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World Journal of Clinical Cases 2021年第17期9卷 4381-4387页

作者： Da-Wei Xu guang-Liang Li jiong-Han Zhang Fei He Emergency Medicine The Affiliated Suqian Hospital of Xuzhou Medical UniversitySuqian 223800Jiangsu ProvinceChina Intensive Care Unit The Infectious Disease Control CenterSuqian 223800Jiangsu ProvinceChina Emergency Medicine Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210008Jiangsu ProvinceChina

BACKGROUND Since the outbreak of coronavirus disease 2019(COVID-19)in Wuhan,China in December 2019,the overall fatality rate of severe and critical patients with COVID-19 is high and the effective therapy is *** SUMMARY In this case report,we describe a case of the successful combination of the prone position(PP)and high-flow nasal oxygen(HFNO)therapy in a spontaneously breathing,severe COVID-19 patient who presented with fever,fatigue and hypoxemia and was diagnosed by positive throat swab COVID-19 RNA *** therapy significantly improved the patient's clinical symptoms,oxygenation status,and radiological characteristics of lung injury during hospitalization,and the patient showed good tolerance and avoided ***,we did not find that medical staff wearing optimal airborne personal protective equipment(PPE)were infected by the new coronavirus in our *** We conclude that the combination of PP and HFNO could benefit spontaneously breathing,severe COVID-19 *** therapy does not increase risk of healthcare workers wearing optimal airborne PPE to become infected with virus particles.

关键词： COVID-19 Hypoxemia High-flow nasal oxygen Intubation and prone position Case report

A simplified dynamic method for field capacity estimation and its parameter analysis

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Water Science and Engineering 2014年第4期7卷 351-362页

作者： Zhen-tao CONG Hua-fang Lü guang-heng ni Department of Hydraulic Engineering Tsinghua University

This paper presents a simplified dynamic method based on the definition of field capacity. Two soil hydraulic characteristics models, the Brooks-Corey （BC） model and the van Genuchten （vG） model, and four soil data groups were used in this study. The relative drainage rate, which is a unique parameter and independent of the soil type in the simplified dynamic method, was analyzed using the pressure-based method with a matric potential of -1/3 bar and the flux-based method with a drainage flux of 0.005 cm/d. As a result, the relative drainage rate of the simplified dynamic method was determined to be 3% per day. This was verified by the similar field capacity results estimated with the three methods for most soils suitable for cultivating plants. In addition, the drainage time calculated with the simplified dynamic method was two to three days, which agrees with the classical definition of field capacity. We recommend the simplified dynamic method with a relative drainage rate of 3% per day due to its simple application and clearly physically-based concept.

关键词： field capacity simplified dynamic method pressure-based method flux-basedmethod soil water HYDRUS

Emerging novel targets for nonalcoholic fatty liver disease treatment: Evidence from recent basic studies

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World Journal of Gastroenterology 2023年第1期29卷 75-95页

作者： guang-Yan Wang Xiao-Yan Zhang Chun-jiong Wang You-Fei Guan Department of Physiology and Pathophysiology Tianjin Medical UniversityTianjin 300070China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Tianjin 300070China NHC Key Laboratory of Hormones and Development Chu Hsien-I Memorial Hospital and Tianjin Institute of EndocrinologyTianjin 300070China Health Science Center East China Normal UniversityShanghai 200241China Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of Physiology and Pathophysiology School of Basic Medical SciencesDalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Key Laboratory for Nuclear Receptors in Major Metabolic Diseases Dalian 116044Liaoning ProvinceChina

Nonalcoholic fatty liver disease(NAFLD),a leading chronic disease worldwide,affects approximately a quarter of the global *** steatohepatitis(NASH)is an advanced form of NAFLD and is more likely to progress to liver fibrosis than simple *** is also identified as the most rapidly growing cause of hepatocellular *** in the past decade,several phase II/III clinical trials have shown promising results in the use of novel drugs targeting lipid synthase,farnesoid X receptor signaling,peroxisome proliferatoractivated receptor signaling,hepatocellular injury,and inflammatory signaling,proven pharmaceutical agents to treat NASH are still ***,continuous exploration of the mechanism underlying the pathogenesis of NAFLD and the identification of novel therapeutic targets remain urgent tasks in the *** the current review,we summarize studies reported in recent years that not only provide new insights into the mechanisms of NAFLD development but also explore the possibility of treating NAFLD by targeting newly identified signaling *** also discuss evidence focusing on the intrahepatic targets involved in the pathogenesis of NAFLD as well as extrahepatic targets affecting liver metabolism and function.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Pharmaceutical strategies Liver microenvironment Gut-liver axis Adipose tissue-liver axis

Tree-based backoff protocol for fast RFID tag identification

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The Journal of China Universities of Posts and Telecommunications 2013年第2期20卷 37-41页

作者： ZHENG Jia-li QIN Tuan-fa ni guang-nan School of Computer and Electronic Information Guangxi University Institute of Computing Technology Chinese Academy of Science

This paper proposes a tree-based backoff （TBB） protocol that reduces the number of iterations implemented in the procedure of tag collision arbitration in radio frequency identification （RFID） systems. This is achieved by employing the following mechanisms： one is send the request command iteratively to all tags in the interrogation zone until a single tag is identified. The other is backward to the parent node instead of root node to obtain the request parameters and send the request command again until all tags are identified. Compared with the traditional tree-based protocol, on average, simulated results show that the TBB protocol reduces the number of the iterations by 72.3% and the identification delay by 58.6% and achieves the goal of fast tag identification.

关键词： RFID tag collision arbitration tree-based anti-collision protocol

Memory Trace for Fear Extinction:Fragile yet Reinforceable

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Neuroscience Bulletin 2024年第6期40卷 777-794页

作者： Ying Liu Shuai Ye Xin-ni Li Wei-guang Li Department of Rehabilitation Medicine State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceHuashan HospitalInstitute for Translational Brain ResearchFudan UniversityShanghai200032China

Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing *** on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear *** brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain *** questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction *** this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

关键词： Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations

Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo

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Zoological Research 2020年第4期41卷 395-409页

作者： Lei Liu Da-Wei Song guang-Lu Liu Li-Peng Shan Tian-Xiu Qiu jiong Chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Ningbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesMeishan CampusNingbo UniversityNingboZhejiang 315832China Key Laboratory of Applied Marine Biotechnology of Ministry of Education Meishan CampusNingbo UniversityNingboZhejiang 315832China School of Chemistry&Chemical Engineering Zhoukou Normal UniversityZhoukouHenan 466001China

Spring viremia of carp virus(SVCV)causes devastating losses in *** has an advantageous structure for the design of novel antiviral agents with high affinity and *** this study,we evaluated a hydroxycoumarin medicine,i.e.,7-(6-benzimidazole)coumarin(C10),regarding its anti-SVCV effects in vitro and in *** showed that up to 12.5 mg/L C10 significantly inhibited SVCV replication in the epithelioma papulosum cyprini(EPC)cell line,with a maximum inhibitory rate of>97%.Furthermore,C10 significantly reduced cell death and relieved cellular morphological damage in SVCV-infected *** mitochondrial membrane potential(ΔΨm)also suggested that C10 not only protected mitochondria,but also reduced apoptosis in SVCVinfected *** in vivo studies,intraperitoneal injection of C10 resulted in an anti-SVCV effect and substantially enhanced the survival rate of virusinfected ***,C10 significantly enhanced antioxidant enzyme activities and decreased reactive oxygen species(ROS)to maintain antioxidant-oxidant balance within the host,thereby contributing to inhibition of SVCV *** up-regulation of six interferon(IFN)-related genes also demonstrated that C10 indirectly activated IFNs for the clearance of SVCV in *** was beneficial for the continuous maintenance of antiviral effects because of the low viral loads in ***,C10 is suggested as a therapeutic agent with great potential against SVCV infection in aquaculture.

关键词： vivo thereby maintain

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五边形石墨烯氧气吸附与解离特性研究

原子与分子物理学报 2025年第4期42卷 40-44页

作者：吴旌贺丁雅妮郭梦雨陈卫光史金磊河南财政金融学院创新创业学院郑州450046 郑州师范学院物理与电子工程学院郑州市低维纳米材料重点实验室郑州450044

基于密度泛函理论的第一性原理计算方法,研究了O_(2)在五边形石墨烯(PG)上的吸附与解离动力学行为.研究结果表明,PG并不能有效地激发O_(2),形成稳定的氧吸附结构需要克服约0.54 eV势垒,并且吸附的O_(2)分解需要克服约0.82 eV势垒.然而,O... 详细信息

基于密度泛函理论的第一性原理计算方法,研究了O_(2)在五边形石墨烯(PG)上的吸附与解离动力学行为.研究结果表明,PG并不能有效地激发O_(2),形成稳定的氧吸附结构需要克服约0.54 eV势垒,并且吸附的O_(2)分解需要克服约0.82 eV势垒.然而,O_(2)分解后的PG衬底结构却能使后续吸附的O_(2)分子自动分解,破坏C-C键,以致PG在空气中难以稳定存在.基于此,为了避免PG结构在空气中被氧化,我们进一步提出将过渡金属原子吸附PG,使得O_(2)更容易被过渡金属原子吸附与激发,从而避免了PG被氧化.

关键词：五边形石墨烯 O_(2)吸附与解离第一性原理计算

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A Deepfake Detection Algorithm Based on Fourier Transform of Biological Signal

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Computers, Materials & Continua 2024年第6期79卷 5295-5312页

作者： Yin ni Wu Zeng Peng Xia guang Stanley Yang Ruochen Tan School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan430023China School of Mathematics and Computer Science Wuhan Polytechnic UniversityWuhan430048China Paul G.Allen School of Computer Science and Engineering University ofWashingtonSeattleWA98195USA School of Computer Science and Engineering University of CaliforniaSanDiegoCA92093USA

Deepfake-generated fake faces,commonly utilized in identity-related activities such as political propaganda,celebrity impersonations,evidence forgery,and familiar fraud,pose new societal *** current deepfake generators strive for high realism in visual effects,they do not replicate biometric signals indicative of cardiac *** this gap,many researchers have developed detection methods focusing on biometric *** methods utilize classification networks to analyze both temporal and spectral domain features of the remote photoplethysmography(rPPG)signal,resulting in high detection ***,in the spectral analysis,existing approaches often only consider the power spectral density and neglect the amplitude spectrum—both crucial for assessing cardiac *** introduce a novel method that extracts rPPG signals from multiple regions of interest through remote photoplethysmography and processes them using Fast Fourier Transform(FFT).The resultant time-frequency domain signal samples are organized into matrices to create Matrix Visualization Heatmaps(MVHM),which are then utilized to train an image classification ***,we explored various combinations of time-frequency domain representations of rPPG signals and the impact of attention *** experimental results show that our algorithm achieves a remarkable detection accuracy of 99.22%in identifying fake videos,significantly outperforming mainstream algorithms and demonstrating the effectiveness of Fourier Transform and attention mechanisms in detecting fake faces.

关键词： Deepfake detector remote photoplethysmography fast fourier transform spatial attention mechanism

A New Feature Vector Using Selected Line Spectra for Pulsar Signal Bispectrum Characteristic Analysis and Recognition

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Chinese Journal of Astronomy and Astrophysics 2007年第4期7卷 565-571页

作者： Zhen-Hua Xie Lu-Ping XU guang-Ren ni Yan Wang School of Electronic Engineering Xidian University Xi＇an 710071 National Time Service Center Chinese Academy of Sciences Xi＇ an 710600

Average pulse profiles of pulsar signals are analyzed using the bispectrum technique. The result shows that there are nonlinear phase couplings between the two frequency axes of the bispectrum charts, which indicate nonlinear factors in the generation and propagation of pulsar signals. Bispectra can be used as feature vectors of pulsar signals because of their being translation invariant. A one-dimension selected line spectrum algorithm for extracting pulsar signal characteristic is proposed. Compared with selected bispectra, the proposed selected line spectra have the maximum interclass separability measurements from the point of view of the whole one-dimension feature vector. Recognition experiments on several pulsar signals received at several frequency bands are carried out. The result shows that the selected line spectrum algorithm is suitable for extracting pulsar signal characteristics and has a good classification performance.

关键词： pulsars: general-stars: magnetic fields-stars: fundamental parameters (classification)

Preparation of Nanocrystalline 430L Stainless Steel by HEBM and SPS

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Journal of Iron and Steel Research International 2008年第4期15卷 73-76页

作者： ni Hong-wei HE Hang LI guang-qiang LIU Jing Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University ofScience and Technology Wuhan 430081 Hubei China Xiangtan Iron and Steel Group Co Ltd Xiangtan411100 Hunan China

Preparation of nanocrystalline 430L stainless steel by both high-energy ball milling and spark plasma sintering technique has been investigated. The results have shown that the hardness can be improved markedly with an increase in sintering temperature and holding time. The lower the apparent porosity of nanocrystalline 430L stainless steel, the higher is the Vickers-hardness. The tensile strength reached a maximum value of 713 MPa when the sampie was sintered at 1 173 K for 10 min, and then it evidently decreased with an increase in sintering temperature and holding time because of the growth of crystalline grain.

关键词： ferritic stainless steel nanocrystalline spark plasma sintering