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Assessing the mechanism of citywide test-trace-isolate Zero-COVID policy and exit strategy of COVID-19 pandemic

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Infectious Diseases of Poverty 2022年第5期11卷 97-98页

作者： Pei Yuan Yi Tan Liu Yang Elena Arufo nicholas H.Ogden Guojing Yang Haixia Lu Zhigui Lin Weichuan Lin Wenjun ma meng Fan Kaifa Wang Jianhe Shen Tianmu Chen Huaiping Zhu Laboratory of mathematical Parallel Systems(LAmPS) Department of Mathematics and StatisticsYork University4700 Keele StreetTorontoON M3J1P3Canada Key Laboratory of Tropical Translational medicine of ministry of Education and School of Tropical medicine and Laboratory medicine The First Afliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikouHainanChina 不详

Background:Countries that aimed for eliminating the cases of COVID-19 with test-trace-isolate policy are found to have lower infections,deaths,and better economic performance,compared with those that opted for other mitigation ***,the continuous evolution of new strains has raised the question of whether COVID-19 eradication is still possible given the limited public health response capacity and fatigue of the *** aim to investigate the mechanism of the Zero-COVID policy on outbreak containment,and to explore the possibility of eradication of Omicron transmission using the citywide test-trace-isolate(CTTI)***:We develop a compartmental model incorporating the CTTI Zero-COVID policy to understand how it contributes to the SARS-CoV-2 *** employ our model to mimic the Delta outbreak in Fujian Province,China,from September 10 to October 9,2021,and the Omicron outbreak in Jilin Province,China for the period from march 1 to April 1,*** and sensitivity analyses were conducted using dynamical system and Latin Hypercube Sampling/Partial Rank Correlation Coefcient(PRCC).Results:Calibration results of the model estimate the Fujian Delta outbreak can end in 30(95%confdence interval CI:28–33)days,after 10(95%CI:9–11)rounds of citywide *** emerging Jilin Omicron outbreak may achieve zero COVID cases in 50(95%CI:41–57)days if supported with sufcient public health resources and population compliance,which shows the efectiveness of the CTTI Zero-COVID ***:The CTTI policy shows the capacity for the eradication of the Delta outbreaks and also the Omicron ***,the implementation of radical CTTI is challenging,which requires routine monitoring for early detection,adequate testing capacity,efcient contact tracing,and high isolation compliance,which constrain its benefts in regions with limited ***,these challenges become even more acute in the face of more contagious variant

关键词： COVID-19 Transmission model Zero-COVID policy Citywide testing Test-trace-isolate Exit strategy

Bench-top aqueous two-phase extraction of isolated individual single-walled carbon nanotubes

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Nano Research 2015年第5期8卷 1755-1769页

作者： Navaneetha K. Subbaiyan A. nicholas G. Parra-Vasquezt Sofie Cambre miguel A. Santiago Cordoba Sibel Ebru Yalcin Christopher E. Hamilton Nathan H. mack Jeffrey L. Blackburn Stephen K. Doorn Juan G. Duque Chemistry Division Physical Chemistry and Applied Spectroscopy Group (C-PCS) Center for Integrated Nanotechnologies (CINT) and Materials Science & Technology Division (MST-7) Los Alamos National Laboratory Los Alamos New Mexico 87544 USA Experimental Condensed matter Physics Laboratory University of Antwerp Antwerp B-2610 Belgium National Renewable Energy Laboratory Golden Colorado 80401 USA

Isolation and purification of single-walled carbon nanotubes （SWCNTs） are prerequisites for their implementation in various applications. In this work, we present a fast （-5 min）, low-cost, and easily scalable bench-top approach to the extraction of high-quality isolated SWCNTs from bundles and impurities in an aqueous dispersion. The extraction procedure, based on aqueous two-phase （ATP） separation, is widely applicable to any SWCNT source （tested on samples up to 1.7 nm in diameter） and independent of defect density, purity, diameter, and length. The extracted dispersions demonstrate that the removal of large aggregates, small bundles, and impurities is comparable to that by density gradient ultracentrifugation, but without the need for high-end instrumentation. Raman and fluorescence-excitation spectroscopy, single-nanotube fluorescence imaging, atomic force and transmission electron microscopy, and thermogravimetric analysis all confirm the high purity of the isolated SWCNTs. By predispersing the SWCNTs without sonication （only gentle stirring）, full-length, pristine SWCNTs can be isolated （tested up to 20 μm）. Hence, this simple ATP method will find immediate application in the generation of SWCNT materials for all levels of nanotube research and applications, from fundamental studies to high-performance devices.

关键词： carbon nanotubes aqueous two-phase (ATP)separation aggregate removal isolation sorting

Buffer Standards for the Biochemical pH of the Zwitterionic Buffer <i>N</i>-Tris-(Hydroxymethyl) methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Open Journal of Physical Chemistry 2012年第1期2卷 41-46页

作者： Rabindra N. Roy Lakshmi N. Roy Blake m. Bodendorfer Zachary m. Downs Stephen D. Rocchio Joshua T. Wollen Jessica m. Stegner Isaac B. Henson nicholas W. Grove Lauren A. Dieterman Hoffman Department of Chemistry Drury University Springfield USA

The authors have undertaken the determination of pH values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = ***-1. similar to that of blood. These buffer solutions have been evaluated in the temperature range of 5℃ to 55℃ using an extended version of the Debye-Hückel equation. The pH values are reported using 1) the Debye-Hückel extension of the Bates-Guggenheim convention in the tempera- ture range 5℃ to 55℃ and 2) with and without liquid junction correction at 25℃ and 37℃. These TES buffer solutions are recommended as secondary standard references for pH measurements in the range of pH 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 ***-1.

关键词： Ionic Strength Liquid Junction Potentials Second Dissociation Constant Buffer Solutions Activity Coefficients

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超深砂岩储层中的天然气组分预测

国外油气勘探 1994年第1期6卷 1-15页

作者： Colin Barker nicholas E.Takach 朱岳年张成君

油气生成受控于动力学。因而取决于时间和温度,但和岩石的类型基本无关。最终形成受温度、压力和古地矿物学控制的一种热力学稳定组合的成分。本文选用了一种最低自由能值的计算程序,计算地下3048～12192m深的碎屑岩储层中各种矿物组合... 详细信息

油气生成受控于动力学。因而取决于时间和温度,但和岩石的类型基本无关。最终形成受温度、压力和古地矿物学控制的一种热力学稳定组合的成分。本文选用了一种最低自由能值的计算程序,计算地下3048～12192m深的碎屑岩储层中各种矿物组合的热力学平衡的气体组分。在纯净砂岩储层中,甲烷浓度随深度增加而降低,大约在7620m深处消失。但是,如果还存在石墨残渣,则甲烷可继续生成,一直持续到12192m。看来气体组分受石墨与水反应生成的甲烷,与甲烷被水氧化形成的二氧化碳和氢气之间的平衡所影响。在有含铁矿物存在的情况下,当甲烷被氧化时,地层中的赤铁矿减少,而磁铁矿增加。随着地层埋深的增加,高温使地层中的方解石胶结物热分解成二氧化碳,冲淡了甲烷的浓度,形成无经济价值的气体组合。当储层矿物组合中有含硫矿物时,如黄铁矿和硬石膏,会生成硫化氢。这对深部研究很有意义。另外,热力学计算表明,地下深度达到平衡的气体组分与储层矿物之间存在极大的相关性。

关键词：天然气储集层砂岩油气田

Temporal trends of per-and polyfluoroalkyl substances(PFAS)in the influent of two of the largest wastewater treatment plants in Australia

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Emerging Contaminants 2019年第1期5卷 211-218页

作者： Hue T.Nguyen Sarit L.Kaserzon Phong K.Thai Soumini Vijayasarathy Jennifer Bräunig nicholas D.Crosbie Anders Bignert Jochen F.mueller Queensland Alliance for Environmental Health Sciences(QAEHS) The University of QueenslandBrisbaneQLD4102Australia melbourne Water Corporation DocklandsVIC3001Australia Swedish museum of Natural History Box 5000710405StockholmSweden Faculty of Environment University of ScienceVietnam National UniversityHo Chi Minh CityViet nam

Per-and polyfluoroalkyl substances(PFAS)are found ubiquitously in wastewater treatment plants(WWTPs)due to their multiple sources in industry and consumer *** Australia,limited spatial data are available on PFAS levels inWWTPs influent,while no temporal data have been *** aim of this study was to investigate the occurrence and temporal trend of PFAS in the influent of two large WWTPs in Australia(WWTP A and B)over a four-year *** influent samples were collected over one week at different seasons from 2014 to *** perfluoroalkyl acids(PFAA)(*** perfluoroalkyl carboxylic acids(PFCAs)and four perfluoroalkyl sulfonic acids(PFSA))were detected with mean S11PFAA concentrations of 57±3.3e94±17 ng/L at WWTP A,and 31±6.1e142±73 ng/L at WWTP *** highest mean concentrations were observed for perfluorohexanoate(PFHxA)(20±2 ng/L)in WWTP A,and perfluorooctane sulfonate(PFOS)(17±13 ng/L)in WWTP *** precursor 6:2 fluorotelomer sulfonate was detected over five sampling periods from Aug 2016 to Oct 2017,with mean concentrations of 37±18e138±51 ng/L for WWTP A and 8.8±4.5e29±5.1 ng/L for WWTP *** concentration of 6:2 FTS(1.8e11 folds)than those of PFOA and PFOS in WWTP A indicate a likely substitution of C8 PFAA by fluorotelomer-based PFAS in this *** trends(annual and seasonal)in per-capita mass load were observed for some PFAA,increasing for PFPeA,PFHxA,PFHpA,PFNA,and PFHxS,while decreasing for PFBS and PFOS in either ***,elevated levels of PFOS in October 2017 were observed at both WWTPs with the highest per capita mass load of up to 67 mg/day/*** some PFAS release trends,longer sampling periods would be required to achieve acceptable statistical power.

关键词： Per-and polyfluoroalkyl substances(PFAS) 6:2 fluorotelomer sulfonate(6:2 FTS) Temporal trends Wastewater treatment plant(WWTP) Influent Power Effect size

美国电化学学会1976年秋季会议文摘选译——激活的硫化锌钡的发光性质

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发光学报 1977年第Z1期 3-4页

作者： m.H.Higton.,D.m.nicholas,A.Vecht,丁丽娜秦晤士工艺学校、材料科学部秦晤士工艺学校、材料科学部秦晤士工艺学校、材料科学部伦敦伦敦伦敦

有人报道过硫化钡—硫化锌系统的一种玻璃相,而且因为硫化钡和硫化锌都是有名的发光体基质晶格,所以我们曾经设想这个系统可能产生出一种玻璃发光体。然而我们对硫化钡和硫化锌之间的相互作用做了详细的探索,并没有发现玻璃相,却制备出

关键词：硫化锌发光体玻璃相硫化物金相相组成钡化合物硫化钡光致发光

Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

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Bone Research 2018年第1期6卷 83-94页

作者： Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep makam nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio Julia F.Charles michael C.Ostrowski Sudarshana m.Sharma Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State University Wexner Medical Center College of Veterinary medicine The Ohio State University Department of Biochemistry and molecular Biology and Hollings Cancer Center Medical University of South Carolina Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Division of Rheumatology and Immunology Department of Internal Medicine The Ohio State University Wexner Medical Center Department of Biomedical Informatics The Ohio State University Wexner Medical Center

Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and mITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states.

关键词： Genome-wide GWASs mITF

Synovial lipomatosis: A rare cause of knee pain in an adolescent female

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World Journal of Orthopedics 2015年第3期6卷 369-373页

作者： nicholas miladore mary A Childs Vani J Sabesan Department of Orthopaedic Surgery Western Michigan University Homer Stryker M.D.School of Medicine Department of Orthopaedic Surgery Wayne State University School of Medicine

Synovial lipomatosis is a benign proliferative disease of the subsynovial adipose which can lead to a variety of presentations. Cases of synovial lipomatosis in children or adolescents are rare. This case report describes an adolescent patient with a rare bilateral presentation of synovial lipomatosis. She had been treated for years prior to her presentation for juvenile idiopathic arthritis. She presented with chronic bilateral knee pain, swelling, and mechanical symptoms. Bilateral mR imaging demonstrated effusions, hypertrophy of the synovium, and polyp-like projections of tissue with the same signal intensity as fat which is pathognomonic for synovial lipomatosis. Arthroscopic synovectomy and extensive debridement of polyp like fat projections of the right knee was performed. Histopathology was consistent with the synovial lipomatosis diagnosis. Postoperatively, the patient was satisfied with her outcome with improved pain relief and function in her right knee.

关键词： Synovial lipomatosis Lipomatosis Knee arthroscopy Lipoma arborescens Arthroscopy Villous lipomatous proliferation of the synovial membrane Knee pain

辽河三角洲翅碱蓬湿地不同植被覆盖度下的土壤对碳的扣留

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中国地质 2014年第2期41卷 648-657页

作者：余雪洋叶思源 nicholas Lawrence Yuknis Edward A.Laws 赵广明袁红明丁喜桂王锦青岛大学山东青岛266071 国土资源部海洋油气资源与环境地质重点实验室山东青岛266071 青岛海洋地质研究所山东青岛266071 路易斯安那州立大学

为研究辽河三角洲湿地的固碳能力,2010年5月在辽河三角洲双台子河口东侧的两个翅碱蓬湿地区域采取7个柱状样,通过对样品的化学分析测试,并利用210Pb测年法确定的沉积速率研究了土壤对碳的扣留速率,其结果表明：有机碳浓度分别与各营养... 详细信息

为研究辽河三角洲湿地的固碳能力,2010年5月在辽河三角洲双台子河口东侧的两个翅碱蓬湿地区域采取7个柱状样,通过对样品的化学分析测试,并利用210Pb测年法确定的沉积速率研究了土壤对碳的扣留速率,其结果表明：有机碳浓度分别与各营养元素浓度间有显著的正相关关系（p＜0.01）,指示沉积物中的有机物质对营养元素有很强的富集能力,同时营养元素促进植物的生长,从而影响土壤碳的加积速率.研究区总碳浓度范围为10.5～14.6 g/kg,其中约83％为有机碳,其相应的土壤对总碳和有机碳扣留速率分别为98.02～260.37 g/m2/a（均值171.84 g/m2/a）和81.17～229.98 g/m2/a（均值141.29 g/m2/a）.本研究区,土壤对碳的扣留速率主要受土壤的沉积速率控制,并与高程有显著的相关关系（p＜0.01）.土壤对碳扣留机制的研究有助于加深对全球碳循的理解.

关键词：辽河三角洲湿地碳扣留营养成分 210Pb测年