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Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods：Association with particle constituents

引用

Journal of Environmental Sciences 2016年第9期28卷 201-210页

作者： Bin Wang Ning Li Furong Deng nicholas buglak George Park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo Institute of Reproductive & Child Health/Ministry of Health Key Laboratory of Reproductive Health School of Public Health Peking University Beijing 100192 China Department of Pathobiology & Diagnostic Investigation College of Veterinary Medicine Michigan State University East Lansing 48824 USA Department of Occupational & Environmental Health Sciences School of Public Health Peking University Beijing 100191 China Laboratory for Earth Surface Processes College of Urban & Environmental Sciences Peking University Beijing 100871 China Jiangsu Provincial Academy of Environmental Science Nanjing 210036 China

Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter（PM） *** presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM 〈 2.5 μm（PM2.5）pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian *** investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial *** PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in *** samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several *** PM samples potently increased the release of interleukin-6（IL-6） and interleukin-8（IL-8）.Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on *** was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of *** study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM.

关键词： Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings

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