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基于地基高分辨率太阳吸收光谱观测大气中硝酸的时空分布

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光学学报 2020年第2期40卷 17-27页

作者：章惠芳王薇刘诚单昌功胡启后孙友文 nicholas jones 安徽大学物质科学与信息技术研究院安徽合肥230601 中国科学院合肥物质科学研究院安徽光学精密机械研究所环境光学与技术重点实验室安徽合肥230031 中国科学技术大学地球和空间科学学院安徽合肥230026 University of Wollongong School of ChemistryAustraliaNew South WalesWollongong 2522

利用高分辨率傅里叶变换红外光谱(FTIR)技术探测合肥地区大气硝酸(HNO3)的浓度,基于最优估算法由中红外太阳吸收光谱反演出HNO3的垂直廓线和柱总量。获得了2017年大气HNO3的垂直廓线和柱总量的时间序列,分析了HNO3的季节变化、浓度探测... 详细信息

利用高分辨率傅里叶变换红外光谱(FTIR)技术探测合肥地区大气硝酸(HNO3)的浓度,基于最优估算法由中红外太阳吸收光谱反演出HNO3的垂直廓线和柱总量。获得了2017年大气HNO3的垂直廓线和柱总量的时间序列,分析了HNO3的季节变化、浓度探测敏感性高度、反演平均核和自由度等特征。不同季节大气HNO3的垂直廓线表明,HNO3在20~30km的大气平流层浓度较高,在对流层浓度较低。HNO3的柱浓度显示出明显的季节变化,春季出现最大值,冬季出现最小值,季节变化幅值为9.82×10^15 molecule/cm2。为了对地基FTIR的观测进行比对,选取Aura MLS卫星数据产品与地基测量数据进行比对。比对结果表明,地基遥感观测与卫星数据显示出的季节变化一致;尽管卫星偏柱量整体小于地基遥感的柱总量,但两者的相关系数为0.83,表明两者具有较好的一致性。地基观测结果验证了地基FTIR技术观测大气中HNO3时空分布的可靠性和准确性。

关键词：大气光学傅里叶变换红外光谱技术硝酸垂直廓线柱浓度

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斜拉桥的气动弹性分析

世界桥梁 1991年第3期 23-34+52页

作者： Robert H.Scanlani ,nicholas P.jones ,张海龙武汉城市建设学院

斜拉桥对于风载的气动弹性效应是气动荷载与耦联的结构位移的复杂的相互作用问题。本文提出一个对此种结构根据颤振微分方程以实验为基础的分析方法。该法的主要优点是把系统的三维复杂问题简化合并,并保持能看出其所包含的物理力学作... 详细信息

斜拉桥对于风载的气动弹性效应是气动荷载与耦联的结构位移的复杂的相互作用问题。本文提出一个对此种结构根据颤振微分方程以实验为基础的分析方法。该法的主要优点是把系统的三维复杂问题简化合并,并保持能看出其所包含的物理力学作用过程。文后有两个算例,对正在修建及竣工后的双桥面结构进行了介绍、讨论。同时也介绍了该法与三维风洞实验的关系。最后,也注意到入风的干扰效应,用颤振微分过程能成功地解释在全比例试验和在实桥中所观察到的现象。

关键词：风速颤振结构振动桥面结构导数斜拉索桥斜拉桥空气动力弹性气动弹性

大鼠模型中用尿激酶纤溶酶原激活剂和受体系统的肽抑制剂抑制脉络膜新生血管形成

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美国医学会眼科杂志（中文版） 2005年第3期17卷 162-162页

作者： Arup Das Nathan Boyd Terence R. jones nicholas Talarico Paul G. McGuire 刘欣怡（译）

目的：为确定在动物模型中尿激酶型纤溶酶原激活剂（uPA）和尿激酶型纤溶酶原激活酶受体系统（uPAR）在脉络膜新生血管形成（CNV）中所起的作刷及其系统是否抑制脉络膜新生血管范嗣。方法：用裂隙灯激光释放系统光凝来引发鼠脉络膜新生... 详细信息

目的：为确定在动物模型中尿激酶型纤溶酶原激活剂（uPA）和尿激酶型纤溶酶原激活酶受体系统（uPAR）在脉络膜新生血管形成（CNV）中所起的作刷及其系统是否抑制脉络膜新生血管范嗣。方法：用裂隙灯激光释放系统光凝来引发鼠脉络膜新生血管形成。在这些动物的视网膜脉络膜上刷逆转录酶-多聚酶链反应和免疫细胞化学分析测验尿激酶型纤溶酶原激活酶的表达。两周后动物腹腔注射尿激酶型纤溶酶原激活酶．

关键词：尿激酶纤溶酶原激活剂脉络膜新生血管新生血管形成受体系统大鼠模型尿激酶型纤溶酶原激活剂逆转录酶-多聚酶链反应抑制剂动物模型

Antitangling and manufacturable Fog Harps for high‐efficiency water harvesting

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Droplet 2023年第4期2卷 38-44页

作者： Jimmy K.Kaindu Kevin R.Murphy nicholas G.Kowalski Alexandra N.jones Matthew Davis Fleming Brook S.Kennedy Jonathan B.Boreyko Department of Mechanical Engineering Virginia TechBlacksburgVirginiaUSA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVirginiaUSA School of Architecture and Design Virginia TechBlacksburgVirginiaUSA Samscreen Inc. ConklinNew YorkUSA

Fog Harps harvest substantially more water than conventional mesh‐based ***,to date,all large‐scale Fog Harps have been impractically hand‐wound at low wire tensions and suffer from elastocapillary wire ***,we develop large‐scale and high‐tension Fog Harps that are manufacturable and *** Fog Harps retain the record‐setting fog harvesting efficiency(η≈17%)of their optimized scale‐model counterparts,while uniquely enabling practical real‐life *** was achieved by adapting the industrial process for making harp screens,a pre‐existing technology used for screening solid *** critical tension required to minimize wire tangling was rationalized by an improved elastocapillary tangling model.

关键词： harvesting capillary rational

Fibrous Hamartoma of Infancy at the Hand: A Case Report with Complications

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Open Journal of Orthopedics 2015年第3期5卷 46-52页

作者： nicholas Sacksteder Daniel jones David S. Brink Joao Panattoni Department of Orthopaedic Surgery Saint Louis University School of Medicine St. Louis MO USA Department of Pathology and Pediatrics Saint Louis University School of Medicine St. Louis MO USA

Fibrous Hamartoma of Infancy is a benign subdermal tumor most commonly presenting at the proximal appendages. Here we present a case of Fibrous Hamatoma of Infancy at the hand with discussion of its challenging excision and post-operative complications. This case highlights the delicate and challenging nature of pediatric hand surgery.

关键词： Fibrous Hamartoma Fibrous Hamartoma of Infancy Pediatric Hand

Breaking the biotrophic interfacial complex:How genome editing can lead to rice blast resistance

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Molecular Plant 2023年第8期16卷 1243-1245页

作者： Vincent Were nicholas J.Talbot The Sainsbury Laboratory University of East AngliaNorwich Research ParkNorwich NR47UHUK

Genome editing is a transformational technology—by precisely altering the coding or regulatory sequence of a specific gene,it is now possible to change specific traits within a wide variety of *** a consequence,plant breeding can be taken to a new level of precision,and many countries are moving rapidly to adopt new legislation to permit genome editing(Greenwood et al.,2023).However,genome editing has so far seldom been used to develop disease-resistant *** is because plant immunity often depends on single dominant resistance genes,which encode immune receptors that recognize secreted effectors deployed by plant pathogens(jones and Dangl,2006).In this context,genetic modification has proven to be a much more powerful technology so far to introduce these genes from distinct varieties,or even different species,to develop disease resistant crop species(Greenwood et al.,2023),especially when multiple disease-resistance loci can be introduced together to provide more durable resistance(Luo et al.,2021).Genome editing can be used in an innovative way to resurrect previously effective resistance genes(Contreras et al.,2023),but it has been less effective at introducing new forms of disease resistance to crops.

关键词： breeding resistance editing

Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families

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Open Journal of Genetics 2013年第4期3卷 243-252页

作者： Shirley Y. Hill Bobby L. jones nicholas Zezza Scott Stiffler Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh USA

Background: A previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878. The KIAA0040 gene has been mapped to this region (1q24-q25). A recent genome-wide association study using SAGE (the Study of Addiction: Genetics and Environment) and COGA (Collaborative Study on the Genetics of Alcoholism) found five SNPs within the KIAA0040 gene significantly associated with alcohol dependence. A meta-analysis using data from these sources also found the KIAA0040 gene significantly associated with alcohol dependence. Methods: Using family data consisting of 1000 individuals with phenotypic data (762 with both phenotype and DNA), finer mapping of a 0.3 cM region that included the KIAA0040 gene and a flanking gene was undertaken using SNPs with minor allele frequency (MAF) ≥ 0.15 and pair-wise linkage disequilibrium (LD) of r2 < 0.8 using the HapMap CEU population. Results: Significant FBAT p-values were observed for six SNPs, four within the KIAA0040 gene (rs2269650, rs2861158, rs1008459, rs2272785) and two adjacent to KIAA0040 (rs10912899 and rs3753555). Five haplotype blocks of varying size were identified using HAPLOVIEW. Analysis using the haplotype-based test function of FBAT revealed one two-SNP block (rs1008459rs2272785) associated with alcohol dependence. This block showed a pattern of transmission in which one haplotype, CT, with a frequency of 0.577 was found to be over-transmitted to affected offspring (p = 0.017) while another haplotype, AG, with a frequency of 0.238 was found to be under-transmitted to affected offspring (p = 0.006). A three-SNP block (rs1008459rs2272785-rs375355) showed an overall significant association (p = 0.011) with alcohol dependence with the haplotype ACT over-transmitted to affected offspring (p = 0.016) and the haplotype GAG undertransmitted (p = 0.002). Conclusions: Family-based association analysis shows the

关键词： KIAA0040 Alcohol Dependence Multiplex Families

Extraterrestrial Impacts and Geomagnetic Reversals

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Journal of Applied Mathematics and Physics 2022年第3期10卷 952-959页

作者： Pirooz Mohazzabi Michael J. Connolly Julia A. jones John D. Skalbeck nicholas A. Potter Department of Mathematics and Physics University of Wisconsin-Parkside Kenosha WI USA Department of Geosciences University of Wisconsin-Parkside Kenosha WI USA

The existing data on the confirmed extraterrestrial impacts and geomagnetic reversals are examined. Differential rotation of the inner core of the Earth relative to the rest of the planet has been observed through seismic records. Differential rotation between the inner and outer core is thought to be related to the geomagnetic field of the Earth. Extraterrestrial impacts with the surface of the Earth have been shown to cause changes in this differential rotation. It is shown in this paper that there is a strong correlation between the dates of major impacts and geomagnetic reversals. This strongly supports the possibility of major extraterrestrial impacts being one of the causes of geomagnetic reversals as has been suggested previously.

关键词： Earth Extraterrestrial Impact Geomagnetic Reversal

Phagocytosed Polyhedrin-Cytokine Cocrystal Nanoparticles Provide Sustained Secretion of Bioactive Cytokines from Macrophages

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BioDesign Research 2021年第1期2021卷 47-58页

作者： Astrid Wendler nicholas James Michael H.jones Christian Pernstich Cell Guidance Systems Ltd. Maia BuildingBabraham Research CampusCambridge CB223ATUK

Many cells possess the ability to engulf and incorporate particles by *** active process is characteristic of microorganisms as well as higher order *** mammals,monocytes,macrophages,and microglia are among the so-called professional *** addition,cells such as fibroblast and chondrocytes are classified as nonprofessional *** phagocytes play important roles in both the innate and adaptive immune responses,wound healing,and tissue ***,these cells are increasingly studied as targets and vectors of therapeutic intervention to treat a range of *** phagocytes are notoriously difficult to transfect limiting their study and ***,efforts have shifted towards the development of nanoparticles to deliver a cargo to phagocytic cells via ***,this approach carries significant technical challenges,particularly for protein *** have focused on the development of nanoscale cocrystalline protein depots,known as PODS®,that contain protein cargos,including ***,we show that PODS are readily phagocytosed by nonprofessional as well as professional phagocytic cells and have attributes,such as highly sustained release of cargo,that suggest potential utility for the study and exploitation of phagocytic cells for drug *** and macrophages that ingest PODS retain normal characteristics including a robust chemotactic ***,the PODS-cytokine cargo is secreted by the loaded cell at a level sufficient to modulate the behavior of surrounding nonphagocytic *** results presented here demonstrate the potential of PODS nanoparticles as a novel molecular tool for the study and manipulation of phagocytic cells and for the development of Trojan horse immunotherapy strategies to treat cancer and other diseases.

关键词： sustained healing professional