs 0%,P = 0.042),while failure was associated with severecalcification(30.4% vs 9.7%,P = 0.047) and a JCTO score > 3(56.5% vs 17.1% P = 0.003). Following multiple regression analysis the degree of lesion complexity(J-CTO score > 3),IVUS use,involvement of an experienced CTO operator and LAD CTO location were significant predictors of successful re-PCI. Overall the complication rate was low,with the only MACCE two periprocedural MI's neither of which required intervention. CONCLUSION Re-PCI substantially increases the overall success rate of CTO revascularization. Predictors of re-PCI success included the use of IVUS,the involvement of an experienced CTO operator in the repeat attempt and the location of the CTO.

关键词： Repeat percutaneous coronary intervention Chronic total occlusion

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COVID-19 in the endoscopy unit:How likely is transmission of infection?Results from an international,multicenter study

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World Journal of Gastrointestinal Endoscopy 2021年第9期13卷 416-425页

作者： Ioannis S Papanikolaou Georgios Tziatzios Alexandros Chatzidakis Antonio Facciorusso Stefano Francesco Crinò Paraskevas Gkolfakis Gjorgi Deriban Mario Tadic Goran Hauser Antonios Vezakis ivan Jovanovic nicola Muscatiello Anna Meneghetti Konstantinos Miltiadou Kalina Stardelova Alojzije Lacković Maria-Zoi Bourou Srdjan Djuranovic Konstantinos Triantafyllou Hepatogastroenterology Unit 2nd Department of Internal Medicine-PropaedeuticNational and Kapodistrian University of Athens"Attikon"University General HospitalAthens 12462Greece Gastroenterology Unit Department of Surgical and Medical SciencesUniversity of Foggia AOUFoggia 1245Italy Gastroenterology and Digestive Endoscopy Unit The Pancreas InstituteUniversity of VeronaVerona 37138Italy Department of Gastroenterology Hepatopancreatology and Digestive OncologyErasme University HospitalUniversitéLibre de BruxellesBrussels 1070Belgium Department of Medical Oncology Institut Jules BordetBrussels 1000Belgium University Clinic of Gastroenterohepatology Medical FacultyUniversity"Ss.Cyril and Methodius"SkopjeSkopje 12345Republic of North Macedonia Department of Gastroenterology Dubrava University Hospital ZagrebZagreb 10040Croatia Clinical Hospital Center Rijeka Faculty of MedicineUniversity of RijekaRijeka 51000Croatia 2nd Department of Surgery Aretaieio HospitalSchool of MedicineNational and Kapodistrian University of AthensAthens 11528Greece Clinical Center of Serbia Clinic for Gastroenterology and HepatologyUniversity of Belgrade Faculty of MedicineBeograd 12345Serbia

BACKGROUND Coronavirus disease 2019(COVID-19)significantly affected endoscopy practice,as gastrointestinal endoscopy is considered a risky procedure for transmission of infection to patients and personnel of endoscopy units(PEU).AIM To assess the impact of COVID-19 on endoscopy during the first European lockdown(March-May 2020).METHODS Patients undergoing endoscopy in nine endoscopy units across six European countries during the period of the first European lockdown for COVID-19(March-May 2020)were *** to the endoscopy procedure,participants were stratified as low-or high-risk for potential COVID-19 infection according to the European Society of Gastrointestinal Endoscopy(ESGE)and the European Society of Gastroenterology and Endoscopy Nurses and Associates(ESGENA)joint statement,and contacted 7-14 d later to assess COVID-19 infection *** were questioned regarding COVID-19 symptoms and/or infection via questionnaire,while information regarding hospitalizations,intensive care unitadmissions and COVID-19-related deaths were *** number of weekly endoscopies at each center during the lockdown period was also *** A total of 1267 endoscopies were performed in 1222 individuals across nine European endoscopy departments in six ***-seven(7%)were excluded because of initial positive *** the 1135 pre-endoscopy low risk or polymerase chain reaction negative for COVID-19,254(22.4%)were tested post endoscopy and 8 were eventually found positive,resulting in an infection rate of 0.7%[95%CI:0.2-0.12].The majority(6 of the 8 patients,75%)had undergone *** the 163 PEU,5[3%;(95%CI:0.4-5.7)]tested positive during the study period.A decrease of 68.7%(95%CI:64.8-72.7)in the number of weekly endoscopies was recorded in all centers after March *** centers implemented appropriate personal protective measures(PPM)from the initial phases of the *** COVID-19 transmission in endoscopy unit

关键词： COVID-19 SARS-CoV-2 Gastrointestinal endoscopy Personal protection measures Transmission Lockdown

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