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Cryptotanshinone switches target from estrogen receptor α to breast cancer resistance protein(BCRP/ABCG2) to reverse multidrug resistance in breast cancer

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中国药理学与毒理学杂志 2019年第10期 885-886页

作者： ni wen-ting FAN Hui YU Su-yun CHEN wen-xing LU Yin Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica School of Pharmacy Nanjing University of Chinese Medicine

OBJECTIVE Targeting individual molecule is not only difficult to cure multigenic cancers, but also prone to inducing resistance. The so-cal ed multidrug resistance(MDR) in breast cancer is highly associated with estrogen receptor α induction and the overexpression of breast cancer resistance protein(BCRP) ***, one of the strategies to overcome MDR is to inhibit the expression of the transporter by small molecule inhibitors. METHODS Western blotting and RT-PCR were used respectively for quantification of protein expression and m RNA, non-reducing gradientgel electrophoresis and fluorescence resonance energy transfer(FRET) microscopy imaging for determination of BCRP dimer. RESULTS Cryptotanshinone(CPT) a natural anti-cancer compound,was found to bind BCRP and inhibit its membrane dimerization to attenuate its transport function. And this process is dependent on estrogen receptor α(ERα) in breast cancer. Furthermore, the resistant breast cancer cells with high BCRP expression are also sensitive to CPT followed with the inhibition of membrane dimer of BCRP although they are ERα-negative, suggesting that BCRP expression is essential to CPT reversing the ***, the combination of CPT and chemotherapy drugs could obviously enhance the chemotherapeutic effect in vitro. CONCLUSION Totally, we thought that CPT is a novel natural BCRP inhibitor via blocking the formation of BCRP membrane dimer. At the presence of ERα, it functions via ERα regulation, but directly propels BCRP at the absence of ER in resistant cells. CPT can target multi molecules and switch the target from ERα to BCRP in ERα-negative breast cancer, contributing to decrease the occurrence of resistance and reverse multidrug resistance in breast cancer.

关键词： cryptotanshinone breast cancer resistance protein estrogen receptor α multidrug resistance

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Effects of medical adhesives in prevention of complications after endoscopic submucosal dissection

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World Journal of Gastroenterology 2013年第17期19卷 2704-2708页

作者： Yi Zhang Ying Chen Chun-Ying Qu Min Zhou Qian-wen ni Lei-Ming Xu Department of Digestive Endoscopy Xinhua Hospital School of Medicine Shanghai Jiaotong University Shanghai Key Laboratory of Pediatric Digestion and Nutrition

AIM:To evaluate the use of medical adhesive spray in endoscopic submucosal dissection (ESD). METHODS:Patients who underwent ESD between January 2009 and June 2012 (n = 173) were enrolled in the prospective randomized study. Two patients undergoing surgery due to severe intraoperative hemorrhage and failed hemostasis were excluded, and the remaining 171 patients were randomly divided into two groups:group A (medical adhesive group, n = 89) and group B (control group, n = 82). In group A, a medical adhesive spray was evenly applied after routine electrocoagulation and hemostasis using hemostatic clip after ESD. Patients in group B only treated with routine wound management. Intraoperative and postoperative data were collected and compared. RESULTS:In all 171 patients, ESD was successfully completed. There was no significant difference in the average treatment time between groups A and B (59.4 min vs 55.0 min, respectively). The average length of hospital stay was significantly different between group A and B (8.89 d vs 9.90 d, respectively). The incidence of intraoperative perforation was 10.1% in group A and 9.8% in group B, and was not significantly different between the two groups. In all cases, perforations were successfully managed endoscopically and with conservative treatment. The incidence of postoperative delayed bleeding in group A was significantly lower than that in group B (0.00% vs 4.88%, respectively). CONCLUSION:ESD is an effective minimally invasive treatment for gastrointestinal precancerous lesions or early-stage gastrointestinal cancer. Medical adhesive spray is effective in preventing delayed bleeding after ESD, and can thus reduce the average length of hospital stay.

关键词： Endoscopic submucosal dissection Medical adhesive Early-stage gastrointestinal cancer Postoperative delayed bleeding Intraoperative hemorrhage

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Separation of strontium from associated elements with selective specific resin and extraction chromatography

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Chinese Chemical Letters 2013年第7期24卷 633-635页

作者： Shu-Chao Wu Chao-Yang Sun wen-ni Wang Ying-Ting He Sheng-Hong Hu Cun-Jiang Zheng Faculty of Earth Sciences China University of Geosciences Zhejiang Institute of Geology & Mineral Resources Key Laboratory of Global Change and Marine-Atmospheric Chemistry State Oceanic Administration

In this paper, separation of Sr from associated elements （Na, K, Ca, Mg, and Ba） was carried out using an extraction chromatographic column packed with Sr selective specific resin consisting of an octanol solution of 4,4＇（5＇）-bis（t-butylcyclohexo）-lS-crown-6 sorbed on an inert polymeric support. Using 8.0 mol/L HNO3 as the eluent, Ba and associated elements were eluted immediately from the column, whereas Sr was strongly retained. The adsorbed Sr could then be stripped from the column as the eluent was changed to 0.05 mol/L HNO~. Complete Sr/Ba separation was demonstrated to be feasible in that Ba could be washed from the column leaving pure Sr by adequate rinsing with 8.0 mol/L HN03. Furthermore, matrix effect could be effectively eliminated and the selectivity of the method was improved. The method was applied for the determination of Sr in the high purity barium carbonate （BaCO3） product and seawater. The recoveries of Sr in 2 samples were determined to be 93.2% and 109%, respectively.

关键词： Strontium Extraction chromatography Selective specific resin

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Carbon dots crosslinked gel polymer electrolytes for dendrite-free and long-cycle lithium metal batteries

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SmartMat 2022年第2期3卷 323-336页

作者： Zun-Hui Huang Ji-Shi Wei Tian-Bing Song Jia-wen ni Fei Wang Huan-Ming Xiong Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghaiChina Department of Materials Science Fudan UniversityShanghaiChina

Lithium metal batteries(LMBs)with extremely high energy densities have several advantages among energy storage ***,the uncontrolled growth of dendrites and the flammable liquid electrolytes(LEs)often cause safety *** solid-state batteries seem to be the ultimate choice,but solvent-free electrolytes usually fail in terms of conductivity at room ***,gel polymer electrolytes(GPEs)with a simple manufacturing process and high ionic conductivity are considered as the most competitive candidates to resolve the present ***,we design a polymeric network structure via esterification and amidation reactions between polyethylene glycol(PEG)and carbon dots(CDs).After incorporation with polyvinylidene fluoride and some LEs,the as-prepared PEG-CDs composite electrolytes(PCCEs)show a high ionic conductivity of 5.5 mS/cm and an ion transference number of 0.71 at room temperature,as well as good flexibility and *** the PCCEs are assembled with lithium metal anodes and LiFePO4 or LiCoO2 cathodes,both the cycling stability and the retention rate of these LMBs show excellent performance at room temperature.

关键词： carbon dot crosslinking structure gel polymer electrolyte lithium metal battery solid electrolyte interface

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Clinical characteristics and beta-cell function of Chinese children and adolescents with type 2 diabetes from 2009 to 2018

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World Journal of Pediatrics 2019年第4期15卷 405-411页

作者： Zhen-Ran Xu Miao-Ying Zhang Jin-wen ni Ruo-Qian Cheng Zhang-Qian Zheng Li Xi Fei-Hong Luo Department of Pediatric Endocrinology and Inherited Metabolic Diseases Children's Hospital of Fudan University399 Wan Yuan RoadShanghai 201102China

Background The limited available studies have unveiled different natural histories and prognosis associated with pediatric type 2 diabetes (T2D) and adult *** date,data on the clinical features,metabolic profiles and beta-cell function characteristics are still limited in the Chinese pediatric T2D *** A total of 56 children with T2D,31 with prediabetes and 159 with obesity were *** characteristics,metabolic profiles,beta-cell function and insulin resistance were *** The mean onset age of T2D was 12.35 ± 1.99 (7.9-17.8) years,and 7% of children were younger than 10 years;55% of them were male,57% had a family history of diabetes and 64% had classic symptoms,and 25% had a low or high birth weight.89% of T2D patients were obese or overweight.A total of 58% of the patients with prediabetes were *** fast serum C-peptide level was highest in the obesity group (P nificant difference between the T2D and prediabetes *** mean homeostatic model of assessment of beta-cell function was the highest in the obesity group and was lowest in the T2D group (P ning and intervention program for T2D is recommended in high-risk or obese Chinese pediatric populations starting at 7 years.

关键词： Diabetes mellitus,type 2 Obesity Prediabetic state

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COVID-19 infection and inactivated vaccination:Impacts on clinical and immunological profiles in Chinese children with type 1 diabetes

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World Journal of Diabetes 2024年第12期15卷 2276-2284页

作者： Zhen-Ran Xu Li Xi Jing Wu Jin-wen ni Fei-Hong Luo Miao-Ying Zhang Department of Pediatric Endocrinology and Inherited Metabolic Diseases National Children’s Medical CenterChildren's Hospital of Fudan UniversityShanghai 201102China

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has been linked to an increased incidence of diabetes and diabetic ketoacidosis(DKA).However,the relationship between COVID-19 infection and progression to type 1 diabetes(T1D)in children has not been well *** To evaluate the influence of COVID-19 infection and inactivated vaccine adminis-tration on the progression of T1D among Chinese *** A total of 197 newly diagnosed patients with T1D were retrospectively enrolled from Children's Hospital of Fudan University between September 2020 and December *** patients were divided into three groups based on their history of COVID-19 infection and vaccination:the infection group,the vacci-nation-only group,and the non-infection/non-vaccination *** clinical assessments and detailed immunological evaluations were performed to delineate the characteristics and immune responses of these *** The incidence of DKA was significantly higher in the COVID-19 infection group(70.2%)compared to the non-infection/non-vaccination group(62.5%)and vac-scination-only group(45.6%;P=0.015).Prior COVID-19 infection was correlated with increased DKA risk(OR:1.981,95%CI:1.026-3.825,P=0.042),while vacci-nation was associated with a reduced risk(OR:0.558,95%CI:0.312-0.998,P=0.049).COVID-19 infection mildly altered immune profiles,with modest dif-ferences in autoantibody positivity,lymphocyte distribution,and immunoglobulin ***,HLA-DR3 po-sitive children with a history of COVID-19 infection had an earlier T1D onset and lower fasting C-peptide levels than the HLA-DR3 negative children with a history of infection(both Pnificantly lowers DKA incidence at T1D *** findings are valuable for guiding future vaccination and T1D risk surveillance strategies in epidemic scenarios in the general pediatric

关键词： COVID-19 infection Diabetic ketoacidosis Type 1 diabetes Vaccination Immune profiles

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Can Brats Be Promising?

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The Journal of Human Rights 2007年第2期6卷 20-21页

作者： WU ni & wen CHIHUA

It＇s that time of the year again. As millions of his peers anxiously await the results of their university entrance examinations, the successful investment analyst and author of Essentials of Speculation on Stocks an... 详细信息

关键词： Can Brats Be Promising Be high

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A penetrative addictive for water infusion in coal seams

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Journal of University of Science and Technology Beijing 2003年第2期10卷 16-20页

作者： Longzhe Jin, wen ni, Qingsong Wang, and Wei WeiCivil and Environmental Engineering School, University of Science and Technology Beijng, Beijing 100083, China Univ Sci & Technol Beijing Sch Civil & Environm Engn Beijing 100083 Peoples R China

The manufacturing process, characteristics, and application results of arod-like penetrative additive (the penetrative rod) were discussed. The components and functions ofthe penetrative rod were studied carefully. A large number of orthogonal combined tests were carriedout and over 100 sample molds were made. Ultimately the components were decided after carefulselection among these molds, mainly including hygroscopic major components and auxiliary *** results of on-site practical application show that such an addictive can increase the waterpenetrative ability effectively and has a remarkable effect on preventing dust production duringcoal seam excavation. The penetrating radius, the infusing velocity and the dust-preventive effectwere systematically studied.

关键词： coal seam water infusion penetrative penetrative rod additive

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Effects of integrin-targeted photodynamic therapy on pancreatic carcinoma cell

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World Journal of Gastroenterology 2013年第39期19卷 6559-6567页

作者： Min Zhou Qian-wen ni Shan-Ying Yang Chun-Ying Qu Peng-Cheng Zhao Jian-Cheng Zhang Lei-Ming Xu Digestive Endoscopic Diagnosis and Treatment Center Xinhua HospitalSchool of MedicineShanghai Jiaotong University Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition School of Materials Science and Engneering Shanghai University

AIM:To investigate the effects of photodynamic therapy with quantum dots-arginine-glycine-aspartic acid(RGD)probe as photosensitizer on the proliferation and apoptosis of pancreatic carcinoma ***:Construction of quantum dots-RGD probe as photosensitizer for integrin-targeted photodynamic therapy was *** cells were treated with photodynamic therapy(PDT),the proliferation of SW1990 cells were measured by methyl thiazolyl tetrazolium *** changes,cell cycle retardance and apoptosis were observed under fluoroscope and flow *** expression of myeloid cell leukemia-1(Mcl-1),protein kinase B(Akt)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)mRNA were detected by reverse transcriptionpolymerase chain *** amount of reactive oxygen species were also evaluated by fluorescence ***:The photodynamic therapy with quantum dots-RGD probe as photosensitizer significantly inhibited cell proliferation(Pnificant cell apoptosis rate compared to control cells(F=130.617,Pnificant number of cells producing reactive oxygen species compared to control cells(F=3262.559,Pnificantly inhibits cell proliferation and increases apoptosis in SW1990 cells.

关键词： Pancreatic carcinoma Targeted probe Photodynamic therapy Apoptosis Reactive oxygen species

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考虑界面效应的砂土静力触探物质点法模拟

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铁道工程学报 2019年第7期36卷 6-11,18页

作者：文妮张博武汉铁路职业技术学院武汉430205 中国电建集团中南勘测设计研究院有限公司长沙410014

研究目的:静力触探试验广泛应用于工程领域,但室内及原位试验在探究土体内部应变演化机理方面具有一定的困难。相比之下,数值模拟更加高效节约,也更有利于探究土体内部应变演化机理。传统的有限单元法是常用的一种数值方法,但在计算大... 详细信息

研究目的:静力触探试验广泛应用于工程领域,但室内及原位试验在探究土体内部应变演化机理方面具有一定的困难。相比之下,数值模拟更加高效节约,也更有利于探究土体内部应变演化机理。传统的有限单元法是常用的一种数值方法,但在计算大变形问题时会出现网格畸变问题,造成数值困难。基于上述背景,本文引入一种固体力学中的新型数值计算方法--物质点法,能有效避免网格畸变问题,非常适用于岩土大变形问题的分析研究。因此,本文采用物质点法针对静力触探试验开展三维数值模拟工作,探究锥体贯入过程中土体内部塑性变形区域的演化规律及锥头贯入阻力随深度的变化规律;分析砂土内摩擦角、锥体尺寸等因素的变化对贯入阻力的影响;分析静力触探锥体与土体接触面的界面效应,即不同的摩擦系数对锥头贯入阻力的影响。研究结论:(1)采用广义插值物质点法模拟静力触探试验是合理且可行的;(2)随着锥体的贯入,其周围土体将逐渐屈服,产生弹塑性变形并形成明显的破坏区域;随着贯入深度的增大,锥体贯入阻力先逐渐增大,再趋于稳定;(3)根据土体强度及锥体尺寸参数试验,锥头最大贯入阻力随砂土内摩擦角的增大而增大,随锥尖角的增大而增大,随截面面积的增大而减小;(4)锥-土摩擦系数对于贯入阻力的大小具有显著影响,随着摩擦系数的逐渐增大,最大贯入阻力逐渐增大,两者近似呈线性规律;(5)本研究成果主要应用于静力触探试验机理的分析研究工作。

关键词：广义插值物质点法静力触探试验大变形破坏参数试验界面效应

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