检索结果-南通市图书馆

Visualising the heart of chaos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第12期10卷 2256-2257页

作者： nicholas j.Lambert Harald G.L.Schwefel Department of Physics University of OtagoDunedinNew Zealand The Dodd-Walls Centre for Photonic and Quantum Technologies DunedinNew Zealand

The intra-cavity electro-magnetic field distribution in a microdisk resonator can be visualised by inducing a phase shift via a scanning probe beam.

关键词： resonator chaos Visual

Interference from HONO in the measurement of ambient air NO2 via photolytic conversion and quantification of NO

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Environmental Sciences 2021年第9期33卷 184-193页

作者： nicholas j.Gingerysty Charles A.Odame-Ankrah Nick jordan Hans D.Osthoff Department of Chemistry University of CalgaryCalgary AB T2N 1N4Canada Global Analyzer Systems Ltd. Calgary AB T2E 7L6Canada

The reference method to quantify mixing ratios of the criteria air pollutant nitrogen dioxide(NO_(2)) is NO-O_(3) chemiluminescence(CL), in which mixing ratios of nitric oxide(NO) are measured by sampling ambient air directly, and mixing ratios of NO_(x)(= sum of NO and NO_(2))are measured by converting NO_(2) to NO using, for example, heated molybdenum catalyst or,more selectively, photolytic conversion(P-CL).In this work, the nitrous acid(HONO) interference in the measurement of NO_(2) by P-CL was *** with two photolytic NO2 converters are *** first used radiation centered at 395 nm, a wavelength region commonly utilized in *** second used light at 415 nm, where the overlap with the HONO absorption spectrum and hence its photolysis rate are *** ratios of NO_(2),NO_(x) and HONO entering and exiting the converters were quantified by Thermal Dissociation Cavity Ring-down Spectroscopy(TD-CRDS).Both converters exhibited high NO_(2) conversion efficiency(CF_(NO2);> 90%) and partial conversion of *** of CF against flow rate were consistent with photolysis frequencies of 4.2 s^(-1) and 2.9 s^(-1) for NO_(2) and 0.25 s^(-1) and 0.10 s^(-1) for HONO at 395 nm and 415 nm, *** larger than predicted from the overlap of the emission and HONO absorption *** results imply that measurements of NO2 by P-CL marginally but systematically overestimate true NO_(2) concentrations,and that this interference should be considered in environments with high HONO:NO_(2) ratios such as the marine boundary layer or in biomass burning plumes.

关键词： Photolytic conversion of NO_(2) HONO interference

100pT/cm single-point MEMS magnetic gradiometer from a commercial accelerometer

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2020年第1期6卷 602-614页

作者： josh javor Alexander Stange Corey Pollock nicholas Fuhr David j.Bishop Department of Mechanical Engineering Boston UniversityBostonMA 02215USA Division of Materials Science and Engineering Boston UniversityBostonMA 02215USA Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Physics Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA

Magnetic sensing is present in our everyday interactions with consumer electronics and demonstrates the potential for the measurement of extremely weak biomagnetic fields,such as those of the heart and *** this work,we leverage the many benefits of microelectromechanical system(MEMS)devices to fabricate a small,low-power,and inexpensive sensor whose resolution is in the range of biomagnetic *** present,biomagnetic fields are measured only by expensive mechanisms such as optical pumping and superconducting quantum interference devices(SQUIDs),suggesting a large opportunity for MEMS technology in this *** prototype fabrication is achieved by assembling micro-objects,including a permanent micromagnet,onto a postrelease commercial MEMS accelerometer using a pick-and-place *** this system,we demonstrate a room-temperature MEMS magnetic *** air,the sensor’s response is linear,with a resolution of 1.1 nT cm^(−1),spans over 3 decades of dynamic range to 4.6µT cm^(−1),and is capable of off-resonance measurements at low *** a 1mTorr vacuum with 20 dB magnetic shielding,the sensor achieves a 100 pT cm^(−1) resolution at *** resolution represents a 30-fold improvement compared with that of MEMS magnetometer technology and a 1000-fold improvement compared with that of MEMS gradiometer *** sensor is capable of a small spatial resolution with a magnetic sensing element of 0.25 mm along its sensitive axis,a>4-fold improvement compared with that of MEMS gradiometer *** calculated noise floor of this platform is 110 fTcm^(−1) Hz−1/2,and thus,these devices hold promise for both magnetocardiography(MCG)and magnetoencephalography(MEG)applications.

关键词： accelerometer magnetometer everyday

Concurrent chemoradiation for high-risk prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Clinical Oncology 2015年第4期6卷 35-42页

作者： Benjamin T Cooper nicholas j Sanfilippo Department of Radiation Oncology New York University School of Medicine

There are estimated to be 220800 cases of prostate cancer diagnosed in 2015, making up 26% of all cancer diagnoses. Fortunately, adenocarcinoma of the prostate is often a highly treatable malignancy. Even though the majority of prostate cancer patients present with localized disease, prostate cancer still accounts for over 27000 deaths a year. There is a subset of patients thatare likely to recur after locoregional treatment that is thought of as a "high-risk" population. This more aggressive subset includes patients with clinical stage greater than T2 b, Gleason score greater than 7, and prostate specific antigen greater than 20 ng/d L. The rate of biochemical relapse in this high risk group is 32%-70% within five years of definitive focal therapy. Given these discouraging outcomes, attempts have been made to improve cure rates by radiation dose escalation, addition of androgen depravation therapy, and addition of chemotherapy either sequentially or concurrently with radiation. One method that has been shown to improve clinical outcomes is the addition of chemotherapy to radiotherapy for definitive treatment. Concurrent chemoradiation with 5-fluorouracil, estramustine phosphate, vincristine, docetaxel, and paclitaxel has been studied in the phase I and/or II setting. These trials have identified the maximum tolerated dose of chemotherapy and radiation that can be safely delivered concurrently and established the safety and feasibility of this technique. This review will focus on the addition of concurrent chemotherapy to radiotherapy in the definitive management of high-risk prostate cancer.

关键词： Prostate cancer Chemoradiation Highrisk prostate cancer Concurrent chemotherapy Chemotherapy Intensity modulated radiation therapy

Characterization of colonic dendritic cells in normal and colitic mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2005年第40期11卷 6338-6347页

作者： Sheena M Cruickshank nicholas R English Peter j Felsburg Simon R Carding Institute of Molecular and Cellular Biology Antigen Presentation Research Group Department of Clinical Science

AIM： Recent studies demonstrating the direct involvement of dendritic cells （DC） in the activation of pathogenic T cells in animal models of inflammatory bowel disease identify DC as important antigen presenting cells in the colon. However, very little is known about the properties of colonic DC. METHODS： Using immunohistochemistry, electron microscopy and flow cytometry we have characterized and compared colonic DC in the colon of healthy animals and interleukin-2-deficient （IL2-/-） mice that develop colitis. RESULTS： In the healthy colon, DC resided within the lamina propria and in close association with the basement membrane of colonic villi. Type i myeloid （CD11c^＋, CD11b^＋, B220, CD8） DC made up the largest （40-45%） population and all DC expressed low levels of CD80, CD86, and CD40, and had high endooltic activity consistent with an immature phenotype. In colitic IL2-/- mice, colonic DC numbers increased four- to five-fold and were localized within the epithelial layer and within aggregates of T and B cells. They were also many more DC in mesenteric lymph nodes （MLN）. The majority （〉85%） of DC in the colon and MLN of IL2./ mice were type 1 myeloid, and expressed high levels of MHC class II, CD80, CD86, CD40, DEC 205, and CCR5 molecules and were of low endocytic activity consistent with mature DC. CONCLUSION： These findings demonstrate striking changes in the number, distribution and phenotype of DC in the inflamed colon. Their intimate association with lymphocytes in the colon and draining lymph nodes suggest that they may contribute directly to the ongoing inflammation in the colon.

关键词： Colonic dendritic cells Interleukin 2 Colitis

Themis regulates metabolic signaling and effector functions in CD4^(+) T cells by controlling NFAT nuclear translocation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第9期18卷 2249-2261页

作者： Mukul Prasad joanna Brzostek Namrata Gautam Renu Balyan Vasily Rybakin nicholas R.j.Gascoigne Translational Immunology Programme Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University of Singapore5 Science Drive 2Singapore 117545Singapore H.Lee Moffitt Cancer Center and Research Institute TampaFLUSA Torque Therapeutics CambridgeMAUSA

Themis is a T cell lineage-specific molecule that is involved in TCR signal *** effects of germline Themis deletion on peripheral CD4^(+)T cell function have not been described *** this study,we found that Themis-deficient CD4^(+)T cells had poor proliferative responses,reduced cytokine production in vitro and weaker inflammatory potential,as measured by their ability to cause colitis in *** T cells are quiescent,whereas activated T cells have high metabolic *** of these metabolic demands depends upon nutrient availability and upregulation of nutrient intake channels after efficient TCR signal transduction,which leads to metabolic reprogramming in T *** tested whether defects in effector functions were caused by impaired metabolic shifts in Themis-deficient CD4^(+)T cells due to inefficient TCR signal transduction,in turn caused by the lack of *** found that upon TCR stimulation,Themis-deficient CD4^(+)T cells were unable to upregulate the expression of insulin receptor(IR),glucose transporter(GLUT1),the neutral amino acid transporter CD98 and the mTOR pathway,as measured by c-Myc and pS6 *** analysis of activated Themis-deficient CD4^(+)T cells showed more oxidative phosphorylation(OXPHOS)than aerobic glycolysis,indicating defective metabolic ***,we found reduced NFAT translocation in Themis-deficient CD4^(+)T cells upon TCR *** previously reported ChIP-seq and RNA-seq data,we found that NFAT nuclear translocation controls IR gene ***,our results describe an internal circuit between TCR signal transduction,NFAT nuclear translocation,and metabolic signaling in CD4^(+)T cells.

关键词： Immunometabolism NFAT nuclear translocation Insulin receptor mTOR Mitochondria

Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2005年第47期11卷 7525-7530页

作者： Maria Gazouli Gerassimos Mantzaris Athanassios j Archimandritis George Nasioulas nicholas P Anagnou Department of Biology School of MedicineUniversity of AthensAthens 11725Greece Department of Gastroenterology Evagelismos HospitalAthens 11521Greece Department of Internal Medicine Hippokration General HospitalSchool of MedicineUniversity of AthensAthens 11527Greece Molecular Biology Department Research Center HYGEIA "Antonis Papayiannis" AthensGreece

AIM: To validate novel single nucleotide polymorphisms (SNPs) in Greek patients with Crohn's disease (CD).METHODS: A total of 120 patients with CD, 85 patients with UC, and 100 unrelated healthy controls were genotyped. Genotyping was performed by allele-specific PCR or by PCR-RFLP ***: Our results showed that the 1672T and -207C alleles were obviously over-represented in CD patients only (P＜0.01 and P＜0.05, respectively) compared to the control population. The G113A polymorphism was completely absent in our studied population. The odds ratio for the carriage of the TC haplotype was 2.21 for CD patients as compared with controls. Additionally, the frequency of the TC haplotype was increased in patients with ileocolitis or colitis, and was mainly associated with the fibrostenotic phenotype of the disease. Furthermore, when the TC haplotype was compared jointly with the carriage of at least one mutation of the NOD2/CARD15 gene, there was an increased risk for CD, but not for UC, compared to controls. Regarding the location of the disease, the concomitant presence of the TC haplotype and NOD2/CARD15 mutations was mainly associated with ileocolitis or ileitis. CONCLUSION: Collectively, our results suggest that the 1672T variant of the OCTN1 gene and the -207C variant of the OCTN2 gene represent risk factors for CD in the Greek population.

关键词： Crohn's disease SNPs OCTN1 OCTN2 DLG5

Vertical response of microbial community and degrading genes to petroleum hydrocarbon contamination in saline alkaline soil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Environmental Sciences 2019年第7期31卷 80-92页

作者： Qinglong Liu jingchun Tang Xiaomei Liu Benru Song Meinan Zhen nicholas j.Ashbolt College of Environmental Science and Engineering Nankai University Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education) Tianjin Engineering Research Center of Environmental Diagnosis and Contamination Remediation School of Public Health University of Alberta

A column microcosm was conducted by amending crude oil into Dagang Oilfield soil to simulate the bioremediation process. The dynamic change of microbial communities and metabolic genes in vertical depth soil from 0 to 80 cm were characterized to evaluate the petroleum degradation potential of indigenous microorganism. The influence of environmental variables on the microbial responds to petroleum contamination were analyzed. Degradation extent of 42.45% of n-alkanes(C8–C40) and 34.61% of 16ΣPAH were reached after 22 weeks. Relative abundance of alkB, nah, and phe gene showed about 10-fold increment in different depth of soil layers. Result of HTS profiles demonstrated that Pseudomonas, Marinobacter and Lactococcus were the major petroleum-degrading bacteria in0–30 and 30–60 cm depth of soils. Fusarium and Aspergillus were the dominant oil-degrading fungi in the 0–60 cm depth of soils. In 60–80 cm deep soil, anaerobic bacteria such as Bacteroidetes, Lactococcus, and Alcanivorax played important roles in petroleum *** analysis(RDA) and correlation analysis demonstrated that petroleum hydrocarbons(PHs) as well as soil salinity, clay content, and anaerobic conditions were the dominant effect factors on microbial community compositions in 0–30, 30–60, and 60–80 cm depth of soils, respectively.

关键词： Column microcosm Molecular analyses Petroleum hydrocarbons Microbial community Catabolic genes Saline alkaline soil

Longitudinal bicyclist,driver,and pedestrian perceptions of autonomous vehicle communication strategies

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

journal of Traffic and Transportation Engineering(English Edition) 2023年第1期10卷 31-44页

作者： nicholas N.Ferenchak Department of Civil Construction&Environmental EngineeringUniversity of New MexicoAlbuquerqueNM 87131USA

We sought to better understand how autonomous vehicle(AV)communication strategies impact human road users’*** specifically,we explored the impact of different external human-machine interface(eHMI)designs on task load,comfort,trust,and *** accomplish this,we created virtual reality(VR)scenarios where human participants interacted with AVs in biking,driving,and pedestrian *** were brought back after initial testing to explore acclimation and learning *** designs included a text-based grille eHMI,a text-based roof eHMI,a text-based driver-side door eHMI,anon-textual LED windshield strip eHMI,and a non-textual side mirror arrow *** presence of an eHMI was the strongest positive predictor of comfort,trust,and acceptance outcomes in the statistical models when controlling for all other *** was a clear divide between text-based eHMIs and non-text eHMIs with text-based eHMIs experiencing better perception *** LED Windshield experienced the worst perception *** were perception acclimation effects detected which were most notable for task load(which decreased over time)and comfort(which increased over time).Perception scores for the different eHMI designs tended to cluster over ***,the acclimation effects had less of an impact than the presence of an *** outcomes had weaker relationships with participant characteristics than with AV *** suggest that eHMI presence and design,AV behavior,and acclimation are most impactful in terms of perceptions.

关键词： Vehicle automation Communication Human-automation interaction Technology acceptance Virtual reality