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Active tracking of rejected dried blood samples in a large program in Nigeria

World Journal of Virology 2016年第2期5卷 73-81页

作者： Auchi Inalegwu Sunny Phillips Rawlings Datir Christopher Chime Petronilla Ozumba Samuel Peters Obinna Ogbanufe Charles Mensah Alash'Le Abimiku Patrick Dakum nicaise ndembi Institute of Human Virology US Centers for Disease Control and Prevention Embassy of the United States of America Institute of Human Virology University of Maryland School of Medicine

AIM: To study the impact of rejection at different levels of health care by retrospectively reviewing records of dried blood spot samples received at the molecular laboratory for human immunodeficiency virus(HIV) early infant diagnosis(EID) between January 2008 and December ***: The specimen rejection rate, reasons for rejection and the impact of rejection at different levels of health care was examined. The extracted data were cleaned and checked for consistency and then deduplicated using the unique patient and clinic identifiers. The cleaned data were ciphered and exported to SPSS version 19(SPSS 2010 IBM Corp, New York, United States) for statistical ***: Sample rejection rate of 2.4%(n = 786/32552) and repeat rate of 8.8%(n = 69/786) were established. The mean age of infants presenting for first HIV molecular test among accepted valid samples was 17.83 wk(95%CI: 17.65-18.01) vs 20.30 wk(95%CI: 16.53-24.06) for repeated samples. HIV infection rate was 9.8% vs 15.9% for accepted and repeated samples. Compared to tertiary healthcare clinics, secondary and primary clinics had twofold and three-fold higher likelihood of sample rejection, respectively(P < 0.05). We observed a significant increase in sample rejection rate with increasing number of EID clinics(r = 0.893, P = 0.041). The major reasons for rejection were improper sample collection(26.3%), improper labeling(16.4%) and insufficient blood(14.8%). CONCLUSION: Programs should monitor pre-analytical variables and incorporate continuous quality improvement interventions to reduce errors associated with sample rejection and improve patient retention.

关键词： Human immunodeficiency virus Prevention of mother-to-child transmission Early infant diagnosis Dried blood spot Pre-analytical error Sample rejection

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Africa aims to avert an mpox pandemic

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四川生理科学杂志 2024年第10期46卷 2323-2323页

作者： nicaise ndembi nicaise ndembi is the Africa mpox incident manager for the Continental Preparedness and Response Plan Africa Centres for Disease Control and Prevention Addis Ababa Ethiopia. Salim S. Abdool Karim is the chair of the Africa Centres for Disease Control and Prevention Emergency Consultative Group Addis Ababa Ethiopia director of the Centre for the AIDS Programme of Research in South Africa University of KwaZulu-Natal Durban South Africa and a professor in the Department of Epidemiology Mailman School of Public Health Columbia University New York NY USA.

Last month,when the world's most populus country,India,reported its first case of the new,highly transmissible clade Ib mpox variant,the challenge of containing the virus was once again *** a few weeks before that in August,the World Health Organization(WHO)and the Africa Centres for Disease Control and Prevention(Africa CDC)declared mpox a public health emergency in response to its spread in *** then,cases of clade Ib mpox have been reported in Sweden,Thailand,and *** mpox is not yet a global pandemic,the new variant may tip the scales in that direction if the world does not act quickly to mitigate its spread in Africa.

关键词： Africa spread Sweden

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