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Rapid Simultaneous Determination of Four Ganoderic Acids in Ganoderma(Chinese Name:Lingzhi)by Direct Infusion-Multiple Reaction Monitoring Cubed

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Journal of Analysis and Testing 2024年第1期8卷 52-62页

作者： nian wu Bo Peng Ting Li Pengfei Tu Shengpeng Wang Bo Li Wenjing Liu Yuelin Song Modern Research Center for Traditional Chinese Medicine Beijing Research Institute of Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China Amway(China)Botanical Research Center Wuxi 214011China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipa 999078China Amway(Shanghai)Innovation&Science Co. LtdShanghai 201508China School of Pharmacy Henan University of Chinese MedicineZhengzhou 450046China

Attributing to the rapid demand expansion for the edible medicinal materials in the market,the limited throughput of highperformance liquid chromatography-multiple reaction monitoring(HPLC-MRM)cannot fully address the measurement workload for a huge number of testing ***,it is urgent to pursue more efficient approaches for the quality *** of the greater selectivity of MRM cubed(MRM^(3))over MRM,there might be a chance to omit the time-intensive LC *** current study,we attempted to develop a direct infusion(DI)-MRM^(3) program,and the applicability was thereafter assessed through simultaneous determination of four ganoderic acids(GAs)in one of the most famous tonic herbal medicines namely Ganoderma(Chinese name:Lingzhi).Primary parameters such as Q1>Q3>QLIT ion transitions,collision energy(CE),and excitation energy were optimized by programming online energy-resolved mass spectrometry with authentic compounds.A single DI-MRM measurement merely costed four minutes,and in spite of the wide occurrences of isomers,satisfactory selectivity was *** validation assays demonstrated the method to be sensitive,precise,accurate,and *** quantitative results from DI-MRM^(3) were also justified by conducting LC-MRM measurements in *** differences occurred for the content patterns between the two original sources namely Ganoderma lucidum and ***,and,moreover,either cultivar or harvest time showed dramatical influence on the quantitative features of the four targeted *** importantly,DI-MRM3 is a meaningful analytical option for rapid quantitative analysis of herbal medicines,because of the comparable reliability,nonetheless,less consumptions of both measurement time and solvent,compared with LC-MRM.

关键词： Direct infusion Multiple reaction monitoring cubed High-throughput quantitative analysis Ganoderic acids Ganoderma

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Adiposity in Chinese people with type 1 diabetes

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World Journal of Diabetes 2024年第7期15卷 1404-1408页

作者： nian-Wei wu Xia-Fei Lyu Zhen-Mei An She-Yu Li Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Guideline and Rapid Recommendation Chinese Evidence-based Medicine CenterCochrane China Center and MAGIC China CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Adiposity,synonymous with obesity,is prevalent among both children and adults with type 1 diabetes in *** literature underscored the pathophysiological and socioeconomic factors associated with adiposity,and consistently highlighted its impact on cardiovascular,kidney,and metabolic diseases among Chinese individuals with type 1 *** and managing adiposity in individuals with type 1 diabetes are complicated and entail comprehensive approaches including lifestyle modifications,cognitive-behavioral therapy,insulin dose titration,and other diabetes treatment *** condition calls for coordination among policymakers,researchers,clinicians,and patients.

关键词： Type 1 diabetes China Metabolic syndrome Obesity Anti-obesity medications

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Intelligent diagnostic model for pterygium by combining attention mechanism and MobileNetV2

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1184-1192页

作者： Mao-nian wu Kai He Yi-Bei Yu Bo Zheng Shao-Jun Zhu Xiang-Qian Hong Wen-Qun Xi Zhe Zhang School of Information Engineering Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Zhejiang Province Key Laboratory of Smart Management and Application of Modern Agricultural Resources Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina School of Mathematical Information Shaoxing UniversityShaoxing 312000Zhejiang ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To evaluate the application of an intelligent diagnostic model for ***:For intelligent diagnosis of pterygium,the attention mechanisms—SENet,ECANet,CBAM,and Self-Attention—were fused with the lightweight MobileNetV2 model structure to construct a tri-classification *** study used 1220 images of three types of anterior ocular segments of the pterygium provided by the Eye Hospital of Nanjing Medical *** classification models—VGG16,ResNet50,MobileNetV2,and EfficientNetB7—were trained on the same dataset for *** evaluate model performance in terms of accuracy,Kappa value,test time,sensitivity,specificity,the area under curve(AUC),and visual heat map,470 test images of the anterior segment of the pterygium were ***:The accuracy of the MobileNetV2+Self-Attention model with 281 MB in model size was 92.77%,and the Kappa value of the model was 88.92%.The testing time using the model was 9ms/image in the server and 138ms/image in the local *** sensitivity,specificity,and AUC for the diagnosis of pterygium using normal anterior segment images were 99.47%,100%,and 100%,respectively;using anterior segment images in the observation period were 88.30%,95.32%,and 96.70%,respectively;and using the anterior segment images in the surgery period were 88.18%,94.44%,and 97.30%,***:The developed model is lightweight and can be used not only for detection but also for assessing the severity of pterygium.

关键词： deep learning attention mechanism pterygium intelligent diagnosis

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World Journal of Clinical Cases 2024年第24期12卷 5589-5595页

作者： Zhi-nian wu Ru JI Ying Xiao Ya-Dong Wang Cai-Yan Zhao Department of Infectious Diseases The Hebei Medical University Third HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND The complexity of immunoglobulin G4(IgG4)-related diseases and their potential connection to hematologic malignancies remains *** article provided a review of the diagnosis and treatment of a patient with IgG4-related sclerosing cholangitis(SC)and essential thrombocythemia(ET),along with an analysis of relevant literature to enhance comprehension of this *** SUMMARY A 56-year-old male was admitted to two hospitals with deteriorating jaundice and pruritus prior to *** our expectations,the patient was first diagnosed with IgG4-SC and ET with the Janus kinase 2 V617F ***,the administration of acetate prednisone significantly resulted in improvements in both IgG4-SC and *** need to pay attention to immune disorders and inflammation as they contribute to the development of various disease *** When IgG4-SC is suspected without histopathological evidence,diagnostic therapy and long-term regular follow-up can lead to positive treatment *** should be mindful of the potential presence of concurrent hematologic diseases in patients with immune disorders.

关键词： Immunoglobulin G4-related sclerosing cholangitis Essential thrombocythemia Autoimmune pancreatitis Janus kinase 2 mutation Glucocorticoids Case report

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基于无人机电力巡检的椭圆稀布阵列天线优化方法研究

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电测与仪表 2024年第7期61卷 88-93页

作者：缪钟灵吴念姚隽雯柯贤彬王丛别士光广东电网有限责任公司机巡作业中心广州510000 国网电力科学研究院武汉南瑞有限责任公司武汉430070

为了提高电力巡检无人机的电磁检测性能,提出了一种基于无人机电力巡检的椭圆稀布阵列天线优化方法。阵列天线的阵列单元稀布排列,能够在保证阵列天线性能的同时,减少阵列单元的数目,从而减少馈电单元的数目。每个阵列单元等幅馈电,可... 详细信息

为了提高电力巡检无人机的电磁检测性能,提出了一种基于无人机电力巡检的椭圆稀布阵列天线优化方法。阵列天线的阵列单元稀布排列,能够在保证阵列天线性能的同时,减少阵列单元的数目,从而减少馈电单元的数目。每个阵列单元等幅馈电,可以有效降低馈电网络设计的复杂程度,这些都能够在一定程度上降低阵列天线的功耗,提高无人机的巡检时间。利用改进智能优化算法,通过优化阵列单元的位置,使方向图的最高旁瓣电平(peak sidelobe level,PSLL)尽量低,因此文中设计的阵列天线具有较低的最高旁瓣电平,从而具有很好的环境抗干扰能力。仿真结果表明,在给定阵列单元数目、最小间距约束和阵列天线尺寸的情况下,提出的方法能够有效降低阵列天线方向图的最高旁瓣电平,对具有41个阵列单元的椭圆阵列天线进行优化,优化后的阵列天线方向图的最高旁瓣电平在-24dB以下。

关键词：电力巡检无人机阵列天线入侵杂草算法差分进化算法最高旁瓣电平

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Self-assembly of nanoparticles at solid-liquid interface for electrochemical capacitors

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Rare Metals 2022年第11期41卷 3591-3611页

作者： Xue Li Chen Chen Qian Niu nian-wu Li Le Yu Bao Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China StateKey Lab of Organic-Inorganic Composites Beijing UniversityofChemicalTechnologyBeijing100029China

Self-assembly of nanoparticles at solid-liquid interface could be promising to realize the assembled functions for various applications,such as rechargeable batteries,supercapacitors,and *** review summarizes the self-assembly of the nanoparticles at solid-liquid interface according to the different driving forces of assembly,including hydrophilic-hydrophobic interactions,solvophobic and electrostatic *** be specific,the self-assembly can be divided into the following two types:surfactant-assisted self-assembly and direct self-assembly of Janus particles(inorganic and amphiphilic copolymer-inorganic Janus nanoparticles).Using the emulsion stabilized by nanoparticles as the template,the self-assembly constructed by the interaction of the nanostructure unit(including metal,metal oxide,and semiconductor,etc.)not only possesses the characteristic of nanostructure unit,but also exhibits the excellent assembly performance in electrochemistry *** application of these assemblies in the area of electrochemical capacitors is ***,the current research progress and perspectives toward the self-assembly of nanoparticles at stabilized solid-liquid interface are proposed.

关键词： Self-assembly Solid-liquid interface Driving force Electrochemical capacitors

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连翘多糖提取工艺优化及抗氧化和抑菌活性研究

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商洛学院学报 2024年第2期38卷 59-65页

作者：何念武董玉珊朱姝俣商洛学院生物医药与食品工程学院/商洛市粮食工程技术研究中心陕西商洛726000

以连翘果实为原料,采用超声波辅助水提醇沉法提取连翘粗多糖,以连翘粗多糖提取率为考察指标,在单因素试验的基础上,采用正交试验对连翘粗多糖提取工艺进行优化,进而采用DPPH法和ABTS法考察连翘多糖体外抗氧化活性,抑菌圈法考察连翘多糖... 详细信息

以连翘果实为原料,采用超声波辅助水提醇沉法提取连翘粗多糖,以连翘粗多糖提取率为考察指标,在单因素试验的基础上,采用正交试验对连翘粗多糖提取工艺进行优化,进而采用DPPH法和ABTS法考察连翘多糖体外抗氧化活性,抑菌圈法考察连翘多糖对大肠埃希菌等食物腐败菌的抑菌活性。结果表明,连翘果实多糖的最佳提取工艺为:料液比1:20(g:mL),提取温度70℃,超声功率70 W,提取时间50 min。在此条件下,连翘果实多糖提取率为1.98%。连翘粗多糖对金黄色葡萄球菌和大肠埃希菌均有良好的生长抑制作用,且对金黄色葡萄球菌的抑制作用优于大肠埃希菌。当连翘粗多糖质量浓度为2.5 mg/mL时,大肠埃希菌的抑菌圈平均直径为10.46 mm,金黄色葡萄球菌抑菌圈平均直径为11.73 mm。连翘多糖对DPPH·和ABTS·有较好的清除能力,并呈现良好的质量浓度-效应关系。连翘多糖不但对食品腐败菌有一定的抑菌活性,还具有良好的体外抗氧化活性。可见,连翘粗多糖具有开发成食品防腐保鲜剂的潜能。

关键词：连翘多糖热水浸提法抗氧化活性抑菌活性

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Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3103-3112页

作者： Xu-nian wu Qian Zhou Ya-Dan Huang Xi Xie Zhe Li Yinuo wu Hai-Bin Luo School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou510006China Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China

Our previous study demonstrated that phosphodiesterase 8(PDE8)could work as a potential target for vascular dementia(Va D)using a chemical probe ***,compound 3a is a chiral compound which was obtained by chiral resolution on HPLC,restricting its usage in ***,a series of non-chiral 9-benzyl-2-chloro-adenine derivatives were discovered as novel PDE8 *** 15 exhibited potent inhibitory activity against PDE8A(IC_(50)=11 nmol/L),high selectivity over other PDEs,and remarkable drug-like properties(worthy to mention is that its bioavailability was up to 100%).Oral administration of 15 significantly improved the c AMP level of the right brain and exhibited dosedependent effects on cognitive improvement in a Va D mouse ***,the X-ray crystal structure of the PDE8A—15 complex showed that the potent affinity and high selectivity of 15 might come from the distinctive interactions with H-pocket including T-shapedπ—πinteractions with Phe785 as well as a unique H-bond network,which have never been observed in other PDE-inhibitor complex before,providing new strategies for the further rational design of novel selective inhibitors against PDE8.

关键词： Phosphodiesterase 8(PDE8) Vascular dementia Structure-based drug design MM-GB/SA Free energy prediction Structure—activity relationship Binding potencies

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Effect of Zn^(2+)-Cu^(2+)combined heavy metal on mechanical properties and microstructure of clayey soil

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Journal of Mountain Science 2022年第9期19卷 2556-2569页

作者： MA Qiang wu nian-ze XIAO Heng-lin LI Wen-tao XIANG Jun-chen School of Civil Engineering Architecture and EnvironmentHubei University of TechnologyWuhan 430068China Innovation Demonstration Base of Ecological Environment Geotechnical and Ecological Restoration of Rivers and Lakes Hubei University of TechnologyWuhan 430068China School of Resources and Civil Engineering Northeastern UniversityShenyang 10819China Science and Technology Innovation Center for Smart Water Conservancy and Resources and Environment Northeastern UniversityShenyang 10819China

The strength deterioration mechanism of soil polluted by heavy metals plays a crucial role in the research of mine site *** this study,an unconfined compressive strength(UCS)test,a pH test,a scanning electron microscopy(SEM)test,a low filed nuclear magnetic resonance(NMR)test,and an X-ray diffraction(XRD)test were conducted on Zn^(2+),Cu^(2+) and the combination of Zn^(2+) and Cu^(2+) polluted soil to investigate the strength deterioration *** results show that both the UCS and pH value of soil decrease with increasing heavy metal *** UCS of Zn^(2+)-Cu^(2+) combined polluted soil is between Zn^(2+) and Cu^(2+) polluted soil at the same total ***,the deterioration rate of combined heavy metal polluted soil is less than the sum of deterioration rate of the two single polluted soils at the same total *** addition,heavy metal cations in polluted soil cause flocculent gels of cosmids to shrink,the micropores to become smaller and the macropores to become *** porosity increases slightly with the increase of heavy metal concentration due to decreased pH *** results from SEM,low field NMR,and pH could explain the dynamic evolution process of soil structure with different heavy metals and concentrations,which provides an experimental basis for mine-site polluted heavy metal treatment technology and the prediction of clayey soil strength deterioration.

关键词： Combined polluted soil Mechanical properties Pore size distribution Microstructure Heavy metal

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拉森钢板桩支护体系在大型机场项目液化深基坑中的应用

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建筑技术开发 2024年第2期51卷 144-146页

作者：詹新彬刘俊刘涛吴年华李安修北京城建集团有限责任公司北京100088 北京冠华英才国际经济技术有限公司北京101200

根据太原武宿国际机场三期改扩建工程项目设备共同沟区域深基坑施工需求及复杂地质环境条件,在小锁口拉森钢板桩应用的基础上,从液化深基坑支护体系的总体部署、设计参数及施工要点的角度系统总结了以拉森钢板桩为主,高压旋喷桩、卸土... 详细信息

根据太原武宿国际机场三期改扩建工程项目设备共同沟区域深基坑施工需求及复杂地质环境条件,在小锁口拉森钢板桩应用的基础上,从液化深基坑支护体系的总体部署、设计参数及施工要点的角度系统总结了以拉森钢板桩为主,高压旋喷桩、卸土放坡为辅的创新支护体系的应用经验,在项目上取得了很好的效果,节省了材料和工期,有利于推进绿色施工,形成了良好的示范作用。

关键词：液化地基深基坑支护体系拉森钢板桩

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