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From hardware store to hospital:a COVID-19-inspired,cost-effective,open-source,in vivo-validated ventilator for use in resource-scarce regions

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Bio-Design and Manufacturing 2022年第1期5卷 133-140页

作者： Matthew H.Park Yuanjia Zhu Hanjay Wang nicholas ATran Jinsuh Jung Michael JPaulsen Annabel M.Imbrie‑moore Samuel Baker Robert Wilkerson Mateo Marin‑Cuartas Danielle M.Mullis Y.Joseph Woo Department of Cardiothoracic Surgery Stanford UniversityFalk Cardiovascular Research Building CV-235300 Pasteur DriveStanfordCA 94305-5407USA Department of Mechanical Engineering Stanford UniversityStanfordCAUSA Department of Bioengineering Stanford UniversityStanfordCAUSA Department of Comparative Medicine Stanford UniversityStanfordCAUSA University Department of Cardiac Surgery Leipzig Heart CenterLeipzigGermany

Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients,and these shortages are especially devastating in developing *** help alleviate this strain,we have designed and tested the accessible low-barrier in vivo-validated economical ventilator(ALIVE Vent),a COVID-19-inspired,cost-effective,open-source,in vivo-validated solution made from commercially available *** ALIVE Vent operates using compressed oxygen and air to drive inspiration,while two solenoid valves ensure one-way flow and precise cycle *** device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large *** functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator *** large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation *** FiO2,respiratory rate,inspiratory to expiratory time ratio,positive-end expiratory pressure,and peak inspiratory pressure were successfully maintained within normal,clinically validated ranges,and the animals were recovered without any *** regions with limited access to ventilators,the ALIVE Vent can help alleviate shortages,and we have ensured that all used materials are publicly *** this pandemic has elucidated enormous global inequalities in healthcare,innovative,cost-effective solutions aimed at reducing socio-economic barriers,such as the ALIVE Vent,can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.

关键词： COVID-19 Ventilator Open-source

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Do intra-operative fluids influence the need for post-operative cardiotropic support after a PDA ligation？

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中国当代儿科杂志 2011年第1期13卷 1-7页

作者： Brigitte LEMYRE 刘玲 Gregory Paul moore Sarah Linda LAWRENCE nicholas J.BARROWMAN Department of Pediatrics University of Ottawa Department of Neonatology Children's Hospital of Guiyang

Objective To investigate the effect of intra-operative intravenous fluids on post-operative hemodynamic *** We performed a retrospective cohort study of 98 preterm infants who underwent a patent ductus arteriosus(PDA) ligation in one NICU between 2001 and *** primary outcome was the need for cardiotropic support within 24 hrs of *** Twenty-seven infants(28%) required post-operative cardiotropic *** amount of intra-operative fluids varied between 0 and 50.4 mL/kg(median:10.2 mL/kg).No intra-operative fluid was recorded in 26 *** were not associated with the need for post-operative cardiotropic support(P=0.10).Using a multivariate logistic regression model,age at ligation,weight at ligation and pre-operative FiO2 were significant predictors of post-operative cardiotropic *** Intra-operative fluids do not appear to be associated with the need for post-operative cardiotropic support.A prospective cohort study may help identify modifiable risk factors and improve outcomes in this population.

关键词：《中国当代儿科杂志》期刊摘要编辑部 PDA

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Cannabinoids function in defense against chewing herbivores in Cannabis sativa L.

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Horticulture Research 2023年第11期10卷 131-140页

作者： George M.Stack Stephen I.Snyder Jacob A.Toth Michael A.Quade Jamie L.Crawford John K.McKay John nicholas Jackowetz Ping Wang Glenn Philippe Julie L.Hansen Virginia M.moore Jocelyn K.C.Rose Lawrence B.Smart Horticulture Section School of Integrative Plant ScienceCornell UniversityCornell AgriTechGenevaNY 14456United States Plant Biology Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853United States Plant Breeding Section School of Integrative Plant ScienceCornell UniversityIthacaNY 14853United States Department of Agricultural Biology Colorado State UniversityFort CollinsCO 80523United States Cirona Labs GenevaNY 14456United States Department of Entomology Cornell UniversityCornell AgriTechGenevaNY 14456United States

In the decades since the first cannabinoids were identified by scientists,research has focused almost exclusively on the function and capacity of cannabinoids asmedicines and intoxicants for humans and other *** little is knownabout the adaptive value of cannabinoid production,though several hypotheses have been proposed including protection from ultraviolet radiation,pathogens,and *** test the prediction that genotypeswith greater concentrations of cannabinoidswill have reduced herbivory,a segregating F2 population of Cannabis sativa was leveraged to conduct lab-and field-based bioassays investigating the function of cannabinoids in mediating interactions with chewing *** the field,foliar cannabinoid concentration was inversely correlated with chewing herbivore *** detached leaves,Trichoplusia ni larvae consumed less leaf area and grew less when feeding on leaves with greater concentrations of *** electron and light microscopy were used to characterize variation in glandular trichome ***-free genotypes had trichomes that appeared *** isolate cannabinoids from confounding factors,artificial insect diet was amended with cannabinoids in a range of physiologically relevant *** grew less and had lower rates of survival as cannabinoid concentration *** results support the hypothesis that cannabinoids function in defense against chewing herbivores.

关键词： function founding ultraviolet

New frontiers for the materials genome initiative

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npj Computational Materials 2019年第1期4卷 776-798页

作者： Juan J.de Pablo nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao Institute for Molecular Engineering University of ChicagoChicagoIL 60615USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Materials Department and Materials Research Laboratory University of CaliforniaSanta BarbaraCA 93106USA Department of Materials Science and Engineering Cornell UniversityIthacaNY 14853USA Department of Physics Colorado School of MinesGoldenCO 80401USA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Physics University of Texas at AustinAustinTX 78712USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Institute of Condensed Matter and Nanosciences UniversitéCatholique de Louvain1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Department of Materials Design and Innovation University of Buffalo–The State University of New YorkBuffaloNY 14260-5030USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of Metallurgical and Materials Engineering Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and *** with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the *** May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and *** article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts.

关键词： utilize frontier accomplishment

High-performance multilayer WSe2 field-effect transistors with carrier type control

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Nano Research 2018年第2期11卷 722-730页

作者： Pudasaini, Pushpa Raj Oyedele, Akinola Zhang, Cheng Stanford, Michael G. Cross, nicholas Wong, Anthony T. Hoffman, Anna N. Xiao, Kai Duscher, Gerd Mandrus, David G. Ward, Thomas Z. Rack, Philip D. Department of Materials Science and Engineering University of Tennessee Knoxville USA Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge USA Bredesen Center for Interdisciplinary Research and Graduate Education University of Tennessee Knoxville USA Materials Science and Technology Division Oak Ridge National Laboratory Oak Ridge USA

In this stud high-performance multilayer WSe2 field-effect transistor （FET） devices with carrier type control are demonstrated via thickness modulation and a remote oxygen plasma surface treatment. Carrier type control in multilayer WSe2 FET devices with Cr/Au contacts is initially demonstrated by modulating the WSe2 thickness. The carrier type evolves with increasing WSe2 channel thickness, being p-type, ambipolar, and n-type at thicknesses 〈 3, - 4, and 〉 5 nm, respectively. The thickness-dependent carrier type is attributed to changes in the bandgap of WSe2 as a function of the thickness and the carrier band offsets relative to the metal contacts. Furthermore, we present a strong hole carrier doping effect via remote oxygen plasma treatment. It non-degenerately converts n-type characteristics into p-type and enhances field-effect hole mobility by three orders of magnitude. This work demonstrates progress towards the realization of high-performance multilayer WSe2 FETs with carrier type control, potentially extendable to other transition metal dichalcogenides, for future electronic and oDtoelectronic alpplications.

关键词： transition metaldichalcogenide field-effect transistors carrier control plasma treatment carrier mobility

THz-Enhanced DC Ultrafast Electron Diffractometer

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Ultrafast Science 2021年第1期1卷 61-67页

作者： Dongfang Zhang Tobias Kroh Felix Ritzkowsky Timm Rohwer Moein Fakhari Huseyin Cankaya Anne-Laure Calendron nicholas H.Matlis Franz X.Kärtner Center for Free-Electron Laser Science Deutsches Elektronen SynchrotronNotkestrasse 8522607 HamburgGermany Collaborative Innovation Center for IFSA School of Physics and AstronomyShanghai Jiao Tong University200240 ShanghaiChina Department of Physics and The Hamburg Centre for Ultrafast Imaging Universität HamburgLuruper Chaussee 14922761 HamburgGermany

Terahertz-(THz-)based electron manipulation has recently been shown to hold tremendous promise as a technology for manipulating and driving the next generation of compact ultrafast electron ***,we demonstrate an ultrafast electron diffractometer with THz-driven pulse *** electron bunches from a conventional DC gun are compressed by a factor of 10 and reach a duration of~180 fs(FWHM)with 10,000 electrons/pulse at a 1 kHz repetition *** resulting ultrafast electron source is used in a proof-of-principle experiment to probe the photoinduced dynamics of single-crystal *** THz-compressed electron beams produce high-quality diffraction patterns and enable the observation of the ultrafast structural dynamics with improved time *** results validate the maturity of THz-driven ultrafast electron sources for use in precision applications.

关键词： pulse Electron repetition

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辛辛那提大学理查德·E·林德纳体育中心

城市环境设计 2016年第1期 172-177页

作者： Bernard Tschumi Kim Starr Phu Hoang Robert Holton Jane Kim Jonathan Chace nicholas Martin Eva Sopeoglou Joel Aviles Chong-zi Cheng Irene Cheng Adam Dayem William Feuerman Thomas Goodwill Daniel Holguin Matthew Hufft Michaela Metcalf Valentin Bontjes van Beek Allis Chee Justin moore

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m2的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何... 详细信息

辛辛那提大学在2001年委托伯纳德·屈米为该校运动员设计一座约22000m2的活动中心,为体育训练、管理、运动医疗和一些教学活动提供集中式的设施。学校统筹部门提出在保留所征用地块原有功能的前提下,项目可以选址在学校体育园区内任何地方。

关键词：理查德辛辛那提大学中庭德纳体育

A history of high-power laser research and development in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone AWE Aldermaston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Formerly of Electrox LetchworthUK Formerly of Central Laser Facility Rutherford LaboratoryDidcotUK Formerly of Ferranti Defence Systems LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Formerly of AWE ReadingUK Formerly of Laser Lines Ltd BanburyUK Formerly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Imaging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK Magna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Emeritus(Physics) University of HullKingston upon HullUK Kentech Instruments Ltd WallingfordUK Department of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Emeritus Department of PhysicsUniversity of StrathclydeGlasgowUK Department of Physics Durham UniversityDurhamUK Professor Emeritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Emeritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance Manx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasma Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK Mirli Books ChelmsfordUK M Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Department of Physics University of YorkYorkUK IC Optical Systems Ltd BeckenhamUK Laser Micromachining Ltd St AsaphUK MBDA UK Ltd Brist

The first demonstration of laser action in ruby was made in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different materials,operating at different *** the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of *** historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. Sanders nicholas Williams Tim H. H. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter J. Campbell Foad J. Rouhani & Huw Naylor Sarah J. Aitken & Matthew Hoare Sarah J. Aitken & Susan E. Davies Sarah J. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学