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World Journal of Otorhinolaryngology-Head and Neck surgery 2021年第9期7卷 71-81页

作者： Emerson E.Lee nicholas s.andresen Bryan McKenzie Jeffrey D.sharon Howard W.Francis Daniel Q.sun Department of Otolaryngology-Head and Neck surgery Johns Hopkins UniversityUSA Inova Fairfax Hospital USA Deportment of Otolaryngology-Head and Neck surgery University of California Son FranciscoUSA Department of Head and Neck surgery and Communication sciences Duke UniversityUSA

Cerebrospinal fluid(CsF)fistulae originating from the fallopian canal of the facial nerve is hypothesized to arise due to atypical patterns of subarachnoid space extension into the geniculate ganglion or more distal regions along the intratemporal course of the facial nerve,but its pathogenesis remains poorly *** a rare etiology of CsF fistulae of the temporal bone,there are significant clinical ramifications due to the risk of recurrent meningitis,difficulty in identifying the anatomic location of the CsF leak,and technical challenges associated with surgical *** present three clinical cases of arachnoid cysts within the geniculate fossa with or without CsF fistulization and provide histopathologic correlates of this rare clinical phenomenon from a human temporal bone *** pediatric and adult patients presented suggest differential pathophysiologic mechanisms associated with CsF *** bone histology reveals atypical patterns of subarachnoid space extension in the fallopian canal that may underlie arachnoid cyst formation and overt CsF leak from the geniculate region.

关键词： Geniculate ganglion Arachnoid cyst Fallopian canal Facial nerve Cerebrospinal fluid otorrhea Cerebrospinal fluid leak subarachnoid space

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Large-scale laboratory investigation of pillar-support interaction

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 71-93页

作者： Akash Chaurasia Gabriel Walton sankhaneel sinha Timothy J.Batchler Kieran Moore nicholas Vlachopoulos Bradley Forbes Colorado school of Mines GoldenCOUSA Equilibrium Mining KolkataWest BengalIndia National Institute of Occupational and safety Hazard(NIOsH) PittsburghPAUSA Royal Military College of Canada(RMC) KingstonOntarioCanada BGC Engineering Inc. KingstonOntarioCanada

Underground mine pillars provide natural stability to the mine area,allowing safe operations for workers and *** prior research has been conducted to understand pillar failure mechanics and design safe pillar ***,limited studies(mostly based on empirical field observation and small-scale laboratory tests)have considered pillar-support interactions under monotonic loading conditions for the design of pillar-support *** study used a series of large-scale laboratory compression tests on porous limestone blocks to analyze rock and support behavior at a sufficiently large scale(specimens with edge length of 0.5 m)for incorporation of actual support elements,with consideration of different w/h *** unsupported and supported(grouted rebar rockbolt and wire mesh)tests were conducted,and the surface deformations of the specimens were monitored using three-dimensional(3D)digital image correlation(DIC).Rockbolts instrumented with distributed fiber optic strain sensors were used to study rockbolt strain distribution,load mobilization,and localized deformation at different w/h *** axial and bending strains were observed in the rockbolts,which became more prominent in the post-peak region of the stress-strain curve.

关键词： Grouted rockbolt Welded wire mesh Porous limestone Digital image correlation Distributed fiber optic sensing Large-scale laboratory tests

La3+ substitution-adjusted magnetic and optical properties with enhanced photocatalytic activity and stability of copper zinc nickel ferrites for wastewater treatment applications

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Journal of Rare Earths 2025年第2期43卷 319-328页

作者： N.s.Al-Bassami General studies Department Jubail Industrial College

Copper-zinc-nickel（Cu-Zn-Ni） ferrite nanoparticles are used for wastewater treatment ***,low degradation efficiency and stability are two main issues that make them unsuitable for actual production *** this paper,the citrate-nitrate auto-combustion method was applied for the formation of Cu0.5Zn0.25Ni0.25LaxFe2-xO4;（0≤x≤0.1;step 0.02）(CZNL) *** the substitution process entails the replacement of a small ion with a larger one,the lattice constant and crystallite size does not exhibit a consistent incremental *** behavior is justified and *** size of all the CZNL ferrite nanoparticles is in the range of 8-12 nm,and the lattice constant is in the range of 8.6230 to 8.4865 *** morphological analysis conducted using field emission-scanning electron microscopy（FE-sEM） reveals that the CZNL exhibits agglomerated spherical *** energy dispersive X-ray spectrameter（EDAX） analysis was employed to confirm the elemental composition of CZNL *** the process entails the substitution of Fe3+magnetic ions with nonmagnetic ions La3+,the magnetic parameters of CZNL nanoferrites show a general decreasing trend as *** 20 K,saturation magnetization Ms shows an overall drop in its values from 59.302 emu/g at x=0.0-41.295 emu/g at x=0.1,the smallest value of 37.87 emu/g is recorded at x=*** highest coercivity（Hc=125.9 Oe） and remanence（Mr=13.32 emu/g） are recorded for x=0.08 and x=0.04 nanoferrite,*** band gap of all the CZNL nanoferrites was determined using the Kubelka-Munk function and Tauc plot for direct permitted *** doping modifies the band gap（within 1.86-1.75 eV）,increases light absorption,induces efficient e/h separation and charge migration to *** nanoferrite Cu0.5Zn0.25Ni0.25La0.06Fe1.94O4achieves a degradation efficiency of 97.3% for methylene blue（MB） dye removal after just 60 *** five recycling processes,the nanoc

关键词： Copper-zinc-nickel Ferrite Photocatalytic properties Rare earths Wastewater treatment

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.VAIsH V.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHsDT) nonlinear O322

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

strain accumulation in the Mentawai Forearc sliver,Indonesia,inferred from continuous GNss-derived strain rate

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Geodesy and Geodynamics 2025年第1期16卷 1-6页

作者： Leni sophia Heliani Cecep Pratama Adi Wibowo David Prambudi sahara susilo susilo sidik Tri Wibowo Ayu Nur safii Oktadi Prayoga Ajat sudrajat Mizan Bustanul Fuady Bisri Evi Dwi Kurniasari sheilla Evelinda nicholas Genta setiawan Gunawan Department of Geodetic Engineering Universitas Gadjah Mada Department of Computer science Universitas Diponegoro Global Geophysics Research Group Institut Teknologi Bandung Research Center for Geological Disaster National Research and Innovation Agency Geospatial Information Agency Meteorological Climatological and Geophysical Agency Graduate school of International Cooperation studies Kobe University Graduate school of Geodetic Engineering Universitas Gadjah Mada

The Mentawai Forearc sliver(MFs) is characterized by oblique deformation formed as slip partitioned between normal and parallel trench plate convergence. The surge of great earthquakes from 2004 to2012 along the adjacent sunda trench left a large unbroken segment known as the Mentawai seismic Gap. Here, we adopted continuous Global Navigation satellite system(GNss) observation data to identify the present regional crustal deformation using geodetic strain rates. The principal strain rate, dilatation rate, and maximum shear strain rate are about 0.13 microstrain/yr, 0.2 microstrain/yr, and 0.1 microstrain/yr, respectively, with the range of its uncertainties between 0.01 and 0.04 microstrain/yr. The dilatation and maximum shear strain rates reveal the spatial coverage of strike-slip duplex and backthrust tectonics along the Mentawai Forearc sliver.

关键词： Mentawai Forearc Dilatation shear Geodetic

Multi-component decompositions, linear superpositions, and new nonlinear integrable coupled KdV-type systems

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Communications in Theoretical Physics 2025年第2期77卷 3-14页

作者： Xiazhi Hao s Y Lou school of Mathematical science Zhejiang University of Technology school of Physical science and Technology Ningbo University

In the realm of nonlinear integrable systems, the presence of decompositions facilitates the establishment of linear superposition solutions and the derivation of novel coupled systems exhibiting nonlinear integrability. By focusing on single-component decompositions within the potential BKP hierarchy, it has been observed that specific linear superpositions of decomposition solutions remain consistent with the underlying equations. Moreover, through the implementation of multi-component decompositions within the potential BKP hierarchy,successful endeavors have been undertaken to formulate linear superposition solutions and novel coupled Kd V-type systems that resist decoupling via alterations in dependent variables.

关键词： integrable system single-component decomposition multi-component decomposition linear superposition integrable coupled KdV-type system

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch