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Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy

Chinese Chemical Letters 2024年第4期35卷 316-320页

作者： Ling-Ling Wu Xiangchuan Meng Qingyang Zhang Xiaowan Han Feiya Yang Qinghua Wang Hai-Yu Hu nianzeng xing Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China

Photoacoustic agents combining photodynamic therapy(PDT) and photothermal therapy(PTT) functions have emerged as potent theranostic agents for combating cancer. The molecular approaches for enhancing the near-infrared(NIR)-absorption and maximizing non-radiative energy transfer are essential for effective photoacoustic imaging(PAI) and therapy applications. In addition, such molecules with high specificity and affinity to cancer cells are urgently needed, which would further decrease the side effect during treatments. In this study, we applied a heavy-atom engineering strategy and introduced p-aminophenol,-thio, and-seleno moieties into NIR heptamethine cyanine(Cy7) skeleton(Cy7-X-NH_(2), X = O, S, Se) to significantly increase photothermal conversion efficiency for PTT and promote intersystem crossing for ***, we designed a series of nitroreductase(NTR)-activated photoacoustic probes(Cy7-X-NO_(2),X = O, S, Se), and target hypoxic tumors with NTR overexpression. Our prostate cancer targeting probe,Cy7-Se-NO_(2)-KUE, exhibited specific tumor photoacoustic signals and effective tumor killing through outstanding synergistic PTT/PDT in vivo. These findings highlighted a versatile strategy for cancer photoacoustic diagnosis and enhanced phototherapy.

关键词： Heavy-atom effect Phototherapy Photoacoustic imaging Hypoxia-responsive Prostate cancer

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Prognostic value of Controlling Nutritional Status score for postoperative complications and biochemical recurrence in prostate cancer patients undergoing laparoscopic radical prostatectomy

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Current Urology 2024年第1期18卷 43-48页

作者： Tianyu Xiong Xiaobo Ye Guangyi Zhu Fang Cao Yun Cui Liming Song Mingshuai Wang Wahafu Wasilijiang nianzeng xing Yinong Niu Department of Urology Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Urology Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Urology Cancer Hospital Chinese Academy of Medical SciencesBeijingChina

Background:Controlling Nutritional Status(CONUT)score was used for screening the preoperative nutritional *** correlation between the CONUT score and the prognosis of patients with prostate cancer(PCa)has yet to be ***,we analyzed the prognostic value of CONUT scores in patients with PCa who underwent laparoscopic radical *** and methods:Data of 244 patients were retrospectively *** variables and follow-up data were *** patients were categorized into 2 groups according to their preoperative CONUT *** complication and incontinence rates were also *** Kaplan-Meier method was used to estimate the median biochemical recurrence-free survival(BCRFS)between the 2 *** and multivariate Cox regression analyses were performed to identify the potential prognostic factors for ***:Patients were categorized into the low-CONUT group(CONUT score<3,n=207)and high-CONUT group(CONUT score≥3,n=37).The high-CONUT group had a higher overall complication rate(40.5%vs.19.3%,p=0.004),a higher major complication rate(10.8%vs.3.9%,p=0.013),and longer postoperative length of stay(8 days vs.7 days,p=0.017).More fever,urinary infection,abdominal infection,scrotal edema,rash,and hemorrhagic events(all p values<0.05)were observed in the high-CONUT group.A higher rate of urinary incontinence was observed in the high-CONUT group at 1(34.4%vs.13.2%,p=0.030)and 3 months(24.1%vs.8.2%,p=0.023)*** high-CONUT group had shorter medium BCRFS(23.8 months vs.54.6 months,p=0.029),and a CONUT score≥3 was an independent risk factor for a shorter BCRFS(hazards ratio,1.842;p=0.026).Conclusions:The CONUT score is a useful predictive tool for higher postoperative complication rates and shorter BCRFS in patients with PCa who undergo laparoscopic radical prostatectomy.

关键词： Controlling Nutritional Status score Prostate cancer Laparoscopic radical prostatectomy Complication Biochemical recurrence

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盆腔动静脉畸形1例报告

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中华泌尿外科杂志 2024年第9期45卷 716-717页

作者：司占南宋刚张勇邢念增国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100021

盆腔动静脉畸形罕见,其内部循环连接比较复杂,一般通过血管造影诊断。本文报道1例盆腔肿物,患者因发现盆腔肿物4年人院。依据术前影像学结果不能确诊,行机器人辅助腹腔镜下盆腔肿物切除术,术后病理为完全闭塞性动静脉畸形。手术顺利,术... 详细信息

盆腔动静脉畸形罕见,其内部循环连接比较复杂,一般通过血管造影诊断。本文报道1例盆腔肿物,患者因发现盆腔肿物4年人院。依据术前影像学结果不能确诊,行机器人辅助腹腔镜下盆腔肿物切除术,术后病理为完全闭塞性动静脉畸形。手术顺利,术后10个月无复发、转移。

关键词：动静脉畸形盆腔动脉栓塞手术治疗

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Adaptive ultra-hypofractionated whole-pelvic radiotherapy in high-risk and very high-risk prostate cancer on 1.5-Tesla MR-Linac:Estimated delivered dose and early toxicity results

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Chronic Diseases and Translational Medicine 2024年第1期10卷 51-61页

作者： Linrui Gao Ran Wei Shirui Qin Yuan Tian Wenlong Xia Yongwen Song Shulian Wang Hui Fang Yu Tang Hao Jing Yueping Liu Yuan Tang Shunan Qi Bo Chen Yexiong Li nianzeng xing Ningning Lu Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina GCP Center/Clinical Research Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Urology State Key Laboratory of Molecular OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background: Magnetic resonance(MR)-guided ultra-hypofractionated radiotherapy with whole-pelvic irradiation(UHF-WPRT)is a novel approach to radiotherapy for patients with high-risk(HR)and very high-risk(VHR)prostate cancer(PCa).However,the inherent complexity of adaptive UHF-WPRT might inevitably result in longer on-couch *** aimed to estimate the delivered dose,study the feasibility and safety of adaptive UHF-WPRT on a 1.5-Tesla ***: Ten patients with clinical stage T3a-4N0-1M0-1c PCa,who consecutively received UHF-WPRT,were enrolled *** contours of the target and organ-at-risks on the position verification-MR(PV-MR),beam-on 3D-MR(Bn-MR),and post-MR(after radiotherapy delivery)were derived from the pre-MR data by deformable image *** physician then manually adjusted them,and dose recalculation was performed *** Prism 9(GraphPad Prism Software Inc.)was utilized for conducting statistical ***: In total,we collected 188 MR scans(50 pre-MR,50 PV-MR,44 Bn-MR,and 44 post-MR scans).With median 59 min,the mean prostate clinical target volume(CTV)-V_(100%)was 98.59%±2.74%,and the mean pelvic CTVp-V_(100%)relative percentages of all scans was 99.60%±1.18%.The median V29 Gy change in the rectal wall was−2%(−18%to 20%).With a median follow-up of 9 months,no patient had acute Common Terminology Criteria for Adverse Events(CTCAE)grade 2 or more severe genitourinary(GU)or gastrointestinal(GI)toxicities(0%).Conclusion: UHF-RT to the prostate and the whole pelvis with concomitant boost to positive nodes using an Adapt-To-Shape(ATS)workflow was technically feasible for patients with HR and VHR PCa,presenting only mild GU and GI *** estimated target dose during the beam-on phase was clinically acceptable based on the 3D-MR-based dosimetry *** trial registration Chinese Clinical Trial Registry ChiCTR2000033382.

关键词： dosimetry hypofractionation magnetic resonance imaging prostate cancer radiation dose radiotherapy

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腹腔镜下体腔内构建邢氏新膀胱的长期疗效分析

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中华医学杂志 2024年第26期104卷 2449-2451页

作者：王明帅张世豪王建文贾博林杨飞亚王文宽张勇邢念增国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院泌尿外科北京首都医科大学附属北京朝阳医院泌尿外科北京

评估腹腔镜下体腔内邢氏新膀胱术后长期生存无复发患者的新膀胱功能。回顾性分析2013年7月至2018年7月于首都医科大学附属北京朝阳医院行腹腔镜下根治性膀胱切除术+体腔内邢氏新膀胱术并长期生存患者的临床资料, 总结存活5年以上患者术... 详细信息

评估腹腔镜下体腔内邢氏新膀胱术后长期生存无复发患者的新膀胱功能。回顾性分析2013年7月至2018年7月于首都医科大学附属北京朝阳医院行腹腔镜下根治性膀胱切除术+体腔内邢氏新膀胱术并长期生存患者的临床资料, 总结存活5年以上患者术后排尿功能及肾功能。共17例患者, 男15例, 女2例, 年龄为(55.9±7.6)岁。均由同一手术团队完成。所有手术均顺利完成, 手术时间是(340±62)min, 17例患者中位随访时间[M(Q1, Q3)]80(70, 96)个月, 白天可尿控17例(100%), 夜间可尿控13例(76.5%), 膀胱中位容量350(200, 400)ml, 复查均未出现肾积水、肌酐升高等情况。本研究表明邢氏新膀胱术患者术后保持了可接受的尿控状况, 膀胱容量良好, 长期随访疗效满意。

关键词：膀胱肿瘤尿控新膀胱术长期随访

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尿液细胞学巴黎报告系统在肿瘤专科医院临床应用的真实世界研究

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中华肿瘤杂志 2024年第7期46卷 703-709页

作者：赵焕张智慧郭会芹韦娜马海玥赵琳琳孙悦王聪常馨香毕新刚邢念增国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院病理科北京100021 郑州大学第一附属医院病理科郑州450052 国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院泌尿外科北京100021

目的探讨尿液细胞学巴黎报告系统(TPS)在临床应用中的实际意义。方法回顾性连续收集2020年1月至2022年6月中国医学科学院肿瘤医院1744份自然排空尿标本(751个尿液标本)细胞学诊断资料,以组织病理诊断为金标准,对比尿液细胞学诊断尿路上... 详细信息

目的探讨尿液细胞学巴黎报告系统(TPS)在临床应用中的实际意义。方法回顾性连续收集2020年1月至2022年6月中国医学科学院肿瘤医院1744份自然排空尿标本(751个尿液标本)细胞学诊断资料,以组织病理诊断为金标准,对比尿液细胞学诊断尿路上皮癌的灵敏度、特异度及每个诊断分类的高级别恶性风险。结果360例患者有组织病理诊断结果,细胞学诊断分类占比分别为未见高级别尿路上皮癌30.1%(226/751)、非典型尿路上皮细胞29.8%(224/751)、可疑高级别尿路上皮癌16.8%(126/751)、高级别尿路上皮癌21.2%(159/751)、非尿路上皮恶性肿瘤2.1%(16/751)。细胞学各个诊断级别所对应的组织病理相关高级别恶性风险分别为27.3%(未见高级别尿路上皮癌)、32.7%(非典型尿路上皮细胞)、74.7%(可疑高级别尿路上皮癌)、96.6%(高级别尿路上皮癌)、100.0%(非尿路上皮恶性肿瘤)。可疑高级别尿路上皮癌高级别恶性风险高于非典型尿路上皮细胞(P<0.001),高级别尿路上皮癌高级别恶性风险高于可疑高级别尿路上皮癌(P<0.001)。以可疑高级别尿路上皮癌为界值,细胞学诊断高级别尿路上皮癌的灵敏度和特异度分别为76.7%(165/215)和85.7%(18/21);以高级别尿路上皮癌为界值,细胞学诊断高级别尿路上皮癌的灵敏度和特异度分别为53.0%(114/215)和100.0%(21/21)。结论尿液细胞学诊断高级别尿路上皮癌有较高的灵敏度和特异度;TPS不同诊断级别的恶性风险不同,肿瘤专科医院的高恶性风险人群导致了各个诊断级别均有相对高的恶性占比及高级别恶性风险;TPS有助于临床管理,有较好的临床应用价值。

关键词：泌尿系肿瘤高级别尿路上皮癌尿液细胞学尿液细胞学巴黎报告系统高级别恶性风险

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SEMA3A-mediated crosstalk between prostate cancer cells and tumor-associated macrophages promotes androgen deprivation therapy resistance

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Cellular & Molecular Immunology 2021年第3期18卷 752-754页

作者： Fei Liu Chao Wang Hai Huang Yue Yang Lihe Dai Sujun Han nianzeng xing Shancheng Ren Department of Urology Shanghai Changhai HospitalShanghaiChina Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Kidney Diseases BeijingChina Department of Urinary Surgery Gongli Hospitalthe Second Military Medical UniversityShanghaiChina Department of Urinary Surgery Ruijin HospitalShanghai Jiao tong University School of MedicineShanghaiChina

Androgen deprivation therapy(ADT)is an important treatment strategy that can be used to delay the progression of prostate ***,after an initial response,which varies significantly among patients,the disease eventually progresses despite the low levels of testosterone in the systemic circulation.1 The mechanism underlying the progression of prostate cancer to castration-resistant prostate cancer(CRPC)is not yet clear,and further investigation is needed.

关键词： cancer deprivation therapy

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Membrane dual-targeting probes:A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection

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Acta Pharmaceutica Sinica B 2023年第3期13卷 1204-1215页

作者： Ling-Ling Wu Qinxin Zhao Qinghua Wang Qingyang Zhang Feiya Yang Bo Zheng Hai-Yu Hu nianzeng xing State Key Laboratory of Bioactive Substances and Function of Natural Medicine Institute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100050China Department of Urology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Urology Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030013China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Fluorescence-guided surgery(FGS)with tumor-targeted imaging agents,particularly those using the near-infrared wavelength,has emerged as a real-time technique to highlight the tumor location and margins during a surgical *** accurate visualization of prostate cancer(PCa)boundary and lymphatic metastasis,we developed a new approach involving an efficient self-quenched near-infrared fluorescence probe,Cy-KUE-OA,with dual PCa-membrane ***-KUE-OA specifically targeted the prostate-specific membrane antigen(PSMA),anchored into the phospholipids of the cell membrane of PCa cells and consequently showed a strong Cy7-de-quenching *** dual–membrane-targeting probe allowed us to detect PSMA-expressing PCa cells both in vitro and in vivo and enabled clear visualization of the tumor boundary during fluorescence-guided laparoscopic surgery in PCa mouse ***,the high PCa preference of Cy-KUE-OA was confirmed on surgically resected patient specimens of healthy tissues,PCa,and lymph node *** together,our results serve as a bridge between preclinical and clinical research in FGS of PCa and lay a solid foundation for further clinical research.

关键词： Activated probe Small molecule nanoparticle Self-assembly Dual-targeting Near-infrared Prostate cancer Fluorescence-guided surgery Metastases

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阴茎背深静脉丛预缝合技术在机器人辅助腹腔镜前列腺根治性切除术中的临床疗效

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中华医学杂志 2024年第38期104卷 3608-3611页

作者：王一凡王明帅杨飞亚陈东韩苏军贾博林张勇邢念增国家癌症中心国家肿瘤临床医学研究中心中国医学科学院北京协和医学院肿瘤医院泌尿外科北京

回顾分析2020年10月至2022年4月在中国医学科学院肿瘤医院接受机器人辅助腹腔镜下Vattikuti泌尿外科研究所前列腺癌根治术(VIP)的33例患者的临床资料, 其中18例采用传统VIP技术, 15例采用预缝合阴茎背深静脉丛(DVC)的VIP技术。传统VIP... 详细信息

回顾分析2020年10月至2022年4月在中国医学科学院肿瘤医院接受机器人辅助腹腔镜下Vattikuti泌尿外科研究所前列腺癌根治术(VIP)的33例患者的临床资料, 其中18例采用传统VIP技术, 15例采用预缝合阴茎背深静脉丛(DVC)的VIP技术。传统VIP组与预缝合DVC VIP组年龄分别为(66.1±7.3)和(66.6±5.7)岁;体质指数(BMI)分别为(24.3±2.9)、(25.3±2.6)kg/m2;医疗费用分别为(91 797.0±7 029.6)和(87 106.6±7 031.4)元, 差异均无统计学意义(均P>0.05)。33例手术均顺利完成, 无中转开放病例。传统VIP组手术时间长于预缝合DVC VIP组[(193.0±37.2)比(171.1±16.1)min)];术中出血量多于预缝合DVC VIP组[(68.3±22.8)比(44.0±9.1)ml)], 均P<0.05, 无患者围手术期输血, 术后30 d内无患者出现并发症。33例患者切缘均为阴性。DVC预缝合技术在机器人辅助腹腔镜VIP前列腺根治性切除术中能够减少术中出血, 缩短手术时间, 疗效较好。

关键词：前列腺肿瘤背深静脉丛机器人根治性前列腺切除术

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Radical Nephrectomy Using a Chevron Incision to Treat Complicated Renal Carcinoma:a Report of 15 Cases

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Chinese Journal of Clinical Oncology 2008年第4期5卷 286-289页

作者： Ning Kang Junhui Zhang Yinong Niu nianzeng xing Department of Urology Beijing ChaoyangHospital Urology Institute Capital Universityof Medical Science Beijing 100020 China.

OBJECTIVE To investigate the outcome and indications for radical nephrectomy with a Chevron incision to treat complicated renal carcinoma. METHODS Large renal carcinomas were found in 15 patients during a preoperative CT and/or MRI examination. A tumor thrombus in the renal vein or inferior vena cava was found in 5 cases, and a complication of metastasis in the contralateral adrenal gland was found in 2 patients. All of the 15 patients underwent a radical nephrectomy by a chevron incision and the postoperative pathological results noted. RESULTS Of the 15 patients who underwent a radical nephrectomy and lymphadenectomy, 5 also received a thrombectomy, and 2 a contralateral adrenalectomy. All surgical operations were safe and successful. The mean operation time was （4.45 ± 0.83） h, and the intraoperative blood loss was （785 ± 910） ml. All patierfts recovered well after the surgery. Multimodal therapy was conducted in these cases, with rigorous follow-up. CONCLUSION In determining the type of incision for surgery of renal carcinoma, a chevron incision is suitable for cases with a large tumor, local nodal metastasis, thrombus of the renal vein or inferior vena cava and complicated metastasis to the contralateral adrenal gland. The incision produces a clear operating field with less intra- and post-operative complications.

关键词： kidney carcinoma chevron incision.

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