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Extranodal natural killer/T-cell lymphoma(nasal type) presenting as a perianal abscess: A case report

World Journal of Clinical Cases 2019年第8期7卷 992-1000页

作者： Yan-ni Liu Yong Zhu Jia-Jun Tan Guang-Shu Shen Shu-Liang Huang Chun-Gen Zhou Shao-Hua Huangfu Rui Zhang Xiao-Bo Huang Ling wang Qi Zhang Bin Jiang Nanjing University of Chinese Medicine Department of Colorectal Surgery The Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Department of Pathology The Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine Department of Medical Imaging The Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

BACKGROUND Extranodal natural killer(NK) T-cell lymphoma(ENKTL), nasal type is a rare subtype of extranodal non-Hodgkin lymphoma characterized by vascular damage and necrosis. The lesions usually present in the nasal cavity and adjacent tissues, however, the disease originates from the gastrointestinal or genitourinary tract in 25% of cases. Since rectal involvement in ENKTL is rare, rectal symptoms in the course of ENKTL are often misdiagnosed and considered to be related to benign diseases such as rectal fistula or perianal *** SUMMARY We report the case of a 24-year-old Han Chinese female who initially presented with a perianal abscess that was subsequently diagnosed as nasal type *** to typical perianal pain, perianal abscess was diagnosed and surgical incision and drainage were performed. After recurrent, severe anal hemorrhages leading to hypovolemic shock and multiple surgeries, a diagnosis of ENKTL was made. The patient's condition gradually deteriorated, and she died shortly after initiation of *** Systemic and neoplastic diseases should be included in the differential diagnosis of any potentially benign perianal abscess complicated with recurrent hemorrhages.

关键词： Extranodal natural killer T-cell lymphoma Perianal abscess Lymphoma Rectal involvement Case report

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捻转血矛线虫虫卵孵化及幼虫L3培养条件的优化

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动物医学进展 2024年第9期45卷 73-76页

作者：马梅清贾晓晴马园郝陆瑶张艳妮李倩楠李炎夫邵瑾杜山丁玉林张磊王瑞内蒙古农业大学兽医学院/农业农村部动物疾病临床诊疗技术重点实验室/国家级动物医学实验教学中心内蒙古呼和浩特010000 内蒙古乌兰察布市四子王旗农牧科技局内蒙古乌兰察布011800

捻转血矛线虫病是由捻转血矛线虫(Haemonchus contortus)寄生于牛、羊等反刍动物的皱胃所引起的一类消化道线虫病。为了优化捻转血矛线虫的体外培养技术,得到纯化的虫株以及稳定的样品,为捻转血矛线虫抗原和基因的分离鉴定、病原检测、... 详细信息

捻转血矛线虫病是由捻转血矛线虫(Haemonchus contortus)寄生于牛、羊等反刍动物的皱胃所引起的一类消化道线虫病。为了优化捻转血矛线虫的体外培养技术,得到纯化的虫株以及稳定的样品,为捻转血矛线虫抗原和基因的分离鉴定、病原检测、疫苗研制及虫体耐药性试验奠定基础。论文对培养基类型、培养液体积、抗生素及二甲基亚砜(DMSO)对捻转血矛线虫卵孵化和虫体生长发育的影响。结果表明,NCTC-109培养基可作为捻转血矛线虫体外培养的首选培养基,200μL培养液体积为最佳培养体积,青-链霉素及两性霉素B的终浓度分别不得超过20%及6.25%,DMSO终浓度要控制在0.625%以下。不同培养基及浓度,常用的抗菌药物和DMSO对捻转血矛线虫的发育均有不同程度的毒性。

关键词：捻转血矛线虫体外培养二甲基亚砜 NCTC-109

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Super-Flexible Through-the-Scope Self-Expandable Metallic Stent Insertion for the Management of Malignant Tortuous Hepatic or Splenic Flexure Colonic Obstruction

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Chinese Medical Journal 2018年第11期131卷 1381-1384页

作者： Kai Yang Yue-Qi Zhu ni-Wei Chen Zhi-Gang wang Ying-Sheng Cheng Department of Radiology and Medical Imaging Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital Shanghai 200233 China Department of Gastroenterology Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital Shanghai 200233 China Department of Surgery Shanghai Jiao Tong University Affiliated Shanghai Sixth People's Hospital Shanghai 200233 China

To the Editor： The methods for obstruction of colon cancer include emergency surgery or self-expanding metallic stents （SEMSs）. SEMS insertion was shown to be a safe, easy, and effective treatment for left-sided malignant colon obstruction, for palliative treatment or as bridge to resection. The cases reported of SEMS insertion in the colon proximal to the splenic flexure were 〈5% of all studies. The long distances and the tortuosity of the distal bowel make it difficult to advance and position the stent in the target proximal colon, and obstruction of right colon has traditionally been managed by acute operation.

关键词： COLORECTAL OBSTRUCTION PLACEMENT

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Proteomics provides individualized options of precision medicine for patients with gastric cancer

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Science China(Life Sciences) 2021年第8期64卷 1199-1211页

作者： Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan wang Shiqi wang Gang Ji Jipeng Li Yongzhan nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi wang Lin Chen Qingchuan Zhao Hongwei wang Lin Shen Jun Qin Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China Department of Pathology The Fourth Medical Center of PLA General HospitalBeijing 100048China State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Department of Digestive SurgeryXijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an 710032China Department of General Surgery&Institute of General Surgery Chinese PLA General Hospital First Medical CenterBeijing 100853China Department of Gastrointestinal Surgery Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of tumor biobank Shanxi Cancer HospitalTaiyuan 030013China Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory BiologyInstitute ofBiomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesInstitute of Biomedical SciencesFudan UniversityShanghai 200433China Life Sciences Institute Zhejiang UniversityHangzhou 310058China

While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been *** patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical *** is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted ***,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of *** identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery *** 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation ***,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care.

关键词： patients chemotherapy cancer

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Peripheral blood transcriptome analysis of patients with ovarian hyperstimulation syndrome through high-throughput sequencing

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Reproductive and Developmental Medicine 2023年第2期7卷 115-121页

作者： Bo Yan Bin Wu Zhi-Qiang wang Yan Wei Ya-Li ni Reproductive Medicine Center Gansu Provincial Maternity and Child-Care HospitalLanzhou 730050China Reproductive Medicine Department Central Hospital Affiliated to Shandong First Medical UniversityJinan 250000China

Objective:Ovarian hyperstimulation syndrome(OHSS)is a frequent iatrogenic complication that arises during assisted reproduction and accounts for approximately 30%of all in vitro fertilization *** high-throughput sequencing,we investigated the peripheral blood transcriptome of patients with ***:Peripheral blood samples were obtained from 15 patients in each of the OHSS high-risk and low-risk groups on the ovum pick-up ***,high-throughput sequencing was used to obtain the peripheral blood transcriptomes of five patients each from the high-and low-risk *** tools were used for mRNA expression profile mapping and screening of differentially expressed genes(DEGs).Bioinformatics techniques were also implemented in the Kyoto Encyclopedia of Genes Genomes(KEGG)signal pathway,Gene Ontology(GO)function,and protein-protein interaction(PPI)network analyses of ***:A total of 20,031 genes were identified and 148 were found to be differentially expressed(P0.58),with 52 upregulated and 96 downregulated *** and KEGG analyses indicated that these genes were involved in extracellular corpuscles(GO:0070062),plasma membrane(GO:0005886),extracellular regions(GO:0005576),immune system response(GO:0006955),PI3K-Akt signaling pathways(hsa04151),cell adhesion molecules(CAMs,hsa04514),focal adhesion(hsa04510),and complement and coagulation cascades(hsa04610).The PPI network and realtime fluorescence quantitative polymerase chain reaction(qPCR)verification predicted that complement C3,von Willebrand factor,and vascular cell adhesion protein 1 proteins are highly implicated in OHSS and may serve as potential biomarkers for future OHSS ***:Transcriptome analysis revealed several DEGs related to OHSS risk factors in the peripheral blood,indicating that these DEGs may be novel players in OHSS development.

关键词： Ovarian hyperstimulation syndrome Transcriptome High-throughput sequencing

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磷酸化纳米铁去除水中Cd^(2+)、Zn^(2+)、ni^(2+)的比较

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环境化学 2024年第6期43卷 1898-1909页

作者：王欣瑶盛杰邹云杰凌岚污染控制与资源化研究国家重点实验室同济大学环境科学与工程学院上海污染控制与生态安全研究院上海200092

重金属污染已成为全球关注的环境问题,镉、镍和锌是工业生产中常见的重金属污染.纳米零价铁是重金属污染控制的重要环境功能材料,其改性优化工作也备受关注.本文采用液相还原法在制备过程中添加KH_(2)PO_(4)合成磷酸化纳米铁(phosphoryl... 详细信息

重金属污染已成为全球关注的环境问题,镉、镍和锌是工业生产中常见的重金属污染.纳米零价铁是重金属污染控制的重要环境功能材料,其改性优化工作也备受关注.本文采用液相还原法在制备过程中添加KH_(2)PO_(4)合成磷酸化纳米铁(phosphorylated nanoscale zero-valent iron,P-nZVI),考察了磷酸化对纳米铁去除Cd^(2+)、Zn^(2+)、ni^(2+)的效果的影响,评估了磷酸化对抗pH、干扰离子影响的效果,并结合XRD、SEM、S/TEM、XPS等表征手段比较了P-nZVI去除3种重金属的作用机制.研究表明,P-nZVI对Cd^(2+)、Zn^(2+)的去除效率均显著优于纳米零价铁(nanoscale zero-valent iron,nZVI),分别为79.6%、90.6%.吸附过程以P-nZVI表面磷酸基团的吸附为主,均可用准二级动力学描述.ni^(2+)的去除包括吸附和还原作用,加剧了铁芯腐蚀,使其去除效率达到92.6%.因此,磷酸化修饰能通过累积零价铁表面负电荷以加速吸附过程;裂纹结构能降低金属离子跨越氧化铁层的阻碍,促进氧化还原,提高Fe0利用率.

关键词：纳米铁磷酸化修饰重金属吸附氧化还原

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Characterization of changes in extracellular polymeric substances and heavy metal speciation of waste activated sludge during typical oxidation solubilization processes

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Journal of Environmental Sciences 2019年第6期31卷 146-158页

作者： Qiongying Xu Huidi wang Qiandi wang Weijun Zhang Dongsheng wang Faculty of Materials Science and Chemistry China University of Geosciences School of Environmental Studies China University of Geosciences Hubei Provincial Engineering Research Center of Systematic Water Pollution Control State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

Biopolymer solubilization is considered to be the rate-limiting stage of anaerobic digestion of waste activated sludge(WAS). Oxidation processes have been proven to be effective in disrupting sludge flocs and causing solubilization of the solid biopolymers. In this study,WAS was treated by NaNO2 or H2 O2 oxidation at p H of 2. The changes in extracellular polymeric substances properties and the speciation of heavy metals were investigated. The results revealed that both NaNO2 and H2 O2 treatments were effective in solubilizing organics in WAS, while the conversion of biopolymers in the two treatment processes was different. Free nitrous acid destroyed the gel network structure of EPS, and organic materials were released from the solid phase to the supernatant. Indigenous peroxidase catalyzed H2 O2 to produce hydroxyl radicals which caused significant solubilization of biopolymers, and the protein-like substances were further degraded into micro-molecule polypeptides or amino acids at high dosages of H2 O2. During the oxidation processes, Zn, Cd and Cu, with excellent mobility, tended to migrate to the supernatant, and thus were easy to remove through the liquid–solid separation process. ni and As showed moderate migration ability, of which the residual fraction tended to transform into reducible and soluble fractions. With poor mobility, Cr and Pb mainly existed in the forms of residual and oxidizable fractions, which were difficult to dissolve and remove from WAS. Both NaNO2 and H2 O2 treatment resulted in the enhancement of sludge solubilization efficiency and heavy metal mobility in WAS, but different heavy metals showed distinct migration and transformation behaviors.

关键词： Extracellular polymeric substances(EPS) Oxidation Biopolymers solubilization Biodegradability Heavy metals

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2型糖尿病合并多代谢紊乱态靶综合治验1例——仝小林院士教学查房实录

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长春中医药大学学报 2024年第5期40卷 473-477页

作者：于晓彤孟祥琨苏浩邓岚田佳星王涵李修洋赵林华倪青中国中医科学院广安门医院北京100053 长春中医药大学长春130117 北京中医药大学北京100029

以广安门医院内分泌科中2型糖尿病合并多代谢紊乱案患者为例,邀请仝小林院士进行教学查房,对早中期2型糖尿病合并多代谢紊乱的中医认识、疾病发展与转归、诊疗要点进行阐述。仝小林院士强调肥胖是脾瘅的基石、分类-分期-分证辨治糖尿病... 详细信息

以广安门医院内分泌科中2型糖尿病合并多代谢紊乱案患者为例,邀请仝小林院士进行教学查房,对早中期2型糖尿病合并多代谢紊乱的中医认识、疾病发展与转归、诊疗要点进行阐述。仝小林院士强调肥胖是脾瘅的基石、分类-分期-分证辨治糖尿病、糖肝共治2型糖尿病合并代谢相关脂肪性肝病;治疗上注重运用靶方靶药,关注有效剂量,预防果态,防治脉损,态靶辨治,提高临床疗效。

关键词： 2型糖尿病脾瘅多代谢紊乱态靶辨治糖肝共治

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Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions

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Chinese Medical Journal 2014年第19期127卷 3364-3370页

作者： Xu Li wang Lefeng Yang Xinchun Li Kuibao Sun Hao Zhang Dapeng wang Hongshi Li Weiming ni Zhuhua Xia Kun Liu Yu Heart Center Beijing Chaoyang.Hospital CapitalMedicl UniversityBeijing 100020

Background Large-scale clinical trials have shown that routine monitoring of the platelet function in patients after percutanous coronary intervention （PCI） is not necessary. However, it is still unclear whether patients received high-risk PCI would benefit from a therapy which is guided by a selective platelet function monitoring. This explanatory study sought to assess the benefit of a therapy guided by platelet function monitoring for these patients. Methods Acute coronary syndrome （ACS） patients （n=384） who received high-risk, complex PCI were randomized into two groups. PCI in the two types of lesions described below was defined as high-risk, complex PCI： lesions that could result in severe clinical outcomes if stent thrombosis occurred or lesions at high risk for stent thrombosis. The patients in the conventionally treated group received standard dual antiplatelet therapy. The patients in the platelet function monitoring guided group received an antiplated therapy guided by a modified thromboelastography （TEG） platelet mapping： If inhibition of platelet aggregation （IPA） induced by arachidonic acid （AA） was less than 50% the aspirin dosage was raised to 200 mg/d; if IPA induced by adenosine diphosphate （ADP） was less than 30% the clopidogrel dosage was raised to 150 mg/d, for three months. The primary efficacy endpoint was a composite of myocardial infarction, emergency target vessel revascularization （eTVR）, stent thrombosis, and death in six months. Results This study included 384 patients; 191 and 193 in the conventionally treated group and platelet function monitoring guided group, respectively. No significant differences were observed in the baseline clinical characteristics and interventional data between the two groups. In the platelet function monitoring guided group, the mean IPA induced by AA and ADP were （69.2＋24.5）% （range, 4.8% to 100.0%） and （51.4＋29.8）% （range, 0.2% to 100.0%）, respectively. The AA- induced IPA of forty-three （22.2%） patients wa

关键词： platelet function antiplatelet therapy, percutanous coronary intervention, acute coronary syndrome

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基于金担载氧化钨纳米线的高性能三乙胺气体传感器研究

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传感技术学报 2022年第9期35卷 1157-1166页

作者：王涛张博倪屹江南大学电子工程系物联网技术应用教育部工程研究中心江苏无锡214122

作为一种有害性气体,三乙胺的检测备受关注。实际上,研究人员近年来已开发出基于多种敏感材料的三乙胺传感器。然而,梳理发现,现有三乙胺传感器的工作温度普遍偏高,且对低浓度三乙胺的检测潜力有限。借助静电纺丝法和高温煅烧工艺,成功... 详细信息

作为一种有害性气体,三乙胺的检测备受关注。实际上,研究人员近年来已开发出基于多种敏感材料的三乙胺传感器。然而,梳理发现,现有三乙胺传感器的工作温度普遍偏高,且对低浓度三乙胺的检测潜力有限。借助静电纺丝法和高温煅烧工艺,成功制备出金担载的氧化钨纳米线。利用X射线粉末衍射、X射线光电子能谱、场发射扫描电子显微镜、透射电子显微镜等手段对样品的微观结构和形貌进行了详尽表征。气敏测试表明,金担载的氧化钨对20×10^(-6)三乙胺的最佳检测温度较纯氧化钨降低了40℃,响应值却提升了4倍。最后给出了相应的敏感机理。

关键词：气体传感器三乙胺检测静电纺丝氧化钨金担载

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