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Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management

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Journal of Pharmaceutical Analysis 2024年第1期14卷 16-38页

作者： nguyen Quang Thu nguyen Tran Nam Tien nguyen thi hai yen Thuc-Huy Duong nguyen Phuoc Long Huy Truong nguyen Department of Pharmacology and PharmacoGenomics Research Center Inje University College of MedicineBusan47392Republic of Korea Department of Chemistry University of EducationHo Chi Minh City700000Viet Nam Faculty of Pharmacy Ton Duc Thang UniversityHo Chi Minh City700000Viet Nam

The spread of tuberculosis(TB),especially multidrug-resistant TB and extensively drug-resistant TB,has strongly motivated the research and development of new anti-TB *** strategies to facilitate drug combinations,including pharmacokinetics-guided dose optimization and toxicology studies of first-and second-line anti-TB drugs have also been introduced and *** chromatography-mass spectrometry(LC-MS)has arguably become the gold standard in the analysis of both endo-and exo-genous *** technique has been applied successfully not only for therapeutic drug monitoring(TDM)but also for pharmacometabolomics *** improves the effectiveness of treatment,reduces adverse drug reactions,and the likelihood of drug resistance development in TB patients by determining dosage regimens that produce concentrations within the therapeutic target *** on TDM,the dose would be optimized individually to achieve favorable *** is essential in generating and validating hypotheses regarding the metabolism of anti-TB drugs,aiding in the discovery of potential biomarkers for TB diagnostics,treatment monitoring,and outcome *** article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two ***,we discussed the advantages and disadvantages of this technique in practical *** pressing need for non-invasive sampling approaches and stability studies of anti-TB drugs was ***,we provided perspectives on the prospects of combining LC-MS-based TDM and pharmacometabolomics with other advanced strategies(pharmacometrics,drug and vaccine developments,machine learning/artificial intelligence,among others)to encapsulate in an all-inclusive approach to improve treatment outcomes of TB patients.

关键词： Tuberculosis Therapeutic drug monitoring LC-MS MIPD Pharmacometabolomics Precision medicine

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越南民众与媒介接触情况调查研究

越南民众与媒介接触情况调查研究

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作者： nguyen thi hai yen 重庆大学

学位级别：硕士

进入二十一世纪以来,随着科学技术的飞速发展,传统媒体以及新媒体的出现给受众的选择越来越多。大众与媒介之间有密切关系,不仅影响媒体发展的趋势,而会影响国家的政治、经济、社会的问题。本文从传播学的视角切入,通过选取越南河内市... 详细信息

进入二十一世纪以来,随着科学技术的飞速发展,传统媒体以及新媒体的出现给受众的选择越来越多。大众与媒介之间有密切关系,不仅影响媒体发展的趋势,而会影响国家的政治、经济、社会的问题。本文从传播学的视角切入,通过选取越南河内市纸桥区的奕望后坊、观花坊与福寿县的福寿小镇、寿禄社为调查对象,采用定量与定性结合的研究方法,结合文献分析、数据统计分析等研究方法。根据越南民众与媒介接触情况、特点以及影响因素,进行探讨民众与报纸、广播、电视、网络等四大媒体接触的类型、内容、习惯等方面的异同点。本文采用SPSS 21.0统计分析软件对283个样本数据分为性别、年龄、职业、婚姻情况、受教育程度的变量进行描述分析和相关性分析。研究发现:(1)电视是越南民众最依赖的媒介渠道,此外,网络、报纸在提供信息方面仍然发挥着重要的作用,相比之下,广播的受众较小;(2)民众对电视传播的内容也是最可靠,其次是报纸,再次是广播,最后是网络;(3)男性人群比女性人群更倾向于媒介接触,年龄越大与媒介接触的需求越少,文职人员、大学生比农民、工人与媒介接触的程度更高,未婚人群与媒介接触多于已婚人群,受教育程度高人群比受教育程度低人群接触媒体更有选择;(4)在越南媒体背景下,民众与媒介接触有所变化。趋势和预测如下:男性人口增多是越南媒体发展的潜力,年轻人更倾向于新媒体,电视、报纸、广播都需要数字化才能生存下去,媒介受众逐渐转为网络媒体以及新媒体,受众与媒介接触的需求越来越高。

关键词：媒介接触越南媒体业大众媒介

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中国电视剧在越南的传播及其影响

中国电视剧在越南的传播及其影响

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作者： nguyen thi hai yen（阮氏海燕）华南理工大学

学位级别：硕士

中国电视剧自20世纪80年代开始发轫,伴随着传播技术的飞速发展、电视受众群体的不断壮大,30多年后的今天,电视剧作为当今电视节目的重要形态,已成为大众文化的一种载体。中国电视剧不仅在国内获得比较大的发展和进步,还不断进入海外市场... 详细信息

中国电视剧自20世纪80年代开始发轫,伴随着传播技术的飞速发展、电视受众群体的不断壮大,30多年后的今天,电视剧作为当今电视节目的重要形态,已成为大众文化的一种载体。中国电视剧不仅在国内获得比较大的发展和进步,还不断进入海外市场,包括东南亚、欧美、非洲等区域。就影响所及以及文化传播的角度来看,中国电视剧对东南亚,特别是对越南的影响力尤为巨大。从上个世纪90年代中越邦交正常化以来,中越两国在政治、经济、教育、科技等领域的合作与交流更为广泛和密切。中国电视剧也是伴随着中越邦交正常化进入越南市场,并在越南吸引了大量各阶层的观众。从中越文化交流的角度看,中国电视剧实际上为越南观众提供了一个了解中国社会和文化的窗口。本文研究的题目是“中国电视剧在越南的传播及其影响”,牵涉到中国和越南两国文化。因此本文将从跨文化传播的视角考察中国电视剧在越南的传播历程、影响因素等,并借此进一步研究越南观众对中国电视剧的接受心理。而在这方面,越南国内几乎没有现存的文献,作为一个留学生,希望能在这个方面填补越南跨文化传播研究的空白。本文通过问卷调查法对越南观众进行研究。研究内容主要有四个方面：第一,中国电视剧在越南的传播途径及手段;第二,中国电视剧在越南的传播效果;第三,中国电视剧输入越南的主要类型及受欢迎情况;第四,中国电视剧对越南社会文化的影响。整个调查围绕这四个部分进行,通过调查资料的归类,并结合跨文化传播的系列理论,分析得出中国电视剧在越南传播过程中跨文化传播的内容,影响因素等。最后根据研究结果提出相应的跨文化传播传播建议,以深入探讨越南观众借助中国电视剧完成的文化融合,从而为两国民众在历史和文化层面的沟通和交流提供学识上的贡献。

关键词：中国电视剧跨文化传播越南观众

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汉越社会称谓语对比与教学研究

汉越社会称谓语对比与教学研究

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作者：阮氏海燕（nguyen thi hai yen）苏州大学

学位级别：硕士

本研究旨在探讨汉越社会称谓语的概念、类型以及越南学生在学习汉语社会称谓语时存在的偏误,并提出相应的教学建议与方法。研究采用问卷调查和分析方法,调查了越南留学生学习汉语社会称谓语的情况。在第一章中,介绍了汉越社会称谓语的... 详细信息

本研究旨在探讨汉越社会称谓语的概念、类型以及越南学生在学习汉语社会称谓语时存在的偏误,并提出相应的教学建议与方法。研究采用问卷调查和分析方法,调查了越南留学生学习汉语社会称谓语的情况。在第一章中,介绍了汉越社会称谓语的概念与类型。汉语和越南语社会称谓语的概念被阐述,并总结了它们各自的特点。这为后续章节的比较研究奠定了基础。第二章对汉越社会称谓语进行了对比研究。首先,对现代汉语和越南语的人称代词称谓语进行比较,揭示了它们之间的差异。接着,通过对姓名称谓语、职务称谓语、拟亲属称谓语、通称称谓语和零称谓语的对比分析,我们进一步探讨了两种语言中称谓语的异同之处。第三章重点分析了越南学生在学习汉语社会称谓语时存在的偏误。通过问卷调查和测试,发现了越南学生在运用汉语社会称谓语方面的偏误类型和成因。这有助于了解学生的学习需求,并针对性地提供教学帮助。最后一章提出了越南留学生汉语社会称谓语的学习策略。明确了学习的重点和难点,并给出了相应的教学建议和方法,旨在帮助学生提高汉语社会称谓语的运用能力。这些建议和方法涉及课堂教学、学习资源的利用以及与中国文化的互动等方面。通过本研究,我们可以更深入地了解汉越社会称谓语的特点和差异,为汉语教学提供更具针对性的指导,同时为越南留学生在学习汉语社会称谓语时提供有效的教学支持。这将有助于促进中越语言文化交流,提升留学生的汉语交际能力和跨文化沟通能力。最终,希望本研究通过分析两种语言的社会称谓语相同之处,可以帮助越南留学生更准确地掌握和使用汉语中的社会称谓语。

关键词：汉越对比社会称谓语教学

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奥巴马任期内的越南—美国经济合作分析

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东南亚纵横 2017年第6期 55-61页

作者：阮氏海燕中国人民大学国际关系学院

奥巴马任期内越南—美国的经济合作取得了重大突破,建立了一系列的政治和法规框架,两国在贸易和投资合作领域取得了诸多成果。但越南与美国的双边经济关系仍然存在重大的阻碍,如美国的贸易保护主义和抵制一体化倾向、政治分歧和偏见、... 详细信息

奥巴马任期内越南—美国的经济合作取得了重大突破,建立了一系列的政治和法规框架,两国在贸易和投资合作领域取得了诸多成果。但越南与美国的双边经济关系仍然存在重大的阻碍,如美国的贸易保护主义和抵制一体化倾向、政治分歧和偏见、越南经济体制吸引力不足、市场经济发育程度低等。推动越美经济合作关系格局优化的道路仍然任重道远。

关键词：奥巴马任期越南-美国经济合作限制性问题

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Transient responses of double-curved sandwich two-layer shells resting on Kerr's foundations with laminated three-phase polymer/GNP/fiber surface and auxetic honeycomb core subjected to the blast load

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Defence Technology（防务技术） 2024年第5期35卷 222-247页

作者： nguyen thi hai Van thi Hong nguyen Researcher&Lecturer Faculty of Industrial EducationThe University of Danang-University of Technology and Education48 Cao ThangDanang550000Viet Nam Researcher&Lecturer Faculty of Mechanical EngineeringThuyloi University175 Tay SonDong DaHanoi100000Viet Nam

this work uses refined first-order shear theory to analyze the free vibration and transient responses of double-curved sandwich two-layer shells made of auxetic honeycomb core and laminated three-phase polymer/GNP/fiber surface subjected to the blast *** of the two layers that make up the double-curved shell structure is made up of an auxetic honeycomb core and two laminated sheets of three-phase polymer/GNP/*** exterior is supported by a Kerr elastic foundation with three *** key innovation of the proposed theory is that the transverse shear stresses are zero at two free surfaces of each *** contrast to previous first-order shear deformation theories,no shear correction factor is ***'s exact solution was used to treat the double-curved shell problem with a single title boundary,while the finite element technique and an eight-node quadrilateral were used to address the other boundary *** ensure the accuracy of these results,a thorough comparison technique is employed in conjunction with credible *** problem model's edge cases allow for this kind of *** study's findings may be used in the post-construction evaluation of military and civil works structures for their ability to sustain explosive *** addition,this is also an important basis for the calculation and design of shell structures made of smart materials when subjected to shock waves or explosive loads.

关键词： Blast load Two-layer shell Polymer/GNP/Fiber surface Auxetic honeycomb Shear connectors

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Application of extreme gradient boosting in predicting the viscoelastic characteristics of graphene oxide modified asphalt at medium and high temperatures

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 899-917页

作者： Huong-Giang thi HOANG hai-Van thi MAI Hoang Long nguyen hai-Bang LY University of Transport Technology Hanoi 100000Vietnam

Complex modulus(G^(*))is one of the important criteria for asphalt classification according to AASHTO M320-10,and is often used to predict the linear viscoelastic behavior of asphalt *** addition,phase angle(φ)characterizes the deformation resilience of asphalt and is used to assess the ratio between the viscous and elastic *** is thus important to quickly and accurately estimate these two *** purpose of this investigation is to construct an extreme gradient boosting(XGB)model to predict G^(*)andφof graphene oxide(GO)modified asphaltat medium and high *** data sets are gathered from previously published experiments,consisting of 357 samples for G^(*)and 339 samples forφ,and the se are used to develop the XGB model using nine inputs representing theasphalt binder *** findings show that XGB is an excellent predictor of G^(*)andφof GO-modified asphalt,evaluated by the coefficient of determination R^(2)(R^(2)=0.990 and 0.9903 for G^(*)andφ,respectively)and root mean square error(RMSE=31.499 and 1.08 for G^(*)andφ,respectively).In addition,the model’s performance is compared with experimental results and five other machine learning(ML)models to highlight its *** the final step,the Shapley additive explanations(SHAP)value analysis is conducted to assess the impact of each input and the correlation between pairs of important features on asphalt’s two physical properties.

关键词： complex modulus phase angle graphene oxide asphalt extreme gradient boosting machine learning

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Successful containment of a COVID-19 outbreak in Bach Mai Hospital by prompt and decisive responses

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 234-235页

作者： Van Minh Hoang thi Phuong Thao Tran thi Ngoc Phuong nguyen thi hai yen nguyen Quang Tuan nguyen Hanoi University of Public Health HanoiVietnam Bach Mai Hospital HanoiVietnam

In low-and middle-income countries,tertiary care hospitals frequently face an extremely heavy workload and shoulder an even heavier burden during the COVID-19 *** Mai Hospital(BMH),one of the leading tertiary hospitals in Vietnam,is on the frontline in the fierce battle against *** letter aims to describe how BMH tackles the COVID-19 outbreak in the hospitallevel battle,which could support policymakers in time-management and well-preparation for this unpredictable pandemic.

关键词： prompt income policy

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Investigation of Polymorphisms in Coding Region of OsHKT1in Relation to Salinity in Rice

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Rice science 2016年第6期23卷 334-338页

作者： pham quynh-hoa tran xuan-an nguyen thi-nha-trang tran thi-thuy-anh hoang hai-yen nguyen thi-hong-van tang thi-hanh do thi-phuc Faculty of Biology VNU University of ScienceHanoi334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Agronomy Vietnam National University of AgricultureNgo Xuan Quang StreetTrau QuyGia LamHanoiVietnam

Rice （Oryza sativa） is sensitive to salinity, but the salt tolerance level differs among cultivars,which might result from natural variations in the genes that are responsible for salt tolerance. High-affinitypotassium transporter （HKTs） has been proven to be involved in salt tolerance in plants. Therefore, wescreened for natural nucleotide polymorphism in the coding sequence of OsHKT1, which encodes the HKTprotein in eight Vietnamese rice cultivars differing in salt tolerance level. In total, seven nucleotidesubstitutions in coding sequence of OsHKT1 were found, including two non-synonymous and five synonymoussubstitutions. Further analysis revealed that these two non-synonymous nucleotide substitutions （G50Tand T1209A） caused changes in amino acids （Gly17Val and Asp403Glu） at signal peptide and the loop ofthe sixth transmembrane domain, respectively. To assess the potential effect of these substitutions on theprotein function, the 3D structure of HKT protein variants was modelled by using PHYRE2 webserver. Theresults showed that no difference was observed when compared those predicted 3D structure of HKTprotein variants with each other. In addition, the codon bias of synonymous substitutions cannot clearlyshow correlation with salt tolerance level. It might be interesting to further investigate the functional roles ofdetected non-synonymous substitutions as it might correlate to salt tolerance in rice.

关键词： polymorphism salt stress OsHKT1 gene rice

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Fuzzy MCDM Model for Selection of Infectious Waste Management Contractors

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Computers, Materials & Continua 2022年第8期72卷 2191-2202页

作者： nguyen Van Thanh nguyen Hoang hai nguyen thi Kim Lan Faculty of Commerce Van Lang UniversityHo Chi Minh CityVietnam International Education Institute Van Lang UniversityHo Chi Minh CityVietnam

Healthcare supply chains are under pressure to drive down costs because of digital business,shifting customer needs and new *** waste generated from medical facilities includes medical activities and daily-life activities of patients and their family *** to statistics of the Department of Health EnvironmentalManagement,Vietnam currently has more than 13,500 medical facilities,including hospitals from central to provincial and district levels and private hospitals and medical *** medicine generates about 590 tons of medical waste/day and is estimated to be about 800 tons/*** waste includes ordinary medical waste and hazardous medical waste;in which ordinary medical waste accounts for about 80%–90%,only about 10%–20%is hazardous medical waste including infectious waste and non-infectious hazardous *** is an environmental and occupational health issue that needs attention in developing countries like *** large amounts of medical waste to ensure environmental and personal hygiene,doing so inefficiently creates potential hazards to the environment and increases operating ***,hospitals lack objective criteria and methods to evaluate and select the most optimal infectious medical waste,relying instead on their own subjective assessment and prior ***,the author proposed a fuzzy multicriteria decision making(MCDM)model including Fuzzy Analytic hierarchy process(FAHP)and the Weighted Aggregated Sum-Product Assessment(WASPAS)for infectious medical waste contractors’selection in this *** proposed Fuzzy MCDM method is in-tended to provide a more efficient,accurate method in the selection of infectious medical waste contractors than subjective assessment methods,thus reduce potential risks to *** results of this study can be applied to evaluate and select contractors in other industries.

关键词： MCDM model fuzzy theory fuzzy AHP WASPAS medical waste contractors

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