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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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World Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H W M Lemlijn-Slenter Karolina AP Wijnands Gijs van der Hamsvoort Luuk P van Iperen nico Wolter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BACKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuedered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health Chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

Laser material processing optimization using bayesian optimization: a generic tool

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Light(Advanced Manufacturing) 2024年第3期5卷 75-85页

作者： Tobias Menold Volkher Onuseit Matthias Buser Michael Haas nico Bär Andreas Michalowski Institut fuer Strahlwerkzeuge(IFSW) University of Stuttgart70569 StuttgartGermany Graduate School of Excellence advanced Manufacturing Engineering(GSaME) University of Stuttgart70569 StuttgartGermany

Optimizing laser processes is historically challenging,requiring extensive and costly *** solve this issue,we apply Bayesian optimization for process parameter optimization to laser cutting,welding,and *** demonstrate how readily available Bayesian optimization frameworks enable efficient optimization of laser processes with only modest expert *** studies on laser cutting,welding,and polishing highlight its adaptability to real-world manufacturing ***,the examples emphasize that with suitable cost functions and boundaries an acceptable optimization result can be achieved after a reasonable number of experiments.

关键词： Bayesian optimization Design of experiments Laser cutting Laser welding Laser polishing

Investigations on the aging behavior of transparent bioplastics for optical applications

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InfoMat 2020年第2期2卷 424-433页

作者： Jana Baltscheit nico Schmidt Finn Schröder Jörg Meyer Photonics and Materials Science Hamm-Lippstadt University of Applied ScienceLippstadtGermany Department of Natural Science Paderborn UniversityPaderbornGermany

In this study,the optical properties of transparent bioplastics have been *** long-term technological goal is to establish biopolymers in a new market segment for demanding optical applications and to contribute to a more sustainable economy.A collection of transparent bioplastics has been tested with respect to the long-term stability and the possibility of an application in optical components for LED *** focus of materials testing was on the influence of short wavelength visible radiation as well as thermal *** results show,that some materials may be candidates for subsequent feasibility *** the best of our knowledge,the application of such polymers in complex technical products and in particular in luminaires has not yet been *** use of bio-based plastics for optical components therefore represents a novelty and has a high development potential.

关键词： (blue)LED irradiance (photo)degradation biobased plastics renewable materials transparent optics

Prehabilitation prior to intestinal resection in Crohn’s disease patients:An opinion review

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World Journal of Gastroenterology 2022年第22期28卷 2403-2416页

作者： Michiel T J Bak Marit F E Ruiterkamp Oddeke van Ruler Marjo J E Campmans-Kuijpers Bart C Bongers nico L U van Meeteren C Janneke van der Woude Laurents P S Stassen Annemarie C de Vries Department of Gastroenterology and Hepatology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery IJsselland HospitalCapelle aan den IJssel 2906 ZCNetherlands Department of Surgery Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Gastroenterology and Hepatology University Medical Center Groningen and University of GroningenGroningen 9713 GZNetherlands Department of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6200 MDNetherlands Department of Epidemiology Care and Public Health Research InstituteMaastricht UniversityMaastricht 6200 MDNetherlands Department of Anaesthesiology Erasmus MC University Medical Center RotterdamRotterdam 3015 GDNetherlands Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

Patients with Crohn’s disease(CD)are at a considerable risk for intestinal *** 25%of patients with CD will undergo an intestinal resection within 10 years of *** complications after CD surgery have been reported in 20%-47%of the *** general and CD-related risk factors are associated with postoperative complications,and comprise non-modifiable(e.g.,age)and potentially modifiable risk factors(e.g.,malnutrition).Prehabilitation focuses on the preoperative period with strategies designed to optimize modifiable risk factors concerning the physical and mental condition of the individual *** aim of prehabilitation is to enhance postoperative recovery and return to or even improve preoperative functional *** improvement of nutritional status,physical fitness,cessation of smoking,psychological support,and critical revision of preoperative use of CD medication are important *** of the effect on postoperative outcome in CD patients are scarce,and guidelines lack recommendations on tailored *** this opinion review,we review the current evidence on the impact of screening and management of nutritional status,physical fitness,CD medication and laboratory values on the postoperative course following an intestinal resection in CD *** addition,we aim to provide guidance for individualized multimodal prehabilitation in clinical practice concerning these modifiable factors.

关键词： Crohn’s disease Prehabilitation strategies Nutrition Physical fitness Medication Laboratory values

Effects of undigested protein-rich ingredients on polarised small intestinal organoid monolayers

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1026-1032页

作者： Soumya K.Kar Bart van der Hee Linda M.P.Loonen nico Taverne Johanna J.Taverne-Thiele Dirkjan Schokker Mari A.Smits Alfons J.M.Jansman Jerry M.Wells Host Microbe Interactomics Group Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands Laboratory of Microbiology Wageningen University&ResearchStippeneng 46708 WE WageningenThe Netherlands Wageningen Livestock Research Wageningen University&ResearchDe Elst 16708 WD WageningenThe Netherlands

Here, we describe the use of monolayers of intestinal epithelial cells derived from intestinal organoids and transcriptomics to investigate the direct effects of dietary protein sources on epithelial function. Mechanically dissociated 3 D organoids of mouse duodenum were used to generate a polarized epithelium containing all cell types found in the tissue of origin. The organoid-derived cell monolayers were exposed to 4%(w/v) of ‘undigested(non-hydrolysed)-soluble' fraction of protein sources used as feed ingredients [soybean meal(SBM) and casein], or alternative protein sources(spray dried plasma protein, and yellow meal worm), or controls for 6 h prior to RNA isolation and transcriptomics. All protein sources altered expression of unique biological processes in the epithelial cells. Exposure of intestinal organoids to SBM downregulated expression of retinol and retinoid metabolic processes as well as cholesterol and lipid biosynthetic pathways, consistent with the reported hypotriglyceridaemic effect of soy protein in vivo. These findings support the use of intestinal organoids as models to evaluate complex interactions between dietary ingredients and the intestinal epithelium and highlights some unique host effects of alternative protein sources in animal feed and potentially human food.

关键词： Alternative protein sources Casein Intestinal organoids Organoids Soybean meal Spray dried plasma protein Transcriptomics Yellow meal worm

Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting

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World Journal of Gastroenterology 2006年第28期12卷 4504-4510页

作者： Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze nico P de Villiers Stephen Hough Department of Internal Medicine and Gastroenterology ImmunologyHepatology and GI- research laboratoryUniversity of PretoriaSouth Africa Department of Internal Medicine and Endocrinology University of StellenboschSouth Africa Department of Internal Medicine and Gastroenterology1 Hepatology and GI- research laboratoryUniversity of PretoriaSouth Africa Department of Hepatology and GI- research laboratory University of PretoriaSouth Africa Department of Chemical Pathology University of PretoriaSouth Africa Department of Ampath pathology PretoriaSouth Africa Department of Surgery Grootte Schuur HospitalUniversity of Cape TownSouth Africa MRC Liver Research Centre Grootte Schuur HospitalUniversity of Cape TownSouth Africa Department of Genecare Molecular Genetics Christiaan Barnard Memorial HospitalCape TownSouth Africa

AIM： TO study if T-cell activation related to portasystemic shunting causes osteoclast-mediated bone loss through RANKL-dependent pathways. We also investigated if T-cell inhibition using rapamycin would protect against bone loss in rats. METHODS： Portasystemic shunting was performed in male Sprague-Dawley rats and rapamycin 0.1 mg/kg was administered for 15 wk by gavage. Rats received powderized chow and supplemental feeds to prevent the effects of malnutrition on bone composition. Weight gain and growth was restored after surgery in shunted animals. At termination, biochemical parameters of bone turnover and quantitative bone histology were assessed. Markers of T-cell activation, inflammatory cytokine production, and RANKL-dependent pathways were measured. In addition, the roles of IGF-1 and hypogonadism were investigated. RESULTS： Portasystemic shunting caused low turnover osteoporosis that was RANKL independent. Bone resorbing cytokine levels, including IL-1, IL-6 and TNFα, were not increased in serum and TNFα and RANKL expression were not upregulated in PBMC. Portasystemic shunting increased the circulating CD8＋ T-cell population. Rapamycin decreased the circulating CD8＋ T-cell population, increased CD8＋ CD25＋ T-regulatory cell population and improved all parameters of bone turnover. CONCLUSION： Osteoporosis caused by portasystemic shunting may be partially ameliorated by rapamycin in the rat model of hepatic osteodystrophy.

关键词： Osteopenia Liver disease Portasystemic shunting T-lymphocyte Rapamycin

自动测定煤中的有机硫——扫描电子显微镜及能量扩散X射线微量分析的应用

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煤炭转化 1986年第4期 80-83页

作者： JanM.Timmer,nico van der Burgh,李伟雄荷兰全国自然科学研究中心荷兰应用科学研究协会技术部

用扫描电子显微镜结合能量扩散X射线显微分析全自动地测定煤中的有机硫。只要煤中的黄铁矿含量低,用这种方法得到的值就与通常传统的方法得到的值相当一致。然而,煤中的黄铁矿含量高时,这种分析方法给出的有机硫的值就相当低。其误差可... 详细信息

用扫描电子显微镜结合能量扩散X射线显微分析全自动地测定煤中的有机硫。只要煤中的黄铁矿含量低,用这种方法得到的值就与通常传统的方法得到的值相当一致。然而,煤中的黄铁矿含量高时,这种分析方法给出的有机硫的值就相当低。其误差可能系由于在湿法分析中黄铁矿杂质抽提的不完全,导致黄铁矿含量低,因而得出有机硫的值就高。本文提出的方法不仅主要作为测定有机硫的一种方法,还提供了另外的资料,如该法可在单个煤样和几种煤样的混合物之间进行鉴别。

关键词：有机硫百分数扫描电子显微镜煤样

增强治理而非推进民主:地方政府采纳参与式治理的原因

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国际行政科学评论（中文版） 2020年第3期 1-21页

作者：丹尼尔·库伯勒菲利普·E.罗查特吴秀允尼可·范德·海顿刘娟凤(译) 熊缨(审校) 瑞士苏黎世大学民主研究中心瑞士苏黎世大学政治学系不详

参与式治理的创新已经受到广泛的讨论,但其实施却鲜少得到检验。本文试图解释在既有民主制度的背景下,地方政府为什么要采取参与式治理。我们运用2000—2012年1505个瑞士城镇实行微型公众协商(min-publics)的数据库来验证5个关于实施参... 详细信息

参与式治理的创新已经受到广泛的讨论,但其实施却鲜少得到检验。本文试图解释在既有民主制度的背景下,地方政府为什么要采取参与式治理。我们运用2000—2012年1505个瑞士城镇实行微型公众协商(min-publics)的数据库来验证5个关于实施参与式治理的假设。研究发现,瑞士城镇中的微型公众协商是政策导向性的程序,只涉及一小部分市民。实施微型公众协商的城镇是那些没有"城镇大会"传统的地方,它们的公共服务存在增长压力,其特点是政治团体众多,政党和社区纽带强,且公共管理高度专业化。我们的结论是,参与式治理扩张的动力源于在集团利益强大且分裂的不利背景中提高治理水平的需求。

关键词：地方政府微型公众协商参与式治理瑞士