检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

受控的空气污染物暴露与心律失常风险

环境与职业医学 2014年第10期31卷 787-787页

作者： Jeremy P.Langrish Simon J.Watts Amanda J.Hunter Anoop S.V.Shah Jenny A.Bosson Jon Unosson Stefan Barath magnus Lundbck Flemming R.Cassee Ken Donaldson Thomas Sandstrm Anders Blomberg David E.Newby nicholas L.mills

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露... 详细信息

[背景]流行病学研究报道了空气污染暴露与心血管疾病发病率和死亡率增加之间的关联。空气污染物暴露可以影响心脏自主神经节律并降低心率变异性,可能增加心律失常的风险,特别是在敏感的患者群体中。[目的]研究在可控制的空气污染物暴露期间和之后,统计分析了健康志愿者和冠状动脉心脏疾病患者的心律失常发生率。[方法]分析数据来自13个随机双盲交叉研究,包括282名参加者(140名健康志愿者和142例稳定性冠状动脉心脏疾病患者)的连续心电图记录。记录研究人群每次暴露时发生心律失常的情况。[结果]在稀释的柴油车尾气、木材烟雾、臭氧、浓缩的环境颗粒物、工程碳纳米颗粒或空气污染高环境水平的暴露期间或者之后,无论在健康志愿者或冠状动脉心脏疾病患者中,任何形式心律失常的发生均没有增加。[结论]急性、可控制的空气污染物暴露不增加受试者发生心律失常的短期风险。研究中所采用的这些技术,对于确定涉及空气污染不利影响的重要病理生理途径依然至关重要,并且在为环境和公共卫生政策决策提供信息中也起着重要的作用。

关键词：空气污染物心律失常短期风险健康志愿者患者群体摘要心脏自主神经心脏疾病

在线全文

学校读者我要写书评

暂无评论

胚胎移植技术的应用及其发展

国外畜牧科技 1989年第1期16卷 15-20页

作者： J.m.Sreenan 郭年藩

动物胚胎移植首次成功(Heape 1891)距今已近一百年了。在这期间,又有多种动物胚胎移植试验成功,技术也不断改进。但是,进展较大的还是近二十年间。1981年Betterid-ge总结了胚胎移植历史,列出了13种动物胚胎移植首次成功的时间和试验者[... 详细信息

动物胚胎移植首次成功(Heape 1891)距今已近一百年了。在这期间,又有多种动物胚胎移植试验成功,技术也不断改进。但是,进展较大的还是近二十年间。1981年Betterid-ge总结了胚胎移植历史,列出了13种动物胚胎移植首次成功的时间和试验者[兔1891Heape;大鼠1933 nicholas;绵羊1934Warwick等;山羊(自身重移植)1934Warwick等;小鼠1942 Fekete＆Lit-tle;奶牛(流产)1949 Umbaugh;山羊1949 Warwick＆Berry;奶牛1951Willett等;猪1951 Kvasnickii;

关键词：胚胎移植繁殖生物学畜牧业

应激诱导p38mAPK磷酸化Drosha及对其介导细胞生存的抑制作用

在线全文

学校读者我要写书评

暂无评论

科学新闻 2016年第1期 79-79页

作者：杨倩 Wenming Li Hua She Juan Dou Duc m.Duong Yuhong Du Shao-Hua Yang nicholas T.Seyfried Haian Fu Guodong Gao Zixu mao 第四军医大学唐都医院神经外科全军神经生物学会

文章简介microRNA(miRNA)是一类小分子非编码RNA,广泛存在于真核生物中,通过调控其靶mRNA的翻译而影响多种细胞生命活动。核RNA酶Ⅲ的Drosha蛋白剪切miRNA初级转录本是miRNA经典生物合成步骤的关键环节。越来越多的证据表明miRNA的生物... 详细信息

文章简介microRNA(miRNA)是一类小分子非编码RNA,广泛存在于真核生物中,通过调控其靶mRNA的翻译而影响多种细胞生命活动。核RNA酶Ⅲ的Drosha蛋白剪切miRNA初级转录本是miRNA经典生物合成步骤的关键环节。越来越多的证据表明miRNA的生物合成过程可以被多种因素调节,然而,人们并不清楚Drosha自身是怎样被调控的。本研究发现,应激可以影响Drosha的生物学功能c正常情况下,Drosha与DGCR8(DiGeorge syndrome critical

关键词：应激反应调控调节控制 p38mAPK Drosha 神经外科神经组织神经元 RNA

Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency—UK Environmental Nanoscience Initiative Joint Program

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Protection 2018年第4期9卷 385-404页

作者： mitch m.Lasat Kian Fan Chung Jamie Lead Steve mcGrath Richard J.Owen Sophie Rocks Jason Unrine Junfeng Zhang Office of Research and Development United States Environmental Protection AgencyWashington DCUSA National Heart and Lung Institute Imperial CollegeLondonUK Centre for Environmental Nanoscience and Risk University of South CarolinaColumbiaUSA University of Birmingham EdgbastonUK Rothamsted Research HarpendenUK Business School University of ExeterExeterUK Institute for Resilient Futures Cranfield UniversityCranfieldUK Department of Plant and Soil Sciences University of KentuckyLexingtonUSA nicholas School of the Environment Duke UniversityDurhamUSA

Nanotechnology has significant economic, health, and environmental benefits, including renewable energy and innovative environmental solutions. manufactured nanoparticles have been incorporated into new materials and products because of their novel or enhanced properties. These very same properties also have prompted concerns about the potential environmental and human health hazard and risk posed by the manufactured nanomaterials. Appropriate risk management responses require the development of models capable of predicting the environmental and human health effects of the nanomaterials. Development of predictive models has been hampered by a lack of information concerning the environmental fate, behavior and effects of manufactured nanoparticles. The United Kingdom (UK) Environmental Nanoscience Initiative and the United States (US) Environmental Protection Agency have developed an international research program to enhance the knowledgebase and develop risk-predicting models for manufactured nanoparticles. Here we report selected highlights of the program as it sought to maximize the complementary strengths of the transatlantic scientific communities by funding three integrated US-UK consortia to investigate the transformation of these nanoparticles in terrestrial, aquatic, and atmospheric environment. Research results demonstrate there is a functional relationship between the physicochemical properties of environmentally transformed nanomaterials and their effects and that this relationship is amenable to modeling. In addition, the joint transatlantic program has allowed the leveraging of additional funding, promoting transboundary scientific collaboration.

关键词： Aquatic Environment Consumer Products manufactured Nanomaterials Predictive models Terrestrial Ecosystem

An Earth-mass planet in a time of COVID-19:KmT-2020-BLG-0414Lb

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan maoz matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto man Cheung Alex Li Yutaka matsubara Yasushi muraki Shota miyazaki Greg Olmschenk Clément Ranc nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KmT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(m1,m2,m3)~(0.3 m⊙,1.0 m⊕,17 mJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KmT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

出生第一年交通相关空气污染暴露与7岁时行为评分

在线全文

学校读者我要写书评

暂无评论

环境与职业医学 2013年第9期30卷 657-657页

作者： nicholas C.Newman Patrick Ryan Grace Lemasters Linda Levin David Bernstein Gurjit K.Khurana Hershey James E.Lockey manuel Villareal Tiina Reponen Sergey Grinshpun Heidi Sucharew Kim N.Dietrich

[背景]交通相关的空气污染(TRAP)对发育中大脑的潜在影响受到越来越多的关注。由于流行病学研究有限,TRAP暴露对儿童期行为的影响尚不完全清楚。[目的]采用一种TRAP替代品(归因于交通的元素碳,ECAT)探讨生命早期TRAP暴露与7岁时注意力缺... 详细信息

[背景]交通相关的空气污染(TRAP)对发育中大脑的潜在影响受到越来越多的关注。由于流行病学研究有限,TRAP暴露对儿童期行为的影响尚不完全清楚。[目的]采用一种TRAP替代品(归因于交通的元素碳,ECAT)探讨生命早期TRAP暴露与7岁时注意力缺失/多动症(ADHD)症状之间的关联。[方法]从辛辛那提儿童过敏与空气污染研究(CCAAPS)出生队列中,收集婴儿期ECAT暴露和7岁时行为得分的数据。入组CCAAPS的儿童,其父母中至少有一位患遗传性过敏症,并且出生居所距离一条主要公路m或者>1500m。这些儿童的随访时间为自婴儿期至7岁。根据27个空气采样点的测量值和土地利用回归模型,估计生命第一年的ECAT暴露。当儿童7岁时,由家长填写完成儿童行为评估系统(第2版)。通过过度活跃(hyperactivity)、注意力问题(attention problem)、攻击性(aggression)、行为问题(conduct problems)和非典型(atypicality)分量表对ADHD相关症状进行评估。[结果]儿童生命第一年中ECAT暴露位于最高三分位数,与其7岁时处于"风险"范围的过度活跃T评分明显相关[调整后比值比(aOR)=1.7;95%CI:1.0～2.7]。对母亲教育程度分层后发现,在母亲具有较高教育程度的儿童中关联性更强(aOR=2.3;95%CI:1.3～4.1)。[结论]婴儿期ECAT暴露与儿童较高多动症评分相关,这种关联限于母亲具有高中以上教育程度的儿童。

关键词：行为评分空气污染交通遗传性过敏症 TRAP 儿童期流行病学生命早期

在线全文

学校读者我要写书评

暂无评论

有限群体中选择的遗传和克隆反应

国外畜牧学（草食家畜） 1992年第2期 21-23页

作者： I.J.m.de Boer 储明星

前言在现行奶牛遗传改良计划中,繁殖力是一个限制因素,牛胚胎克隆通过核移植已经成功(marx,1988;Prather等,1987)。但在实践应用中还需要完成以下两步。一是重复克隆,生产大批完全相同的个体(克隆系)。二是贮存的冷冻胚胎进一步克隆,... 详细信息

前言在现行奶牛遗传改良计划中,繁殖力是一个限制因素,牛胚胎克隆通过核移植已经成功(marx,1988;Prather等,1987)。但在实践应用中还需要完成以下两步。一是重复克隆,生产大批完全相同的个体(克隆系)。二是贮存的冷冻胚胎进一步克隆,进行被克隆的基因型测定(Smith,1989)。克隆被用来提高产生下一代公母牛的选择准确性,通过克隆的胚胎而不是精液在商业群中传播遗传优势。有几项研究(menwissen,1990b;nicholas,1983;Woolliams,1989)

关键词：奶牛有限群体遗传克隆

在线全文

学校读者我要写书评

暂无评论

小鼠Rad1基因剔除引发皮肤肿瘤易感性

生物物理学报 2009年第S1期25卷 452-452页

作者：韩璐胡志上刘宇恒王向远 Kevin m.Hopkins Howard B.Lieberman 杭海英国家大分子重点实验室生物物理研究所中国科学院系统中心实验室生物物理研究所中国科学院 Department of Genetics & Development and Obstetrics & Gynecology and The Institute for Human Nutritionand Herbert Irving Comprehensive Cancer CenterColumbia University Medical Center1130St.Nicholas AvenueRoom311BNew YorkNY10032 Center for Radiological Research Columbia UniversityCollege of Physicians and Surgeons630W.168th St.New YorkNY10032 Department of Environmental Health Sciences Columbia UniversityMailman School of Public Health60Haven AvenueSuite B1New YorkNY10032

生物时刻都面对着细胞内源自由基和环境污染物及辐射等 DNA 损伤因素。DNA 复制过程中也会产生 DNA 损伤。生物经过长期进化。

关键词： mrad1 mrad9 基因打靶肿瘤发生 DNA损伤