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Prevalence of anti-HAV antibodies in multitransfused patients with beta-thalassemia

World Journal of Gastroenterology 2008年第10期14卷 1559-1563页

作者： Dimitrios Siagris Alexandra Kouraklis-Symeonidis Irini Konstantinidou Myrto Christofidou Ioannis Starakis Alexandra Lekkou Christos Papadimitriou Alexandros Blikas nicholas zoumbos Chryssoula Labropoulou-Karatza Department of Internal Medicine Patras University HospitalPatras 26504 Greece

AIM: To detect the prevalence of anti-HAV IgG antibodies in adult multitransfused beta-thalassemic patients. METHODS: We studied 182 adult beta-thalassemic patients and 209 controls matched for age and sex from the same geographic area, at the same time. Anti-HAV IgG antibodies, viral markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection were evaluated. RESULTS: Anti-HAV IgG antibodies were detected more frequently in thalassemic patients (133/182; 73.1%) than in healthy controls (38/209; 18.2%, P < 0.0005). When we retrospectively evaluated the prevalence of anti-HAV IgG antibodies in 176/182 (96.7%) thalassemic patients, whose medical history was available for the previous ten years, it was found that 83 (47.2%) of them were continuously anti-HAV IgG positive, 16 (9.1%) acquired anti-HAV IgG antibody during the previous ten years, 49 (27.8%) presented anti-HAV positivity intermittently and 28 (15.9%) were anti-HAV negative continuously. CONCLUSION: Multitransfused adult beta-thalassemic patients present higher frequency of anti-HAV IgG antibodies than normal population of the same geographic area. This difference is difficult to explain, but it can be attributed to the higher vulnerability of thalassemics to HAV infection and to passive transfer of anti-HAV antibodies by blood transfusions.

关键词： Hepatitis A virus Anti-HAV antibodies Beta-thalassemia Multiple transfusions Hepatitis C virus

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