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Mechanisms exploration of Angelicae Sinensis Radix and Ligusticum Chuanxiong Rhizoma herb-pair for liver fibrosis prevention based on network pharmacology and experimental pharmacologylogy

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Chinese Journal of Natural Medicines 2021年第4期19卷 241-254页

作者： WU jian-Zhi LI ya-jing HUANG Guang-Rui XU Bing ZHOU fei LIU Run-Ping GAO Feng GE jun-De CAI ya-jie ZHENG qi LI Xiao-jiaoyang School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

Angelicae Sinensis Radix(Danggui)and Ligusticum Chuanxiong Rhizoma(Chuan Xiong)herb-pair(DC)have been frequently used in Traditional Chinese medicine(TCM)prescriptions for hundreds of years to prevent vascular diseases and alleviate ***,the mechanism of DC herb-pair in the prevention of liver fibrosis development was still *** the present study,the effects and mechanisms of DC herb-pair on liver fibrosis were examined using network pharmacology and mouse fibrotic *** on the network pharmacological analysis of 13 bioactive ingredients found in DC,a total of 46 targets and 71 pathways related to anti-fibrosis effects were obtained,which was associated with mitogen-activated protein kinase(MAPK)signal pathway,hepatic inflammation and fibrotic ***,this hypothesis was verified using carbon tetrachloride(CCl_4)-induced fibrosis *** of liver functional enzyme activities and histopathological examination showed that DC dramatically reduced bile acid levels,inflammatory cell infiltration and collagen deposition caused by CCl_*** increased expression of liver fibrosis markers,such as collagen 1,fibronectin,α-smooth muscle actin(α-SMA)and transforming growth factor-β(TGF-β),and inflammatory factors,such as chemokine(C-C motif)ligand 2(MCP-1),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and IL-6 in fibrotic mice were significantly downregulated by DC herb-pair through regulation of extracellular signal-regulated kinase 1/2(ERK1/2)-protein kinase B(AKT)signaling ***,these results suggest that DC prevents the development of liver fibrosis by inhibiting collagen deposition,decreasing inflammatory reactions and bile acid accumulation,which provides insights into the mechanisms of herbpair in improving liver fibrosis.

关键词： Angelicae Sinensis Radix Ligusticum Chuanxiong Rhizoma Liver fibrosis Herb-pair Network pharmacology

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Difference in failure patterns of pT3-4N0-3M0 esophageal cancer treated by surgery vs surgery plus radiotherapy

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World Journal of Gastrointestinal Oncology 2019年第12期11卷 1172-1181页

作者： ya Zeng wen Yu qi Liu Wei-Wei Yu Zheng-fei Zhu Wei-Xin Zhao jun Liu jia-Ming Wang Xiao-Long Fu Yuan Liu Xu-Wei Cai Department of Radiation Oncology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200030China Department of Radiation Oncology Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s HospitalShanghai 200030China Department of Statistics Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China

BACKGROUND There has been no study comparing the difference in the failure patterns between patients with or without postoperative radiotherapy(PORT)after esophagectomy for pT3-4N0-3M0 esophageal squamous cell carcinoma(ESCC).AIM To investigate the difference in the failure patterns of stage pT3-4N0-3M0 ESCC patients with or without *** Patients with stage pT3-4N0-3M0 ESCC,who underwent surgery with or without PORT,were enrolled in this *** primary endpoint was to investigate the difference in the failure patterns between patients with or without PORT after *** secondary endpoint was to estimate whether patients with stage pT3-4 ESCC could achieve a disease-free survival(DFS)advantage after receiving adjuvant *** analyses were performed by the Kaplan-Meier method,Cox regression model,and Chi-squared test or Fisher’s exact *** In total,230 patients with stage pT3-4N0-3M0 ESCC were included in this ***-six patients who received PORT were screened from a prospective cohort(S+R arm).And 174 patients involving surgery alone were retrospectively selected from July 2006 to October 2014(S arm).There were no significant differences in the clinical or pathological characteristics of patients between the two arms,except for tumor location(P=0.031).The failure patterns between the two arms were significantly different(Pnificantly higher proportion of locoregional recurrence and a lower proportion of distant metastasis than those in the S+R arm(92.0%vs 35.7%,Pnificant(12.7 vs 8 mo,P=0.048).Univariate analysis and multivariate analysis both demonstrated that the number of lymph node metastases≥3(HR=0.572,95% CI:0.430-0.762,P<0.001)was an independent poor prognostic factor for DFS in patients with stage pT3-4N0-3M0 *** PORT could improve DFS and local c

关键词： Esophageal squamous cell carcinoma Postoperative radiotherapy Failure patterns Disease-free survival

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黄河流域农田土壤重金属污染特征及其优先控制源分析

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环境科学 2024年第3期45卷 1724-1738页

作者：李军李旭李开明焦亮台喜生臧飞曹素珍兰州城市学院城市环境学院兰州730070 西北师范大学甘肃省绿洲资源环境与可持续发展重点实验室兰州730070 兰州大学草地农业科技学院兰州730020

农田土壤环境质量评价与污染溯源解析是保障国家粮食安全和农业可持续发展的基础,也是扎实推进国家净土保卫战的重要前提.基于2000~2023年黄河流域农田土壤重金属(As、 Cd、 Cr、 Cu、 Hg、 ni、 Pb和Zn)含量数据,采用地累积指数法对重... 详细信息

农田土壤环境质量评价与污染溯源解析是保障国家粮食安全和农业可持续发展的基础,也是扎实推进国家净土保卫战的重要前提.基于2000~2023年黄河流域农田土壤重金属(As、 Cd、 Cr、 Cu、 Hg、 ni、 Pb和Zn)含量数据,采用地累积指数法对重金属污染特征进行评价,利用正定矩阵因子分解(PMF)模型定量解析重金属的来源贡献,并通过运用蒙特卡洛(Monte Carlo)模拟和人体健康风险评价模型相耦合的方法评价重金属污染的潜在健康风险,实现优先污染源和污染元素的确定.结果表明:(1)研究区农田土壤所有重金属的含量均值均低于《土壤环境质量农用地土壤污染风险管控标准》(GB 15618-2018)(pH>7.5)的筛选值,但分别有21.69%、 5.56%和1.23%的样点Cd、 As和Zn含量超出其筛选值,Cd超标率最高.(2)Hg和Cd为偏中度污染,Cu和Pb为轻度污染,其余元素均为无污染.(3)农田土壤重金属主要来源为交通-工业源、自然-农业源、工业-自然源和农业-工业源,贡献率分别为37.04%、 26.69%、 21.72%和14.55%.(4)农田土壤重金属对成人与儿童存在致癌健康风险,但不具有非致癌风险;As和Cd为人体健康风险优先控制元素,工业-自然源和农业-工业源为研究区优先控制源.

关键词：黄河流域 Monte Carlo模拟正定矩阵因子分解(PMF)模型源解析健康风险评价

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The evolution of the nasopharyngeal carcinoma staging system over a 10-year period:implications for future revisions

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Chinese Medical Journal 2020年第17期133卷 2044-2053页

作者： Si-qi Tang yan-Ping Mao Cheng Xu Rui Guo wen-fei Li Ling-Long Tang Ying Sun jun Ma Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhouGuangdong 510060China

Background:The classification criteria and staging groups for nasopharyngeal carcinoma described in the Union for International Cancer Control/American Joint Committee on Cancer(UICC/AJCC)staging system have been revised over *** study assessed the proportion of patients whose staging and treatment strategy have changed due to revisions of the UICC/AJCC staging system over the past 10 years(ie,from the sixth edition to the eighth edition),to provide information for further ***:We retrospectively reviewed 1901 patients with non-metastatic nasopharyngeal carcinoma treated in our cancer center between November 2009 and june *** Akaike information criterion and Harrell concordance index were applied to evaluate the performance of the staging ***:In total,25(1.3%)of the 1901 patients who were staged as T2a according to the sixth edition system were downgraded to T1 in the eighth edition;430(22.6%)staged as N0 in the sixth edition were upgraded to N1 in the eighth edition;106(5.6%)staged as N1/2 in the sixth edition were upgraded to N3 in the eighth *** addition,51(2.7%)and 25(1.3%)of the study population were upstaged from stage Ⅰ to stage Ⅱ and stage Ⅱ to stage IVa,respectively;10(0.5%)was downgraded from stage Ⅱ to stage Ⅰ.The survival curves of adjacent N categories and staging groups defined by eighth classification system were ***,there was no significant difference in the locoregional failure-free survival(P=0.730)and disease-free survival(P=0.690)rates between the T2 and T3 categories in the eighth edition classification ***:Modifications to the tumor-node-metastasis staging system over the past 10 years have resulted in N classification changes in numerous *** the eighth edition tumor-node-metastasis staging system better predicts survival outcomes,the T classification could be simplified in future revisions.

关键词： Nasopharyngeal carcinoma Tumor-node metastasis staging system Prognosis

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镍基单晶叶片H_(2)SO_(4)-FeCl_(3)化铣剂及其化铣工艺研究

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铸造 2024年第5期73卷 632-636页

作者：费则元张明俊赵国旗谢宏伟江森海装沈阳局驻沈阳地区某军事代表室辽宁沈阳110043 中国航发沈阳黎明航空发动机有限责任公司辽宁沈阳110043 贵州工程应用技术学院机械学院贵州毕节551700 东北大学冶金学院辽宁沈阳110819

本文研究了H_(2)SO_(4)-FeCl_(3)化铣剂的配制及其化铣DD5单晶高温合金的能力,采用失重速率和OM、SEM、EDS和AFM表征手段分析化铣剂的化铣效果及能力。研究表明,H_(2)SO_(4)-FeCl_(3)化铣剂合适的配制为:H_(2)SO_(4)浓度4.8 mol·L^(-1)... 详细信息

本文研究了H_(2)SO_(4)-FeCl_(3)化铣剂的配制及其化铣DD5单晶高温合金的能力,采用失重速率和OM、SEM、EDS和AFM表征手段分析化铣剂的化铣效果及能力。研究表明,H_(2)SO_(4)-FeCl_(3)化铣剂合适的配制为:H_(2)SO_(4)浓度4.8 mol·L^(-1),FeCl_(3)浓度0.16 mol·L^(-1),两者体积比为4∶1。该化铣剂对DD5单晶铸造合金中ni和Al元素有较强的腐蚀能力,化铣速率快,对Mo、W、Ta和Re元素腐蚀能力较弱,化铣速度较慢;在室温下,化铣较为均匀,表层形成了富含Cr和Co的耐腐蚀氧化物,Cr和Co的腐蚀能力较弱;70℃高温下化铣剂对Cr和Co元素有较强的腐蚀能力,化铣速率明显提高。

关键词：镍基单晶叶片化铣剂化铣 DD5合金

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Pareto-based multi-objective node placement of industrial wireless sensor networks using binary differential evolution harmony search

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Advances in Manufacturing 2016年第1期4卷 66-78页

作者： Ling Wang Lu An Hao-qi ni Wei Ye Panos M. Pardalos Min-Rui fei Shanghai Key Laboratory of Power Station AutomationTechnology School of Mechatronics Engineering andAutomation Shanghai University Shanghai 200072 People'sRepublic of China Department of Industrial and Systems Engineering Centerfor Applied Optimization University of Florida GainesvilleFlorida 32611 USA

The reliability and real time of industrial wireless sensor networks （IWSNs） are the absolute requirements for industrial systems, which are two fore- most obstacles for the large-scale applications of IWSNs. This paper studies the multi-objective node placement problem to guarantee the reliability and real time of IWSNs from the perspective of systems. A novel multi-objective node deployment model is proposed in which the reliabil- ity, real time, costs and scalability of IWSNs are addressed. Considering that the optimal node placement is an NP-hard problem, a new multi-objective binary differential evolu- tion harmony search （MOBDEHS） is developed to tackle it, which is inspired by the mechanism of harmony search and differential evolution. Three large-scale node deploy- ment problems are generated as the benCHmarks to verify the proposed model and algorithm. The experimental results demonstrate that the developed model is valid and can be used to design large-scale IWSNs with guaranteed reliability and real-time performance efficiently. Moreover, the comparison results indicate that the proposed MOB- DEHS is an effective tool for multi-objective node place- ment problems and superior to Pareto-based binary differential evolution algorithms, nondominated sorting genetic algorithm II （NSGA-II） and modified NSGA-II.

关键词： Industrial wireless sensor networks (IWSNs)Node placement Harmony search Differential evolutionPareto Real time Reliability

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DRM:基于迭代归并策略的GPU并行SpMV存储格式

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计算机工程与科学 2024年第3期46卷 381-394页

作者：王宇华何俊飞张宇琪徐悦竹崔环宇哈尔滨工程大学计算机科学与技术学院黑龙江哈尔滨150001 电子政务建模仿真国家工程实验室黑龙江哈尔滨150001

稀疏矩阵向量乘(SpMV)在线性系统的求解问题中具有重要意义,是科学计算和工程实践中的核心问题之一,其性能高度依赖于稀疏矩阵的非零分布。稀疏对角矩阵是一类特殊的稀疏矩阵,其非零元素按照对角线的形式密集排列。针对稀疏对角矩阵,在... 详细信息

稀疏矩阵向量乘(SpMV)在线性系统的求解问题中具有重要意义,是科学计算和工程实践中的核心问题之一,其性能高度依赖于稀疏矩阵的非零分布。稀疏对角矩阵是一类特殊的稀疏矩阵,其非零元素按照对角线的形式密集排列。针对稀疏对角矩阵,在GPU平台上提出的多种存储格式虽然使SpMV性能有所提升,但仍存在零填充和负载不平衡的问题。针对上述问题,提出了一种DRM存储格式,利用基于固定阈值的矩阵划分策略和基于迭代归并的矩阵重构策略,实现了少量零填充和块间负载平衡。实验结果表明,在NVIDIA■ Tesla■ V100平台上,相比于DIA、HDC、HDIA和DIA-Adaptive格式,在时间性能方面,该存储格式分别取得了20.76,1.94,1.13和2.26倍加速;在浮点计算性能方面,分别提高了1.54,5.28,1.13和1.94倍。

关键词： GPU SpMV 稀疏对角矩阵零填充负载平衡

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The Efficiency of a Small-World Functional Brain Network

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Chinese Physics Letters 2012年第4期29卷 236-239页

作者： ZHAO qing-Bai ZHANG Xiao-fei SUI Dan-ni ZHOU Zhi-jin CHEN qi-Cai TANG Yi-Yuan Key Laboratory of Adolescent Cyberpsychology and Behavior(Ministry of Education) and Hubei Human Development and Mental Health Key LaboratorySchool of PsychologyCentral China Normal UniversityWuhan 430079 Foreign Language College Shenyang UniversityShenyang 110044 College of Life Science Central China Normal UniversityWuhan430079 Institute of Neuroinformatics and Laboratory for Brain and Mind Dalian University of TechnologyDalian 116024 Department of Psychology University of OregonEugeneOR 97403USA

We investigate whether the small-world topology of a functional brain network means high information processing efficiency by calculating the correlation between the small-world measures of a functional brain network and behavioral reaction during an imagery *** brain networks are constructed by multichannel eventrelated potential data,in which the electrodes are the nodes and the functional connectivities between them are the *** results show that the correlation between small-world measures and reaction time is task-specific,such that in global imagery,there is a positive correlation between the clustering coefficient and reaction time,while in local imagery the average path length is positively correlated with the reaction *** suggests that the efficiency of a functional brain network is task-dependent.

关键词： network Efficiency Small

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生成式AI的大模型提示工程:方法、现状与展望

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智能科学与技术学报 2024年第2期6卷 115-133页

作者：黄峻林飞杨静王兴霞倪清桦王雨桐田永林李娟娟王飞跃澳门科技大学创新工程学院工程科学系中国澳门999078 青岛智能产业技术研究院山东青岛266109 中国科学院自动化研究所复杂系统管理与控制国家重点实验室北京100190 中国科学院自动化研究所多模态人工智能系统全国重点实验室北京100190 中国科学院大学人工智能学院北京100049

大语言模型和视觉语言模型在各领域的应用中展示出巨大潜力,成为研究热点。然而,幻觉、知识迁移、与人类意图对齐等问题仍然影响着大模型的性能。首先,探讨了提示工程与对齐技术基本原理,提出基于提示优化、专家反馈机制及实时调整机制... 详细信息

大语言模型和视觉语言模型在各领域的应用中展示出巨大潜力,成为研究热点。然而,幻觉、知识迁移、与人类意图对齐等问题仍然影响着大模型的性能。首先,探讨了提示工程与对齐技术基本原理,提出基于提示优化、专家反馈机制及实时调整机制的引导概念,提升了大语言模型在跨领域应用中的性能;其次,深入分析提示工程的核心技术,如多步推理处理复杂任务的原理;然后,针对各领域的实际应用,讨论提示工程的发展现状;最后,总结提示工程面临的挑战并展望其未来发展方向。提示工程在理论与应用方面的发展,为提升大模型在实际应用中的性能提供了全面的解决方案。

关键词：提示工程对齐技术生成式AI 大语言模型视觉语言模型

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Age-period-cohort analysis of pulmonary tuberculosis reported incidence, China, 2006-2020

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Infectious Diseases of Poverty 2022年第4期11卷 62-71页

作者： Zhe Dong qi-qi Wang Shi-Cheng Yu fei Huang jian-jun Liu Hong-yan yao yan-Lin Zhao Chinese Center for Disease Control and Prevention BejingChina

Background:Tuberculosis(TB)poses a severe public health challenge in China and *** study evaluated the effects of age,period,and birth cohort on reported incidence trends of TB based on population and refined the characteristics of high-risk ***:Aggregate data that reported pulmonary tuberculosis(PTB)cases from China Tuberculosis Management Information System(TBIMS)from 2006 to 2020 were used to analyze effect coefficients through the age-period-cohort(APC)model based on intrinsic estimator(IE)method,and converted them into relative risk(RR)to estimate ***:A total of 14.82 million cases of PTB were reported in China from 2006 to 2020,showing a continuous downward *** reporting rate increased with age by age group,with 70-74 years old being 2-3 times higher than that in 20-24 years *** analysis model showed that age effects were bimodal in 20-24 years old[RR=2.29,95%confidence interval(CI):1.73-3.03]and 70-74 years old(RR=1.95,95%CI:1.67-2.27),and lower than the overall average in the groups under 15 years *** results showed that the risk was higher for women under age 40 than men and higher for men over *** risk was higher in urban than in rural areas under 30 years old and slightly higher in rural than in urban between 30 and 64 years *** risk for 15-34 years old was significantly higher in the east than in other *** period effects showed a decreasing trend,and the risk was higher in rural in recent *** for cohorts born in 1961-1965 and 2001-2005,where theRR increased,the later the cohort was born,the lower the *** cohort 1926-1930 in eastern had the highest risk(RR=3.49,95%CI:2.44-4.98).Conclusions:The reported incidence of PTB continued to decline in China from 2006 to *** young(20-24 years old)and the elderly(70-74 years old)were equally at high *** were differences in the age,period and cohort effects on PTB incidence among gender,urban-rural and *** findings

关键词： Pulmonary tuberculosis Reported incidence Age-period-cohort model China

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