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Clinical validation of the early embryo viability assessment system: Analysis for the blastocyst morphology and pregnancy outcomes

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Asian pacific Journal of Reproduction 2024年第5期13卷 219-227页

作者： Vu D Hop An M Cuong Phi t t Anh nguyen t L Huong Le Hoang nguyen V Hanh Assisted Reproductive technology Centre Tam Anh General HospitalHanoiVietnam institute of Biotechnology Vietnam Academy of Science and TechnologyHanoiVietnam

Objective:to determine the relationship between the early embryo viability assessment(EEVA)and blastocyst morphological parameters and pregnancy ***:t.is retrospective cohort study was conducted on 291 intracytoplasmic sperm injection cycles including 2522 embryos with indications of prolonging embryo culture to the blastocyst stage in the Genea embryo review incubator,and 511 single vit.ified-warmed blastocyst transfer cycles from January 2020 to June *** EEVA system produced an EEVA score from E1(best)to E5(worse)for the potential of blastocyst *** morphology was *** association between the EEVA score and each type of blastocyst morphology,implantation rate,clinical pregnancy,and ongoing pregnancy were assessed using generalized estimating ***:the inner cell mass A(iCM A),trophectoderm A(tE A),blastocoele expansion degree of 3,4,5,6,7 rates were higher with lower the EEVA *** adjusted odd ratio(aOR)(E5 vs E1)was 0.3 for iCM A,0.174 for tE A and 0.210 for BL3,4,5,6,7(all Pting a significant association between lower EEVA scores and improved embryo *** implantation,clinical pregnancy,and ongoing pregnancy rate were also higher with lower the EEVA *** aOR of E5 vs E1 was 0.245 for implantation,0.185 for clinical pregnancy and 0.200 for ongoing pregnancy rate(Pions:there were associations between blastocyst morphology,pregnancy outcome and EEVA *** good blastocyst morphology and pregnancy outcomes are higher with lower the EEVA score.

关键词： Automated embryo assessment Blastocyst Early embryo viability assessment Genea embryo review incubator

Prevalence and outcomes of neonates with severe COViD-19:An observational study at Children’s Hospital 1 in Ho Chi Minh City,Vietnam

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Asian Pacific Journal of tropical Medicine 2024年第9期17卷 392-399,I0001页

作者： Phung nguyen the nguyen tran thanh thuc nguyen thanh Hung Ngo Ngoc Quang Minh Dang Quoc Duy tran Minh Nhut nguyen Hoang Dung tran nguyen Ai Nuong Dinh nguyen Cam tu Department of Pediat.ics University of Medicine and Pharmacy at Ho Chi Minh cityHo Chi Minh CityVietnam Children’s Hospital 1 Ho Chi Minh CityVietnam Pediat.ic Department School of MedicineVietnam National University Ho Chi Minh CityVietnam

Objective:to evaluate the impact of the severe COViD-19 pandemic on neonates and develop strategies to improve their ***:We conducted an observational cross-sectional study at Children's Hospital 1(CH1)from July 25,2021,to May 31,*** neonates who had fever or respiratory symptoms or were born from mothers with COViD-19 and had a positive Rt-PCR SARS-CoV-2 result would be *** classified neonates with COViD-19 into 2 groups:mild/moderate and severe for *** between groups were analyzed using Fisher's exact test/Chi-square test for categorical variables and Student's t-test/Wilcoxon Rank Sum test for continuous ***:t.is study included 88 newborns who had positive Rt-PCR SARS-CoV-2 *** severity COViD-19 rate among neonatal cases was found to be 13.6%(12/88),with a corresponding mortality rate of 1.1%(1/88).All severe cases showed lung abnormalities as evident on chest X-ray *** addition to respiratory symptoms,a higher incidence of gastrointestinal manifestations,such as vomiting and diarrhea,was observed in the severe group,indicating a compelling *** administration of anticoagulant and anti-inflammatory drugs in the study group resulted in a satisfactory outcome with no significant ***:the COViD-19 pandemic has had a substantial impact on the well-being of *** management of COViD-19 in t.is population presents significant challenges.

关键词： COViD-19 Neonate Anti-inflammatory Anticoagulant

EP Aquarii:A New Picture of the Circumstellar Envelope

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Research in Astronomy and Astrophysics 2024年第3期24卷 83-105页

作者： Pham t.Nhung Do t.Hoai Pierre Darriulat Pham tuan-Anh Pham N.Diep nguyen B.Ngoc tran t.thai Department of Astrophysics Vietnam National Space CenterVietnam Academy of Science and Technology18Hoang Quoc VietNghia DoCau GiayHa Noivietnam

New analyses of earlier ALMA observations of oxygen-rich AGB star EP Aquarii are presented,which complete a previously published analysis and offer a different.interpretation of the morpho-kinematics of the circumstellar *** birth of the equatorial density enhancement(EDE)is shown to occur very close to the star where evidence for rotation has been *** to the star and where outflows have been observed:their interaction with the gas of the nascent EDE is seen to play an important role in the development of the wind and the evolution of its radial velocity from 8 to 10 km s^(-1) on the polar symmetry axis to~2 km s^(-1) at the *** implies complex morpho-kinematics:making reliable interpretations with reasonable confidence is *** particular,it questions an earlier interpretation implying the presence of a white dwarf companion orbiting the star at an angular distance of -0″4 from its *** proposes instead an interpretation in terms of a standard mass ejection associated with a shock wave leaving a void of emission in its *** Doppler velocity wings are seen to consist of two components,the upper velocity end of the global wind,reaching above±12 km s^(-1),and an effective line broadening,confined wit.in 200 mas from the center of the star,reaching above±20 km s^(-1) and interpreted as caused by the pattern of shock waves resulting from the interaction between stellar pulsation and convective cell partition.

关键词： stars AGB and post-AGB-(stars) circumstellar matter-radio lines stars

Discovering peptides and computational investigations of a multiepitope vaccine target Mycobacterium tuberculosis

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Synthetic and Systems Biotechnology 2024年第3期9卷 391-405页

作者： truc Ly nguyen Heebal Kim Department of Agricultural Biotechnology and Research institute of Agriculture and Life Sciences Seoul National UniversitySeoul08826Republic of Korea interdisciplinary Program in Bioinformatics Seoul National UniversitySeoul08826Republic of Korea eGnome Inc.Seoul05836Republic of Korea

Mycobacterium tuberculosis(MtB)is the causative agent of tuberculosis(tB),a prevalent airborne infectious *** the availability of the Bacille Calmette-Guerin vaccine,its global efficacy remains modest,and tuberculosis persists as a significant global public health *** t.is challenge and advancing towards the End MtB Strategy,we developed a multiepitope vaccine(MEV)based on immunoinformatics and compu-tational *** screening of MBt prot.in identified immune-dominant epitopes based on Major Histocompatibility Complex(MHC)allele binding,immunogenicity,antigenicity,allergenicity,toxicity,and cytokine *** epitopes were integrated into an MEV construct with adjuvant and linkers,forming a fully immunogenic vaccine *** analyses encompassed the evaluation of immunological and physicochemical properties,determination of tertiary structure,molecular docking with toll-Like Receptors(tLR),molecular dynamics(MD)simulations for all atoms,and immune *** MEV comprises 534 amino acids,featuring 6 cytotoxic t lymphocyte,8 helper t lymphocyte,and 7 linear B lymphocyte epitopes,demonstrating high antigenicity and ***,molecular docking studies and t.iplicate MD simulations revealed enhanced interactions and stability of MEV with the tLR4 complex compared to *** addition,the immune simulation indicated the capacity to effectively induce elevated levels of an-tibodies and cytokines,emphasizing the vaccine’s robust.immunogenic *** study presents a promising MEV against tB,exhibiting favorable immunological and physicochemical *** findings provide theoretical support for tB vaccine *** study aligns with the global initiative of the End MtB Strategy,emphasizing its potential impact on addressing persistent challenges in tB control.

关键词： Mycobacterium tuberculosis tuberculosis Multiepitope vaccine Docking molecular Molecular dynamics simulation immune simulation

A Complex Fuzzy LStM Network for temporal-Related Forecasting Problems

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Computers, Materials & Continua 2024年第9期80卷 4173-4196页

作者： nguyen tho thong nguyen Van Quyet Cu nguyen Giap nguyen Long Giang Luong t.i Hong Lan institute of information technology Vietnam Academy of Science and TechnologyHoang Quoc VietCau GiayHanoi100000Vietnam Academic Affairs Department Thai Nguyen University of EducationThai Nguyen250000Vietnam Center of Science and technology Research and Development Thuongmai UniversityHo Tung MauCau GiayHanoi100000Vietnam Faculty of information technology Hanoi University of IndustryBac Tu LiemHanoi100000Vietnam

time-stamped data is fast and constantly growing and it cont.ins significant.information thanks to the quick development ofmanagement platforms and systems based on the internet and cut.ing-edge information communication *** the time series data including time series prediction has many practical *** new techniques were developed for use with various types of time series data in the prediction *** those,t.is work suggests a unique strategy to enhance predicting quality on time-series datasets that the timecycle matters by fusing deep learning methods with fuzzy *** order to increase forecasting accuracy on such type of time-series data,t.is study proposes integrating deep learning approaches with fuzzy ***,it combines the long short-termmemory network with the complex fuzzy set theory to create an innovative complex fuzzy long short-term memory model(CFLStM).the proposed model adds a meaningful representation of the time cycle element thanks to a complex fuzzy set to advance the deep learning long short-term memory(LStM)technique to have greater power for processing time series *** on standard common data sets and real-world data sets published in the UCi Machine Learning Repository demonstrated the proposedmodel’s utility compared to other well-known forecasting *** results of the comparisons supported the applicability of our proposed strategy for forecasting time series data.

关键词： Complex fuzzy set long short-term memory(LStM) CFLStM t-CFLStM

Genetics of Gallstone Disease and their Clinical Significance: A Narrative Review

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Journal of Clinical and translational Hepatology 2024年第3期12卷 316-326页

作者： Christopher J.Costa Minh thu t.nguyen Haleh Vaziri George Y.Wu Department of Medicine University of Connecticut Health CenterFarmingtonCTUSA Division of Gastroenterology and Hepatology University of Connecticut Health CenterFarmingtonCTUSA

Gallstone(GS)disease is common and arises from a combination of genetic and environmental *** genetic abnormalities specifically leading to cholesterol GSs are rare,there are clinically significant gene variants associated with cholesterol *** contrast,most bilirubin GSs can be att.ibuted to genetic *** pathogenesis of cholesterol and bilirubin GSs differs *** GSs are notably influenced by genetic variants wit.in the ABC prot.in superfamily,including ABCG8,ABCG5,ABCB4,and ABCB11,as well as genes from the apolipoprot.in family such as ApoB100 and ApoE(especially the E3/E3 and E3/E4 variants),and members of the MUC ***,bilirubin GSs are associated with genetic variants in highly expressed hepatic genes,notably UGt1A1,ABCC2(MRP2),ABCC3(MRP3),CFtR,and MUC,alongside genetic defects linked to hemolytic anemias and conditions impacting *** genetic cases constitute a small portion of GS disease,recognizing genetic predisposition is essential for proper diagnosis,treatment,and genetic counseling.

关键词： Gallstones Cholelit.iasis AtP-binding cassette transporters ABCG8 prot.in Human UDP-glucuronosyltransferase A1

Anti‐sloshing control:Flatness‐based trajectory planning and tracking control with an integrated extended state observer

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iEt Cyber-Systems and Robotics 2024年第3期6卷 31-48页

作者： Khanh nguyen Viet Minh Do Duc thanh Cao Duc tung Lam nguyen School of Elect.ical and Electronic Engineering Hanoi University of Science and TechnologyHanoiVietnam Vietnam Maritime University HaiphongVietnam

the phenomenon of sloshing causes a significantly negative impact on a wide range of indust.ies.A time‐optimal flatness‐based trajectory planning and Lyapunov‐based model predictive control(LMPC)is proposed for trajectory tracking of a transmit.ing cylindrical cont.iner filled with ***,t.is research presents an equivalent discrete model based on a mass‐spring‐damper ***,after the flatness of the adopted non‐linear model for 2D is established,time‐optimal trajectories are introduced.A control method called LMPC is shown to solve the problem of orbital tracking,which allows set.ing limits for state *** addition,to ensure system performance,a linear extended state observer(LESO)is integrated to cope with system ***,the efficiency of the proposed approach for liquid sloshing suppression and tracking is illustrated by simulations.

关键词： control dynamic model motion planning

越南北江农林大学中文专业 ——教学现状调查及发展策略研究

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越南北江农林大学中文专业 ——教学现状调查及发展策略研究

作者：阮氏清水（nguyen t.i tHANH thuy）广西大学

学位级别：硕士

integrating immunoinformatics and computational epitope prediction for a vaccine candidate against respiratory syncytial virus

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infectious Disease Modelling 2024年第3期9卷 763-774页

Respiratory syncytial virus(RSV)poses a significant global health threat,especially affecting infants and the *** t.is,the present study proposes an innovative approach to vaccine design,utilizing immunoinformatics and computational *** analyzed RSV's structural prot.ins across both subtypes A and B,identifying potential helper t lymphocyte,cytotoxic t lymphocyte,and linear B lymphocyte *** such as antigenicity,allergenicity,toxicity,and cytokine-inducing potential were rigorously ***,we evaluated the conservancy of these epitopes and their population coverage across various RSV *** comprehensive analysis identified six major histocompatibility complex class i(MHC-i)binding,five MHC-ii binding,and three B-cell *** were integrated with suitable linkers and adjuvants to form the ***,molecular docking and molecular dynamics simulations demonstrated stable interactions between the vaccine candidate and human toll-like receptors(tLR4 and tLR5),with a notable preference for *** simulation analysis underscored the vaccine's potential to elicit a strong immune *** study presents a promising RSV vaccine candidate and offers theoretical support,marking a significant advancement.in vaccine development ***,the promising in silico findings need to be further validated through additional in vivo studies.

关键词： Respiratory syncytial virus Multiepitope vaccine immunoinformatics Docking molecular Molecular dynamics simulation immune simulation