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Prevalence and classification of equinus foot in bilateral spastic cerebral palsy

World Journal of Pediatrics 2019年第3期15卷 276-280页

作者： Axel Horsch Marco G(o)tze Andreas Geisbüsch nicholas beckmann Stefanos Tsitlakidis Gregor Berrsche Matthias Klotz Heidelberg University Hospital Clinic for Orthopedics and Trauma SurgerySchlierbacher Landstr.200a69118 HeidelbergGermany

Background Equinus is a common deformity in children with bilateral spastic cerebral palsy (BSCP).While dynamic equinus usually is treated by conservative therapy,fixed contractures need surgical *** choose the appropriate surgical method,it is important to discriminate between isolated gastrocnemius shortening and combined gastrosoleus complex *** In a retrospective study 938 patients with BSCP were *** underwent gait analysis and clinical examination.248 patients (496 limbs) met the inclusion *** from motion analysis and clinical examination were used to calculate the prevalence and to further classify fixed equinus *** The prevalence of equinus was 83.3%.During clinical exam 246 (59.6%) limbs showed combined gastrosoleus complex contracture and 167 (40.4%) isolated gastrocnemius *** at stance and mean DF at initial contact were significantly reduced in combined contracture,while *** was increased (P < 0.05).Conclusions Corroborating the results of previous studies,in this study there was a high prevalence of fixed equinus in patients with *** prevalence of equinus correlated with increasing *** half of the patients with fixed equinus show a different involvement of gastrocnemius and soleus muscle,we recommend to apply Silfverski(o)ld's test to discriminate between those two types to choose the appropriate surgical therapy.

关键词： Cerebral palsy Classification Equinus foot Equinus prevalence Gait analysis

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Clinical outcomes for men with positive surgical margins after radical prostatectomy—results from the South Australian Prostate Cancer Clinical Outcomes Collaborative community-based registry

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Asian Journal of Urology 2023年第4期10卷 502-511页

作者： Kerri R.beckmann Michael E.O'Callaghan Andrew D.Vincent Kim L.Moretti nicholas R.Brook Cancer Epidemiology and Population Health Research University of South AustraliaAdelaideAustralia Translational Oncology and Urology Research Division of Pharmaceutical and Cancer StudiesKings College LondonLondonUK South Australian Prostate Cancer Clinical Outcomes Collaborative Flinders Medical CentreAdelaideAustralia The Freemason's Foundation Centre for Men's Health Adelaide Medical SchoolUniversity of AdelaideAdelaideAustralia Discipline of Surgery University of AdelaideAdelaideAustralia Department of Urology Royal Adelaide HospitalAdelaideAustralia

Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear *** confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes are affected is *** study investigated factors associated with PSMs following RP and determined their impact on clinical outcomes(BCR,second treatment[radiotherapy and/or androgen deprivation therapy],and prostate cancer-specific mortality[PCSM]).Methods The study cohort included men diagnosed with prostate cancer(pT2-3b/N0/M0)between January 1998 and June 2016 who underwent RP from the South Australian Prostate Cancer Clinical Outcomes Collaborative *** associated with risk of PSMs were identified using Poisson *** impact of PSMs on clinical outcomes(BCR,second treatment,and PCSM)was assessed using competing risk *** Of the 2827 eligible participants,28%had PSMs—10%apical,6%bladder neck,17%posterolateral,and 5%at multiple *** follow-up was 9.6 years with 81 deaths from prostate cancer *** of PSM increased with higher pathological grade and pathological tumor stage,and greater tumour volume,but decreased with increasing surgeon volume(odds ratio[OR]:0.93;95%confidence interval[CI]:0.88-0.98,per 100 previous prostatectomies).PSMs were associated with increased risk of BCR(adjusted sub-distribution hazard ratio[sHR]2.5;95%CI 2.1-3.1)and second treatment(sHR 2.9;95%CI 2.4-3.5).Risk of BCR was increased similarly for each PSM location,but was higher for multiple margin *** found no association between PSMs and *** Our findings support previous research suggesting that PSMs are not independently associated with PCSM despite strong association with *** PSM rates remains an important objective,given the higher likelihood of secondary treatment with associated comorbidities.

关键词： Prostate cancer Positive surgical margin Biochemical recurrence Radical

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Degradation behavior and osseointegration of Mg-Zn-Ca screws in different bone regions of growing sheep:a pilot study

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Regenerative Biomaterials 2023年第1期10卷 1-14页

作者： Romy Marek Hanna C´wieka nicholas Donohue Patrick Holweg Julian Moosmann Felix beckmann Iva Brcic Uwe Yacine Schwarze Kamila Iskhakova Marwa Chaabane Sandra Sefa Berit Zeller-Plumhoff Annelie-Martina Weinberg Regine Willumeit-Ro¨mer Nicole Gabriele Sommer Department of Orthopaedics and Traumatology Medical University of Graz8010 GrazAustria Institute of Metallic Biomaterials Helmholtz-Zentrum Hereon GmbH21502 GeesthachtGermany National Institute for Bioprocessing Research and Training University College DublinDublin 4Ireland Institute of Materials Physics Helmholtz-Zentrum Hereon GmbH21502 GeesthachtGermany D&R Institute of Pathology Medical University of Graz8010 GrazAustria Department of Dental Medicine and Oral Health Medical University of Graz8010 GrazAustria SCANCO Medical AG 8306 Wangen-BruttisellenSwitzerland

Magnesium(Mg)-based implants are highly attractive for the orthopedic field and may replace titanium(Ti)as support for fracture *** determine the implant-bone interaction in different bony regions,we implanted Mg-based alloy ZX00(Mg<0.5 Zn<0.5 Ca,in wt%)and Ti-screws into the distal epiphysis and distal metaphysis of sheep *** implant degradation and osseointegration were assessed in vivo and ex vivo after 4,6 and 12weeks,using a combination of clinical computed tomography,medium-resolution micro computed tomography(mCT)and high-resolution synchrotron radiation mCT(SRmCT).Implant volume loss,gas formation and bone growth were evaluated for both implantation sites and each bone region ***,histological analysis of bone growth was performed on embedded hard-tissue *** demonstrate that in all cases,the degradation rate of ZX00-implants ranges between 0.23 and 0.75mm/*** highest degradation rates were found in the ***-to-implant contact varied between the time points and bone types for both ***,bone-volume-to-total-volume was higher around ***,we found an increased cortical thickness around the ZX00-screws when compared with the *** results showed the suitability of ZX00-screws for implantation into the distalmeta-and epiphysis.

关键词： biodegradable implants magnesium-based alloys computed tomography Mg-Zn-Ca sheep histology

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