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World Journal of Emergency Medicine 2020年第1期11卷 54-59页

作者： Harith Fernando nicholas Adams Biswadev Mitra Emergency and Trauma Centre The Alfred HospitalMelbourneVictoriaAustralia National Trauma Research Institute The Alfred HospitalMelbourneVictoriaAustralia Department of Epidemiology and Preventive Medicine Monash UniversityMelbourneVictoriaAustralia

Dear editor,Patients with supraventricular tachycardia(SVT)commonly present to the emergency department(ED).Current guidelines[1,2]do not recommend routine pathology testing and a report on the topic has questioned their role.A systematic review concluded that troponin testing is commonly performed with a high proportion of positive fi ndings,but these results were not associated with major adverse cardiac events.[3]The conclusions of this review were limited by paucity of data and heterogeneity among studies.

关键词： tachycardia routine pathology

SRMD:Sparse Random Mode Decomposition

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Communications on Applied Mathematics and Computation 2024年第2期6卷 879-906页

作者： nicholas Richardson Hayden Schaeffer Giang Tran University of Waterloo WaterlooONCanada University of British Columbia VancouverBCCanada University of California Los AngelesCAUSA

Signal decomposition and multiscale signal analysis provide many useful tools for timefrequency *** proposed a random feature method for analyzing time-series data by constructing a sparse approximation to the *** randomization is both in the time window locations and the frequency sampling,which lowers the overall sampling and computational *** sparsification of the spectrogram leads to a sharp separation between time-frequency clusters which makes it easier to identify intrinsic modes,and thus leads to a new data-driven mode *** applications include signal representation,outlier removal,and mode *** benchmark tests,we show that our approach outperforms other state-of-the-art decomposition methods.

关键词： Sparse random features Signal decomposition Short-time Fourier transform

Multimodal label-free microscopy

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 17-38页

作者： Nicolas Pavillon Katsumasa Fujita nicholas Isaac Smith Biophotonics LaboratoryImmunology Frontier Research Center(IFReC Department of Applied Physics Osaka UniversitySuitaOsaka 565-0871Japan

This paper reviews the different multimodal applications based on a large ext ent of label-freeinaging modalities,ranging from linear to nonlinear optics,while also inchuding *** put specific emphasis on multimodal measurements going across the usual boundaries between imaging modalities,whereas most multimodal platforms combine techniquesbased on similar light interactions or similar hardware *** this review,we limitthe scope to focus on applications for biology such as live cells or tissues,since by their nat ure ofbeing alive or fragile,we are often not free to take liberties with the image acquisition times andare forced to gather the maximum amount of information possible at one *** such samples,imaging by a given label-free method usually presents a challenge in obt aining suficient opticalsignal or is limited in terms of the types of observable *** imaging is thenparticularly attractive for these samples in order to maximize the amount of measured *** multimodal imaging is always useful in the sense of acquiring additional infor-mation from additional modes,at times it is possible to attain information that could not bediscovered using any single mode alone,which is the essence of the progress that is possible usinga multimodal approach.

关键词： Optical microscopy nonlinear optics microspectroscopy

Long Waves Associated with Bichromatic Waves

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China Ocean Engineering 2001年第2期16卷 281-289页

作者：董国海叶文亚 nicholas Dodd The State Key Laboratory of Coastal and O ffshore Engineering Dalian University of Technology Dalian 116023 China Coastal Group HR Wallingford Howbery Park W allingford OX10 8BA U. K.

A numerical model of low frequency waves is presented. The model is based on that of Roelvink (1993), but the numerical techniques used in the solution are based on the so-called Weighted- Average Flux (WAF) method with Time-Operator- Splitting JOS) used for the treatment of the source terms. This method allows a small number of computational points to be used, and is particularly efficient in modeling wave setup. The short wave (or primary wave) energy equation is solved with a traditional Lax-Wendroff technique. A nonlinear wave theory is introduced. The model described in this paper is found to be satisfactory in modeling low frequency waves associated with incident bichromatic waves.

关键词： incident waves bichromatic waves long waves wave breaking

Cell-type resolved transcriptomic approaches for dissecting selective vulnerability in neurodgeneration

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Neural Regeneration Research 2024年第7期19卷 1411-1413页

作者： Caleb A.Wood nicholas M.Tran Department of Neuroscience Baylor College of MedicineHoustonTXUSA Department of Molecular and Human Genetics Baylor College of MedicineHoustonTXUSA

A common feature among neurodegenerative conditions is that ce rtain neuronal populations are selectively vulnerable to loss(Fu et al.,2018).By corollary,other neurons are selectively resilient,suggesting they may possess unique features that support their survival.U nderstanding the basis of neuronal resilience or vulnerability would provide a logical strategy to identify factors that could be targeted therapeutically.

关键词： selective targeted

Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

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World Journal of Gastroenterology 2015年第14期21卷 4126-4135页

作者： nicholas G Theodorakis Yining N Wang Vyacheslav A Korshunov Mary A Maluccio nicholas J Skill Division of Transplant Surgery Department of SurgerySchool of MedicineIndiana University School of Medicine University of Rochester

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and *** reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully *** hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible NOS isoform gene knockout ***: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PVL or sham surgery and were given either thalidomide or *** nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO *** TNFα level was quantified by enzyme-linked immunosorbent ***α m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain *** was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 *** to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PVL mice when compared to sham operated control *** contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PVL mice when compared to sham *** TNFα level in both sham and PVL mice was below the detection limit of the commercial ELISA ***, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- *** acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-***, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PVL mice, aft

关键词： Portal hypertension Thalidomide Nitric oxide Knock

Intraoperative cholangiography 2020:Quo vadis? A systematic review of the literature

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 145-153页

作者： Konstantinos Georgiou Gabriel Sandblom nicholas Alexakis Lars Enochsson First Department of Propaedeutic Surgery Hippokration General Hospital of AthensAthens Medical SchoolNational and Kapodistrian University of AthensAthens 10679Greece Department of Clinical Science and Education Department of SurgeryKarolinska InstitutetSödersjukhusetStockholm 17177SESweden Department of Surgical and perioperative Sciences SurgeryUmeåUniversityUmeå90187SESweden

Background: There are few randomized controlled trials with sufficient statistical power to assess the effectiveness of intraoperative cholangiography(IOC) in the detection and treatment of common bile duct injury(BDI) or retained stones during cholecystectomy. The best evidence so far regarding IOC and reduced morbidity related to BDI and retained common bile duct stones was derived from large populationbased cohort studies. Population-based studies also have the advantage of reflecting the outcome of the procedure as it is practiced in the community at large. However, the outcomes of these population-based studies are conflicting. Data sources: A systematic literature search was conducted in 2020 to search for articles that contained the terms “bile duct injury”, “critical view of safety”, “bile duct imaging” or “retained stones” in combination with IOC. All identifed references were screened to select population-based studies and observational studies from large centers where socioeconomic or geographical selections were assumed not to cause selection bias. Results: The search revealed 273 references. A total of 30 articles fulflled the criteria for a large observational study with minimal risk for selection bias. The majority suggested that IOC reduces morbidity associated with BDI and retained common bile duct stones. In the short term, IOC increases the cost of surgery. However, this is offset by reduced costs in the long run since BDI or retained stones detected during surgery are managed immediately. Conclusions: IOC reduces morbidity associated with BDI and retained common bile duct stones. The reports reviewed are derived from large, unselected populations, thereby providing a high external validity. However, more studies on routine and selective IOC with well-defned outcome measures and sufficient statistical power are needed.

关键词： Cholangiography Cholecystectomy Bile duct stones Bile duct injury Cost

Digital re-analysis of lost architecture and the particular case of Lutyens＇ Liverpool Metropolitan Cathedral

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Frontiers of Architectural Research 2016年第2期5卷 265-275页

作者： nicholas Webb Andre Brown School of Architecture University of Liverpool Liverpool L69 7ZN United Kingdom

Research and critique of unbuilt or destroyed works of architecture is traditionally carried out through the examination of surviving information such as drawings, models, photographs, biographies and monographs. The case study presented here demonstrates that this approach cannot always give a fuU-picture of the architect or designer＇s intentions, and may miss inconsistencies in the design and links to other precedents or antecedents in such schemes. Here, we employ strategic contemporary digital representation techniques to re-present and re-analyse the evidence available for a particular architectural project. We describe a systematic methodology, which shows that these techniques can challenge or enhance current understanding. The focus therefore is on the digital re-analysis process that has been devised. Sir Edwin Lutyens＇ unbuilt Liverpool Metropolitan Cathedral design, that would have delivered one of the largest cathedrals in the world, is used as a case study. The findings reveal new information about the cathedral by following structured lines of enquiry generated from the study of primary and secondary source data, as well as serendipitous results that occur as a potential by-product of the methodological process.

关键词： Unbuitt architecture Digitalcritique Forensic anatysis Digitat modetting

76nt RNAs are transported axonally into regenerating axons and growth *** are they doing there?

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Neural Regeneration Research 2016年第3期11卷 390-391页

作者： nicholas A.Ingoglia Binta Jalloh Department of Pharmacology and Physiology New Jersey Medical SchoolRutgers University Department of Cell Biology Emory University

Successful nerve regeneration requires not only that neurons reconstruct new axons distal to the site of injury,but also those growing axons must navigate through the neuropil to make appropriate synaptic connections with target *** this is an imposing task for the thousands of axons that may occupy a regenerating nerve in the peripheral nervous system or a tract inthe central nervous system, the billions of neurons in the developing brain must accomplish similar tasks making connections that number in the trillions. How do neurons do this？

关键词： reconstruct cones distal doing synaptic axonal regeneration occupy transported likely

Androgen deprivation therapy for prostate cancer： not so simple

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Asian Journal of Andrology 2011年第2期13卷 187-188页

作者： nicholas N Tadros Mark Garzotto Division of Urology Oregon Health ＆ Science UniversityPortland OR 97239 USA and 2portland VA MedicalCenter 3710 SW US Veterans Hospital Pd. PortlandOR 97239 USA

Prostate cancer （PC） is the second most diagnosed visceral malignancy in men worldwide, with over 900 000 new diagnoses each year.1 Approximately 50% of patients treated in industrialized nations will receive androgen deprivation therapy （ADT） at some point in their lifetimes.2 The use of ADT as a treatment approach is likely to increase as new drug developments have focused on intensifying the effect of reducing androgen receptor activation.

关键词： Androgens Physics Wells