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Removal of baseline wander from ECG signal based on a statistical weighted moving average filter

Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第5期12卷 397-403页

作者： Xiao HU Zhong XIAO nizhang School of Mechanical and Electric Engineering Guangzhou University Guangzhou 510006 China Guangdong General Hospital Guangzhou 510080 China

Baseline wander is a common noise in electrocardiogram (ECG) *** effectively correct the baseline and to preserve more underlying components of an ECG signal,we propose a simple and novel filtering method based on a statistical weighted moving average *** a and b are theminimum and maximum of all sample values within a moving window,***,the whole region [a,b] is divided into M equal sub-regions without ***,three sub-regions with the largest sample distribution probabilities are chosen (except M<3) and incorporated into one region,denoted as [a 0,b 0 ] for ***,for every sample point in the moving window,its weight is set to 1 if its value falls in [a 0,b 0 ];otherwise,its weight is ***,all sample points with weight 1 are averaged to estimate the *** algorithm was tested by simulated ECG signal and real ECG signal from *** results showed that the proposed filter could more effectively extract baseline wander from ECG signal and affect the morphological feature of ECG signal considerably less than both the traditional moving average filter and wavelet package translation did.

关键词： ECG signal Baseline wander Morphological feature Moving average filter Wavelet package translation

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Sequential changes of serum ferritin levels and their clinical significance in lamivudine-treated patients with chronic viral hepatitis B

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World Journal of Gastroenterology 2004年第7期10卷 972-976页

作者： Zheng-WenLiu Qun-YingHan nizhang WenKang DepartmentofInfectiousDiseases FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofInfectiousDiseases FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To study the sequential changes of serum ferritin levels in lamivudine-treated patients with chronic viral hepatitis B and the clinical implications. METHODS: Thirty-eight patients with chronic viral hepatitis B were prospectively studied during their treatment with lamivudine. Each patient received 100 mg oral lamivudine daily for 12 mo, and was observed and tested for blood biochemistry and hepatitis B virus (HBV) DNA levels and serum ferritin levels at baseline and at 3, 6 and 12 mo during the treatment. Serum HBV DNA levels were quantitatively determined using fluorescent quantitative polymerase chain reaction (FQ-PCR), and serum ferritin levels were measured by radioimmunoassay. The sequential changes of serum ferdtin levels and their relationships with virological, serological and biochemical responses in the patients were analyzed. RESULTS: All the patients had a baseline HBV DNA level higher than 1×10^7 copies/L as determined by FQ-PCR and positive HBsAg and HBeAg and abnormal ALT levels. At the end of the 12-mo treatment, 19 of the 38(50.00%) patients had undetectable serum HBV DNA levels by FQ-PCR, and 12(31.58%) became negative for serum HSeAg and 10(26.32%) had seroconversion from HBeAg to HBeAb. Nineteen out of the 38(50.00%) patients had biochemically normal ALT levels after 12-mo lamivudine treatment. Sequential determination showed bhat lamivudine treatment significantly reduced ferritin levels in chronic hepatitis B patients. When the patients were divided into different groups according to their posttreatment virological, serological and biochemical responses for analysis of the sequential changes of ferritin levels, it was found bhat the decrease of ferritin levels in HBV DNA-negative group was significantly more obvious than that in HBV DNApositive group at 6 mo during the treatment (P=-0.013). Consecutive comparisons showed that ferritin levels at 3 mo of treatment were obviously decreased as compared with the baseline levels (P<0.05) in HB

关键词：慢性乙型肝炎抗病毒治疗血清学检查铁蛋白临床意义 FQ-PCR

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Correlation of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function in Chinese patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2005年第22期11卷 3357-3362页

作者： Zheng-WenLiu nizhang Qun-YingHan Jun-TaoZeng Yong-LieChu Jian-MingQiu Ya-WenWang Lie-TingMa xiao-Qinwang DepartmentofInfectiousDiseases FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina CentralMedicalLaboratory FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina DepartmentofInfectiousDiseases FirstHospitalXi'anJiaotongUniversityXi'an710061ShaanxiProvinceChina

AIM: To determine serum leptin levels and investigate their correlations with anthropometric and metabolic parameters and biochemical liver function in patients with chronic hepatitis C virus (HCV) infection and their potential clinical ***: Forty-two chronic HCV-infected patients without anti-viral treatment were enrolled in this study, 30 patients had chronic hepatitis C, 10 had cirrhosis, and 2 had hepatocellular carcinoma (HCC). Thirty age- and sex-matched healthy individuals served as controls. Serum leptin levels were determined by ELISA. The biochemical liver function and serum lipids were determined at the same time. The height and body weight of patients and controls were measured, and body mass index (BMI) and body fat were calculated simultaneously. The correlations of serum leptin levels with anthropometric and metabolic parameters and biochemical liver function were assessed ***: The mean of serum leptin levels in patients with chronic hepatitis C, HCV-associated cirrhosis, HCVassociated HCC and control groups was (6.13±3.94),(5.25±4.21), (4.17±0.28), and (3.59±3.44) ng/mL, respectively. The serum leptin level in patients with chronic hepatitis C was significantly higher than that in controls. The serum leptin levels between cirrhotic patients and controls and between male and female cirrhotic patients had no significant difference. Serum leptin levels were positively-correlated with body fat, BMI, and apolipoprotein B (Apo B) in patients with chronic HCV infection. The serum alanine aminotransferase (ALT) levels were closelycorrelated with BMI in patients with chronic hepatitis C. CONCLUSION: HCV infection interferes with fat and lipid metabolism in patients with chronic HCV infection and leptin may play a role in hepatosteatosis.

关键词： Chronic hepatitis C Leptin Anthropometric parameter Lipid metabolism

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山东、云南板栗重金属砷、铅、镉含量及风险评估

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山东农业大学学报（自然科学版） 2018年第3期49卷 490-494页

作者：张延平陈振超陈松武莫润宏倪张林汤富彬中国林业科学研究院亚热带林业研究所浙江杭州311400 广西壮族自治区林业科学研究院广西南宁530000

采用原子荧光光谱法和石墨炉原子吸收光谱法分别对我国山东省130份、云南省77份板栗样品的砷、铅和镉的含量进行测定,采用单因子污染指数、综合因子污染指数法对板栗中砷、铅和镉等重金属的污染进行评价,并采用靶标危害系数法对食用板... 详细信息

采用原子荧光光谱法和石墨炉原子吸收光谱法分别对我国山东省130份、云南省77份板栗样品的砷、铅和镉的含量进行测定,采用单因子污染指数、综合因子污染指数法对板栗中砷、铅和镉等重金属的污染进行评价,并采用靶标危害系数法对食用板栗造成的健康风险进行评估。结果表明,山东、云南两省板栗重金属砷、铅、镉的含量分别为ND-0.051 mg/kg,ND-0.120 mg/kg,ND-62μg/kg,板栗重金属含量均未超标。山东、云南两省板栗的砷、铅、镉污染指数均远低于1,综合污染指数评价表明云南省板栗重金属污染指数相对较高,云南省玉溪市板栗P综达0.3572;山东省板栗重金属污染指数相对较低,山东省日照市板栗P综最低为0.0615。人体健康风险评估结果表明:山东、云南两省板栗靶标危害系数最大仅为0.01018,均低于1,成人日最大食用板栗35 g,儿童25 g,远不会对人体造成健康危害。儿童食用板栗的重金属风险高于成年人,其靶标危害系数约为成人的2.678倍。本文总结了山东、云南两省板栗主产区的砷、铅、镉等重金属的污染情况,拟为全国板栗主产区重金属含量及质量安全风险评估研究提供有益的参考依据。

关键词：板栗重金属污染风险评估

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